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JP3194953B2 |
This invention relates to peptide aldehyde analogs that inhibit the thrombin or Factor Xa. The compounds are thought useful for preventing or treating conditions in mammal characterized by abnormal thrombosis.
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JP3194232B2 |
Disclosed is a semicarbazide derivative represented by formula (1) or a terminal-blocked form thereof: wherein R<1> represents a terminal isocyanate group-free polyisocyanate residue or a terminal isocyanate group-free triisocyanate resi...
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JP2001509794A |
The invention relates to novel arylalkyl compounds of the general formula (I)in whichm represents the numbers 0 to 5,n represents the numbers 0 to 4,Q represents O, S, SO or SO2,R1 represents hydrogen or optionally substituted alkyl,R2 r...
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JP3187535B2 |
PURPOSE: To provide a novel hydrazine deriv. which is effective for the suppression of the protease or retroviruses and more particularly protease aspartate and is used for the treatment of the diseases induced by the retroviruses. CONST...
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JP3186067B2 |
Compounds having the structural formula: (I) wherein: R is C1-C6 hydroxyalkyl, C1-C6 haloalkyl, C1-C6 alkyl, C7-C9 aralkyl, or nitroso; R' is C1-C4 alkyl; and R'' is C1-C4 alkyl. These compounds exhibit insecticidal and miticidal activity.
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JP3179599B2 |
PURPOSE: To obtain a new compound useful for preventing and/or treating thrombosis, arteriosclerosis, ischemic cardiopathy, gastric ulcer, hypertension, etc., due to its agonistic action on PGI2 receptors. CONSTITUTION: The objective com...
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JP3174347B2 |
There are described compounds of formula (I*) wherein R1 is lower alkoxycarbonyl, R2 is secondary or tertiary lower alkyl or lower alkylthio-lower alkyl, R3 is phenyl that is unsubsituted or substituted by one or more lower alkoxy radica...
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JP2001506606A |
Aminoguanidine and alkoxyguanidine compounds, including compounds of the formula:wherein X is O or NR<9 >and R<1>-R<4>, R<6>-R<9>, R<11>, R<12>, R, R, R, Y, Z, n and m are set forth in the specification, as well as hydrates, solvates or ...
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JP3159704B2 |
Compositions useful in methods of disinfecting contain azoic compounds of the general formula wherein R1, R2, R3 and R4 are identical or different and each represents an atom of hydrogen or an aliphatic or aromatic hydrocarbon radical co...
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JP2001505209A |
The invention features pharmaceutical compositions that include hydroxyguanidines. The compositions can be used, for example, for treating or preventing ischemic diseases, hypoxia,or arrhythmias.
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JP2001097941A |
To provide a method for preparing an aminoarylhydrazide compound useful as an intermediate for synthesizing coloring matter. This method for preparing the aminoarylhydrazide comprises reacting a compound of general formula (I) (R1 and R2...
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JP2001064244A |
To obtain amines having a configuration under industrially practicable reactional conditions by reducing a solution of a specific compound in the presence of a boron compound with a reducing agent. (A) A solution of a compound represente...
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JP2001501592A |
Boron compound complexing reagents, intermediate reagents of those reagents and methods of synthesizing these reagents are disclosed. These reagents, including those shown as General Formula (I) and General Formula (II) may be used, afte...
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JP3132824B2 |
The present invention is directed to coating compositions comprising a) polyisocyanates having a content of isocyanate groups blocked by blocking agents of about 10 to 35% by weight and containing about 0.5 to 10.0 % by weight of structu...
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JP2001011038A |
To obtain a new isocyanate in high yield by eliminating the hydroxyl group from a hydroxamic acid in the presence of an acid halide or acid anhydride and a base.This new isocyanate, a compound of formula II (e.g. 1- hexylnonyl cyanate), ...
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JP2000514815A |
A composition, which comprises at least one compound of the formulain which A1, A2, R1 and R2 are as defined in claim 1, or, if appropriate, an E/Z isomer, an E/Z isomer mixture and/or a tautomer thereof, in each case in free form or in ...
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JP2000281640A |
To obtain a new compound having an excellent inhibiting activity to many kinds of proteases and useful as a protease inhibitor. This compound is represented by formula I [R1 is H or an amino protecting group; R2 is H, an alkyl or the lik...
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JP2000511181A |
The invention concerns a process for preparing 2,2'-(1-methyl-1,2-ethanediylidene)bisÄhydrazine carboximidamideÜ comprising the steps of : a) reacting aminoguanidine hydrochloride with methylglyoxal aldehyde or methylglyoxal dimethyl a...
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JP2000511180A |
Process for the preparation of 2,2'-(1-methyl-1,2-ethanediylidene)bisÄhydrazine carboximidamideÜ by a) removing impurities from aminoguanidine bicarbonate ; b) reacting the aminoguanidine bicarbonate with methylglyoxal dimethyl acetal ...
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JP2000217944A |
To improve a property for removing formaldehyde without using latex including a carbonyl radical or the like by preparing a constituent material for removing formaldehyde by using specific semicarbazide. A constituent material for removi...
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JP3073201B2 |
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JP3071962B2 |
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JP2000204073A |
To obtain a new compound meeting its preservation stability under a wide range of conditions while maintaining its stable color developing and fading ability, and useful as a color developing/fading control agent capable of giving quick ...
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JP2000508630A |
PCT No. PCT/EP97/01325 Sec. 371 Date Sep. 18, 1998 Sec. 102(e) Date Sep. 18, 1998 PCT Filed Mar. 17, 1997 PCT Pub. No. WO97/36883 PCT Pub. Date Oct. 9, 1997The invention relates to novel (1,3,4)-oxadiazine derivatives of formula (I), to ...
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JP2000507588A |
Amidino and benzamidino compounds, including compounds of the formula: I wherein R1-R4, R6-R9, Y, Z, n and m are set forth in the specification, as well as hydrates, solvates or pharmaceutically acceptable salts thereof, that inhibit pro...
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JP3054875B2 |
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JP2000159738A |
To obtain a new compound which contains a modified hydrazide group, and is useful as a raw material for a polyisocyanate-based resin.This compound, which contains a modified hydrazide group corresponding to the formula [R is a moiety obt...
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JP3041444B2 |
PURPOSE: To industrially and advantageously obtain a carbazinic acid derivative useful as an intermediate for medicines, a raw material, etc., for agrochemicals in a high yield at a low cost by reacting sodium salt of monochlorourea with...
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JP2000119242A |
To obtain the subject composition equipped with a low temperature- curing property and preservation stability simultaneously and capable of forming a membrane excellent in waterproof property, soil resistance, etc. by containing a specif...
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JP2000109788A |
To obtain a hydrazine derivative having both low-temperature curability and storage stability, capable of forming a coating film having excellent water resistance, hardness, or the like, by making the composition include a specific compo...
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JP2000503639A |
Branched hydrazone linkers for linking a targeting ligand such as an antibody to a therapeutically active drug. The point of branching is at a polyvalent atom and the number of drugs increases by a factor of two for each generation of br...
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JP3021669B2 |
A compound of the formula wherein R is a) phenyl; phenyl(C1-C4 alkoxy); phenoxy; or benzyl; the phenyl ring of each substituent being optionally substituted with one or more of halogen, nitro, C1-C8 alkyl, C1-C8 alkoxy, C1-C8 haloalkyl, ...
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JP3021719B2 |
The present invention is directed to a new class of compound which are useful as inhibitors of the biosynthesis of nitric oxide.
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JP3017714B2 |
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JP3018264B2 |
A process is described for the preparation of alkylated azaglycine derivatives of the formula I, X-(A)n-N(R)-NH-CO-NH2, (I> in which X represents an amino protective group, C1-C8-alkanoyl, C8-C14-arylcarbonyl or C6-C14-aryl-C1-C4-alkanoy...
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JP2000502684A |
The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging) using compounds of formula (I), wherein alk is a straight or branched chain alkylene group containing from 2 to 8 carbon ...
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JP3009573B2 |
Pharmaceutically pure physiologically active N-aminoarginine (i.e., the L or D,L form) or pharmaceutically acceptable salt thereof is administered in a nitric oxide synthesis inhibiting amount to a subject in need of such inhibition (e.g...
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JP2000500742A |
Disclosed herein is a compound of the formula known as 2-[N-(N-benzyloxycarbonyl-L-leucinyl)]-2'-[N'-[4-(N,N-dimeth
ylaminomethyl)benzyloxy]carbonyl-L-leucinyl]carbohydrazide; and pharmaceutically acceptable salts, hydrates and solvates ...
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JP2994760B2 |
Compounds having the structural formula xy or C1-C6 alkyl; R1 is fluorenyl, thienyl, pyridyl or thiazolyl, unsubstituted or substituted by one or more substituents selected from C1-C4 alkoxy, C1-C4 alkyl, C1-C4 alkylthio, halogen, C1-C4 ...
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JP2993856B2 |
PURPOSE: To obtain the subject compound in high yield and in a much more reduced consumption amount of a carbon dioxide gas than a conventional method, by reacting a hydrazine compound with a liquid carbon dioxide gas under pressure. CON...
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JP2982873B2 |
To obtain a new compound useful e.g. as a hair tonic and a preparation for external use for skin, having excellent hair development-stimulating effects and hair-growing effects. This derivative is expressed by formula I [out of A and B, ...
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JPH11513391A |
Analogs of the antitumor antibiotics CC-1065 and the duocarmycins incorporate the 1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one (CBI) alkylation subunit. The CBI-based analogs have potent cytotoxic activity and are useful as efficac...
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JPH11512109A |
PCT No. PCT/FR96/01349 Sec. 371 Date Mar. 3, 1998 Sec. 102(e) Date Mar. 3, 1998 PCT Filed Apr. 9, 1996 PCT Pub. No. WO97/09303 PCT Pub. Date Mar. 13, 1997An alpha -hydrazino acid derivative of general formula (I) is described, wherein R1...
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JPH11511153A |
PCT No. PCT/EP96/03456 Sec. 371 Date Feb. 9, 1998 Sec. 102(e) Date Feb. 9, 1998 PCT Filed Aug. 5, 1996 PCT Pub. No. WO97/07091 PCT Pub. Date Feb. 27, 1997The present invention relates to novel fluorobutenic acid hydrazides of the formula...
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JP2952712B2 |
A process for producing semicarbazide which comprises reacting a compound of formula (I) with ammonia in the absence or presence of a catalyst comprising a chloride, hydroxide, sulfate, carbonate, acetate, salicylate, amine complex or et...
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JPH11509540A |
PCT No. PCT/FR96/01095 Sec. 371 Date Jan. 6, 1998 Sec. 102(e) Date Jan. 6, 1998 PCT Filed Jul. 15, 1996 PCT Pub. No. WO97/03678 PCT Pub. Date Feb. 6, 1997Cyclo-oxygenase inhibitor and amidine derivative salts, preparation methods therefo...
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JPH11509531A |
1-Amino-3-benzyluracils I(X=oxygen, sulfur;R1=C1-C4-haloalkyl;R2=H, halogen; R3, R7=H, CN, SCN, halogen, C1-C4-haloalkyl, C1-C4-haloalkoxy, C1-C4-haloalkylthio;R4=H, CN, SCN, halogen, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy, C1-C4-hal...
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JPH11508569A |
PCT No. PCT/EP96/02695 Sec. 371 Date Dec. 23, 1997 Sec. 102(e) Date Dec. 23, 1997 PCT Filed Jun. 21, 1996 PCT Pub. No. WO97/02255 PCT Pub. Date Jan. 23, 1997Bis-oxime derivatives of the formula I W is oxygen or sulfur, and the other subs...
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JPH11193266A |
To obtain a silver halide photographic material excellent in image quality such as sharpness, graininess, resolving power or color reproducibility and providing a stable and ultrahigh contrast image even by treatment with a developer at ...
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JPH11507626A |
Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
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