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WO/2024/016638A1 |
An antihistamine compound having a structure represented by formula (I), a pharmaceutically acceptable salt and a preparation method therefor, and a use of the antihistamine compound having a structure represented by formula (I) and the ...
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WO/2024/003913A1 |
A process for the preparation of biguanidine compounds of formula (I) and triazine compounds of formula (IV); wherein R1, R2 and R3 are each independently hydrogen or an optionally substituted C1-C4 alkyl group, wherein the optional subs...
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WO/2023/241117A1 |
A synthesis method for an easily-soluble guanidinoacetic acid complex, comprising: first, adding guanidine hydrochloride into an alkaline solution A to generate free guanidine and obtain a solution B; then dropwise adding chloroacetic ac...
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WO/2023/201712A1 |
The present invention provides a clofoctol derivative, which has a structure represented by general formula (1). The clofoctol derivative has high efficiency, low toxicity, wide antibacterial spectrum, fast sterilization speed, excellent...
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WO/2023/192165A1 |
In various embodiments, the present disclosure pertains to compositions and methods for prevention or treatment of cancer, prevention, treatment or inhibition of viral or microbial infection or replication, or prevention, treatment or in...
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WO/2023/180219A1 |
A method for synthesis of halide salts of the general formula: Zn+X- n; the method comprising reacting a first reactant being formate salt with a second reactant being a diatom halogen: X2.
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WO/2023/148783A1 |
The invention provides a novel, economical and practical route for the synthesis of an ester from acid and alcoholic functionalities using Trihalotriazine as coupling agent. Specifically, the invention provides a novel, economical and pr...
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WO/2023/147729A1 |
A continuous synthesis system for metformin hydrochloride. The continuous synthesis system for metformin hydrochloride comprises a continuous feeding unit (10) and a horizontal double-shaft reaction device (20). The horizontal double-sha...
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WO/2023/131355A1 |
The present invention relates to the technical field of antibacterial. Disclosed are a water-soluble chlorhexidine antibacterial, a preparation method therefor and an application thereof. In the present invention, the preparation method ...
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WO/2023/033015A1 |
Provided is a method for producing a Fmoc-protected amino group-containing compound, wherein a raw material amino group-containing compound is not wasted, by-production of Fmoc-β-Ala-OH is suppressed, and the purification of a target su...
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WO/2022/241978A1 |
The present invention belongs to the field of drug synthesis, and disclosed are a method for synthesizing metformin hydrochloride and an application thereof. The method for synthesizing comprises: after dissolving dicyandiamide and dimet...
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WO/2022/164150A1 |
Provided are a method for efficiently producing nafamostat mesylate using a simple process, and a method for producing 6-amidino-2-naphthol mesylate, which is an intermediate of nafamostat mesylate production, at high yield and under mil...
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WO/2022/162604A1 |
The present invention relates to a novel cocrystal, a pharmaceutical composition comprising same and a preparation method therefor. By using the cocrystal of the present invention, cancers, inflammatory diseases, or viral infection disea...
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WO/2022/148053A1 |
The present invention relates to the technical field of pharmaceutical preparations, and in particular to a purification method for metformin hydrochloride, a metformin hydrochloride sustained release tablet and a preparation method ther...
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WO/2022/097813A1 |
The present invention relates to an eco-friendly and highly efficient method for preparing an ester compound based on an esterification reaction using a salt ion-exchange method, and an ester compound thereof. In conventional esterificat...
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WO/2022/051427A1 |
Described herein are compositions and methods for treating cancer in a subject. Using the compositions and methods of the disclosure, a subject may be administered (i) an inhibitor and/or an overrider and (ii) a chemotherapeutic.
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WO/2022/048909A1 |
The present invention concerns a modified method for preparing guanidine acetic acid (GAA) by reacting cyanamide with an excess molar amount of glycine in an aqueous reaction mixture in the presence of a base that avoids high molar amoun...
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WO/2022/048913A1 |
The present invention refers to a method for preparing guanidino acetic acid by reacting cyanamide and glycine in an aqueous reaction mixture in the presence of a base, wherein the ammonia content in the reaction mixture is controlled to...
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WO/2022/045163A1 |
The present invention provides a guanidine fatty acid salt production method through which liquid surface elevation, caused by carbon dioxide generated during production of guanidine fatty acid salt, can be suppressed. This guanidine fat...
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WO/2021/227436A1 |
The present invention belongs to the technical field of medicine synthesis, relates to an antifungal compound, and in particular relates to an antifungal compound, a synthesis method and the use thereof, wherein the antifungal compound i...
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WO/2021/154870A1 |
Described herein, inter alia, are IGF2BP2 inhibitor compounds and methods of using the same.
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WO/2021/105337A1 |
The present invention relates to a process for synthesizing large scale a compound of formula (I), or pharmaceutically acceptable salt thereof, which is useful as the key intermediate for the synthesis of compounds for prophylaxis and tr...
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WO/2021/044445A1 |
The present invention provides a continuous solvent free and additive free process for the synthesis of Metformin Hydrochloride in a screw reactor. >90% conversion of the solid substrates without solvent is obtained in a screw reactor to...
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WO/2021/040441A1 |
The present invention relates to a method for preparing a biguanide-based compound with a high yield. More specifically, the present invention relates to a method for preparing a biguanide-based compound, the method comprising the steps ...
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WO/2021/012274A1 |
The present invention provides a preparation method for metformin hydrochloride. The preparation method comprises: heating raw materials comprising dicyandiamide and dimethylamine hydrochloride by means of microwave, and making the two r...
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WO/2021/008845A1 |
The invention relates to a new crystal modification of N-(aminoiminomethyl)-2-aminoethanoic acid, to crystal mixtures and to a method for producing the crystal modification and the crystal mixtures according to the invention.
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WO/2021/008844A1 |
The present invention relates to a novel crystal modification of N-(aminoiminomethyl)-2-aminoethanoic acid and to a process for the production of said crystal modification.
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WO/2021/008843A1 |
The present invention relates to novel crystal modification of N-(aminoiminomethyl)-2-aminoethanoic acid and to a process for producing said crystal modification.
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WO/2021/008846A1 |
The invention relates to a method for producing N-(aminoiminomethyl)-2-aminoethanoic acid containing N-(aminoiminomethyl)-2-aminoethanoic acid in a thermodynamically metastable crystal modification.
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WO/2021/002689A1 |
The present invention relates to a method for producing peramivir trihydrate, which is an inhibitor of neuraminidase infection, as an anti-influenza agent. According to the production method of the present invention, peramivir trihydrate...
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WO/2020/262455A1 |
The present invention provides a means for increasing the solubility of even a poorly soluble amino acid without changing to an expensive peptide and also without changing the pH, and is characterized in that at least two kinds of amino ...
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WO/2020/210252A1 |
A process to extract carbon from hydrophobic waste comprises: combining the hydrophobic waste with an oxide of an active metal to form a storable, moisture-resistant feedstock for high-temperature processing; heating the feedstock in a f...
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WO/2020/184797A1 |
The present invention relates to: an eco-friendly method capable of synthesizing an unnatural amino acid-based antibacterial and antibiotic preservative, which has excellent antibacterial and antibiotic performance, in a high yield and w...
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WO/2020/107500A1 |
The present invention provides a 2-(1-acyloxypentyl) benzoic acid salt formed by basic amino acid or aminoguanidine, a preparation method thereof, a pharmaceutical preparation containing the salt and the uses of the pharmaceutical prepar...
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WO/2019/154769A1 |
The present invention relates to an improved process for the preparation of metformin hydrochloride, an important drug in the first line treatment of Type II Diabetes.
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WO/2019/100261A1 |
A metformin hydrochloride synthesis system and a preparation method therefor, the synthesis system comprising a reaction apparatus (20), the reaction apparatus (20) being provided with a feed opening and a reactant discharge opening, and...
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WO/2019/092319A1 |
The present invention relates to a method of producing a bicyclic guanidine and its derivatives. In particular, the present invention relates to a method of producing triazabicyclodecene (TBD) and its derivatives, particularly alkyl deri...
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WO/2019/073476A1 |
The present invention relates to the field of chemistry for the preparation of gabapentin salt of formula (I). More particularly the present invention relates to a continuous process for preparation of gabapentin salt (I) by means of the...
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WO/2018/233326A1 |
A hydrogen sulfide donor in an organic salt form and a preparation method therefor. The hydrogen sulfide donor is a salt structure formed by organic compounds with an alkaline structure and hydrogen sulfide. The hydrogen sulfide donor ha...
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WO/2018/231843A1 |
A compound according to Formula (I):, wherein Z is: (II).
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WO/2018/210633A1 |
The present invention relates to a method for the production of phenylguanidines or the salts thereof by reacting an aniline that has electronegative substituents with a cyanamide-containing mixture.
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WO/2018/156454A1 |
Provided are methods of preventing or suppressing an allergic reaction to food by administering an inhibitor of the unfolded protein response (UPR) and uses of a composition comprising an inhibitor of the UPR for treating or preventing a...
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WO/2018/135977A1 |
The invention relates to the field of pharmaceutical chemistry, namely to new biologically active substances and their use and to a method of production. In particular, the invention relates to a derivative of creatine - phenylcreatine, ...
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WO/2017/114226A1 |
Disclosed in the present invention is a method for separating and purifying a creatine mother liquor: by means of a liquor delivery tube, pumping a mother liquor after creatine synthesis to be separated in an electrodialyzer, wherein the...
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WO/2017/063155A1 |
The present invention provides compounds of formula I. The present invention also provides a preparation method for the compounds and a medicine composition comprising the compounds. The medicine composition can be used for treating a bo...
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WO/2017/043842A1 |
The present invention relates to a method for preparing D-arginine and, more particularly, to a method for preparing D-arginine by photosplitting DL-arginine using D-3-bromocamphor-8-sulfonic acid or a salt thereof as a photosplitting ag...
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WO/2017/042126A1 |
The invention relates to a method for producing biguanide salts of formula (III) and s-triazines of the formula (V). R1 and R2 respectively represent hydrogen, halogen and alkyl and R3 and R4 each represent hydrogen, alkyl, cycloalkyl an...
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WO/2017/036357A1 |
Provided are a cathepsin K inhibitor and application thereof, and specifically is a compound having a structure represented by formula (I) and being used to treat or prevent a cathepsin dependent disease. In particular, the cathepsin is ...
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WO/2017/025560A1 |
The present invention relates to a process for the preparation of the compound N-(3,5-dimethylphenyl)-N'-(2-trifluoromethylphenyl) guanidine of formula (I) which comprises reacting a salt of a compound of formula (II) or a mixture of the...
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WO/2016/202125A1 |
Disclosed are an intermediate, N-[2-[[2-(dimethylamino)ethyl]methylamino]-4-methoxy-5-forma
midine]phenyl-2-propenamide (II), applicable in preparing AZD9291 (I) and a preparation method for the intermediate. Preparation steps comprise: ...
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