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Matches 251 - 300 out of 10,165

Document Document Title
WO/2013/126803A1
The present invention provides compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel, trialkyl, cationic lipids and nucleic acid-lipid particles that provide efficient encapsulation ...  
WO/2013/120257A1
Provided is a method for synthesizing a laevo-p-hydroxyphenylglycine compound, comprising: (1) subjecting an amine compound with a glyoxylic acid ester compound to a nucleophilic addition reaction; subjecting the product obtained in step...  
WO/2013/116715A1
Methods and intermediates useful for preparing a compound of formula I and salts thereof.  
WO/2013/114379A1
The present invention relates to novel polymorphs of N-[2-amino-4-(4-tluorobenzylamino )-phenyl] carbamic acid ethyl ester, processes for preparing them, and pharmaceutical composition comprising them. In one aspect, the present inventio...  
WO/2013/116174A1
The present invention provides novel mGlu2/3 agonists of formula (I) useful in the treatment of neurological or psychiatric disorders.  
WO/2013/114315A1
A method for the preparation of retigabine starting with intermediate III is disclosed, comprising the step of protecting the secondary amine of III with a protecting group followed by N-ethoxycarbonylation of the primary amino group of ...  
WO/2013/107405A1
Provided are methods of treating a cancer characterized by the presence of a mutant allele of IDH1/2 comprising administering to a subject in need thereof a compound described here.  
WO/2013/103973A1
This disclosure provides compounds and compositions which may be modulators of MAGL and/or ABHD6 and their use as medicinal agents, processes for their preparation, and pharmaceutical compositions that include disclosed compunds as at le...  
WO/2013/100567A8
A phenyl carbamate compound; a composition for treating and/or alleviating pain containing the phenyl carbamate compound or a pharmaceutically acceptable salt thereof as an active ingredient; a method of treating and/or alleviating pain ...  
WO/2013/100570A1
A phenyl carbamate compound, a pharmaceutical composition for preventing and/or treating epilepsy comprising the phenyl carbamate compound as an active ingredient, and a use of the phenyl carbamate compound for preventing and/or treating...  
WO/2013/100566A8
A phenyl alkyl carbamate derivative compound and a pharmaceutical composition containing the compound are provided. More specifically, the phenyl alkyl carbamate derivative compound and a pharmaceutically acceptable salt thereof, a compo...  
WO/2013/100567A1
A phenyl carbamate compound; a composition for treating and/or alleviating pain containing the phenyl carbamate compound or a pharmaceutically acceptable salt thereof as an active ingredient; a method of treating and/or alleviating pain ...  
WO/2013/100569A1
A phenyl carbamate compound, a pharmaceutical composition for preventing and/or treating multiple sclerosis comprising the phenyl carbamate compound as an active ingredient, and a use of the phenyl carbamate compound for preventing and/o...  
WO/2013/099623A1
As represented by formula (1), (1) when hydrolysis reaction of methyl laurate was performed by adding methyl laurate (2 mmol) and water (8 ml) to a pyrosulfuric acid ammonium salt catalyst (5 mol%) and heating the mixture to 60°C for 24...  
WO/2013/100571A9
A composition for treating and/or preventing ALS containing the phenyl carbamate compound or a pharmaceutically acceptable salt thereof as an active ingredient; a method of treating and/or preventing ALS comprising administering the phen...  
WO/2013/100566A1
A phenyl alkyl carbamate derivative compound and a pharmaceutical composition containing the compound are provided. More specifically, the phenyl alkyl carbamate derivative compound and a pharmaceutically acceptable salt thereof, a compo...  
WO/2013/100568A1
A phenyl carbamate compound; a composition for treating and/or preventing stroke containing the phenyl carbamate compound or a pharmaceutically acceptable salt thereof as an active ingredient; a method of treating and/or preventing strok...  
WO/2013/100571A1
A composition for treating and/or preventing ALS containing the phenyl carbamate compound or a pharmaceutically acceptable salt thereof as an active ingredient; a method of treating and/or preventing ALS comprising administering the phen...  
WO/2013/094390A1
A photo-curable composition contains a radicalpolymerizable monomer (A), a photopolymerization initiator (B), and a compound (C) Serving as a sensitizer and having the following general formula(1). X1 and X2 are selected from the group c...  
WO/2013/067679A1
A method for preparing polymethylene polyphenyl polyamino formate is provided, which is carried through the condensation of phenylaminoformate with methylating reagent under the catalyzation of phase-transfer acidic catalyst. The method ...  
WO/2013/070118A1
This invention relates to novel substituted 4,5-diamino-3-alkyloxy- cyclohex-1-ene carboxylic acids, esters thereof or pharmaceutically acceptable salts and/or hydrates, to novel antiviral medicines - inhibitors of the activity of neuram...  
WO/2013/065825A1
Provided is a cationic lipid expressed in the following formula (I), which facilitates introduction of a nucleic acid into a cell, a composition containing the cationic lipid and the nucleic acid, a method for introducing the nucleic aci...  
WO/2013/067163A1
In one aspect, the invention relates to compounds having the formula: (I) where R1-R6, a, b, and Z are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. I...  
WO/2013/060950A1
The invention relates to a method for preparing a compound comprising at least one β-hydroxy-urethane unit and/or at least one γ-hydroxy-urethane unit, consisting in reacting a compound (A) comprising at least one cyclocarbonate reacti...  
WO/2013/062028A1
Provided are a novel compound having an antiviral effect, particularly HIV replication-inhibiting activity, and a medical drug, particularly an anti-HIV drug, containing the same. The compound is represented by Formula (I) (where the bro...  
WO/2013/062024A1
Provided is a plant disease control agent which, regardless of where employed, effectively controls a wide range of plant pathogens. This plant disease control agent contains, as an active component, a compound represented by formula (I)...  
WO/2013/060097A1
The present invention provides compounds having the structure represented by general formula I, pharmaceutically acceptable salts thereof, preparation methods therefor and a use thereof in the preparation of a medicine for the treatment ...  
WO/2013/057439A3
The invention relates to a polyurethane resin composition which comprises a pre-polymer and a polymer plasticiser and which can also comprise at least one component selected from the group containing: a masked polyisocyanate, a diluent p...  
WO/2013/057429A3
The present invention relates to a polymerisable plasticiser formed by a hydrocarbon chain, one end of which bears more than one isocyanate function, said hydrocarbon chain comprising and/or being substituted by an aromatic ring and/or a...  
WO/2013/057439A2
The invention relates to a polyurethane resin composition which comprises a pre-polymer and a polymer plasticiser and which can also comprise at least one component selected from the group containing: a masked polyisocyanate, a diluent p...  
WO/2013/057430A1
The invention relates to polyurethane resin compositions and, in particular, stable, ready-to-use polyurethane resin compositions comprising: a masked polyisocyanate having formula (I), wherein B represents alkyl and A represents a group...  
WO/2013/057429A2
The present invention relates to a polymerisable plasticiser formed by a hydrocarbon chain, one end of which bears more than one isocyanate function, said hydrocarbon chain comprising and/or being substituted by an aromatic ring and/or a...  
WO/2013/053940A1
The present invention provides a method for the synthesis of 18F-labelled biomolecules, which is amenable to automation. The present invention also provides a cassette for automating the method of the invention. The method of the present...  
WO/2013/053941A1
The present invention provides a method for the synthesis of 18F-labelled biomolecules, which is amenable to automation. The present invention also provides a cassette for automating the method of the invention. The method of the present...  
WO/2013/055572A1
Novel fluorinated compounds, their method of preparation and use are disclosed, as well as the incorporation of new and old fluorinated compounds in controlled radical polymerization processes to efficiently produce polymer compositions ...  
WO/2013/038603A1
A polymerizable monomer which, when used in a dental material, can increase the mechanical strength of the dental material and can impart good handleability to the dental material is an adamantane derivative represented by formula (1). (...  
WO/2013/036674A1
The present invention provides compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 and R5 are as defined and described herein, compositions thereof, and methods of using the same.  
WO/2013/030193A1
The present invention relates to γ,δ-unsaturated a-amino acids of general formula (I). The present invention also provides a versatile process for the stereospecific synthesis of said compounds of formula (I), involving a Wittig reacti...  
WO/2013/028543A1
The disclosure relates to BAX activators and therapeutic uses relates thereto. In certain embodiments, the disclosure relates to methods of treating or preventing cancer, such as lung cancer, comprising administering a therapeutically ef...  
WO/2013/024383A1
The present invention relates to an improved process for the preparation of Lacosamide having formula (I).  
WO/2013/022047A1
The present invention provides a compound which has an inhibitory activity on lysine-specific demethylase 1 and is useful as a medicinal agent such as a prophylactic or therapeutic agent for cancer and central nervous system diseases. Th...  
WO/2013/016807A1
The present disclosure relates to novel compounds, compositions containing same and methods for treating or preventing a condition associated with a deficient insulin secretion such as diabetes and metabolic syndrome in a subject in need...  
WO/2013/014191A1
It is described a process for the opening of lactone or lactam rings useful in the synthesis of pharmaceutically active compounds and the intermediates thereof, particularly Aliskiren. It has found that by selecting a type of solvent it ...  
WO/2013/014354A1
The invention relates to ceramide-analogue compounds which have a cyclic structure derived from cyclopropane, from cyclobutane or from cyclopentane, the ring bearing two chains consisting of an amide function. Each amide function is link...  
WO/2013/012814A2
The invention provides a method for producing organic carbonates via the reaction of alcohols and carbon monoxide with oxygen adsorbed on a metallic gold or gold alloy catalyst.  
WO/2013/011526A1
An improved, efficient, safe and convenient process for preparation of lisdexamphetamine and its pharmaceutically acceptable salts by using novel mixed anhydride intermediate is provided. A process for preparation of diamino protected am...  
WO/2013/012814A3
The invention provides a method for producing organic carbonates via the reaction of alcohols and carbon monoxide with oxygen adsorbed on a metallic gold or gold alloy catalyst.  
WO/2013/008250A3
A crystalline form of retigabine, process for its preparation and processes for preparation of mixture of known retigabine modifications and pharmaceutical composition are provided.  
WO/2013/003734A3
This disclosure relates to reagents and methods useful in the synthesis of aryl fluorides, for example, in the preparation of 18F labeled radiotracers. The reagents and methods provided herein may be used to access a broad range of compo...  
WO/2012/171941A1
The invention relates to a process for preparation of radiopharmaceutical precursors, and in particular protected amino acid derivatives which are used as precursors for production of radio labelled amino acids for use in in vivo imaging...  

Matches 251 - 300 out of 10,165