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WO/2019/243087A1 |
The present invention relates to a process for the preparation of Droxidopa by means of an improved enzymatic reduction of a compound of formula (II): (II), wherein R1, R2 is independent hydrogen, acetyl, R3 is hydrogen, a C1-C4 linear o...
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WO/2019/235635A1 |
The present invention addresses the problem of providing: a compound or a salt thereof, which constitutes lipid particles that enable the achievement of high nucleic acid encapsulation rate and excellent nucleic acid delivery; and lipid ...
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WO/2019/221210A1 |
Provided are a method for producing a carbamate, said method comprising the following steps (1) and (2), etc.: (1) a step for producing compound (A) having a urea bond by using an organic primary amine having at least one primary amino g...
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WO/2019/222653A1 |
Disclosed herein, inter alia, are silicon containing detectable compounds and methods of use thereof.
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WO/2019/221192A1 |
The present invention provides a method for producing an amino acid aminoalkyl ester or an inorganic acid salt thereof by reacting a compound represented by general formula (I) or a compound represented by general formula (III), or a sal...
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WO/2019/219942A1 |
Provided is a process for producing an amine via a hydroaminoalkylation reaction of a non-aromatic C-C double bond or C-C triple bond, said process comprising a step of reacting a compound comprising a non-aromatic C-C double bond or C-C...
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WO/2019/207591A1 |
The present invention relates to one pot process for the preparation of 4-(1,2-dihydro-2-oxobenzo[d]imidazol-3-yl)butanoic acid of Formula- I, which is a key intermediate and its use in the preparation of Zilpaterol, which comprises cond...
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WO/2019/203951A1 |
Selective potassium channel agonists and methods of use thereof are disclosed. A compound, or a pharmaceutically acceptable salt thereof, having a formula (I) wherein R1 is H or optionally-substituted alkyl; R2 is optionally-substituted ...
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WO/2019/198023A1 |
Subject-matter of the present invention is a process for the preparation of optically active phenyl-beta-amino alcohols by means of a specific reduction of the corresponding phenyl-beta-amino ketones. Further subject-matter of the invent...
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WO/2019/195634A1 |
Compounds are provided having the structure of Formula (I): or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein A, B, L, R3, R4, R5, R6, R8, m and n are as defined herein. Such compounds...
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WO/2019/185877A1 |
The invention relates to a method for the preparation of a 4,5-dihydroxyisoleucine derivative comprising the steps of asymmetric Claisen rearrangement of a Z-aminocrotyl-glycin ester and subsequent kinetic resolution of the product diast...
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WO/2019/185608A1 |
The present invention relates to a catalyst for preparing carbamates, in particular aromatic carbamates, comprising a binary oxide having the formula Li_xMx02, wherein 1. is a metal selected from the lanthanoid series and M is a metal se...
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WO/2019/176732A1 |
[Problem] To provide a production method capable of easily synthesizing a compound having a structure in which a plurality of tetrahydroisoquinoline rings are linked together, using a reduced number of steps. [Solution] It was found that...
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WO/2019/173665A1 |
This disclosure relates to picolinamides of Formula (I) and their use as fungicides.
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WO/2019/172210A1 |
[Problem] To provide a novel compound having great potential as a prodrug-type anticancer agent. [Solution] A compound represented by general formula (I) or a salt thereof
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WO/2019/168025A1 |
Provided is a method for producing morphinan derivatives having the buprenorphine skeleton. In the method, compounds represented by formula (III) are obtained using a Diels-Alder condensation reaction between (I) and (II). By introducing...
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WO/2019/167814A1 |
[Problem] To provide: a production method whereby a mercaptophenol compound is obtained using an industrially preferable reaction for sulfur atom introduction; and an intermediate of the mercaptophenol compound. [Solution] A method for p...
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WO/2019/160419A1 |
The present invention relates to a tripodal squaramide-based monomer based monomer according to formula (I) for the formation of supramolecular polymers: wherein T represents a central atom; n is an integer of from 4 to 12; and R1 is a g...
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WO/2019/160037A1 |
The purpose of the present invention is to provide methods for producing a carboxamide compound, a sulfonamide compound, and an ester compound using an acid halide. The methods for producing a carboxamide compound, a sulfonamide compound...
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WO/2019/157233A1 |
Disclosed herein are compositions for assessing peptidoglycan (PG) biosynthesis in bacteria using modified D-amino acids covalently attached to a molecular rotor and visualizing the labeled PG in bacteria based upon the enhanced fluoresc...
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WO/2019/152801A1 |
The present disclosure features non-canonical or heavy isotope-containing amino acids, where the alpha-amino terminus and/or carboxvlic acid terminus is modified with molecular cages. The molecular cage-modified amino acids are precluded...
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WO/2019/137381A1 |
Provided are prodrugs of (S) -or (R) -ketamine, including isotopically labeled ketamine,composition and uses thereof. Compounds having formula (Ia) or (Ib) as the prodrugs of (S) -or (R) -ketamine, including isotopically labeled ketamine...
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WO/2019/131855A1 |
Provided is a method for collecting a compound represented by general formula (III) (in the formula, R31 is a monovalent to trivalent organic group and n31 is an integer 1-3) from a liquid phase component that is formed as a by-product i...
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WO/2019/125826A1 |
Disclosed herein are amino acid carbamate complexes, methods of synthesis thereof, oral care compositions comprising the same, and methods of making and using thereof.
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WO/2019/121215A1 |
The present invention relates to flame-retarded rigid polyurethane foams and rigid polyurethane/polyisocyanurate foams (also referred to individually or collectively hereinbelow as "rigid PUR/PIR foams") comprising triurethane triols (al...
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WO/2019/123311A1 |
Subject-matter of the present invention is a process for preparing intermediates for the synthesis of optically active beta-amino alcohols by enzymatic reduction of the corresponding beta-amino ketones. Subject-matter of the invention ar...
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WO/2019/107818A1 |
The present invention relates to a method for directly producing a dicarbamate compound from a diamine compound, and more particularly, to a method for directly producing a dicarbamate compound by using a Pd/MOx catalyst, in which a meta...
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WO/2019/091975A1 |
The present invention relates to a method for the synthesis of cyclic depsipeptides, in particular emodepside, from the open form.
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WO/2019/084740A1 |
Disclosed is a method for preparing a Glecaprevir synthetic intermediate. An epoxy cyclopentane is used as a starting material to carry out a ring opening reaction to form 2-hydroxy-1-propenyloxycyclopentane, the same being acetylated to...
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WO/2019/079993A1 |
A flexible wrapping material comprises a coolant gel composition comprising, i) at least one hydrophilic polyurethane prepolymer, ii) a coolant agent, iii) water, and iv) thermally conductive filler.
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WO/2019/077267A1 |
The invention relates to a compound of general formula (I) and the use thereof in cosmetics to protect skin against aggressive external conditions such as air pollution or UV rays, and/or to regenerate skin tissue.
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WO/2019/078027A1 |
Provided is a curable composition that makes it possible to obtain a cured product having excellent adhesion to substrates and excellent biocompatibility. Also provided are a film and a cured product having excellent adhesion to substrat...
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WO/2019/073427A1 |
The present invention relates to an industrially feasible and economically viable process for preparation of trientine dihydrochloride of formula (I) in significantly high yield and purity.
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WO/2019/067599A1 |
The present disclosure is directed to resins and to polymers, copolymers, and blends formed therefrom.
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WO/2019/066578A1 |
The present invention relates to a process for preparing a compound of formula 2 that is an intermediate used to synthesize a dipeptidyl peptidase IV enzyme-inhibiting therapeutic agent for treating diabetes mellitus, which (1) can be pr...
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WO/2019/063296A1 |
The present invention relates to a multistep process for the preparation of organic diisocyanates by converting the corresponding diamine precursors, urea and hydroxy compounds into monomeric diurethanes, converting these diurethanes int...
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WO/2019/059344A1 |
The present invention addresses the problem of providing a novel chemically activated water-soluble prodrug. The present invention provides a compound represented by formula (1), or a pharmacologically acceptable salt thereof (in the for...
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WO/2019/051222A1 |
The present disclosure provides a benzene fused heterocyclic derivative of Formula (I): --̅-̅-̅ is a single or double bond; n is an integer of 0 or 1; A is -CH2-, -CH(OH)-, or - C(O)-; G is C or N; X is -CH2-, O, or -C(O)-; Y is alkyl...
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WO/2019/051198A1 |
Indoleamine 2,3-dioxygenase-1 prodrugs and methods of use thereof are disclosed.
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WO/2019/045355A1 |
A novel method for preparing rivastigmine pamoate is disclosed.
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WO/2019/037791A1 |
Provided are a long-acting rasagiline prodrug and a preparation method and use thereof. The long-acting rasagiline prodrug has a structure of formula (I), wherein, T is selected from (II) or not present; R1 and R2 are each independently ...
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WO/2019/035453A1 |
Provided is a catalyst represented by general formula (1). In general formula (1), R1-R14 each independently represent a hydrogen atom or a substituent.
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WO/2019/026994A1 |
The present invention provides a pharmaceutical composition for the treatment or prevention of cognitive function diseases or disorders, wherein the pharmaceutical composition contains a compound represented by formula (I), an enantiomer...
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WO/2019/019795A1 |
Disclosed in the present invention is a synthesis method for a sacubitril intermediate, the synthesis method belonging to the chemical-pharmaceutical field and comprising the following steps: performing a reaction of glycine and di-tert-...
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WO/2019/018422A1 |
The present disclosure pertains to peptide nucleic acid (PNA) monomers and oligomers, as well as methods and compositions useful for the preparation of PNA monomer precursors (e.g. PNA Monomer Esters, Backbone Esters and Backbone Ester A...
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WO/2019/008156A1 |
The present invention provides novel compounds of formula (I) that are useful as inhibitors of the PD-1/PD-L1 protein/protein interaction. The compounds may be used in the treatment of cancer, infectious diseases and neurodegenerative di...
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WO/2019/009317A1 |
Provided are: a novel compound usable as an organic tag which has a high stability under acidic conditions in peptide synthesis, etc.; and a method for highly efficiently producing a peptide wherein the compound is used as an organic tag.
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WO/2019/004114A1 |
Provided is a production method for efficiently synthesizing a compound (1-2) which is an important intermediate in production of edoxaban. The method comprises dripping a compound (1-1) into a solution A that is obtained by causing a re...
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WO/2018/230829A1 |
The present invention relates to a pharmaceutically acceptable salt of alkylcarbamoyl naphthalenyloxy octenoylhydroxyamide or of a derivative thereof and a method for preparing same, and can improve moisture stability while maintaining t...
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WO/2018/221604A1 |
The present invention provides a method for industrially producing: a pyrimidine compound having pest control efficacy; 2-[4-(trifluoromethyl)phenyl]ethylamine, which is a production intermediate of the pyrimidine compound; a phenylethyl...
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