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JPH0223542B2 |
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JPH02131458A |
NEW MATERIAL:A compound shown by formula I [X is-(CH2)1-5 or group shown by formula II; Y is H or residue after removal of OH from carboxy of amino acid or peptide; m is 0, 1 or 2; n is 1 or 2; with the proviso that Y is group except H w...
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JPH0219110B2 |
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JPH0291057A |
NEW MATERIAL: A compd. represented by formula I (wherein R1 is alkyl, alkenyl or alkynyl; R2 is -C≡N, -NO2 or -CF3; and R3 and R4 are each -R2, H, alkyl, alkenyl, alkynyl or alkoxy), its tautomer and salt. EXAMPLE: 4-[[(Cyanoimino) [(1...
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JPH0211582B2 |
The present invention relates to (-)-15-Deoxyspergualin of the formula and its salts, a process for the preparation of these compounds and intermediates of these compounds. (-)-15-Deoxyspergualin has carcinostatic activity and can, there...
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JPH029581B2 |
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JPH027564B2 |
@ An agricultural and horticultural fungicide of low phytotoxicity comprising as an active ingredient an addition salt between a fungicidal guanidine compound and an acid having an oleophilic group with at least 9 carbon atoms in total. ...
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JPH026459A |
PURPOSE: To obtain a compound useful as a medicine in a high purity and high yields in a nonpolluting advantageous manner by reacting 3aminomethylcyclohexanecarboxylic acid with an O-alkylisourea derivative in a polar protonic solvent. C...
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JPH024760A |
PURPOSE: To obtain a highly pure compound useful as an element for the synthesis of medicines by extracting it from the mixture formed in the production of a mercaptosilane with an aliphatic ketone. CONSTITUTION: A by-product mixture com...
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JPH02763A |
PURPOSE: To extend the life of a catalyst easily and to obtain guanidine nitrate continuously and industrially, by reacting urea with excess ammonium nitrate while elevating the temperature in the presence of a silicon dioxide catalyst w...
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JPH01287083A |
NEW MATERIAL: A compound of formula I {wherein R1 is H, a 1-4C alkyl, a 1-4C alkoxyl, a halogen, trifuoromethyl or the like; R2 is H, OH, a 1 or 2C alkoxyl, a 1 or 2 alkyl or 1 or 2C alkylcarbonyl; R3 and R4 are each a 1-4C alkyl; X is f...
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JPH0153272B2 |
Process for the preparation of cimetidine, wherein N-cyano-N min -methyl-N sec -(2-mercaptoethyl)guanidine is reacted with 4-halomethyl-5-methyl-1H-imidazole in water or in a water-containing medium at the pH-range of 8.0 to 9.5. Pure ci...
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JPH0139419B2 |
Guanidine hydrochloride is produced from cyanogen chloride in a new manner. The cyanogen chloride is reacted with ammonia in the absence of a solvent at a temperature of about 140 DEG to 220 DEG C. It is advantageous to add an ammonium s...
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JPH0135000B2 |
NEW MATERIAL:A compound of formula I: [R is formula III (R1 is H or 1-5C alkyl group); Ar is 1,2,3,4-tetrahydro-8-quinolyl group which may be substituted by at least one 1-5C alkyl group], and its pharmacentically acceptable salts. EXAMP...
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JPS6335629B2 |
The invention relates to guanidine derivatives of imidazoles and thiazoles which are histamine H-2 antogonists and which inhibit the secretion of gastric acid, to methods for their manufacture, to pharmaceutical compositions containing t...
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JPS6316387B2 |
2,4-Disubstituted thiazole compounds of the formulaor a pharmaceutically acceptable acid addition salt thereof whereinX is NH and Y is CH or N, orX is S and Y is CH;R1 is certain straight or branched chain alkyl groups, (R3)2C6H3, or (R3...
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JPS62238257A |
Diarylguanidines can be isolated from the crude melt from the reaction of arylamines and cyanogen chloride in excellent quality and yield by dissolving the hot melt in water, extracting this solution with at least one polar, water-insolu...
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JPS62158249A |
Compounds of the general formula I whereinR₁ is hydrogen or methyl;R₂ and R₃, which are the same or different, represent hydrogen or methyl, or taken together, form the amidine system to which an imidazole or imidazoline ring is bo...
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JPS62148463A |
Diaryl guanidines can be obtained in a high degree of purity and in high yields from the crude melt obtained from the reaction of arylamines and cyanogen chloride by dissolving the hot melt in water, extracting this solution with a mixtu...
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JPS627909B2 |
Guanidine pantoate, which is a new salt of pantoic acid, is of use in the preparation of the optically active isomers of pantolactone and therefrom D-pantothenic acid.
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JPS625907B2 |
The invention relates to guanidine derivatives of imidazoles and thiazoles which are histamine H-2 antogonists and which inhibit the secretion of gastric acid, to methods for their manufacture, to pharmaceutical compositions containing t...
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JPS6157307B2 |
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JPS6156231B2 |
The invention relates to guanidine derivatives of imidazoles and thiazoles which are histamine H-2 antogonists and which inhibit the secretion of gastric acid, to methods for their manufacture, to pharmaceutical compositions containing t...
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JPS61221167A |
1. Process for the preparation of substituted guanidines of the formula (I) see diagramm : EP0195971,P9,F4 in which R represents a radical see diagramm : EP0195971,P9,F5 wherein R**7 represents hydrogen or optionally substituted radicals...
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JPS6140667B2 |
Prodn. of guanidine derivs. of formula (I) comprises reacting a mercaptan deriv. of formula Het-(CH2)m-SM (III) is reacted with a guanidine of formula (IV). In the formulae, Het is opt. substd. 5- or 6-membered heterocyclic residue with ...
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JPS6187656A |
PURPOSE: To obtain an aqueous solution containing guanidine phosphate component useful as a flame-retarding treatment agent for paper and plywood in high concentration, easily, by carrying out the addition reaction of guanidine carbonate...
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JPS6115868A |
PURPOSE: To obtain the titled compound useful as an antikallikrein agent, in high yield and in one step, by reacting -guanidinocaproic acid with ethyl p- hydroxybenzoate in the presence of a sulfonic acid anhydride and an acid acceptor. ...
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JPS611063B2 |
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JPS6054313B2 |
The invention provides a process for the preparation of 2-isopropylamino-pyrimidine, the process comprising reacting bis(isopropylguanidine)sulphate with 1,1,3,3-tetraethoxy-propane in stoichiometric proportions at 40 DEG -60 DEG C., in ...
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JPS6028819B2 |
The invention relates to a series of new compounds, to methods for preparing the compounds, to compositions containing said compounds which are useful in the human and veterinary medical practice, and to methods for treating patients suf...
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JPS606647A |
PURPOSE: To produce the titled compound useful as an immunoactivator and analgesic agent, easily, in high yield, by condensing an α-amino acid derivative with a malonic acid diester alkali metal salt, and removing the protecting group f...
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JPS5945672B2 |
N-[2-(Substituted amido)phenyl]-N',N''-bis-carbonylguanidines bearing an optionally substituted phenoxy, phenylthio, phenylsulfinyl or phenylsulfonyl group in the 4- or 5-position of the 2-(substituted amido)phenyl group are anthelmintic...
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JPS59152365A |
The present invention relates to a process for manufacturing guanylurea sulfamate, whereby dicyandiamide and sulfaminic acid are reacted in an aqueous or organic-aqueous medium at a temperature within the range 70 DEG C.-105 DEG C. Guany...
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JPS5934163B2 |
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JPS59130856A |
1-Cyano-3-(fluoroalkyl)guanidines of the formula: (I) in which R1, R2 and R3 are the same or different members of the class of hydrogen, fluorine, lower alkyl or lower alkenyl provided that at least one member is fluorine or fluoro-subst...
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JPS59101454A |
PURPOSE: To carry out the crystallization of the titled compound in a short time, by reacting dicyandiamide with ammonium sulfamate under molten condition, casting the molten liquid in a thin film, generating seed crystals at the surface...
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JPS5978156A |
PURPOSE: To obtain the titled compound useful as an original drug of an injection for pancreatitis treatment, etc., by subjecting a p-(6-guanidiniumcaproyloxy) benxoic acid to ethyl esterification with ethanol in the presence of an acidi...
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JPS5915904B2 |
N-[2-(Substituted amido)phenyl]-N',N''-bis-carbonylguanidines bearing an optionally substituted phenoxy, phenylthio, phenylsulfinyl or phenylsulfonyl group in the 4- or 5-position of the 2-(substituted amido)phenyl group are anthelmintic...
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JPS59500B2 |
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JPS58177960A |
PURPOSE: To obtain the titled compound useful as a remedy for pancreatitis inexpensively in high yield, by reacting a polyhalogenophenyl ester of 6-guanidinocaproic acid or its salt with ethyl p-hydroxybenzoate. CONSTITUTION: A novel pol...
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JPS5833842B2 |
N-[2-(Substituted amido)phenyl]-N',N''-bis-carbonylguanidines bearing an optionally substituted phenoxy, phenylthio, phenylsulfinyl or phenylsulfonyl group in the 4- or 5-position of the 2-(substituted amido)phenyl group are anthelmintic...
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JPS5899458A |
(+)-6-methoxy- alpha -methyl-2-naphthalene acetate of N,N''-bis (4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecan-d
iimidoamide, possessing the formula (I) (I) has high bioavailability by the cutaneous route which enables it to ...
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JPS5827792B2 |
Prodn. of guanidine derivs. of formula (I) comprises reacting a mercaptan deriv. of formula Het-(CH2)m-SM (III) is reacted with a guanidine of formula (IV). In the formulae, Het is opt. substd. 5- or 6-membered heterocyclic residue with ...
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JPS5823867B2 |
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JPS5748106B2 |
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JPS5745737B2 |
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JPS5715745B2 |
Method of producing N-(guanylureidoacetyl)- alpha -aminophenylacetic acid and the utility thereof in the production of N-(guanylureidoacetyl)- alpha -aminophenylacetyl chloride and the utility of the latter compound for producing the tit...
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JPS577605B2 |
The present invention relates to mixtures of guanidated aliphatic polyamines, or their acid addition salts, having antimicrobial or pesticidal effect. More particularly the invention relates to such mixtures which have a total degree of ...
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JPS5523823B2 |
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JPS5440547B1 |
A process of preparing by reacting 4-thiomethyl-5-methyl imidazole with N-cyano-N'-methyl-N''-(2-chloroethyl) guanidine in a two-phase system under the conditions of phase transfer catalysis.
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