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Patent Searching and Data


Matches 1,001 - 1,050 out of 6,138

Document Document Title
WO/2002/000612A1
A novel class of compounds, which act to antagonize the action of the glucagon hormone on the glucagon receptor. Owing to their antagonizing effect of the glucagon receptor the compounds may be suitable for the treatment and/or preventio...  
WO/2001/098256A1
This invention relates to compounds of the formula (I) which are thyroid receptor ligands, and are preferably selective for the thyroid hormone receptor $g(b), to methods of preparing such compounds and to methods for using such compound...  
WO/2001/098235A2
The invention relates to 3,4-dihydroxybenzyl-substituted carbonic acid derivatives, to their production, and to their use as antioxidants or free-radical scavengers, especially in cosmetic and pharmaceutical preparations and in foodstuff...  
WO2001051456A3
Hydroxyamidines and related compounds are provided which are suitable as antibacterial agents.  
WO/2001/096297A2
Compounds of the formula (I), where the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions ...  
WO/2001/094301A2
The present invention relates to compounds of formula (I), in which R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿, A, X, m and n have the meanings indicated in the claims. The compounds of the formula (I) are valuable pharmacologically active...  
WO/2001/094300A1
The invention relates to acylphenyl urea derivatives and the physiologically compatible salts and physiologically functional derivatives thereof. Such compounds correspond to the formula (I) wherein the radicals have the cited meanings. ...  
WO/2001/094357A1
New spisulosine derivatives of use in treating tumors are of the formula (I) wherein: each X is the same or different, and represents H, OH, OR', SH, SR', SOR', SO¿2?R', NO¿2?, NH¿2?, NHR', N(R')¿2?, CN, halogen, C(=O)H, C(=O)CH¿3?,...  
WO/2001/092213A2
Compounds of the formula (I) in which: R?1¿ is (CH¿2?)¿n?Y; n is 1 or 2; Y is NHSO¿2?R?2¿ or X?1¿-W-X?2¿-R?3¿; X?1¿ is O or NH; W is C=O, C=S, C=NH, or SO¿2?; X?2¿ is O or NH, provided that X?1¿ and X?2¿ are not both O; R?2...  
WO/2001/092210A1
This invention provides certain compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, their use in treating human or animal disorders. The compounds of the invention are useful as modulators of th...  
WO/2001/092229A1
The invention provides TNF-$g(a) production inhibitors useful as remedies for autoimmune diseases such as rheumatoid arthritis. Novel compounds of the general formula [1] or salts thereof exhibit excellent TNF-a production inhibiting act...  
WO/2001/092218A2
Novel 'bispolyamine' inhibitor compounds of polyamine transport are disclosed. These compounds are useful pharmaceutical agents for treating diseases where it is desired to inhibit polyamine transport or other polyamine binding proteins,...  
WO/2001/090051A1
The invention is concerned with novel N-(4-carbamimidoyl-phenyl)-glycine derivatives of the formula (I) wherein X and R?1¿ to R?5¿ are as defined in the description and in the claims, as well as hydrates or solvates and/or physiologica...  
WO/2001/087840A1
Novel propanoic acid derivatives are integrin receptor antagonists or inhibitors, in particular of the avb3 integrin receptor. The compounds of the invention are for instance useful for the treatment of solid tumors by inhibition of angi...  
WO2000056681A9
This invention provides combinatorial chemistry libraries containing thiourea and urea compounds of formula (I), in which X is S or O; R and R1 are individually (CHR) -Ar; and the other variables are as defined in the claims. In addition...  
WO/2001/085681A2
1-(3-methoxybenzyl)-3-substituted thiourea antioxidant compounds and improved lipids compositions which are supplemented with amounts of such antioxidant compounds effective for augmenting oxidative stability of the base lipid are provid...  
WO/2001/085706A1
Compounds of formula (I) wherein X is oxygen or sulfonyl, R is a ring, R?1¿ is cycloalkyl, y and z are 0 or 1, and R?2¿ is -CO-NHR?3¿ or a heteroaromatic ring having a ring nitrogen atom adjacent to the connecting ring carbon atom, ar...  
WO/2001/083429A1
Compounds represented by the formular (A), tautomers thereof, or medicinally acceptable salts of both exhibit an NOS-inhibitory activity and are useful as drugs in the treatment of various diseases.  
WO/2001/083427A1
To provide PPAR$g(g) modulators seemingly usable in remedies for involutional osteoporosis which inhibit the accelerated differentiation of adipocytes and promote the formation and differentiation of osteoblasts from stem cells, or remed...  
WO/2001/081298A2
The present invention relates to compounds of general formula (I), processes for their preparation, pharmaceutical compositions containing them as well as their use for the production of pharmaceutical compositions for the treatment of i...  
WO2001028987A8
The present application describes modulators of CCR3 of formula (I) or pharmaceutically acceptable salt forms thereof, useful for the prevention of inflammatory diseases such as asthma and other allergic diseases.  
WO/2001/077077A1
Compounds of formula (I) wherein R¿1?, L, L', alk, W and Z have the meanings as defined hereinbefore; and pharmaceutically acceptable salts thereof; are useful as inhibitors of microcosmal triglyceride transfer protein (MTP) and of apol...  
WO/2001/074761A1
Substituted tetracycline compounds, methods of synthesis, and methods of use are discussed. Tetracyclines useful for treating tetracycline related disorders are also discussed. Intermediates useful for synthesizing other tetracycline com...  
WO2001021577A3
A melanin-concentrating hormone antagonist which comprises a compound of formula (I) wherein Ar<1> is a cyclic group which may have substituents; X is a spacer having a main chain of 1 to 6 atoms; Y is a bond or a spacer having a main ch...  
WO/2001/070675A2
The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell pr...  
WO/2001/070684A2
One aspect of the present invention relates to novel peptidomimetic compounds. A second aspect of the present invention relates to the use of the novel peptidomimetic compounds as ligands - agonists or antagonists - for various cellular ...  
WO2000071506A9
Compounds of formula (I), wherein R<1> and R<2> are substituents on the A rings and are, independently, -SO2NR<7>2, -C(O)NR<7>2, -NR<7>SO2R<7>, -NR<7>C(O)R<7>, -SO2OR<7>, -C(O)OR<7>, -OSO2R<7>, or -OC(O)R<7>, R<3> and R<4> are, independe...  
WO2001028498A3
Novel retro-anandamides are presented which have high affinities for the cannabinoid CB1 and/or CB2 receptor sites. Further, most of the analogs exhibit greater metabolic stability than arachidonylethanolamide. The improved receptor affi...  
WO/2001/066515A1
A urea-urethane compound represented by the following formula; a process for producing the compound; a color developer comprising the urea-urethane compound; and a color former containing a colorless or light-colored leuco dye. (In the f...  
WO2001019780A3
The invention relates to compounds of formula (I) as well as the salts and stereoisomers thereof used in the production of medicaments for the treatment of cardiovascular diseases.  
WO2001008633A3  
WO/2001/058855A1
Substituted phenylalanines are provided comprising an hydantoin, urea or 2-hydroxyl, 2-methylpropionyl group, dimers thereof and alkyl, polyfluoroamido and haloarylamino derivatives thereof, as well as radiolabeled derivatives thereof. T...  
WO2001009096A3
Compounds of formula (I), are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.  
WO/2001/058854A1
Compound (2-hydroxy-2-methyl-N-(4-X-3-(trifluoromethyl)phenyl)-3-(2,2 ,2-perfluoroacylamino)propionamide) applied topically, specifically inhibits and/or eliminates cutaneous androgen receptors and thus finds cosmetic use in skin afflict...  
WO/2001/058859A1
The invention generally relates to a novel kind of arginine mimetics which are inhibitors of the factor X¿a?. The invention also relates to pharmaceutical compositions that contain said mimetics and to the use of said arginine mimetics ...  
WO2000055124A3
The present invention relates to novel cysteine protease inhibitors; the pharmaceutically acceptable salts and N-oxides thereof; their uses as therapeutic agents and the methods of their making.  
WO/2001/056988A1
Compounds having an Rho kinase inhibitory activity. These compounds include the compound of general formula (I): Het-X-Z, pharmaceutically acceptable salts thereof and solvates of the same, wherein Het represents a monocyclic or dicyclic...  
WO/2001/056978A1
The invention relates to positional isomer diethyloctandioldicarbamates and diethyloctandioldiallophanates, to a method for the production thereof and to the use thereof as synthetic building blocks and constituents of adhesives, luting ...  
WO2000071506A3
Compounds of formula (I), wherein R<1> and R<2> are substituents on the A rings and are, independently, -SO2NR<7>2, -C(O)NR<7>2, -NR<7>SO2R<7>, -NR<7>C(O)R<7>, -SO2OR<7>, -C(O)OR<7>, -OSO2R<7>, or -OC(O)R<7>, R<3> and R<4> are, independe...  
WO/2001/056975A1
The invention concerns novel substituted imide derivatives of general formula (I), wherein R?1¿ represents optionally substituted cycloalkyl; R?2¿ represents optionally substituted alkyl or optionally substituted cycloalkyl; R?3¿ repr...  
WO/2001/057105A1
The invention concerns a novel aqueous composition that can be hardened physically, thermally and/or with actinic radiation, containing a compound of general formula (I): X[NH-C(=O)-NH-Y-NH-C(=O)-OR]¿2? having at least one urea and uret...  
WO/2001/055146A1
The present invention relates to a compound with aryl-amidines, particularly amidinoaryl-cyclopropanes, amidinoarylmethyl-pyrroles, amidinoaryl-benzenes, amidinoaryl-pyridines, or amindonoaryl-alanines, represented by formula (1), a phar...  
WO/2001/055081A2
Esters derived from fatty acids and juvenoid alcohols of the general formula (I), in which X means the oxygen atom or the NH group, Y means the NH group or the oxygen atom, R means methyl, ethyl, 1-propyl, 2-methylethyl or propargyl and ...  
WO/2001/055095A1
The present invention refers to new classes of polymerisable monomers, to molecularly imprinted polymers obtainable by polymerisation of at least one of the monomers and a crosslinking monomer in the presence of a template molecule. The ...  
WO/2001/053279A1
A compound of formula (I) where D is a VLA-4 specificity determinant which does not impart significant IIB/IIIa activity; R?41¿ is a group of the formula (V): U - (CH¿2?)¿d? - V - T wherein U is selected from oxygen, sulphur, a direct...  
WO/2001/052900A2
Polyazacarboxylates and their peptide conjugates which are useful for imaging, diagnosis and therapy are disclosed. Particularly, this invention relates to compositions of two or more peptides that are conjugated to a molecule of polyaza...  
WO/2001/051487A1
There is disclosed a genus of non-peptidyl compounds, wherein said compounds are VLA-4 inhibitors useful in treating inflammatory, autoimmune, and respiratory diseases, and wherein said compounds comprise a compound of formula (1.0.0) an...  
WO/2001/051456A2
Hydroxyamidines and related compounds are provided which are suitable as antibacterial agents.  
WO/2001/047875A1
The present invention is directed to a series of novel substituted aminoalkylamide derivatives, pharmaceutical compositions containing them and their use in the treatment of reproductive disorders and affective conditions. Further, the c...  
WO/2001/045678A2
The invention relates to a composition which comprises as its constituents (a) a local anaesthetic and (b) an anti-inflammatory compound and/or an immunostimulant compound and/or a compound which acts as a supporting material for the loc...  

Matches 1,001 - 1,050 out of 6,138