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WO/1996/039382A1 |
A compound of formula (I) wherein R1 is cyano, thiocarbamoyl, a group of formula (a) in which R4 is hydrogen, lower alkyl which may have optionally substituted aryl, acyl, optionally substituted aryl, lower alkylthio or 1-lower alkylindo...
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WO/1996/034851A1 |
The present invention provides a compound of formula (I), (II), (III) or (IV), processes for the preparation of the compounds of the invention, intermediates useful in these processes, a pharmaceutical composition, and methods of using t...
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WO/1996/034850A1 |
The present invention provides a compound of formula (I) processes for the preparation of the compounds of the invention, intermediates useful in these processes, a pharmaceutical composition, and methods of using the compounds of the in...
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WO/1996/034856A1 |
This invention is concerned with 2-ureido-benzamide compounds of formula (1), in which R1 is H, halogen, alkyl, alkoxy or dialkylamino and R2 is H, halogen, hydroxy, nitro, alkyl, alkoxy, cycloalkylmethoxy, alkylthio, alkylsulfinyl, alky...
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WO/1996/034852A1 |
The present invention relates to novel tetracycline derivatives, to intermediates used in their preparation, to pharmaceutical compositions containing them and to their medicinal use. The active compounds of the present invention are use...
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WO/1996/033160A1 |
The present invention provides dihalopropene compounds of general formula (I), wherein R1 is C1-C10 alkyl or the like; L is C(=O)NH or the like; R2, R3 and R4 are independently halogen or the like; R5, R6 and R7 are independently hydroge...
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WO/1996/032377A1 |
Compounds having the structure of general formula (I) or a pharmaceutically acceptable salt thereof have activity as inhibitors of cyclooxygenase and 5-lipoxygenase, reduce the biosynthesis of leukotrienes B4, C4, D4, and E4 and cyclooxy...
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WO/1996/032366A1 |
Naphthol derivatives represented by general formula (I), wherein Y and Y' represent each -(CONH)n-X or -COR; X represents phenyl, naphthyl, anthraquinonyl, benzimidazolonyl or carbazolyl; R represents hydroxy, C1-6 alkoxy, halogeno, benz...
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WO/1996/031527A1 |
Disclosed herein are compounds which inhibit human immunodeficiency virus (HIV) protease activity and inhibit HIV replication in human cells. Thus, the compounds are indicated for the treatment of HIV infections. The compounds can be rep...
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WO/1996/031461A1 |
Phenoxyethylamine derivatives of general formula (I) having high affinity for the 5-HT1A receptor, methods for preparing same, pharmaceutical compositions containing said derivatives, and their use, in particular as gastric acid secretio...
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WO/1996/030329A1 |
The invention relates to substituted benzenes and derivatives thereof, useful as neuraminidase inhibitors, to pharmaceutical compositions comprising such compounds, and to methods of using these compounds for treating viral and other inf...
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WO/1996/029304A1 |
The small nonpeptides of the instant invention are tachykinin antagonists. The compounds are highly selective and functional NK3 antagonists expected to be useful in the treatment of pain, depression, anxiety, panic, schizophrenia, neura...
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WO/1996/028416A1 |
Aminophenol derivatives represented by general formula (1), salts thereof or optical isomers thereof, and a gastrin receptor antagonist, a cholecystokinin receptor antagonist and a remedy for digestive tract diseases containing the same,...
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WO/1996/028427A1 |
This invention is directed to benzamidine derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to tr...
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WO/1996/025157A1 |
This invention relates to the novel use of phenyl ureas in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
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WO/1996/025387A1 |
Compounds of a class of alkyl carboxy amino acid analogs of glutamic acid according to formula I act as specific regulators of kainic acid EAA receptor cation channel, wherein R1 is 1) CH3, or 2) halogen; R2 and R3 are independently 1) H...
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WO/1996/025444A1 |
A process for producing polyisocyanates containing one or more biuret groups, by reacting a) an aliphatic or cycloaliphatic isocyanate with several isocyanate groups (isocyanate a) with b) a tertiary alcohol or a mixture of water and a t...
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WO/1996/024590A1 |
The invention concerns 3-(4-cyanophenyl)uracils of formula (I), wherein A = H, CH3, NH2; Y = -O-, -S-; R1 = H, halogen; R2 = H, halogen, C1-C6-alkyl, C1-C6-alkyl halide, C1-C6-alkylthio, C1-C6-alkylsulphenyl, C1-C6-alkylsulphonyl; R3 = H...
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WO/1996/023767A1 |
In a process for the production of urea, substantially pure ammonia and carbon dioxide are reacted in a reaction space (1) from which comes out a reaction mixture subjected to stripping (2) to obtain a partially purified mixture sent to ...
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WO/1996/022971A1 |
Novel high-potency sweeteners of formula (I), wherein Y is a CH group or a nitrogen atom, A is an oxygen atom, n is 1 or 2, and R is a 3,4-disubstituted phenyl group, and physiologically acceptable salts thereof. Such compounds are usefu...
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WO/1996/022966A1 |
The present invention relates to novel compounds that are useful for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. This invention also relates to pharmaceutical formulations comprising these compounds...
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WO/1996/022275A1 |
Chiral hydroxyethylamine, hydroxyethylurea or hydroxyethylsulfonamide isostere containing retroviral protease and renin inhibitors can be prepared by multi-step syntheses that utilize key chiral amine intermediates. This invention is a c...
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WO/1996/022277A1 |
The invention provides compounds of formula (I) and (II) wherein X and Y are independently chlorine, bromine, iodine, a mesyl group CH3SO3 or a tosyl group OSO2phenyl (wherein phenyl is optionally substituted by 1, 2, 3, 4 or 5 substitue...
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WO/1996/020171A1 |
Disclosed herein are compounds of formula (1), wherein R1 is (1-3C)alkyl, R2 is hydrogen or (1-3C)alkyl and R3 is (1-3C)alkyl, or a therapeutically acceptable salt thereof. The compounds are useful for treating herpes infections.
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WO/1996/019437A1 |
The present invention provides 2,5-diamino-3,4-disubstituted-1,6-diphenylhexane (DAD) isosteres comprising benzamide, sulfonamide and anthranilamide subunits, a pharmaceutical composition comprising such compounds, a method of using such...
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WO/1996/018372A2 |
Novel cationic amphiphiles are provided that facilitate transport of biologically active (therapeutic) molecules into cells. The amphiphiles contain lipophilic groups derived from steroids, from mono or dialkylamines, or from alkyl or ac...
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WO/1996/018606A1 |
A compound represented by general formula (I) and salts thereof, wherein R1 and R5 represent each carboxyl, sulfo or a derivative thereof; R2 represents hydrogen, lower alkyl, (substituted) phenyl-lower alkyl, lower alkoxy or (substitute...
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WO/1996/018405A1 |
Administration of argininosuccinate synthetase activity reducing agents, e.g., argininosuccinate synthetase induction blocking agents (e.g., antibiotics that bind to DNA sequences present in the upstream regulatory region of the arginino...
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WO/1996/016030A1 |
Iminooxymethylene anilides have the formula (I), in which the substituents and indices have the following meanings: R stands for hydrogen, optionally substituted alkyl, alkenyl, alkinyl, cycloalkyl, cycloalkenyl, cycloalkinyl, alkylcarbo...
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WO/1996/016054A1 |
Certain novel cycloalkenyl-N-hydroxyurea compounds having the ability to inhibit the 5-lipoxygenase enzyme and having formula (I), and the pharmaceutically acceptable salts thereof, wherein A is selected from optionally substituted pheny...
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WO/1996/015106A1 |
The present invention provides a compound of formula (I), wherein Ar is (a) phenyl, naphthyl and biphenyl, each optionally substituted with C1-4 alkyl, C1-4 haloalkyl, C1-4 hydroxyalkyl, C1-4 alkoxy, C1-4 haloalkoxy, C2-4 alkoxyalkoxy, C...
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WO/1996/014293A1 |
A compound represented by general formula (I) and salts thereof, wherein R1 and R4 represent carboxyl optionally converted into an ester, amide or hydroxamate group; R2 represents lower alkyl or phenyl lower alkyl; and R3 represents hydr...
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WO/1996/011902A1 |
The present invention relates to compounds of formula (I), wherein: A, B and D are various ring systems as defined in the description, R1 is one of a variety of groups as defined in the description, R3 is hydrogen or C1-4 alkyl and Z is ...
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WO/1996/012059A2 |
Substrates are made oil-, water- and soil-repellent and/or provided with soil-release properties by applying to them urea linkage-containing alkoxypolyoxyalkylene fluorocarbamates prepared by reacting: (a) at least one polyisocyanate whi...
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WO/1996/010559A1 |
Urea derivatives of formula (I), wherein R1 is a group of formula (1) (in which R4 is aryl which may have suitable substituent(s), or heterocyclic group which may have suitable substituent(s), and Y is bond, lower alkylene, -S-, -O-, (a)...
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WO/1996/009297A1 |
Novel compounds, compositions and methods effective for the prevention and treatment of mast-cell mediated inflammatory disorders are described. The compounds, compositions and methods are effective for the prevention and treatment of in...
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WO/1996/009282A1 |
The invention provides low viscosity iodinated aryl compounds, useful as X-ray contrast agents, of formula (I), wherein n is 0 or 1, and where n is 1 each C6R5 moiety may be the same or different; each group R is a hydrogen atom, an iodi...
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WO/1996/009285A1 |
The invention provides iodinated bis phenyl compounds, useful as X-ray contrast agents, of formula (I) (wherein each C6R5 moiety may be the same or different; each R denotes a hydrogen or iodine atom or a group M, two or three non-adjace...
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WO/1996/008469A1 |
The present invention is the novel synthesis of sterically hindered penta-substituted guanidines by a process in which (1a) an isocyanate is reacted first with a di-substituted amine or (1b) a urea is reacted with two moles of a mono-sub...
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WO/1996/008466A1 |
A compound of formula (I) wherein R1 and R2 are H, a hydrocarbon group or a heterocyclic group, or R1 and R2 are combinedly a spiro ring; R3 is a hydrocarbon group, a substituted amino group, a substituted hydroxyl group or a heterocycli...
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WO/1996/006672A1 |
A process for the production of a dehydrated molten urea composition which may be utilized to produce a dry, stable, granular and acidic composition of matter. Also disclosed are various compositions of matter produced from a dehydrated ...
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WO/1996/004297A1 |
The present invention is directed to the process of preparing a peptide comprising reacting a first amino acid or peptide with an amino acid fluoride of formula (I) or the acid fluoride salts thereof wherein BLK is an N-amino protecting ...
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WO/1996/003983A1 |
A method of inhibiting leukotriene biosynthesis, involving administering a compound of formula (I) wherein M, R, R', R'', and n are as defined herein. Also, a pharmaceutical composition involving such a compound and the use of such compo...
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WO/1996/002514A1 |
The invention concerns urea and carbamic acid derivatives of the general formula (R1NR2)-A-R3 (I), in which A and R1 to R3 are defined as in claim 1. The invention further concerns their tautomers and stereoisomers including their mixtur...
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WO/1996/001788A2 |
The present invention relates to a method of forming a 1,3-diamino-3-substituted-2-propanol chemical intermediate from which various chemicals, such as selected protease-inhibitors and other drugs, as well as polymers, can be synthesized...
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WO/1996/000928A1 |
A photothermographic element comprising a support bearing at least one heat-developable, photosensitive, image-forming photothermographic emulsion layer comprising: (a) a photosensitive silver halide; (b) a non-photosensitive, reducible ...
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WO/1995/035286A1 |
Oligopeptide analogs containing sulfonamide, urea or carbamate linkages in the backbone are described. These compounds are useful in the inhibition of HIV protease, the prevention or treatment of infection by HIV and the treatment of AID...
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WO/1995/033711A1 |
The present invention relates to a novel N-phenyl-N'-benzoyl(or nicotinoyl) urea derivative represented by formula (I), which has a strong pesticidal activity, in which X represents C-R4 or N; and R1, R2, R3, R4 and R5 independently of o...
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WO/1995/033460A1 |
This invention relates to the novel compounds and pharmaceutical compositions of formula (I). This invention also relates to a method of treating or reducing inflammation in a mammal in need thereof, which comprises administering to said...
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WO/1995/032945A1 |
The present invention describes compounds, methods and compositions effective to treat mast-cell mediated inflammatory conditions, such as conjunctivitis, asthma and allergic rhinitis. The compounds of the invention comprise novel mono- ...
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