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JPH08291131A |
To obtain a new compound having highly excellent antiarrythmic effect and useful in preventing/treating cardiac arrhythmia, myocardial infarction and the like, also having potent inhibitory activity against cell proliferation, therefore ...
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JPH08509970A |
PCT No. PCT/GB94/00966 Sec. 371 Date Feb. 22, 1995 Sec. 102(e) Date Feb. 22, 1995 PCT Filed May 5, 1994 PCT Pub. No. WO94/26701 PCT Pub. Date Nov. 24, 1994 (II) (III) A process is disclosed for the preparation of NG-monoalkyl-L-arginine ...
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JP2542362B2 |
Synthetic nonapeptide and decapeptide LHRH antagonist analogs having a halo lower alkyl guanadino-substituted amino acyl residue at position six are disclosed herein.
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JPH08259411A |
To produce an antimicrobial composition, containing an alkylguanidine as an active ingredient, capable of inhibiting the growth of microorganisms in various aqueous systems, etc., for industrial purposes and further having storage stabil...
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JPH08225514A |
To obtain the subject compound without exhibiting undesirable disadvantageous salt diuretic property, useful as a medicine for preventing or treating cardiac infarction, arrhythmia and angina pectoris by reacting a specific compound with...
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JP2503056B2 |
In an improved process for the preparation of 1,6-di(N<3>-cyano- N<1>-guanidino)hexane from alkali metal dicyanamide and a hexamethylenediammonium salt in alcoholic solution or suspension, the reaction is carried out in the presence of a...
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JPH0899950A |
To obtain the subject new compound having strongly inhibitory actions on cell proliferation, e.g. proliferation of fibroblast and proliferation of vascular smooth muscle, useful as a medicine for alleviating atherosclerosis and a therape...
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JPH0859598A |
To obtain an arylbenzolyguanidine compound capable of suppressing cell Na+/H+ exchange mechanism, having heart-protecting effect and useful for preventing and treating arrhythmia, angina pectoris and obstruction. This arylbenzolyguanidin...
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JPH0812643A |
PURPOSE: To prepare an o-amino-substituted benzoylguanidine useful as a therapeutic agent for cardiovascular diseases. CONSTITUTION: This compound is represented by formula I [R(1) is NR(50)R(6); R(2) to R(5) are each R(10)-SOa, R(11)R(1...
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JPH07300450A |
PURPOSE: To obtain guanidine inexpensively in a high yield by reacting a primary or secondary amine with a strong acid salt of amidinotriazole. CONSTITUTION: For example, 3-picolylamine, water and rhodium on alumina are added together, d...
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JPH07278071A |
PURPOSE: To obtain betaines with a small amount of the residual starting amine and organic halogen by using a tertiary amine and an ω-haloalkanecarboxylic acid solution with a specific ratio, quaternization of the teriary amine under sp...
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JPH0796504B2 |
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JPH07252204A |
PURPOSE: To provide a method for producing spherulitic nitroguanidine with high apparent density and bulk density, capable of obtaining nitroguanidine as spherical crystals in high yield and supplying a mother liquid to the crystallizati...
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JPH0780848B2 |
The novel sulphonamidocarboxamides of the formula in which X is a group of the formula X<1> or X<2>: T is CH2 or O, and A, M, Q and Y have the meaning given in the description, and hydrates or solvates thereof inhibit the platelet aggreg...
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JPH07228565A |
PURPOSE: To obtain a new compound having low toxicity, chemical stability and excellent immunosuppressive action. CONSTITUTION: A compound of the formula GU-X1-(CH2)a-CONH-X2- CONH-(CH2)4-NH-(CH2)3-NH-Y [Gu is guanidino; X1 is (CH2)5 or ...
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JPH0778038B2 |
Novel NG-protected or unprotected-L-argininal-dibutyl acetals (I) can be prepared from L-argininal derivatives (III) merely by reacting in an azeotropic solvent in the presence of p-toluenesulfonic acid. In the products (I), L-form amoun...
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JPH0776204B2 |
Spergualin-related compounds and their synthetic intermediates are purified by electrodialysis and/or reverse osmosis. Solutions of such compound or intermediate containing inorganic salt (due to elution with inorganic salt solution) can...
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JPH07206802A |
PURPOSE: To rapidly produce a biguanide compound in a high yield through a melt reaction. CONSTITUTION: This method for production of a biguanide compound is carried out by conducting a melt reaction of raw materials composed of an amine...
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JPH07505159A |
A process for the preparation of a substituted guanidine by reacting a substituted cyanamide with ammonia or a substituted amine in the presence of a Lewis acid catalyst. Also disclosed is a process for the preparation of a tri-substitut...
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JPH0745459B2 |
Large flow free crystals of L-arginine phosphate monohydrate (LAP) are produced from a saturated aqueous solution of LAP by rotating seed crystals of LAP in the solution while maintaining the pH of the solution at 2-8, preferably at 2-3 ...
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JPH0742268B2 |
The present invention relates to Spergualin analogues having a phenylene group and salts thereof, and to a process for their preparation. The compounds of the invention exhibit cancer-control activity and can, therefore, be used as medic...
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JPH0730009B2 |
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JPH0753488A |
PURPOSE: To obtain a new compound having improved various physiological actions of conventional agents such as amelioration of dementia and antithrombotic action and expected to develop the nutrient and physiological actions of amino aci...
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JPH078846B2 |
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JPH075538B2 |
The present application relates to novel Spergualin-related nitrile compounds containing a phenylene group and salts thereof, which are useful as starting materials for the synthesis of Spergualin-related compounds containing a phenylene...
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JPH075537B2 |
A process for producing iminoctadine 3-alkylbenzenesulfonates, which comprises reacting triamine of the formula H₂N(CH₂)₈NH(CH₂)₈NH₂ with an O-alkylisourea alkylbenzenesulfonate in the presence or absence of a reaction medium.
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JPH07592B2 |
Benzoylguanidines of the formula I (* CHEMICAL STRUCTURE *) (I) where R(1) or R(2) is equal to R(6)-S(O)n- or R(7)R(8)N-O2S- and the other substituent R(1) or R(2) is in each case equal to H, F, Cl, Br, I, alkyl, alkoxy or phenoxy, R(6)-...
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JPH0610179B2 |
The compound of the formula I wherein R1, R2 and R3 have the significance given in the description, can be used as medicaments for the therapy and prophylaxis of disorders such as thromboses, stroke, cardiac infarct, inflammations and ar...
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JPH069209A |
PURPOSE: To produce a transition metallic carbide having a large surface area and catalytic activity for use in air pollution control, isomerization and hydrodesulfurization processes. CONSTITUTION: A mixture of an acyclic compd. contain...
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JPH05286919A |
PURPOSE: To efficiently racemize an optically active 2-aminonitrile under a mild condition by treating it with a prussiate compound in an organic solvent. CONSTITUTION: An optically active 2-aminonitrile of formula I or II (R is an alkyl...
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JPH0560824B2 |
For the preparation of saline derivatives of mercaptoethansulfonic acid belonging to the class of the salts of alkali metals and of the salts with basic aminoacids, the sodium salt of the acid is obtained with a process comprising the re...
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JPH05112521A |
PURPOSE: To obtain a general production method capable of industrially producing from a new intermediate a nitroguanidine derivative especially having a safe and advantageous property as an agricultural insect pest control agent, useful ...
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JPH0558985A |
PURPOSE: To obtain the subject compound useful as a potassium channel opening medicine by reacting an aniline derivative with an isocyanide derivative in the presence of a dehydrating agent using a specific catalyst while blowing oxygen ...
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JPH0461868B2 |
PCT No. PCT/JP85/00392 Sec. 371 Date Feb. 24, 1986 Sec. 102(e) Date Feb. 24, 1986 PCT Filed Jul. 12, 1985 PCT Pub. No. WO86/00893 PCT Pub. Date Feb. 13, 1986.Amidine compounds of formula (I) (I) and the pharmaceutically acceptable acid a...
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JPH04505318A |
Antimicrobial bis-(pyrrolidonyl alkylene) biguanides having the formula: A-Z-A where A is: X is C2-C4 alkylene; and Z is a bivalent bridging group, and acid addition salts thereof, are provided herein.
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JPH0443063B2 |
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JPH0437826B2 |
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JPH03284658A |
PURPOSE: To remove very small amounts of malodorous substances and impurities such as inorganic salts and concentrate an N-long-chain acylamino acid salt solution by treating the above-mentioned solution with a loose reverse osmosis memb...
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JPH03236366A |
NEW MATERIAL:A guanidinobenzene derivative expressed by formula I or salt of said derivative (R1 is phenyl substituted with amidino or naphthyl substituted with amidino). EXAMPLE: 4-guanidinobenzoic acid-4-amidinobenzamide.2-methane sulf...
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JPH0359899B2 |
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JPH0354933B2 |
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JPH0338265B2 |
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JPH0386852A |
NEW MATERIAL: A compound of formula I (R1 is H, amino protective group, or peptide; R2 is side chain of α-amino acid), hydrate of the same, isostar, or the salt of the same. EXAMPLE: L-phenylalanineamide, N-[(phenylmethoxy)carbonyl]-L-v...
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JPH0312052B2 |
A method for the resolution of DL- alpha -amino acid (except DL-p-hydroxyphenylglycine or (+/-)- alpha -phenylethanesulfonic acid using an optically active alpha -phenylethanesulfonic acid or optically active alpha -amino acid (except op...
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JPH038335B2 |
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JPH0254824B2 |
The present invention reales to novel Spergualin related compounds, and a process for producing the same. More particularly, the invention reales to Spergualin related compounds of the formula: wherein R1 is a lower alkylene group which ...
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JPH0254822B2 |
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JPH0254823B2 |
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JPH0253433B2 |
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JPH0234343B2 |
Poly(oxyalkylene) glycols and polymer-supported poly(oxyalkylene) alcohols are employed as phase-transfer reagents in blocking primary amino functionality of alkali metal salts of amino acids with a benzyloxycarbonyl group.
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