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Matches 1 - 50 out of 10,379

Document Document Title
WO/2020/095983A1
It was discovered that a cyclic sulfamidate could be produced by reacting an aminoacid derivative with a cyclization reagent. In addition, it was discovered that an O-substituted serine derivative could be produced by reacting the cyclic...  
WO/2020/097091A1
Method are disclosed for synthesizing derivatives of acyl-para-aminophenol and for the use of the compounds for treating lymphomas and tumors of the brain and spinal cord.  
WO/2020/081791A1
A composition suitable for 3-D printing comprises, in one embodiment, a photopolymer including one or more thiol monomer, one or more alkene monomer, and a polymerization initiator. In another embodiment, the thiol monomer is selected fr...  
WO/2020/077217A1
Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.  
WO/2020/077140A1
The present disclosure relates to processes for preparing functionalized cyclooctenes and the synthetic intermediates prepared thereby.  
WO/2020/072605A1
The disclosure provides ionizable amine lipids and salts thereof (e.g., pharmaceutically acceptable salts thereof) useful for the delivery of biologically active agents, for example delivering biologically active agents to cells to prepa...  
WO/2020/064701A1
The present invention generally relates to the formation, chemistry and application of biologically active compositions. More particularly, the present invention relates to certain dyes, specifically porphyrin and chlorin derivatives, in...  
WO/2020/063399A1
Provided is a method for the light-induced decarboxylation coupling of an active carboxylic acid ester under non-metal catalysis, the method comprising the steps of reacting an active carboxylic acid ester compound represented by formula...  
WO/2020/059768A1
The present invention provides a halogen compound that can be advantageously used for production of a 1,1-disubstituted hydrazine compound and preparation of a polymerizable compound. A compound according to the present invention is repr...  
WO/2020/057047A1
Disclosed are a carbon dioxide reversibly protected chain-extending cross-linking agent, and a preparation method therefor and the use thereof. The carbon dioxide reversibly protected chain-extending cross-linking agent has a chemical st...  
WO/2020/048299A1
The present invention belongs to the technical field of pharmaceutical and chemical engineering and mainly provides a pharmaceutical cocrystal and a preparation method therefor. The pharmaceutical cocrystal is formed by ralinepag and iso...  
WO/2020/040049A1
This composition includes a compound (A) represented by general formula (1) and a compound (B) represented by general formula (2), wherein the contained amount of the compound (B) is 0.00002-2.0 parts by mass with respect to 100 parts by...  
WO/2020/040048A1
This composition includes a compound (A) represented by general formula (1) and a compound (B) represented by general formula (2), wherein the contained amount of the compound (B) is 0.00002-0.2 parts by mass with respect to 100 parts by...  
WO/2020/040050A1
Provided are: a composition that has excellent stability during storage and excellent stability during use; and a production method for the composition. The composition according to the present invention includes a compound (A) represent...  
WO/2020/040045A1
Provided are: a composition that has excellent stability during storage and excellent stability during use; and a production method for the composition. This composition includes a compound (A) represented by general formula (1), and a c...  
WO/2020/035769A1
The present invention relates to solriamfetol or novel salts thereof and its process for preparation. More particularly the present invention relates to solriamfetol dibenzoyl-D-tartaric acid salt or solriamfetol di-p-toluoyl-D-tartaric ...  
WO/2020/030663A1
The present invention provides a new building block for peptide synthesis, which introduces a cleavage site that can be used to generate cleavable fragments subsequent to a peptide sequence.  
WO/2020/030931A1
The invention relates to a method of functionalising a diacetylene compound of formula (II) to form a diacetylene compound of formula (I): wherein x is from 1 to 20; Q is selected from an amide having the formula (IV) and an ester having...  
WO/2020/032184A1
The present invention provides: a technique of allowing an active component, particularly nucleic acid, to be introduced into a cell with excellent efficiency; and a cationic lipid, etc., for use in the technique. The cationic lipid acco...  
WO/2020/031986A1
The present invention addresses the problem of providing: a compound which exhibits high solubility in a solvent, while having a satisfactory sensitivity (base generation capacity); a polymerizable composition which contains this compoun...  
WO/2020/026162A1
The present invention relates to a novel, integrated, four-step, continuous-flow process for the preparation of the active pharmaceutical ingredient (API) described by the chemical structure (I),1-(2-(4-(3-(trifluoromethyl)phenyl)piperaz...  
WO/2020/023793A1
Described herein are compounds, pharmaceutical compositions and medicaments that include such compounds, and methods of using such compounds to modulate transient receptor potential vanilloid 1 receptor (TRPV1) activity.  
WO/2020/012339A1
The invention is directed to substituted carbon-linked bicycloalkane derivatives. Specifically, the invention is directed to compounds according to Formula (X): (X) wherein C', D', L2', L3', R1', R2', R3', R4', R5', R6', R7', R8', z1', z...  
WO/2020/008340A1
The present technology provides a process for selectively preparing an (E)-(2- (chloromethyl)-3-fluoroallyl)carbamate compound by refluxing an (E/Z)-(2-(chloromethyl)- 3-fluoroallyl)carbamate compound in an organic solvent, followed by c...  
WO/2020/006340A1
The invention relates to chemically reactive and/or biologically active compounds, reagents and compositions thereof. More particularly, the invention provides novel reagents that are useful in chemical synthesis, functionalization, deli...  
WO/2020/006177A1
Disclosed herein are small molecule Vascular Adhesion Protein- 1 (VAP-1) modulator compositions, pharmaceutical compositions, the use and preparation thereof.  
WO/2019/243414A1
The present invention relates to soluble epoxide hydrolase (sEH) inhibitors of formula (I) to processes for their obtention and to their therapeutic indications.  
WO/2019/243087A1
The present invention relates to a process for the preparation of Droxidopa by means of an improved enzymatic reduction of a compound of formula (II): (II), wherein R1, R2 is independent hydrogen, acetyl, R3 is hydrogen, a C1-C4 linear o...  
WO/2019/235635A1
The present invention addresses the problem of providing: a compound or a salt thereof, which constitutes lipid particles that enable the achievement of high nucleic acid encapsulation rate and excellent nucleic acid delivery; and lipid ...  
WO/2019/221210A1
Provided are a method for producing a carbamate, said method comprising the following steps (1) and (2), etc.: (1) a step for producing compound (A) having a urea bond by using an organic primary amine having at least one primary amino g...  
WO/2019/222653A1
Disclosed herein, inter alia, are silicon containing detectable compounds and methods of use thereof.  
WO/2019/221192A1
The present invention provides a method for producing an amino acid aminoalkyl ester or an inorganic acid salt thereof by reacting a compound represented by general formula (I) or a compound represented by general formula (III), or a sal...  
WO/2019/219942A1
Provided is a process for producing an amine via a hydroaminoalkylation reaction of a non-aromatic C-C double bond or C-C triple bond, said process comprising a step of reacting a compound comprising a non-aromatic C-C double bond or C-C...  
WO/2018/118830A8
Disclosed is a process for preparing Compound 8: (8) comprising the step of reacting Compound of 7: (7) wherein R is C1-8 alkyl or benzyl in the presence of a base. Also disclosed are intermediates and processes for preparing the interme...  
WO/2019/207591A1
The present invention relates to one pot process for the preparation of 4-(1,2-dihydro-2-oxobenzo[d]imidazol-3-yl)butanoic acid of Formula- I, which is a key intermediate and its use in the preparation of Zilpaterol, which comprises cond...  
WO/2019/203951A1
Selective potassium channel agonists and methods of use thereof are disclosed. A compound, or a pharmaceutically acceptable salt thereof, having a formula (I) wherein R1 is H or optionally-substituted alkyl; R2 is optionally-substituted ...  
WO/2019/198023A1
Subject-matter of the present invention is a process for the preparation of optically active phenyl-beta-amino alcohols by means of a specific reduction of the corresponding phenyl-beta-amino ketones. Further subject-matter of the invent...  
WO/2019/195634A1
Compounds are provided having the structure of Formula (I): or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein A, B, L, R3, R4, R5, R6, R8, m and n are as defined herein. Such compounds...  
WO/2019/185877A1
The invention relates to a method for the preparation of a 4,5-dihydroxyisoleucine derivative comprising the steps of asymmetric Claisen rearrangement of a Z-aminocrotyl-glycin ester and subsequent kinetic resolution of the product diast...  
WO/2019/185608A1
The present invention relates to a catalyst for preparing carbamates, in particular aromatic carbamates, comprising a binary oxide having the formula Li_xMx02, wherein 1. is a metal selected from the lanthanoid series and M is a metal se...  
WO/2019/176732A1
[Problem] To provide a production method capable of easily synthesizing a compound having a structure in which a plurality of tetrahydroisoquinoline rings are linked together, using a reduced number of steps. [Solution] It was found that...  
WO/2019/173665A1
This disclosure relates to picolinamides of Formula (I) and their use as fungicides.  
WO/2019/172210A1
[Problem] To provide a novel compound having great potential as a prodrug-type anticancer agent. [Solution] A compound represented by general formula (I) or a salt thereof  
WO/2019/168025A1
Provided is a method for producing morphinan derivatives having the buprenorphine skeleton. In the method, compounds represented by formula (III) are obtained using a Diels-Alder condensation reaction between (I) and (II). By introducing...  
WO/2019/167814A1
[Problem] To provide: a production method whereby a mercaptophenol compound is obtained using an industrially preferable reaction for sulfur atom introduction; and an intermediate of the mercaptophenol compound. [Solution] A method for p...  
WO/2019/160419A1
The present invention relates to a tripodal squaramide-based monomer based monomer according to formula (I) for the formation of supramolecular polymers: wherein T represents a central atom; n is an integer of from 4 to 12; and R1 is a g...  
WO/2019/160037A1
The purpose of the present invention is to provide methods for producing a carboxamide compound, a sulfonamide compound, and an ester compound using an acid halide. The methods for producing a carboxamide compound, a sulfonamide compound...  
WO/2019/157233A1
Disclosed herein are compositions for assessing peptidoglycan (PG) biosynthesis in bacteria using modified D-amino acids covalently attached to a molecular rotor and visualizing the labeled PG in bacteria based upon the enhanced fluoresc...  
WO/2019/152801A1
The present disclosure features non-canonical or heavy isotope-containing amino acids, where the alpha-amino terminus and/or carboxvlic acid terminus is modified with molecular cages. The molecular cage-modified amino acids are precluded...  
WO/2019/137381A1
Provided are prodrugs of (S) -or (R) -ketamine, including isotopically labeled ketamine,composition and uses thereof. Compounds having formula (Ia) or (Ib) as the prodrugs of (S) -or (R) -ketamine, including isotopically labeled ketamine...  

Matches 1 - 50 out of 10,379