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WO2003051276B1 |
Compounds of formula (I) or (II) wherein R1 , R2 , R3 , R4 , W, Q, G, X and Y are as defined in the specification, as well as salts, enantiomers thereof and pharmaceutical compositions including the compounds are prepared. They are usefu...
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WO/2004/026845A1 |
The present invention relates to a new process for the synthesis of high purity 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine of formula (I) using 2,3-dichlorobenzoyl cyanide and an aminoguanidine salt as starting materials. 2,3-dich...
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WO/2004/024737A1 |
The invention relates to a method for binding heteroatom-carbon bonds. According to said method, a lithium compound (II) is first generated by reacting aliphatic or aromatic halogen compounds (I) with lithium metal, said compound is then...
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WO/2004/017898A2 |
The present invention is directed to processes for the preparation of 3-chloromethyl-1,2,4-triazolin-5-one. This compound is useful as an intermediate in the synthesis of compounds which possess pharmacological activity. Also disclosed a...
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WO/2003/106400A1 |
The method for preparing hydrazodicarbonamide(HDCA) using biuret as a starting material is disclosed. The method comprises the steps of; obtaining metal monohalobiuret salt by reacting a biuret with a metal hypohalogen compound, or by re...
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WO/2003/089615A2 |
Methods for evaluating the antiviral activity of test compounds are provided. Further aspects of the methods involve the retroviral capsid protein of HIV-1. In another aspect, methods of reducing mortality associated with AIDS with a com...
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WO/2003/079984A2 |
The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms...
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WO/2003/078386A1 |
The present invention relates to novel naphthyl semicarbazone, naphthylhydrazone, naphthyl thiosemicarbazone, and naphthyl thiohydrazone compounds. The invention also relates to therapeutic uses of such compounds and&sol or their iron co...
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WO/2003/074475A2 |
The invention relates to novel aryl ketones of formula (I), in which Z represents groupings (II) and (III) and A1, A2, A3, R1, R2, R3, R4, R5, R6, R7, X, Y, and m have the meaning indicated in the description, the use thereof as plant tr...
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WO/2003/074479A1 |
The invention relates to the novel compounds of formula (I), wherein R, R1, R2 and R3 are defined as in claim 1. The novel compounds are inhibitors of coagulation factor Xa and are used in the prophylaxis and/or therapy of thromboembolic...
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WO/2003/048108A2 |
Novel acyl urea, thiourea, carbamate, thiocarbamate and related compounds are provided which are effective in inhibiting the cytokine−mediated inflammatory response in cultured cells, in ameliorating bone destruction, in an animal mode...
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WO/2003/037849A2 |
The invention pertains to acicular hydrazine-based diurea derivative crystals of the formula R'HN-CO-NH-NH-CO-NHR wherein R and R' independently are unsubstitued or substituted hydrocarbyl groups with an average length of the crystals ra...
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WO/2003/035601A1 |
The present invention relates to a method and apparatus for preparing hydrazodicarbonamide using urea as starting material economically and environmentally desirably. The apparatus includes a pyrolysis furnace to obtain biuret and ammoni...
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WO/2003/031396A1 |
The invention relates to salts of guanidine derivatives corresponding to formula 2, wherein X represents a valence bond, −CH2−NH−, −CH2−NH−NH−, or −CH=N−NH− and R represents a straight or branched C1−C30 alkyl, C3âˆ...
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WO/2003/029188A2 |
The present invention describes pesticidal β-substituted nitrostyrene and cyanostyrene compounds having the formula I: wherein A,Ar,R,R1,Y,X,k,l, and m are as defined herein. The present invention is directed to compositions that includ...
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WO/2003/024407A2 |
The present invention features compounds useful for inhibiting Rnase P activity. These compounds can be used as therapeutics for treating or preventing a variety of bacterial infections. The compounds belong to several classes including ...
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WO/2003/018557A1 |
The invention concerns the use of compounds of general formula (I), wherein: n represents an integer from 1 to 10; R¿1? and R¿6?, independently of each other, represent a hydrogen atom, a group useful for protecting nitrogen atoms in p...
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WO/2003/016246A1 |
A method of effecting a nucleophilic substitution of an alcohol to produce a target product includes the steps of: reacting the alcohol and a nucleophile with an azodicarboxylate and a phosphine. At least one of the azodicarboxylate and ...
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WO/2003/008393A1 |
The invention relates to a method for producing 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine (lamotrigine) by ring closure reaction from $g(a)-oxo-2,3-dichlorophenyl acetamidino-aminoguanidino hydrazone.
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WO/2003/006426A1 |
The present invention provides novel aromatic guanylhydrazone compounds and relates to the use of a class of aromatic guanylhydrazones compounds as pharmaceutically active agents, especially for the prophylaxis and/or treatment of neurod...
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WO/2003/000198A2 |
Peptidomimetic compositions for selective inhibition of neuronal nitric oxide synthase.
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WO/2002/098420A1 |
The present invention is directed to optionally substituted 4-substituted-1-(arylmethylidene)thiosemicarbazide, 4-substituted-1-(arylcarbonyl)thiosemicarbazide and analogs thereof, represented by the Formulae (I) and (II), wherein A¿1,?...
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WO/2002/096884A2 |
The invention relates to novel substituted benzoylketones of formula (I), in which Q = O (oxygen) or S (sulphur), R?1¿ - R?5¿ and Z have the meaning given in the description and several methods for production thereof and use thereof as...
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WO/2002/096867A2 |
The present invention is directed in part towards methods of modulating the function of protein kinases with phenol- and hydroxynaphthalene-based compounds. The methods incorporate cells that express a protein kinase. In addition, the in...
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WO/2002/092574A1 |
The invention relates to novel substituted benzoylcyclohexenones of formula (I), in which Q, R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, Y and Z are defined as per the description. The invention also relates to a method for their production and t...
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WO/2002/092019A2 |
Halogenated derivatives of two synthetic anti-tuberculosis agents, thioacetazone and $i(p)-aminosalicylic acid, have been synthesized. In general, the halogenated compound has the structure of Structure (I), wherein X¿1? is a halogen an...
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WO/2002/085838A1 |
The present invention relaters to copper-catalyzed carbon-heteroatom and carbon-carbon bond-forming methods. In certain embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-nitrogen bond between the ...
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WO/2002/080896A1 |
The present invention relates to the use of benzylideneamino guanidines of general formula (I) as melanocortin receptor agonists or antagonist, and in particular, the use of benzylideneamino guanidines which show selectivity to the MC1 a...
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WO/2002/081430A2 |
The present invention relates to novel benzylideneamino guanidines of general formula and to the use of these benzylideneamino guanidines as melanocortin receptor agonists or antagonists. The invention further relates to benzylideneamino...
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WO/2002/074735A2 |
Novel compounds of formula (I), where X, Y, Z, R, R?1¿, R?2¿ and R?3¿ have the meanings given in claim 1 are inhibitors of the coagulation factor Xa and may be used for prophylaxis and/or therapy of thromboembolitic diseases and for t...
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WO/2002/070541A2 |
Nobel PDF inhibitors and novel methods for their use are provided.
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WO/2002/068377A1 |
(R) -2-Arylpropionamide compounds of formula (I) are described. The process for their preparation and pharmaceutical preparations thereof are also described. The 2-Arylpropionamides of the invention are useful in the prevention and treat...
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WO/2002/044126A2 |
The present invention relates to novel, non-peptidic small organic compounds having an affinity for cyclophilin (CyP)-type immunophilin proteins. In the compounds of this invention, at least two carbo-or heterocyclic groups are attached ...
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WO/2002/038553A2 |
he present invention is directed to compounds represented by the following structural formula (I'), and pharmaceutically acceptable salts, solvates and hydrates thereof, R1 is a substituted or unsubstituted group selected from C¿1?-C¿8...
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WO/2002/036548A2 |
The invention relates to a novel method for carrying out the stereoselective, palladium-catalyzed production of hydrazino cycloalkenes of general formula (Ia) and of diamino bicycloalkanes of general formula (IV), in which A, R?1¿, R?2Â...
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WO/2002/034729A1 |
New process for the preparation of 1,5-disubstituted-3-amino-1,2,4-triazoles of the general formula (I), wherein the meaning of R is C¿1-5?alkyl group; C¿3-13?cycloalkyl-C¿0-4?alkyl group, optionally substituted by one or more C¿1-3?...
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WO/2002/032226A1 |
Ectoparasitic insect pest controllers for animals, containing hydrazine derivatives of the general formula (I) as the active ingredient, and methods for application of the same: (I) [wherein A is (II) (III) (IV) (V) (wherein R?4¿ and R?...
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WO/2002/012178A1 |
The present invention provides novel compounds and use of compounds of general formula (I) as ligands to the melanocortin receptors and/or for treatment of disorders in the melanocortin system: Wherein X and Y are independently chosen fr...
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WO/2002/002515A1 |
Compounds useful in pest control, represented by the general formula [I] wherein A, B and C are each hydrogen, halogeno, trifluoro- methylsulfonyloxy, alkyl, alkylthioalkyl, or the like; X is a single bond, methylene, ethylene, or the li...
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WO/2002/000613A2 |
The present invention relates to inhibitors of Hepatitis B Virus (HBV). A class of guanyl hydrazones are disclosed to be powerful inhibitors of HBV infection. Such compounds are useful for the treatment of HBV infection, in particular ch...
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WO/2001/096286A2 |
The invention relates to a highly active, highly specific urokinase inhibitor which is suitable for therapeutic applications and can be synthesized in an extremely simple manner. Surprisingly, it was found that amidino benzylamine deriva...
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WO/2001/079157A1 |
Compounds having the formula are methionine aminopeptidase type 2 (MetAP2) inhibitors and are useful for inhibiting angiogenesis. Also disclosed are MetAP2-inhibiting compositions and methods of inhibiting angiogenesis in a mammal.
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WO/2001/064627A1 |
The invention relates to a method for producing dinitro-diaza-alkanes and intermediate products hereto from alkylamines and esters. According to the inventive method, a dialkylester of a dicarboxylic acid is converted with an alkylamine ...
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WO/2001/056553A2 |
The present invention relates to aromatic guanylhydrazone compounds and their use as pharmaceutically active agents, especially for prophylaxis and treatment of virally caused diseases and infections, including opportunistic infections. ...
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WO/2001/049652A1 |
A method for synthesizing hydrazodicarbonamide (HDCA) by a reaction of monohalobiuret metal salt having the formula 1 or 2, which is derived from biuret, and ammonia, wherein M is a metal and X is a halogen. The monohalobiuret metal salt...
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WO/2001/042227A1 |
Triazolone compounds of general formula [I], fungicides containing the same as the active ingredient; and intermediates for the production of the compounds. In said formula, R?1¿ is optionally substituted phenyl or the like; and T is op...
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WO2001030749B1 |
The present invention relates to novel compounds, pharmaceutical compositions containing the same as well as a method for treatment of parasitic disorders, wherein said compounds are administered. The present compounds are especially wel...
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WO/2001/040163A1 |
Disclosed is a method for preparing a t-butoxycarbonylated amine compound and, more particularly, a method for preparing a t-butoxycarbonylated amine compound where an amine compound is reacted with a t-butylchloroformate in an aqueous o...
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WO/2001/032599A1 |
Disclosed herein is an improvement in a method for making compounds having the structural formulae (I) or (II) wherein: X is a) phenyl; lower phenylalkoxy, phenoxy; or benzyl; or b) one subtituent from group a) and one or more substituen...
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WO/2001/025191A1 |
Compounds having formula (I) wherein R is hydrogen or CO¿2?CH(CH¿3?)¿2?, useful as intermediate in the preparation of the miticide bifenazate, methods for their preparation, and methods for the preparation of bifenazate.
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