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WO/2014/184762A1 |
The invention relates to new amino-isocyanonaphthalene compound, which are solvatochromic fluorophores. Their fluorescent properties were investigated in detail by steady-state and time dependent methods.
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WO/2014/143561A1 |
Compounds of formula (I): where R1, R2, R3, R4a, R4b, R5, R6 and R7 are defined herein, or stereoisomers or pharmaceutically acceptable salts thereof, are described herein. Such compounds have activity as SHIP1 modulators, and thus may b...
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WO/2014/136952A1 |
The present invention provides a stable, easy-to-manufacture nitrile-oxide compound that can be represented by formula (I) (in which R1 represents a hydrocarbon group; R2 and R3 each independently represent a hydrogen atom or a hydrocarb...
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WO/2014/023956A1 |
The present invention provides an anthraquinone compound of formula I (such as the compounds of formulae II to X) and processes for making the same. The invention further provides pharmaceutical compositions for use in the treatment of c...
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WO/2014/018249A1 |
A continuous process for making amine oxide surfactant comprising the steps of (a) providing the following components; a tertiary amine composition and an aqueous hydrogen peroxide composition, (b) mixing the components from step a) in a...
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WO/2013/067084A1 |
Silylated nitrones and methods of detecting and/or superoxide using silylated nitrones are disclosed herein.
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WO/2013/053770A1 |
The present invention relates to methods of inhibiting the formation or agglomeration of gas hydrates using amine oxides. The invention further relates to compositions comprising amine oxides that find use as gas hydrate inhibitors, as w...
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WO/2013/039787A1 |
Disclosed herein are novel amidic nitrone and a method of manufacturing a data storage media comprising mixing the amidic nitrone, as a photochromic dye, with an organic material or an inorganic material to form a holographic composition...
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WO/2012/109535A2 |
The present invention relates to the discovery of new class of hydrolysable amino acid derivatives and absorbable polyester amides, polyamides, polyepoxides, polyureas and polyurethanes prepared therefrom. The resultant absorbable polyme...
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WO/2012/106588A2 |
The present invention encompasses the finding that improvements can be achieved in manufacture of isocyanates through the use of a substitute for or a precursor of phosgene. Methods and compositions utilized in accordance with the presen...
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WO/2012/095425A1 |
The invention relates to polynitrons produced by oxidizing secondary amines, to the use of said polynitrons for cross-linking unsaturated polymers, to a curable composition, comprising (a) a polynitron, which is based on the addition of ...
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WO/2012/064417A1 |
The present invention comprises a compound of a compound of Formula 1 wherein Rf is a C2 to C-12 perfluoroalkyl optionally interrupted by one to four moieties each independently selected from the group consisting of -CH2-, -O-, -S-, -S(O...
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WO/2012/000306A1 |
Phenyl nitrone compounds containing stilbene segment and pharmaceutically acceptable salts thereof are provided. The above compounds can be used for treating cancer and also can be used as neuroprotective agent. Preparation method of the...
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WO/2011/103933A1 |
The present invention relates to a process for the preparation of a compound of the general Formula (I), comprising: a) reacting a compound of the general Formula (II) with a compound of the Formula III R2COOH and a compound of the gener...
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WO/2011/046082A1 |
Provided is an oxime ether derivative represented by formula (I), or a salt thereof. (1) (In the formula, X represents a halogen atom, an alkyl group, or the like; Y represents an oxygen atom or the like; Z represents an oxygen atom or t...
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WO/2010/118968A1 |
The present invention refers to nitric oxide donor aspirin derivatives, a process for their preparation and pharmaceutical compositions containing -them. Formula (I) wherein R is selected from the group consisting of A) (R0) t -CH (ONO2)...
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WO/2010/096123A2 |
The present invention is directed to novel amino acid prostaglandin salts and methods of making and using them.
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WO/2010/069849A1 |
Process for the manufacture of solid Mn+(HDO)n salts wherein HDO is the anion of N'-hydroxy-N-cyclohexyldiazenium oxide, and Mn+ is a metal cation by precipitation with an acid from an alkaline solution of an HDO-salt with monovalent cat...
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WO/2010/067204A1 |
Provided herein are impurities of cinacalcet, (R)-α-methyl-N-[3-[3-(trifluoromethyl) phenyl]propyl]-1-(5,6,7,8-tetrahydronaphthalene)methaneamine
(tetrahydro cinacalcet impurity), (R)-α-Methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-1...
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WO/2009/136281A1 |
Nitroderivatives of prostaglandins having improved pharmacological activity and enhanced tolerability are described. They can be employed for the treatment of glaucoma and ocular hypertension.
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WO/2009/137765A1 |
Amines and amine derivatives that improve the buffering range, and / or reduce the chelation and other negative interactions of the buffer and the system to be buffered. The reaction of amines or polyamines with various molecules to form...
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WO/2009/127398A2 |
A conjugated linoleic acid (CLA) derivative having the structure (I) wherein n is an integer from 1 to 10; and wherein the broken lines at positions 9 and 11, or at positions 10 and 12, are each double bonds separated by a single bond, a...
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WO/2009/074310A1 |
The invention relates to polyfunctional nitrons (optionally in the form of nitron-terminated polymers) and the use thereof as a cross-linking and dulling agent, preferably for the production of stable molding materials and fillers, and t...
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WO/2009/000797A1 |
The invention concerns venlafaxine-N-oxide and O-desmethylvenlafaxine-N-oxide as prodrugs of venlafaxine and its major (active) metabolite O-desmethylvenlafaxine respectively, to pharmaceutical compositions containing these N-oxides, to ...
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WO/2008/144116A1 |
Pesticidal compounds having the structural formula (I) wherein: R2 is C1-C6 branched or straight chain alkyl; C1-C4 branched or straight-chain haloalkyl; or C3-C6 cycloalkyl; m is 0, 1, or 2; X is selected from the group consisting of: C...
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WO/2008/139152A1 |
The invention provides a method of preparing a therapeutically active compound having reduced hERG activity, which method comprises: (a) selecting a non-N-oxide drug compound containing a basic tertiary amino group, wherein said non-N-ox...
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WO/2008/107843A1 |
A process comprising the steps of continuously adding a catalase enzyme to a process stream, wherein the process stream comprises an amine oxide surfactant and hydrogen peroxide; and mixing the process stream and catalase enzyme.
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WO/2008/053285A1 |
The present invention relates to new synthetic methods for preparing 2- methoxyisobutylisonitrile and metal isonitrile complexes, such as tetrakis(2- methoxyisobutylisonitrile)copper(I) tetrafluroroborate, which are used in the preparati...
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WO/2008/051558A2 |
The present invention provides novel isolated compounds characterized as metabolites or derivatives of desmethylvenlafaxine including hydroxy-DV metabolites, hydroxy-DV-glucuronide metabolites, N-oxide-DV metabolites, and benzyl-hydroxy-...
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WO/2007/102568A1 |
Disclosed is a method for efficiently and economically producing a high-purity aliphatic tertiary amine with few by-products by hydrogenation reduction of a fatty acid amide under mild conditions. Also disclosed is a method for efficient...
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WO2005080314B1 |
A process for the preparation of compound AQ4N of formula (2) or a salt or solvate thereof wherein the said process includes the reaction step: Formula (1), Formula (2), where compound AQ4 of formula (1) is oxidised to compound AQ4N of f...
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WO/2006/066894A1 |
Compounds of general formula (I), wherein R’, R, x and z have the meaning reported in the specification, are useful for treating inflammatory diseases including metabolic syndrome, diabetes, obesity, dyslipidemia, and insulin resistance.
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WO/2006/035891A1 |
Isonitriles represented by the general formula (1) and antifouling agents against the adhesion of aquatics containing the same: (1) wherein R1 is CH2X (wherein X is hydroxy, halogeno, isocyano, amino, substituted amino, or optionally sub...
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WO/2006/000294A1 |
TITLE: The present invention relates to the compounds of the formula (I) to the process for the preparation of them and their therapeutic use, especially their use as antioxidants, as NO generators, and as inhibitors of smooth muscle cel...
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WO/2005/100303A1 |
The inventive indene derivatives of formula (I) are capable of selectively modulating the activities of peroxisome proliferator activated receptors (PPARs), causing no adverse side effects, and thus, they are useful for the treatment and...
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WO/2005/090294A2 |
The present invention is directed to a process of making &agr -aminooxyketone and &agr -hydroxyketone compounds. The synthetic pathway generally involves reacting an aldehyde or ketone substrate and a nitroso substrate in the presence ...
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WO/2005/079270A2 |
The present invention provides aryl nitrones, compositions comprising the same and methods of their use for the treatment or prevention of oxidative, ischemic, ischemia/reperfusion-related and chemokine mediated conditions.
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WO/2005/074598A2 |
Described herein are nitroxyl progenitor compounds, and compositions including, and methods or generating, the compounds thereof, and methods of treating or preventing disease and disease symptoms using the compounds and compositions.
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WO/2005/070879A1 |
The invention concerns a method for producing: a) nitriles of formula (II) and; b) isonitriles of formula (III) by reacting: a) carboxylic acid amides (RCO-NH2), ammonium salts of carboxylic acids (RCOO-NH4+) or carboxylic acids in the p...
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WO/2005/065361A2 |
Compounds are disclosed with activity towards killing dysproliferative cells in vitro and treating cancer in vivo. Cancers such as cancer of the colon, pancreas, prostate, lung, breast, urinary bladder, skin and liver are exemplary. Comp...
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WO/2004/096740A2 |
A process for preparing (+)-p-mentha-2,8-diene-1-ol comprising reacting (+)-limonene oxide with at least one amine in the presence of at least one Lewis acid to form amine adduct intermediates. The amine adduct is then oxidized to form a...
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WO/2004/091613A2 |
Phenyl acetamide compounds are described, including compounds of Formula (I) or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein R3-R6, R11, B, Y and W are set forth in the specification. The compounds of the inven...
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WO/2004/085397A1 |
The invention relates to a process for the preparation of secondary nitroxide radicals from their corresponding secondary amines by oxidation with an organic peracid, comprising the steps a) adding to a reaction vessel a secondary amine,...
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WO/2004/034999A2 |
Disclosed are nitrone compounds and pharmaceutical compositions containing such compounds. The nitrone compounds have one to six additional carbons bridging between the nitrone functionality and the nitrone aryl ring. The disclosed compo...
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WO/2004/014682A1 |
A vehicle door has a supporting frame (10) substantially in the form of a rectangular annular hat beam (13-16) of high-strength steel, which, with its outer side flange (17), carries the outer panel (28) of the door and has its crown (12...
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WO/2004/009067A1 |
The invention relates to metabolites of [2-(3-methoxyphenyl)-cyclohexylmethyl]-dimethylamine as free bases and/or in the form of physiologically acceptable salts, corresponding medicaments, the use of [2-(3-methoxyphenyl)-cyclohexylmethy...
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WO/2004/009066A1 |
The present invention relates to nitric oxide/releasing amidine diazeniumdiolates, compositions comprising same, methods of using same, and a method for preparing same from imidate diayeniumdiolates and primary or secondary amines.
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WO/2004/004648A2 |
The invention describes novel nitrosated nonsteroidal antiinflammatory drugs (NSAIDs) and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated NSAID, and, optionally, at least one compound ...
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WO/2003/102532A2 |
The invention relates to a method for producing chiral isocyanides from amino acids which is characterized by the steps of: (a) formylating the amino acids with formic acid or methyl formiate, (b) allowing the free carboxyl function to r...
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WO/2003/082205A2 |
Disclosed is a compound having the formula (I) pharmaceutically acceptable salts or solvates thereof and pharmaceutical compositions containing the same, wherein the structural variables are as defined herein. The compounds, salts and so...
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