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Matches 1 - 50 out of 10,252

Document Document Title
WO/2019/160419A1
The present invention relates to a tripodal squaramide-based monomer based monomer according to formula (I) for the formation of supramolecular polymers: wherein T represents a central atom; n is an integer of from 4 to 12; and R1 is a g...  
WO/2019/160037A1
The purpose of the present invention is to provide methods for producing a carboxamide compound, a sulfonamide compound, and an ester compound using an acid halide. The methods for producing a carboxamide compound, a sulfonamide compound...  
WO/2019/157233A1
Disclosed herein are compositions for assessing peptidoglycan (PG) biosynthesis in bacteria using modified D-amino acids covalently attached to a molecular rotor and visualizing the labeled PG in bacteria based upon the enhanced fluoresc...  
WO/2019/152801A1
The present disclosure features non-canonical or heavy isotope-containing amino acids, where the alpha-amino terminus and/or carboxvlic acid terminus is modified with molecular cages. The molecular cage-modified amino acids are precluded...  
WO/2019/137381A1
Provided are prodrugs of (S) -or (R) -ketamine, including isotopically labeled ketamine,composition and uses thereof. Compounds having formula (Ia) or (Ib) as the prodrugs of (S) -or (R) -ketamine, including isotopically labeled ketamine...  
WO/2019/131855A1
Provided is a method for collecting a compound represented by general formula (III) (in the formula, R31 is a monovalent to trivalent organic group and n31 is an integer 1-3) from a liquid phase component that is formed as a by-product i...  
WO/2019/125826A1
Disclosed herein are amino acid carbamate complexes, methods of synthesis thereof, oral care compositions comprising the same, and methods of making and using thereof.  
WO/2019/121215A1
The present invention relates to flame-retarded rigid polyurethane foams and rigid polyurethane/polyisocyanurate foams (also referred to individually or collectively hereinbelow as "rigid PUR/PIR foams") comprising triurethane triols (al...  
WO/2019/123311A1
Subject-matter of the present invention is a process for preparing intermediates for the synthesis of optically active beta-amino alcohols by enzymatic reduction of the corresponding beta-amino ketones. Subject-matter of the invention ar...  
WO/2019/107818A1
The present invention relates to a method for directly producing a dicarbamate compound from a diamine compound, and more particularly, to a method for directly producing a dicarbamate compound by using a Pd/MOx catalyst, in which a meta...  
WO/2019/091975A1
The present invention relates to a method for the synthesis of cyclic depsipeptides, in particular emodepside, from the open form.  
WO/2019/084740A1
Disclosed is a method for preparing a Glecaprevir synthetic intermediate. An epoxy cyclopentane is used as a starting material to carry out a ring opening reaction to form 2-hydroxy-1-propenyloxycyclopentane, the same being acetylated to...  
WO/2019/079993A1
A flexible wrapping material comprises a coolant gel composition comprising, i) at least one hydrophilic polyurethane prepolymer, ii) a coolant agent, iii) water, and iv) thermally conductive filler.  
WO/2019/077267A1
The invention relates to a compound of general formula (I) and the use thereof in cosmetics to protect skin against aggressive external conditions such as air pollution or UV rays, and/or to regenerate skin tissue.  
WO/2019/078027A1
Provided is a curable composition that makes it possible to obtain a cured product having excellent adhesion to substrates and excellent biocompatibility. Also provided are a film and a cured product having excellent adhesion to substrat...  
WO/2019/073427A1
The present invention relates to an industrially feasible and economically viable process for preparation of trientine dihydrochloride of formula (I) in significantly high yield and purity.  
WO/2019/067599A1
The present disclosure is directed to resins and to polymers, copolymers, and blends formed therefrom.  
WO/2019/066578A1
The present invention relates to a process for preparing a compound of formula 2 that is an intermediate used to synthesize a dipeptidyl peptidase IV enzyme-inhibiting therapeutic agent for treating diabetes mellitus, which (1) can be pr...  
WO/2019/063296A1
The present invention relates to a multistep process for the preparation of organic diisocyanates by converting the corresponding diamine precursors, urea and hydroxy compounds into monomeric diurethanes, converting these diurethanes int...  
WO/2019/059344A1
The present invention addresses the problem of providing a novel chemically activated water-soluble prodrug. The present invention provides a compound represented by formula (1), or a pharmacologically acceptable salt thereof (in the for...  
WO/2019/051222A1
The present disclosure provides a benzene fused heterocyclic derivative of Formula (I): --̅-̅-̅ is a single or double bond; n is an integer of 0 or 1; A is -CH2-, -CH(OH)-, or - C(O)-; G is C or N; X is -CH2-, O, or -C(O)-; Y is alkyl...  
WO/2019/051198A1
Indoleamine 2,3-dioxygenase-1 prodrugs and methods of use thereof are disclosed.  
WO/2019/045355A1
A novel method for preparing rivastigmine pamoate is disclosed.  
WO/2019/037791A1
Provided are a long-acting rasagiline prodrug and a preparation method and use thereof. The long-acting rasagiline prodrug has a structure of formula (I), wherein, T is selected from (II) or not present; R1 and R2 are each independently ...  
WO/2019/035453A1
Provided is a catalyst represented by general formula (1). In general formula (1), R1-R14 each independently represent a hydrogen atom or a substituent.  
WO/2019/026994A1
The present invention provides a pharmaceutical composition for the treatment or prevention of cognitive function diseases or disorders, wherein the pharmaceutical composition contains a compound represented by formula (I), an enantiomer...  
WO/2019/019795A1
Disclosed in the present invention is a synthesis method for a sacubitril intermediate, the synthesis method belonging to the chemical-pharmaceutical field and comprising the following steps: performing a reaction of glycine and di-tert-...  
WO/2019/018422A1
The present disclosure pertains to peptide nucleic acid (PNA) monomers and oligomers, as well as methods and compositions useful for the preparation of PNA monomer precursors (e.g. PNA Monomer Esters, Backbone Esters and Backbone Ester A...  
WO/2019/008156A1
The present invention provides novel compounds of formula (I) that are useful as inhibitors of the PD-1/PD-L1 protein/protein interaction. The compounds may be used in the treatment of cancer, infectious diseases and neurodegenerative di...  
WO/2019/009317A1
Provided are: a novel compound usable as an organic tag which has a high stability under acidic conditions in peptide synthesis, etc.; and a method for highly efficiently producing a peptide wherein the compound is used as an organic tag.  
WO/2019/004114A1
Provided is a production method for efficiently synthesizing a compound (1-2) which is an important intermediate in production of edoxaban. The method comprises dripping a compound (1-1) into a solution A that is obtained by causing a re...  
WO/2018/230829A1
The present invention relates to a pharmaceutically acceptable salt of alkylcarbamoyl naphthalenyloxy octenoylhydroxyamide or of a derivative thereof and a method for preparing same, and can improve moisture stability while maintaining t...  
WO/2018/221604A1
The present invention provides a method for industrially producing: a pyrimidine compound having pest control efficacy; 2-[4-(trifluoromethyl)phenyl]ethylamine, which is a production intermediate of the pyrimidine compound; a phenylethyl...  
WO/2018/213140A1
Disclosed herein are compounds of Formulae (la), (lb), (Ic), (Id), (le), (If), (Ig), (Ih), (Ik), (Im), (In), (Io), (Ip), (Iq), (Ir), (Is) and (It), methods of synthesizing compounds of Formulae (la), (lb), (Ic), (Id), (le), (If), (Ig), (...  
WO/2018/212206A1
This isocyanate production method is characterized by having: a carbamation step for reacting a carbonic acid ester, an inorganic acid salt of an amino acid derivative, and a basic compound with one another, and obtaining a reaction mixt...  
WO/2018/210711A1
The present invention relates to silica-based heterogeneous zinc compounds which are suitable as catalysts in the reaction of amines with dialkyl carbonates to produce carbamates. The catalysts have the formula [SiO2]-CH2-CHR-X-COOZn[Y],...  
WO/2018/212176A1
[Problem] To provide a photopolymerization sensitizer which gives a practically sufficient photocuring rate without arousing the problem wherein additives including a photopolymerization sensitizer bleed out to the surface during photocu...  
WO/2018/199147A1
Provided is a novel method for producing amide compounds at high stereochemical selectivities. The method according to the present invention for producing amide compounds is provided with an amidation step for reacting, in the presence o...  
WO/2018/195008A1
Anti-CD59 and anti-glycated CD59 antibodies are disclosed. Assays, diagnostics, kits, and assay components including such antibodies are provided. Methods for the assessment of diabetes-related indications are included as well as inhibit...  
WO/2018/187740A1
Cyclooctene conjugates of therapeutic or diagnostic agents have improved aqueous solubility and can release the agents upon contact with a tetrazine-containing biomaterial. The cyclooctene conjugates provide site-selective delivery of ag...  
WO/2018/187667A1
The present disclosure relates to methods for producing polymers and resins, the method including a first reacting of at least a first diamine with a first carbonate-containing compound and a second carbonate-containing compound to produ...  
WO/2018/181986A1
The present invention provides a pharmaceutical composition for treating or preventing cognitive function disease or disorder, the composition comprising a compound represented by formula (I), an enantiomer thereof, a diastereomer thereo...  
WO/2018/179343A1
The present invention provides a pharmaceutical composition for treating or preventing cognitive function disease or disorder, the composition comprising a compound represented by formula (I), an enantiomer thereof, a diastereomer thereo...  
WO/2018/181710A1
A monomer useful as a dental material, a composition, a dental material, and a kit are provided. This monomer for a dental material contains a compound in which a core part (X) and a specific terminal group (Y2) are bonded together direc...  
WO/2018/175595A1
The present disclosure generally provides compounds useful for treating cancer. In some aspects, the disclosure provides small-molecule histone deacetylase inhibitors (HDIs) that are chemically modified to have one or more moieties that ...  
WO/2018/172852A1
The present invention includes novel substituted bicyclic compounds, and compositions comprising the same, that can be used to treat or prevent hepatitis B virus (HBV) infections in a patient. In certain embodiments, the compounds and co...  
WO/2018/166899A1
Provided are processes for the production of PF1022A derivative compounds, including incubating a microorganism strain capable of producing such compounds in a culture medium to produce a resulting culture, said culture medium containing...  
WO/2018/167546A1
The present invention relates to an improved process for the preparation of Daclatasvir dihydrochloride by using compound salt of formula (VIIc).  
WO/2018/167264A1
The present invention relates to a phenalene-1-one compound, a photosensitizer composition comprising said phenalene-1-one compound, an article comprising said phenalene-1-one compound and/or photosensitizer composition and the use thereof.  
WO/2018/162806A1
The present invention relates to a compound of formula (I): (I) as defined in the description. The present invention also relates to a method for extracting biological membrane-associated membrane proteins, comprising a step of bringing ...  

Matches 1 - 50 out of 10,252