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WO/2007/061036A1 |
Disclosed is a contrast medium comprising a fullerene derivative. The fullerene derivative has a water-soluble polymer and a chelating molecule having a metal ion coordinated therein or a molecule bound to a magnetic material both attach...
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WO/2007/062333A2 |
The invention is directed to the L-tartrate salt of trans-3-aminocyclobutyl (lS,2R,3S,4S:,6R,7R,8R-,14R)-4-ethenyl-3-hydroxy-2,4,7, 14-tetramethyl-9- oxotricyclo[5.4.3.01,8]tetradec-6-yl imidodicarbonate (Compound IA.) Compound IA is use...
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WO/2007/062334A2 |
The invention is directed to the ethanedisulfonate salt of trans-4-aminocyclohexyl (lS, 2R, 3S, 4S, 6R, 7R, 8R, 14R )-4-ethenyl-3-hydroxy-2,4J7,14-tetramethyl-9- oxotricyclo[5.4.3.01,8]tetradec-6-yl imidodicarbonate (Compound IA.) Compou...
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WO/2007/056455A2 |
The present invention relates to carbamoyl N-protected aminoindane derivatives, preferably carbamoyl N-Boc aminoindane derivatices, which are useful intermediates for the preparation of compounds used in the treatment of various CNS diso...
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WO/2007/054254A1 |
The invention related to a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially renin inhibitors, such as Aliskiren. Inter alia, the invention relates to a pr...
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WO/2007/056403A2 |
The present invention relates to the asymmetric hydrogenatioπ of acyl enamides for preparing carbamoyl acylamide indan derivatives, which are useful intermediates for the preparation of compounds used in the treatment of various CNS dis...
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WO/2007/056469A2 |
Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.
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WO/2007/049656A1 |
Disclosed are a novel fluoroadamantane derivative and a method for producing the same. Specifically disclosed are a method for producing a compound (2) shown below wherein a compound (1) shown below is reacted with an azide and then subj...
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WO/2007/048642A1 |
The invention relates to a new and useful process for preparing N,N-substituted carbamoyl halides from secondary amines, carbon dioxide, trialkylsilyl chloride and a halogenating agent.
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WO/2007/048557A1 |
Compounds of the formula (I), wherein R1, R2, X and N are as defined in the specification; L is F, NH2, NHAlk or N(Alk)2 n is 1 or 2; A' and A" are terminal groups as defined in the specification. The compounds have utility as HIV-1 prot...
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WO/2007/044100A1 |
The present invention relates to novel methods for the preparation of glutamic acid derivatives and intermediates thereof, and such compounds prepared by the novel methods.
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WO/2007/038677A2 |
Provided are processes for preparing crystalline ladostigil tartrate form A1. Ladostigil tartrate is carbamic acid, ethylmethyl-, (3R)-2,3-dihydro-3-(2-propynylamino)-1H-inden-5-yl ester, (2R,3R)-2,3-dihydroxybutanedioate (2:1), its chem...
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WO/2007/038676A2 |
Provided are polymorphic forms of ladostigil tartrate and methods for preparation thereof.
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WO/2007/034812A1 |
Disclosed are a carrier for use for separation purpose and a method for separation of a compound which enable a chemical reaction to be performed in a liquid phase, enable a compound of interest to be separated from the liquid phase afte...
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WO/2007/035890A1 |
The invention encompasses processes for the synthesis of (S)-(+)-3- (aminomethyl)-5-methylhexanoic acid, (S)-Pregabalin, and intermediates of (S)-Pregabalin.
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WO/2007/035003A1 |
A process for producing optically active 1-methyl-3-phenylpiperazine, which is represented by the formula (11), or a salt thereof. It comprises the following steps (1) to (4) or comprises the following steps (5) to (7) and the step (4). ...
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WO/2007/032498A1 |
A process for producing an intermediate of a compound which shows an effect of inhibiting activated blood coagulation factor Xa and, therefore, is useful as a preventive and a remedy for thrombotic diseases. Namely, a process for produci...
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WO/2007/029364A1 |
It is intended to provide an MGB polyamide hybrid compound which has a function of recognizing a base sequence useful in gene therapy, is efficacious in synthesizing an oligomer and has a high stability. An MGB polyamide hybrid compound ...
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WO/2007/025481A1 |
The present invention relates to a process for preparing (S)-N-ethyl-N-methyl-3-[1-(dimethylamino)ethyl]-phenyl carbamate (i.e. (S)-rivastigmine) ( I ) and tartrate ( II ) thereof, which includes the following steps: reacting 3-(1-(S)-(N...
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WO2007005774A9 |
Novel amino acid derivatives are provided that are useful for management of disorders such as obesity and immunological diseases. The derivatives are also useful in lowering blood glucose levels in hyperglycemic disorders and for treatin...
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WO/2007/027599A1 |
This invention provides compounds of Formula (I) having the structure where R1, R2, R3 and A are defined in the specification or a pharmaceutically acceptable salt thereof useful as antibacterial agents. Compounds according to Formula (I...
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WO2006127941A9 |
Provided is amorphous cinacalcet hydrochloride, processes for the preparation thereof, and pharmaceutical compositions therewith.
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WO/2007/017728A2 |
The present invention relates to novel compounds of the general formula (I), their derivatives, their analogs, their stereoisomers, their pharmaceutically acceptable salts and compositions. The present invention more particularly provide...
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WO/2007/017670A1 |
Compounds of formula (I) have muscarinic M3 receptor modulating activity; Formula(I) wherein A is an oxygen atom or group -N(R12)-;(i) R1 is C1-C6-alkyl or a hydrogen atom; and R2 is a hydrogen atom or a group -R5, -Z-Y-R5 -Z-NR9R10; -Z-...
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WO/2007/017094A1 |
The present invention relates to novel substituted benzyloxy-phenylmethylcarbamate derivatives, processes for their preparation, and their use in medicaments, especially for the prophylaxis and treatment of diseases associated with Cold ...
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WO/2007/017092A1 |
The present invention relates to novel substituted 4-benzyloxy-benzoic acid amide derivatives, processes for their preparation, and their use in medicaments, especially for the prophylaxis and treatment of diseases associated with Cold M...
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WO/2007/017093A1 |
The present invention relates to novel substituted 2-benzyloxy-benzoic acid amide derivatives, processes for their preparation, and their use in medicaments, especially for the prophylaxis and treatment of diseases associated with Cold M...
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WO/2007/014973A2 |
The invention relates to a method of obtaining phenyl carbamates (I), wherein R1 is lower alkyl C1-C5 or benzyl and R2 is methyl, ethyl or propyl, consisting in reacting L-(S)-3-[(1-methylamino)ethyl]phenol, in the presence of a base, wi...
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WO/2007/005583A1 |
The present invention provides methods for preparing TLR-4 receptor agonist E6020 formula(I): and stereoisomers thereof, which compounds are useful as an immunological adjuvants when co-administered with antigens such as vaccines for bac...
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WO/2007/002013A2 |
Acyloxyalkyl carbamate prodrugs of trans-4-(aminomethyl)- cyclohexanecarboxylic acid, pharmaceutical compositions thereof, methods of making prodrugs of trans-4-(aminomethyl)-cyclohexane-carboxylic acid, and methods of using prodrugs of ...
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WO/2007/002343A2 |
Disclosed in embodiments herein is a method of synthesizing device forming monomers using N-(Vinyloxycarbonyloxy) succinimide.
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WO/2007/002639A2 |
The present disclosure provides amide-based, non-nucleoside compounds having antiviral activity against Hepacivirus, such as hepatitis C virus (HCV) , methods and intermediates for synthesizing such compounds, and methods of using the co...
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WO/2007/000098A1 |
The invention, discloses substituted p-trifluoromethyl phenylethers of formula (I), the preparation and the use thereof, wherein each substituent is defined as in the description. The compounds of the invention have broad spectrum activi...
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WO/2006/135694A2 |
Disclosed herein are novel aromatic-containing compounds and methods for using various aromatic-containing compounds for treatment and prevention of diseases and disorders related to the Urotensin II receptor.
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WO/2006/131381A1 |
The invention relates to a method for producing N-aryl carbamates (urethanes) and N-aryl isocyanates. According to said method, aromatic nitro compounds are subjected to a reductive carbonylation in the presence of carbon dioxide and org...
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WO/2006/128657A1 |
The use of a metathesis catalyst in the preparation of a functionalized sphingolipid.
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WO/2006/125451A1 |
The present invention relates to compounds of formula (I) wherein R1, R2, R3, R4, X, W, m and n are as defined in the description and claims. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated ...
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WO/2006/126255A1 |
A process for producing N-(2-bromoethyl)carbamic acid tert-butyl ester in high working efficiency, in high yield and in safety, in a simple operation with easily handling the final product is provided. The process for producing N-(2-brom...
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WO/2006/125688A1 |
The invention relates to benzoyl-substituted serine amides of formula (I), in which the variables R1 to R11 are defined as cited in the description and to their salts that can be used for agricultural purposes. The invention also relates...
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WO/2006/127203A2 |
The present invention is directed to a method of synthizing compounds of formula (I), wherein X, Z, V, R1, R3, R4, G2, n, x, y, and z are defined herein. This invention also includes a method of preparing acid compounds of formula (VII),...
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WO/2006/127932A2 |
Isolated cinacalcet carbamate, processes for the preparation thereof, and processes for the use of cinacalcet carbamate as a reference marker and standard are provided. Also provided are cinacalcet salts substantially free of cinacalcet ...
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WO/2006/122776A1 |
The invention relates to substituted benzo-condensed cycloheptanone derivatives, to methods for producing them, to drugs containing said compounds and to the use of said compounds for producing drugs.
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WO/2006/123767A1 |
Disclosed is a method for commercially producing a spiroaminopyrrolidone derivative as an intermediate for a quinolone antibacterial agent. Specifically disclosed is a method for producing a compound represented by the formula (2) below ...
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WO/2006/120574A2 |
The invention relates to analogs of 4-hydroxyisoleucine, and to lactones, pharmaceutically acceptable salts, and prodrugs thereof, to processes for their preparation, and to pharmaceutical compositions comprising the same. The analogs of...
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WO/2006/120577A1 |
A process for manufacturing (R)-propynylaminoindans, and alternatively, a process for manufacturing (S)- propynylaminoindans. The chiral propynylaminoindans include alkoxy or alkylcarbamates derivatives. The process comprises transfer or...
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WO/2006/122072A2 |
The present invention relates to processes for preparing biaryl ureas derivatives and analogs thereof. The invention also provides compounds useful as intermediates in the processes of the present invention. The process is useful for pre...
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WO/2006/117461A2 |
The invention relates to derivatives of formula (I), wherein R1 is an C5-26-alkyl, C5-26-alkenyl, C5-26 alkynyl group or a polyunsaturated aliphatic carbon group containing from 5 to 26 carbon atoms and comprising at leas two unsaturatio...
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WO2006093823A9 |
This invention provides aryl and heteroaryl compounds of formula (X). The compounds of the invention may be useful as antagonists, or partial antagonist of factor IX and/or factor Xl and thus, may be used to inhibit the intrinsic pathway...
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WO/2006/115230A1 |
A compound having a structure which comprises a backbone and, bonded thereto, a side chain having an amino acid or oligopeptide. The compound is represented by the following general formula (1). [Chemical formula 1] (1) [In the formula (...
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WO/2006/114264A1 |
The invention provides compounds of formula (I), wherein the substituents are as defined in the specification, to processes for their preparation and their use as pharmaceuticals.
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