Document |
Document Title |
WO/2018/199147A1 |
Provided is a novel method for producing amide compounds at high stereochemical selectivities. The method according to the present invention for producing amide compounds is provided with an amidation step for reacting, in the presence o...
|
WO/2018/195008A1 |
Anti-CD59 and anti-glycated CD59 antibodies are disclosed. Assays, diagnostics, kits, and assay components including such antibodies are provided. Methods for the assessment of diabetes-related indications are included as well as inhibit...
|
WO/2018/187740A1 |
Cyclooctene conjugates of therapeutic or diagnostic agents have improved aqueous solubility and can release the agents upon contact with a tetrazine-containing biomaterial. The cyclooctene conjugates provide site-selective delivery of ag...
|
WO/2018/187667A1 |
The present disclosure relates to methods for producing polymers and resins, the method including a first reacting of at least a first diamine with a first carbonate-containing compound and a second carbonate-containing compound to produ...
|
WO/2018/181986A1 |
The present invention provides a pharmaceutical composition for treating or preventing cognitive function disease or disorder, the composition comprising a compound represented by formula (I), an enantiomer thereof, a diastereomer thereo...
|
WO/2018/179343A1 |
The present invention provides a pharmaceutical composition for treating or preventing cognitive function disease or disorder, the composition comprising a compound represented by formula (I), an enantiomer thereof, a diastereomer thereo...
|
WO/2018/181710A1 |
A monomer useful as a dental material, a composition, a dental material, and a kit are provided. This monomer for a dental material contains a compound in which a core part (X) and a specific terminal group (Y2) are bonded together direc...
|
WO/2018/175595A1 |
The present disclosure generally provides compounds useful for treating cancer. In some aspects, the disclosure provides small-molecule histone deacetylase inhibitors (HDIs) that are chemically modified to have one or more moieties that ...
|
WO/2018/172852A1 |
The present invention includes novel substituted bicyclic compounds, and compositions comprising the same, that can be used to treat or prevent hepatitis B virus (HBV) infections in a patient. In certain embodiments, the compounds and co...
|
WO/2018/166899A1 |
Provided are processes for the production of PF1022A derivative compounds, including incubating a microorganism strain capable of producing such compounds in a culture medium to produce a resulting culture, said culture medium containing...
|
WO/2018/167546A1 |
The present invention relates to an improved process for the preparation of Daclatasvir dihydrochloride by using compound salt of formula (VIIc).
|
WO/2018/167264A1 |
The present invention relates to a phenalene-1-one compound, a photosensitizer composition comprising said phenalene-1-one compound, an article comprising said phenalene-1-one compound and/or photosensitizer composition and the use thereof.
|
WO/2018/162806A1 |
The present invention relates to a compound of formula (I): (I) as defined in the description. The present invention also relates to a method for extracting biological membrane-associated membrane proteins, comprising a step of bringing ...
|
WO/2018/159637A1 |
The purpose of the present invention is achieved by using a compound represented by formula [1a] in a liquid crystal composition for a liquid crystal display element. The definitions of symbols in the formula are as described in the spec...
|
WO/2018/160306A1 |
The present disclosure generally relates to hydroxyalkylurethanes obtained from the reaction of amines and alkylene carbonates and their use in gas hydrate inhibitor compositions to effectively inhibit gas hydrate formation in a crude hy...
|
WO/2018/151633A1 |
The present invention relates to a method for producing a compound of formula I, where B is, independently, hydrogen or [see appropriate figure], wherein no more than one B is hydrogen; D is NR1 or O; R1 is H, R, C1-C4 alkyl, unsubstitut...
|
WO/2018/141751A1 |
The invention relates to an economical, single-stage method for producing n-substituted aromatic hydroxylamine of formula (I) R-N(OH)-C(=O)-(O) R1 (I), using hydrogen, by catalytic hydrogenation using optionally modified hydrogenation ca...
|
WO/2018/136014A1 |
There is provided a formulation comprising a mixture of an organogelator powder and at least one solvent having a relative polarity in the range of 0.3 to 0.6, wherein the organogelator powder comprises a compound of formula (I) as defin...
|
WO/2018/133703A1 |
The present invention relates to crystal forms of R228060 hydrochloride and a preparation method and use thereof. The crystal forms CS1 and CS2 of R228060 hydrochloride provided by the present invention have good stabilities, high solubi...
|
WO/2018/118830A1 |
Disclosed is a process for preparing Compound 8: (8) comprising the step of reacting Compound of 7: (7) wherein R is C1-8 alkyl or benzyl in the presence of a base. Also disclosed are intermediates and processes for preparing the interme...
|
WO/2018/114393A1 |
The present invention relates to novel trifluoromethyloxadiazoles of the formula (I) or an N-oxide and/or their agriculturally useful salts and to their use for controlling phytopathogenic fungi, or to a method for combating phytopathoge...
|
WO/2018/117152A1 |
The purpose of the present invention is to provide: a method for producing a 7H-pyrrolo[2,3-d]pyrimidine derivative which is useful as a Janus kinase (JAK) inhibitory agent; an intermediate of the same; and a method for producing the int...
|
WO/2018/101329A1 |
The purpose of the present invention is to develop a therapeutic agent for inflammatory diseases such as inflammatory bowel disease and NASH, said therapeutic agent having few adverse effects and high efficacy. The present invention prov...
|
WO/2018/097580A1 |
The present invention relates to a photoinitiator and a light-shielding photosensitive resin composition containing the same and, more specifically, to: a photoinitiator comprising compounds of two or more groups selected from a group of...
|
WO/2018/096484A1 |
The current invention offers a process for the production of N-Boc-2-amino-3,3-dimethylbutyric acid by a reaction of tert-Leucine with di-tert-butyl-dicarbonate, the process comprising (i) contacting the tert-Leucine with di-tert-butyl-d...
|
WO/2018/090982A1 |
Provided are a benzodicycloalkane derivative, and a preparation method and use thereof. In particular, provided is a compound of formula (I), or a pharmaceutically acceptable salt, stereoisomer or solvate thereof, a preparation method th...
|
WO/2018/086993A1 |
The present invention relates to a process for the synthesis of mono-protected α,ω-diamino alkanes, the use of said proces in a process for the synthesis of a linker drug comprising an α,ω-diamino alkane moiety and the use of the pro...
|
WO/2018/087064A1 |
The invention relates to a method for producing triarylorganoborates from organoboronic acid esters in the presence of an n-valent cation 1/n Kn+, comprising the anhydrous treatment of the reaction mixture, and to the use of the obtained...
|
WO/2018/078351A1 |
Described are compounds for targeting proteases, e.g. serine proteases and their use in the diagnostic methods and methods for treatment of respiratory diseases such as cystic fibrosis. The compounds have the structure [H]-[B]-[A]; where...
|
WO/2018/073124A1 |
The invention relates to the preparation of fluorosubstituted fluoroformate from halosubstituted haloformate by reaction with at least one fluorinating agent in the presence of a catalyst. The further preparation of fluorosubstituted (fl...
|
WO/2018/071327A1 |
This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions con...
|
WO/2018/067971A1 |
The present invention relates to carbamoyl phenylalaninol compounds and methods of using the same to treat disorders.
|
WO/2018/060413A1 |
The present invention relates to a procatalystcomprising the compound represented by formula Aas an internal electron donor (Formula A), wherein R is hydrogen or a methyl group, N is nitrogen atom; O is oxygen atom; and C is carbon atom....
|
WO/2018/060406A1 |
The present invention relates to a procatalyst comprising the compound represented by formula A as an internal electron donor, Formula A wherein R is hydrogen or a methyl group, N is nitrogen atom; O is oxygen atom; and C is carbon atom....
|
WO/2018/050795A1 |
The present invention relates to a process for preparing a carotenoid mono-ester of the formula (I), including the stereoisomers of formula (I), wherein, R1 is e.g. hydrogen, C1-C20-alkyl, C2-C20-alkenyl, C4-C20-alkdienyl, C6-C20-alktrie...
|
WO/2018/043658A1 |
Provided is an economically efficient method by which a carbamic acid ester is able to be produced with high yield and high selectivity. In a method for producing a carbamic acid ester according to the present invention, an amine, carbon...
|
WO/2018/043829A1 |
Provided are a compound represented by a specific formula, a core-shell dye comprising a core comprising the compound and a shell enclosing the core, a photosensitive resin composition comprising the core-shell dye, and a color filter ma...
|
WO/2018/038426A1 |
The present invention relates to: a novel acid addition salt of an optically active diamine derivative; and a preparation method therefor. The diamine derivative acid addition salt of the present invention can prepare edoxaban with high ...
|
WO/2018/032359A1 |
Provided are an ethyl carbamate hapten combination, artificial antigen combination, and method for preparing same and application of same. The ethyl carbamate artificial antigen combination has the molecular structure as shown in formula...
|
WO/2018/033866A1 |
The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril, inter alia via nitro 5 compounds. It further relates to new intermediate comp...
|
WO/2018/028903A1 |
Compounds useful for formulating inks, 3D printing resins, molding resins, coatings, sealants and adhesives which exhibit reduced shrinkage stress and high hardness and stiffness when cured are described which include a single free radic...
|
WO/2018/024828A1 |
A process for the preparation of N-(dialkylaminoalkyl)-carbamic acid esters, in particular (propyl N-[3-(dimethylamino)propyl] carbamate) comprising an oxidative carbonylation reaction of a compound of general structure (II) wherein each...
|
WO/2018/018091A1 |
The present invention relates to compounds and their use in the prophylactic and/or therapeutic treatment of pulmonary fibrosis and/or related conditions.
|
WO/2018/016634A1 |
Provided is a compound represented by formula (0). (0) (In formula (0): RY is a hydrogen atom, a C1–30 alkyl group, or a C6–30 aryl group; RZ is a C1–60 N-valent group or a single bond; each RT is independently an optionally-substi...
|
WO/2018/011823A1 |
Disclosed are compounds and methods for the preparation of Edoxaban. In particular, a camphor sulfonate salt of an amine-protected [(1R,2S,5S)-1,2-amino-5-[(dimethylamino)carbonyl] cyclohexane, an intermediate that may be formed in the s...
|
WO/2018/007919A1 |
The invention relates to a new enantioselective process for producing useful intermediates for the manufacture of NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, ...
|
WO/2017/217553A1 |
[Problem] To provide a novel agricultural chemical, and particularly an herbicide. [Solution] An oxime compound represented by formula (1) and an herbicide containing the same. (In formula (1): B represents B-1 or the like; Q represents ...
|
WO/2017/214634A1 |
This invention is directed to pyrrole, pyrazole, imidazole, triazole, and morpholine based selective androgen receptor degrader (SARD) compounds including heterocyclic anilide rings and their synthetic precursors, R-isomers, and non-hydr...
|
WO/2017/214539A1 |
The application relates to 2-amino-4-(substituted amino)phenyl carbamate derivatives, or pharmaceutically acceptable salts or solvates thereof, as KCNQ2/3 potassium channel modulators, and methods of their uses.
|
WO/2017/211145A1 |
The present invention discloses a micro/nanomaterial, a product thereof with a surface covalently modified with a hydrophilic material, and a manufacturing method. The surface of the micro/nanomaterial comprises a carboxyl group or poten...
|