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Matches 151 - 200 out of 1,314

Document Document Title
WO/2003/024407A2
The present invention features compounds useful for inhibiting Rnase P activity. These compounds can be used as therapeutics for treating or preventing a variety of bacterial infections. The compounds belong to several classes including ...  
WO2003000198A3
Peptidomimetic compositions for selective inhibition of neuronal nitric oxide synthase.  
WO/2003/018557A1
The invention concerns the use of compounds of general formula (I), wherein: n represents an integer from 1 to 10; R¿1? and R¿6?, independently of each other, represent a hydrogen atom, a group useful for protecting nitrogen atoms in p...  
WO2002096884A3
The invention relates to novel substituted benzoylketones of formula (I), in which Q = O (oxygen) or S (sulphur), R<1> - R<5> and Z have the meaning given in the description and several methods for production thereof and use thereof as h...  
WO/2003/016246A1
A method of effecting a nucleophilic substitution of an alcohol to produce a target product includes the steps of: reacting the alcohol and a nucleophile with an azodicarboxylate and a phosphine. At least one of the azodicarboxylate and ...  
WO/2003/008393A1
The invention relates to a method for producing 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine (lamotrigine) by ring closure reaction from $g(a)-oxo-2,3-dichlorophenyl acetamidino-aminoguanidino hydrazone.  
WO/2003/006426A1
The present invention provides novel aromatic guanylhydrazone compounds and relates to the use of a class of aromatic guanylhydrazones compounds as pharmaceutically active agents, especially for the prophylaxis and/or treatment of neurod...  
WO/2003/000198A2
Peptidomimetic compositions for selective inhibition of neuronal nitric oxide synthase.  
WO2002070541A3
Nobel PDF inhibitors and novel methods for their use are provided.  
WO/2002/098420A1
The present invention is directed to optionally substituted 4-substituted-1-(arylmethylidene)thiosemicarbazide, 4-substituted-1-(arylcarbonyl)thiosemicarbazide and analogs thereof, represented by the Formulae (I) and (II), wherein A¿1,?...  
WO/2002/096884A2
The invention relates to novel substituted benzoylketones of formula (I), in which Q = O (oxygen) or S (sulphur), R?1¿ - R?5¿ and Z have the meaning given in the description and several methods for production thereof and use thereof as...  
WO/2002/096867A2
The present invention is directed in part towards methods of modulating the function of protein kinases with phenol- and hydroxynaphthalene-based compounds. The methods incorporate cells that express a protein kinase. In addition, the in...  
WO/2002/092574A1
The invention relates to novel substituted benzoylcyclohexenones of formula (I), in which Q, R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, Y and Z are defined as per the description. The invention also relates to a method for their production and t...  
WO/2002/092019A2
Halogenated derivatives of two synthetic anti-tuberculosis agents, thioacetazone and $i(p)-aminosalicylic acid, have been synthesized. In general, the halogenated compound has the structure of Structure (I), wherein X¿1? is a halogen an...  
WO2002000613A3
The present invention relates to inhibitors of Hepatitis B Virus (HBV). A class of guanyl hydrazones are disclosed to be powerful inhibitors of HBV infection. Such compounds are useful for the treatment of HBV infection, in particular ch...  
WO/2002/085838A1
The present invention relaters to copper-catalyzed carbon-heteroatom and carbon-carbon bond-forming methods. In certain embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-nitrogen bond between the ...  
WO/2002/083842A2
The invention features compounds that inhibit section of a protein encoded by an ARE-mRNA or that modulate regulation of an ARE-mRNA. These compounds are useful for the treatment or prevention of conditions involving proteins encoded by ...  
WO/2002/080896A1
The present invention relates to the use of benzylideneamino guanidines of general formula (I) as melanocortin receptor agonists or antagonist, and in particular, the use of benzylideneamino guanidines which show selectivity to the MC1 a...  
WO/2002/081430A2
The present invention relates to novel benzylideneamino guanidines of general formula and to the use of these benzylideneamino guanidines as melanocortin receptor agonists or antagonists. The invention further relates to benzylideneamino...  
WO/2002/074735A2
Novel compounds of formula (I), where X, Y, Z, R, R?1¿, R?2¿ and R?3¿ have the meanings given in claim 1 are inhibitors of the coagulation factor Xa and may be used for prophylaxis and/or therapy of thromboembolitic diseases and for t...  
WO2002044126A3
The present invention relates to novel, non-peptidic small organic compounds having an affinity for cyclophilin (CyP)-type immunophilin proteins. In the compounds of this invention, at least two carbo-or heterocyclic groups are attached ...  
WO2002036548A3
The invention relates to a novel method for carrying out the stereoselective, palladium-catalyzed production of hydrazino cycloalkenes of general formula (Ia) and of diamino bicycloalkanes of general formula (IV), in which A, R<1>, R<2>,...  
WO/2002/070541A2
Nobel PDF inhibitors and novel methods for their use are provided.  
WO/2002/068377A1
(R) -2-Arylpropionamide compounds of formula (I) are described. The process for their preparation and pharmaceutical preparations thereof are also described. The 2-Arylpropionamides of the invention are useful in the prevention and treat...  
WO/2002/044126A2
The present invention relates to novel, non-peptidic small organic compounds having an affinity for cyclophilin (CyP)-type immunophilin proteins. In the compounds of this invention, at least two carbo-or heterocyclic groups are attached ...  
WO/2002/038553A2
he present invention is directed to compounds represented by the following structural formula (I'), and pharmaceutically acceptable salts, solvates and hydrates thereof, R1 is a substituted or unsubstituted group selected from C¿1?-C¿8...  
WO/2002/036548A2
The invention relates to a novel method for carrying out the stereoselective, palladium-catalyzed production of hydrazino cycloalkenes of general formula (Ia) and of diamino bicycloalkanes of general formula (IV), in which A, R?1¿, R?2...  
WO/2002/034729A1
New process for the preparation of 1,5-disubstituted-3-amino-1,2,4-triazoles of the general formula (I), wherein the meaning of R is C¿1-5?alkyl group; C¿3-13?cycloalkyl-C¿0-4?alkyl group, optionally substituted by one or more C¿1-3?...  
WO/2002/032226A1
Ectoparasitic insect pest controllers for animals, containing hydrazine derivatives of the general formula (I) as the active ingredient, and methods for application of the same: (I) [wherein A is (II) (III) (IV) (V) (wherein R?4¿ and R?...  
WO2001056553A3
The present invention relates to aromatic guanylhydrazone compounds and their use as pharmaceutically active agents, especially for prophylaxis and treatment of virally caused diseases and infections, including opportunistic infections. ...  
WO/2002/012178A1
The present invention provides novel compounds and use of compounds of general formula (I) as ligands to the melanocortin receptors and/or for treatment of disorders in the melanocortin system: Wherein X and Y are independently chosen fr...  
WO/2002/002515A1
Compounds useful in pest control, represented by the general formula [I] wherein A, B and C are each hydrogen, halogeno, trifluoro- methylsulfonyloxy, alkyl, alkylthioalkyl, or the like; X is a single bond, methylene, ethylene, or the li...  
WO/2002/000613A2
The present invention relates to inhibitors of Hepatitis B Virus (HBV). A class of guanyl hydrazones are disclosed to be powerful inhibitors of HBV infection. Such compounds are useful for the treatment of HBV infection, in particular ch...  
WO/2001/079157A1
Compounds having the formula are methionine aminopeptidase type 2 (MetAP2) inhibitors and are useful for inhibiting angiogenesis. Also disclosed are MetAP2-inhibiting compositions and methods of inhibiting angiogenesis in a mammal.  
WO/2001/064627A1
The invention relates to a method for producing dinitro-diaza-alkanes and intermediate products hereto from alkylamines and esters. According to the inventive method, a dialkylester of a dicarboxylic acid is converted with an alkylamine ...  
WO/2001/056553A2
The present invention relates to aromatic guanylhydrazone compounds and their use as pharmaceutically active agents, especially for prophylaxis and treatment of virally caused diseases and infections, including opportunistic infections. ...  
WO/2001/049652A1
A method for synthesizing hydrazodicarbonamide (HDCA) by a reaction of monohalobiuret metal salt having the formula 1 or 2, which is derived from biuret, and ammonia, wherein M is a metal and X is a halogen. The monohalobiuret metal salt...  
WO/2001/042227A1
Triazolone compounds of general formula [I], fungicides containing the same as the active ingredient; and intermediates for the production of the compounds. In said formula, R?1¿ is optionally substituted phenyl or the like; and T is op...  
WO2001030749B1
The present invention relates to novel compounds, pharmaceutical compositions containing the same as well as a method for treatment of parasitic disorders, wherein said compounds are administered. The present compounds are especially wel...  
WO/2001/040163A1
Disclosed is a method for preparing a t-butoxycarbonylated amine compound and, more particularly, a method for preparing a t-butoxycarbonylated amine compound where an amine compound is reacted with a t-butylchloroformate in an aqueous o...  
WO/2001/032599A1
Disclosed herein is an improvement in a method for making compounds having the structural formulae (I) or (II) wherein: X is a) phenyl; lower phenylalkoxy, phenoxy; or benzyl; or b) one subtituent from group a) and one or more substituen...  
WO/2001/030749A1
The present invention relates to novel compounds, pharmaceutical compositions containing the same as well as a method for treatment of parasitic disorders, wherein said compounds are administered. The present compounds are especially wel...  
WO/2001/025191A1
Compounds having formula (I) wherein R is hydrogen or CO¿2?CH(CH¿3?)¿2?, useful as intermediate in the preparation of the miticide bifenazate, methods for their preparation, and methods for the preparation of bifenazate.  
WO/2001/025192A1
The present invention relates to guanidine derivatives and pharmaceutically acceptable acid salts thereof. The invention further relates to pharmaceutical preparations containing said compounds, and the use of said compounds for treatmen...  
WO2000072800A3
This invention relates to the novel use of phenyl ureas in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).  
WO/2001/005753A1
Diacylhydrazine derivatives of general formula (I) wherein X, Y, Z, R?1¿, R?2¿ and R?3¿ have the meanings cited in Claim 1, and the physiologically acceptable salts or solvates thereof, which are integrin inhibitors and can be used to...  
WO/2001/005752A1
The invention concerns a method for making aminoguanidine bicarbonate from an aqueous solution of cyanamide and an aqueous solution of hydrazine hydrate in the presence of CO¿2?. The invention is characterised in that it consists in pro...  
WO2000054591A3
The present invention provides a synergistic insecticidal composition comprising as essential active ingredients a neuronal sodium channel antagonist in combination with one or more compounds selected from the group consisting of pyrethr...  
WO2000035868A3
Methods for the synthesis of alpha -hydroxy- beta -amino acid and amide derivatives and alpha -ketoamide derivatives and novel derivatives made by these methods are provided. These methods involve reacting an N-terminally blocked (protec...  
WO/2000/073280A1
The present invention provides novel cathecol hydrazone derivatives of formula (I) or pharmaceutically acceptable salts thereof, wherein R?1¿ is C¿1-7? alkyl or C¿3-7? cycloalkyl; R?2¿ is hydrogen, hydroxy, C¿1-5? alkyl or -CH¿2?CH...  

Matches 151 - 200 out of 1,314