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JP2000507097A |
(57) [Summary] The present invention relates to isolated RNA molecules having a high affinity for a particular amino acid, methods of isolating the RNA molecules and their use. The RNA molecule is isolated via a method that includes vari...
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JP2000507267A |
The present invention relates to a novel process for preparing N-methyl-D-phenylalanyl-N-[1-[3-[(aminoiminomethyl)amino]pro
pyl]-3,3-difluoro-2-oxohexyl]-L-prolinamide or a pharmaceutically acceptable salt therof and to a key intermediat...
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JP2000504738A |
The present invention relates to a process for the preparation of N-monomethyl-L-arginine hydrochloride comprising reaction of a compound of formula (I) or an acid addition salt thereof, wherein L is a leaving group; with L-ornithine or ...
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JP2000095749A |
To produce the subject compounds useful as intermediates for medicines or as raw materials for chemicals at advantageous costs in advantageous operations by reacting hydrocyanic acid with dimethylamine in the presence of chlorine in an a...
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JP2000086616A |
To provide a simple and practicable method for producing creatine or creatine monohydrate without requiring great expenditures for measuring techniques or regulating techniques in regulating the value of pH using an inorganic acid or an ...
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JP2000080072A |
To obtain L-arginine having a small crystal particle size distribution width in good particle size distribution repeatability and suitable for powder filling treatments by adding a specific amount of L-arginine crystals as seed crystals ...
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JP3009573B2 |
Pharmaceutically pure physiologically active N-aminoarginine (i.e., the L or D,L form) or pharmaceutically acceptable salt thereof is administered in a nitric oxide synthesis inhibiting amount to a subject in need of such inhibition (e.g...
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JP2996366B2 |
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JP2945261B2 |
PURPOSE: To provide new 15-deoxyspergualin homologs useful as therapeutic or preventive immunodepressiors. CONSTITUTION: The analogs are the compds. of formula I [where n is 6 or 8; A is single bond, CH2, CH(OH), CHF, CH(OCH3), CH2NH or ...
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JP2942342B2 |
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JPH11228527A |
To obtain the subject flaky crystal, excellent in filterability, high in purity, good in feeling when applied as a stock materials for cosmetics in high yield by reacting specific compounds with each other under specific conditions in a ...
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JPH11222476A |
To provide a method for simply and inexpensively producing the subject compound in high yield useful as e.g. an energy carrier of cells for supply of nutrition in food and drug fields by reacting a specific haloformamidinium salt with a ...
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JPH11222477A |
To provide a method for simply and inexpensively producing the subject compound in high yield useful as e.g. an energy carrier of cells for supply of nutrition in food and drug fields by subjecting an urea to a reaction so as to form a s...
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JPH11209335A |
To obtain the subject high-purity compound simply in a high yield by using readily obtainable starting raw materials, by reacting calcium cyanamide with a primary or a secondary aminocarboxylic acid. Calcium cyanamide is reacted with a p...
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JPH11209334A |
To obtain the subject high-purity compound simply, economically in a high yield from readily obtainable starting substances, by reacting calcium cyanamide with an alcohol and reacting the obtained isourea derivative with a primary or a s...
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JP2878844B2 |
(S)-N5-[Imino(methylamino)methyl]ornithine hydrochloride, pharmaceutical compositions containing it, its us in medicine and its preparation is described.
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JP2874839B2 |
15-deoxy-spergualin analogues of formula (I) and their addn. salts are new. X = (CH2)n; Y = (CH2)4; T = (CH2)2; A = a single bond, -CH2-, -CH2O-, -CH2NH-, -CH(OH)-, -CHF-, or -CH(OCH3)-; n = 6-8. Intermediate cpds. of formula (II) are al...
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JPH1171339A |
To obtain the subject high-purity compound in high yield by subjecting dicyandiamide to heat reaction with an ammonium salt in an organic solvent containing phenol. (A) Dicyandiamide is subjected to heat reaction with (B) an ammonium sal...
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JPH1160549A |
To obtain the subject compound that is useful as an agrochemical or its intermediate through another simple process instead of the hydrolysis by allowing a specific compound to react with a metal sulfate. The reaction between a compound ...
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JP2860778B2 |
15-Deoxy-spergualin carbamate analogues of formula NH2-C(=NH)NH(CH2)6ACH2NHCO-O-(CH2)4NH(CH2)2-*CH(R)-NH2 (I) and their addn. salts are new. A=CONH or NHCO; R=H or Me; if R is other than H, *C has (R,S) or (R) configuration. Interm...
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JP2853020B2 |
To obtain the subject compound having humidity-retaining action and keratin-softening action and useful as a blend component for skin cosmetics and hair cosmetics, and further, a synthetic intermediate for agrochemicals, medicined and dy...
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JP2854289B2 |
A process for preparing optically active (S)-(-) and (R)-(+)-deoxyspergualin and salts thereof of the formula I by reacting a compound of formula II with a compound of formula III in the presence of a condensing/dehydrating agent and an ...
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JPH10316647A |
To obtain a new derivative having strongly inhibitory actions on Na+/H+ exchange in cells. This compound is shown by formula I [R1 is a phenyl, thienyl, pyridyl or (substituted) polycyclic heterocyclic group each containing 1-3 substitue...
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JPH10195037A |
To obtain a new phenol derivative capable of suppressing formation of foam cell of macrophage by excellent anti-oxidant action and ACAT inhibition action to suppress progress of arteriosclerosis, eliminating active oxygen and suppressing...
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JP2779268B2 |
PCT No. PCT/EP93/00435 Sec. 371 Date Jul. 29, 1994 Sec. 102(e) Date Jul. 29, 1994 PCT Filed Feb. 19, 1993 PCT Pub. No. WO93/17017 PCT Pub. Date Sep. 2, 1993The present invention is concerned with vasoconstricive [(benzodioxan, benzofuran...
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JP2775047B2 |
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JPH10139753A |
To prepare a quaternary salt of nonhygroscopic hexaalkylguanidinium, tetraalkylammonium or tetraalkylphosphonium useful as a phase transfer catalyst in the production of a polymer such as polyetherimide. A quaternary salt of a dihydroxy ...
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JPH10504827A |
The present invention is the novel synthesis of sterically hindered penta-substituted guanidines by a process in which (1a) an isocyanate is reacted first with a di-substituted amine or (1b) a urea is reacted with two moles of a mono-sub...
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JP2738048B2 |
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JP2736787B2 |
Oligomeric cyanoguanidines of the formula I in which, for example, R<1> and R<2> are each phenyl, R is 1,4-phenylene and n is an integer from 1-20, are suitable as latent curing agents for epoxy resins. They are readily soluble in solven...
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JPH1081662A |
To obtain the subject new pharmaceutical compound useful for the prevention and treatment of infarction, the treatment of stenocardia, etc., as an antiarrhythmic agent containing a heart-protecting component. The objective compound is ex...
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JP2728148B2 |
Pharmaceutically pure physiologically active N-aminoarginine (i.e., the L or D,L form) or pharmaceutically acceptable salt thereof is administered in a nitric oxide synthesis inhibiting amount to a subject in need of such inhibition (e.g...
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JPH107645A |
To selectively obtain a alkylnitroguanidine in one step useful for organic intermediates, medicines, agrochemicals, especially penetrative insecticides by alkylating nitroguanidine derivatives with an alkylating agent. According to this ...
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JP2693493B2 |
The compounds comprising a tetraphenylborate ion and a guanidine functional group correspond to the general formula: in which R denotes an organic radical containing at least one other amine functional group. These compounds are empl...
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JPH09309873A |
To provide a simple method for producing camostat mesylate in an industrially good yield. This method for producing camostat mesylate comprises performing an esterification reaction of 4-guanidinobenzoic acid or a reactive derivative the...
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JPH09511765A |
PCT No. PCT/FR96/00203 Sec. 371 Date Oct. 10, 1996 Sec. 102(e) Date Oct. 10, 1996 PCT Filed Feb. 7, 1996 PCT Pub. No. WO96/24579 PCT Pub. Date Aug. 15, 1996The present invention relates to compounds selected from the group consisting of:...
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JPH09278737A |
To obtain a new phenol derivative having excellent lipid peroxidation suppressive activity and macrophage foaming suppressive activity, and useful for preventing/treating ischemic cardiopathy, etc., by reaction of a specific compound wit...
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JPH09278738A |
To obtain an organic base, high in both its diffusion rate and its formation rate, not decomposed during its preservation at room temperature, by heating a base precursor consisting of a salt composed of a carboxylic acid and the organic...
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JP2661903B2 |
A process for the production of a high energy nitrate ester involves reacting, in an inert organic solvent, a heterocyclic compound, selected from oxiranes, oxetanes, N-substituted aziridines and N-substituted azetidines, with either N2O...
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JPH09509095A |
PCT No. PCT/EP95/00629 Sec. 371 Date Aug. 20, 1996 Sec. 102(e) Date Aug. 20, 1996 PCT Filed Feb. 21, 1995 PCT Pub. No. WO95/22398 PCT Pub. Date Aug. 24, 1995A process for recovering guanidine salts from diluted and contaminated aqueous s...
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JPH09227495A |
To obtain a novel phenol derivative which has excellent lipid peroxidation-inhibitory action, macrophage-foaming inhibitory action and oxidized low-density lipoprotein formation-inhibitory action with toxicity reduced, and is useful as a...
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JPH09228210A |
To obtain a fiber-filled body such as Futons (thick bedquilts), excellent in comfortableness and washable with water without causing any dimensional change or wrinkles even when washed with water by composing a ticking and a filling of a...
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JP2636106B2 |
PURPOSE: To produce a biguanide derivative useful as an intermediate for phenoxyalkylamino group-substituted triazine based herbicide in high purity and high yield. CONSTITUTION: A phenoxyalkylamine salt of formula I (R1 and R2 are 1-4C ...
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JPH09136034A |
To provide a method for recovering such quaternary salt that can be recycled as an effective interphase migration catalyst. When a substituted aromatic compound such as salt of a dihydroxyaromatic compound, halophthalimide, and nitrophth...
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JPH09124584A |
To obtain the subject new compound expressed by a specific formula, useful for the production of a medicine for the treatment or prevention of arrhythmia, myocardial infarct and angina pectoris. This substituted benzoylguanidine is a com...
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JPH09124583A |
To obtain the subject new compound of a medicine suppressing cellular Na+/H- countertransporting body, expressed by a specific formula, especially suitable for the treatment of arrhythmia, manifesting a good cardio-protective effect, and...
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JP2586914B2 |
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JP2579323B2 |
An omega -guanidino- alpha -amino acid (or its functional derivative) or a compound containing it may be prepared by the reaction of the omega -amino group of an alpha , omega -diamino acid (or its functional derivative) or a compound co...
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JPH09500110A |
Methods of making unnatural amino acids are provided which unnatural amino acids can be incorporated into peptides which either inhibit or promote the secretion of gonadotropins by the pituitary gland and inhibit the release of steroids ...
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JPH08311011A |
To obtain the subject novel compound, acting as the cellular Na+/H+ antiporter, showing an excellent heart protective function, and useful for treatment and prevention of e.g. arrhythmia, angina pectoris, hypoxia disorder and ischemia di...
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