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WO/2020/207129A1 |
Disclosed is an ammonium salt with a structural formula represented by formula (I). A synthesis method thereof comprises using 8 mol% zinc chloride as a catalyst, 5 mmol of 1-phenyl-1,3-butanedione, 1.2 g of benzylamine, and 40 mL of chl...
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WO/2020/193419A1 |
The present invention relates to novel compounds, pharmaceutical compositions comprising such compounds and their use for treating, alleviating or preventing diseases or disorders relating to the activity of potassium channels.
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WO/2020/196553A1 |
The purpose of the present invention is to provide a method that enables efficient and safe production of an N-substituted trihaloacetamide which also serves as a synthetic intermediate for isocyanate compounds, carbamate compounds, urea...
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WO/2020/189540A1 |
The present invention provides a method for efficiently preparing various optically active aromatic amino acid derivatives by performing a reaction, in the presence of a catalyst, on a specific ester compound by using an aromatic halide ...
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WO/2020/169054A1 |
The present invention relates to crystalline forms I and II of a (E)-α,β-unsatured amide compound, preparation methods therefor, and uses thereof. The crystalline forms all have excellent properties in physical and chemical stability a...
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WO/2020/167829A1 |
The present disclosure provides a method of preparing a compound of Formula I, wherein R1 is C1-C4 alkyl; R2 is C1-C4 alkyl; and R3 is selected from the group consisting of C1-C6 alkyl, (aryl)alkyl, and (heteroaryl)alkyl in >95% chemical...
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WO/2020/158931A1 |
The purpose of the present invention is to provide: a novel compound which is useful as a film forming material for lithography or as a material for forming an optical component; a resin which contains a constituent unit that is derived ...
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WO/2020/150639A1 |
The present disclosure provides therapeutic methods of treating a cancer in a subject with isopropyl (S)-2-((S)-2-acetamido-3-(1H-indol-3-yl)propanamido)-6-diazo
-5-oxohexanoate or isopropyl (S)-2-((S)-6-acetamido-2-((3S,5S,7S)-adamantan...
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WO/2020/148760A1 |
The invention generally concerns a novel class of CB 1 receptor binding molecules and uses thereof.
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WO/2020/145584A1 |
The present invention relates to a novel serine derivative compound having improved blood-brain barrier (BBB) permeability, and a use of same, and more specifically, to a novel serine derivative compound having further improved BBB perme...
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WO/2020/143198A1 |
Ketamine derivatives and pharmaceutical compositons thereof are disclosed. When administered orally the ketamine derivatives provide increased bioavailability of ketamine in the systemic circulation. The ketamine derivatives can be used ...
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WO/2020/137545A1 |
A method for producing an amide, wherein after causing a dehydration condensation of carboxylic acids or a reaction between a carboxylic acid and a halogenated formic acid ester, a first base is reacted therewith and an amine is reacted ...
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WO/2020/123792A1 |
The present disclosure includes compositions and methods for improved DNA amplification reactions. In particular, the present disclosure provides compositions and methods for hot-start PCR applications using DNA polymerase inhibitors tha...
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WO/2020/122182A1 |
The present inventor found that the membrane permeability of a peptide compound can be improved by employing at least one amino acid which has a side chain capable of forming an intermolecular hydrogen bond, as one of the amino acids con...
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WO/2020/119908A1 |
The present invention relates to (meth)acrylate-functionalized waxes and curable compositions, such as anaerobic adhesive compositions, made therewith.
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WO/2020/114150A1 |
A synthesis method for a carbamate using dimethyl sulfoxide ylide, amine and carbon dioxide is provided. The carbamate is obtained by adding dimethyl sulfoxide ylide, an amine and a solvent into a pressure reactor, then adding a catalyst...
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WO/2020/118041A1 |
The disclosure provides ionizable amine lipids and salts thereof (e.g., pharmaceutically acceptable salts thereof) useful for the delivery of biologically active agents, for example delivering biologically active agents to cells to prepa...
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WO/2020/105536A1 |
Provided is a carbamate ester compound represented by the general formula Z-OCONH(CH2)nNHCOO-Z [I] wherein Z is [i], [ii], or [iii] and n is an integer from 2 to 10 (wherein R1 and R2 are each independently a C1-5 lower alkyl group, R3 i...
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WO/2020/104484A1 |
The present invention relates to the synthesis of N-trifluoromethylcarbonyl compounds starting from isothiocyanates, which can be converted into N-trifluoromethylcarbamoyl fluorides or similar compounds, which later on can be derivatized...
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WO/2020/095983A1 |
It was discovered that a cyclic sulfamidate could be produced by reacting an aminoacid derivative with a cyclization reagent. In addition, it was discovered that an O-substituted serine derivative could be produced by reacting the cyclic...
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WO/2020/097091A1 |
Method are disclosed for synthesizing derivatives of acyl-para-aminophenol and for the use of the compounds for treating lymphomas and tumors of the brain and spinal cord.
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WO/2020/081791A1 |
A composition suitable for 3-D printing comprises, in one embodiment, a photopolymer including one or more thiol monomer, one or more alkene monomer, and a polymerization initiator. In another embodiment, the thiol monomer is selected fr...
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WO/2020/077217A1 |
Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.
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WO/2020/077140A1 |
The present disclosure relates to processes for preparing functionalized cyclooctenes and the synthetic intermediates prepared thereby.
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WO/2020/072605A1 |
The disclosure provides ionizable amine lipids and salts thereof (e.g., pharmaceutically acceptable salts thereof) useful for the delivery of biologically active agents, for example delivering biologically active agents to cells to prepa...
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WO/2020/064701A1 |
The present invention generally relates to the formation, chemistry and application of biologically active compositions. More particularly, the present invention relates to certain dyes, specifically porphyrin and chlorin derivatives, in...
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WO/2020/063399A1 |
Provided is a method for the light-induced decarboxylation coupling of an active carboxylic acid ester under non-metal catalysis, the method comprising the steps of reacting an active carboxylic acid ester compound represented by formula...
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WO/2020/059768A1 |
The present invention provides a halogen compound that can be advantageously used for production of a 1,1-disubstituted hydrazine compound and preparation of a polymerizable compound. A compound according to the present invention is repr...
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WO/2020/057047A1 |
Disclosed are a carbon dioxide reversibly protected chain-extending cross-linking agent, and a preparation method therefor and the use thereof. The carbon dioxide reversibly protected chain-extending cross-linking agent has a chemical st...
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WO/2020/048299A1 |
The present invention belongs to the technical field of pharmaceutical and chemical engineering and mainly provides a pharmaceutical cocrystal and a preparation method therefor. The pharmaceutical cocrystal is formed by ralinepag and iso...
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WO/2020/040049A1 |
This composition includes a compound (A) represented by general formula (1) and a compound (B) represented by general formula (2), wherein the contained amount of the compound (B) is 0.00002-2.0 parts by mass with respect to 100 parts by...
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WO/2020/040048A1 |
This composition includes a compound (A) represented by general formula (1) and a compound (B) represented by general formula (2), wherein the contained amount of the compound (B) is 0.00002-0.2 parts by mass with respect to 100 parts by...
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WO/2020/040050A1 |
Provided are: a composition that has excellent stability during storage and excellent stability during use; and a production method for the composition. The composition according to the present invention includes a compound (A) represent...
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WO/2020/040045A1 |
Provided are: a composition that has excellent stability during storage and excellent stability during use; and a production method for the composition. This composition includes a compound (A) represented by general formula (1), and a c...
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WO/2020/035769A1 |
The present invention relates to solriamfetol or novel salts thereof and its process for preparation. More particularly the present invention relates to solriamfetol dibenzoyl-D-tartaric acid salt or solriamfetol di-p-toluoyl-D-tartaric ...
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WO/2020/030663A1 |
The present invention provides a new building block for peptide synthesis, which introduces a cleavage site that can be used to generate cleavable fragments subsequent to a peptide sequence.
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WO/2020/030931A1 |
The invention relates to a method of functionalising a diacetylene compound of formula (II) to form a diacetylene compound of formula (I): wherein x is from 1 to 20; Q is selected from an amide having the formula (IV) and an ester having...
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WO/2020/032184A1 |
The present invention provides: a technique of allowing an active component, particularly nucleic acid, to be introduced into a cell with excellent efficiency; and a cationic lipid, etc., for use in the technique. The cationic lipid acco...
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WO/2020/031986A1 |
The present invention addresses the problem of providing: a compound which exhibits high solubility in a solvent, while having a satisfactory sensitivity (base generation capacity); a polymerizable composition which contains this compoun...
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WO/2020/026162A1 |
The present invention relates to a novel, integrated, four-step, continuous-flow process for the preparation of the active pharmaceutical ingredient (API) described by the chemical structure (I),1-(2-(4-(3-(trifluoromethyl)phenyl)piperaz...
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WO/2020/023793A1 |
Described herein are compounds, pharmaceutical compositions and medicaments that include such compounds, and methods of using such compounds to modulate transient receptor potential vanilloid 1 receptor (TRPV1) activity.
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WO/2020/012339A1 |
The invention is directed to substituted carbon-linked bicycloalkane derivatives. Specifically, the invention is directed to compounds according to Formula (X): (X) wherein C', D', L2', L3', R1', R2', R3', R4', R5', R6', R7', R8', z1', z...
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WO/2020/008340A1 |
The present technology provides a process for selectively preparing an (E)-(2- (chloromethyl)-3-fluoroallyl)carbamate compound by refluxing an (E/Z)-(2-(chloromethyl)- 3-fluoroallyl)carbamate compound in an organic solvent, followed by c...
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WO/2020/006340A1 |
The invention relates to chemically reactive and/or biologically active compounds, reagents and compositions thereof. More particularly, the invention provides novel reagents that are useful in chemical synthesis, functionalization, deli...
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WO/2020/006177A1 |
Disclosed herein are small molecule Vascular Adhesion Protein- 1 (VAP-1) modulator compositions, pharmaceutical compositions, the use and preparation thereof.
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WO/2019/243414A1 |
The present invention relates to soluble epoxide hydrolase (sEH) inhibitors of formula (I) to processes for their obtention and to their therapeutic indications.
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WO/2019/243087A1 |
The present invention relates to a process for the preparation of Droxidopa by means of an improved enzymatic reduction of a compound of formula (II): (II), wherein R1, R2 is independent hydrogen, acetyl, R3 is hydrogen, a C1-C4 linear o...
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WO/2019/235635A1 |
The present invention addresses the problem of providing: a compound or a salt thereof, which constitutes lipid particles that enable the achievement of high nucleic acid encapsulation rate and excellent nucleic acid delivery; and lipid ...
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WO/2019/221210A1 |
Provided are a method for producing a carbamate, said method comprising the following steps (1) and (2), etc.: (1) a step for producing compound (A) having a urea bond by using an organic primary amine having at least one primary amino g...
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WO/2019/222653A1 |
Disclosed herein, inter alia, are silicon containing detectable compounds and methods of use thereof.
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