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Matches 1 - 50 out of 9,469

Document Document Title
WO/2019/004114A1
Provided is a production method for efficiently synthesizing a compound (1-2) which is an important intermediate in production of edoxaban. The method comprises dripping a compound (1-1) into a solution A that is obtained by causing a re...  
WO/2019/006025A1
Aspects of the present disclosure include antibacterial aromatic sulfonyl fluoride agents. The subject aromatic sulfonyl fluoride agents have a pharmacophore that can provide for potent antibacterial activity. The subject agents are comp...  
WO/2019/002447A1
The present invention relates to a process for the production of alkane sulfonic acid with a regulator as well as two specific compounds which can be used as regulator in a respective process.  
WO/2018/228079A1
The present invention discloses a fluorescent probe for detecting a sulfenated protein, having the following structural general formula (I). The fluorescent probe has good stability and can be preserved for long-term use. The fluorescent...  
WO/2018/219728A1
The present invention relates to a process for the manufacturing of methane sulfonic acid (MSA) by reaction of a radical initiator composition with methane and sulfur trioxide comprising the steps (a) preparation of the intiator composti...  
WO/2018/219726A1
The present invention deals with a process for the production of alkanesulfonic acids, in particular methanesulfonic acid, and a method of purification of the raw products.  
WO/2018/211457A2
A method includes combining first components including at least one of CF2=CF-CF2-OSO2Cl or CF2=CF-CF2-OSO2CF3, a polyfluorinated compound having at least one ketone or carboxylic acid halide, and fluoride ion to provide a compound compr...  
WO/2018/212216A1
Provided is a method for producing an optically active isomer, the method including an asymmetry induction step in which an asymmetry-inducing agent is caused to act on chiral molecules having an enantiomeric-excess half-life period less...  
WO/2018/208701A1
Aspects of the invention relate to systems and processes for recovering methanesulfonic acid, in a purified form, from a composition additionally including sulfur trioxide. In accordance with one aspect, the invention provides a process ...  
WO/2018/192954A1
The invention relates to a process for purifying alkanesulfonic anhydride which comprises the following steps of: (a) feeding a stream comprising alkanesulfonic anhydride, sulfuric acid, high boilers and residual low boilers into a melt ...  
WO/2018/186436A1
The present invention provides: a novel anionic hydrophilic group-containing (meth)acrylamide compound represented by formula (I), which is highly durable under acidic and/or alkaline conditions and has excellent antifouling properties a...  
WO/2018/181906A1
Provided is a novel alkyl sulfate ester having a carbonyl group, or a salt of this alkyl sulfate ester. A compound which is characterized by being represented by formula R1-C(=O)-(CR2 2)n-(OR3)p-(CR4 2)q-L-OSO3X. (In the formula, R1 repr...  
WO/2018/172783A1
There is described a method of reducing polymer tar build-up in the production of methyl methacrylate and/or methacrylic acid by the acetone cyanohydrin process. In the method a stabiliser is contacted with the amide stage reaction mediu...  
WO/2018/172677A1
The present invention relates to a method for producing 2-acrylamido-2-methylpropane sulphonic acid comprising at least the following successive steps: 1) mixing acrylonitrile with at least one SO3 delivery compound at a temperature of b...  
WO/2018/172676A1
The present invention relates to a crystalline form hydrated with 2-acrylamido-2-methylpropane sulphonic acid having an x-ray diffraction pattern on powder comprising spikes at 10.58°, 11.2°, 12.65°, 13.66°, 16.28°, 18.45°, 20°, 2...  
WO/2018/169252A1
The present invention relates to an N-benzyl-N-phenoxyl carbonyl-phenyl sulfonamide derivative, which inhibits PGE2 generation by means of inhibiting microsomal prostaglandin E2 synthase-1 (mPGES-1) and has enhanced activity, a method fo...  
WO/2018/161892A1
A benzene sulfonamide compound having structural features of formula (I) or a pharmaceutically acceptable salt thereof, a preparation method therefor, and use thereof as an indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor. Experimental res...  
WO/2018/158333A2
An absorbent material which can be obtained by crosslinking, more particularly by the thermal crosslinking of a polymer material with a sulphosuccinic acid material. The sulfosuccinic acid material is devoid, or substantially devoid of a...  
WO/2018/158333A3
An absorbent material which can be obtained by crosslinking, more particularly by the thermal crosslinking of a polymer material with a sulphosuccinic acid material. The sulfosuccinic acid material is devoid, or substantially devoid of a...  
WO/2018/158334A1
The invention relates to a method for producing sulfosuccinic acid and compounds derived therefrom by reacting fumaric acid, maleic acid, maleic acid anhydride and compounds with sulphur dioxide in the presence of water, derived from sai...  
WO/2018/149991A1
The present invention relates to particular sulfonamide derivatives, the pharmaceutically acceptable addition salts thereof, the hydrates thereof and/or the solvates thereof, and also the use thereof as inverse agonists of retinoid-relat...  
WO/2018/146153A1
The present invention relates to methods for the production of alkane sulfonic acids, especially methane sulfonic acid, from alkane, especially methane, in which a carbocation, particularly a carbenium ion, is formed, as well as to the u...  
WO/2018/144800A1
Provided are compositions, methods and devices for reducing scarring during healing of a tissue wound. The compositions and methods involve use of sphingosine-1 -phosphate (SIP), and/or an expression vector that encodes sphingosine kinas...  
WO/2018/132445A1
A method of: reacting a dihydroxybenzene with bromine to form a bromodihydroxybenzene; reacting the bromodihydroxybenzene with trifluoromethanesulfonyl chloride or trifluoromethanesulfonic anhydride to form a bromotrifluorometiianesulfon...  
WO/2018/117467A1
Disclosed in the specification is a method which selectively separates an R type enantiomer contained in a racemate (R/S=1/1) of N-[4-(1-amino-ethyl)-2,6-difluoro-phenyl]-methanesulfonamide , and then can convert the same back into the r...  
WO/2018/104105A1
The invention relates to a method for producing 3-substituted 2-vinylphenylsulfonates.  
WO/2018/106238A1
Processes and systems for separating a mixture including at least one fluorocarboxylic acid and at least one carboxylic acid are provided herein. In some aspects, the present invention relates to processes and systems configured to provi...  
WO/2018/096138A1
The present invention relates to an alkane-sulfonation process using alkane and sulfur trioxide, especially pure sulfur trioxide (100%) under solvent-free conditions in the presence of an initiator. It further relates to the use of a pre...  
WO/2018/094233A3
Dimethylamine (Me2NH) is reacted with sulfuryl fluoride (S02F2) to form at least a first phase comprising N-(fluorosulfonyl) dimethylamine (FS02NMe2), tetramethylsulfamide (S02(NMe2)2), or a combination thereof. A second phase, which may...  
WO/2018/094233A2
Dimethylamine (Me2NH) is reacted with sulfuryl fluoride (S02F2) to form at least a first phase comprising N-(fluorosulfonyl) dimethylamine (FS02NMe2), tetramethylsulfamide (S02(NMe2)2), or a combination thereof. A second phase, which may...  
WO/2018/087767A1
The invention provides processes for the preparation of HU-910, which are scalable to industrial purposes, using safer reagents and having high yield and pure product and a crystalline structure of HU-910, which is a unique product thereof.  
WO/2018/086507A1
The invention discloses a naphthalene sulfonamide type compound, a preparation method thereof and an application thereof for regulating plant growth activity. A general formula of a structure of the naphthalene sulfonamide type compound ...  
WO/2018/083140A1
The present invention relates to a normal paraffin composition comprising from 45 to 60 wt.% of a fraction of normal paraffin having from 10 to 13 carbon atoms and from 40 to 55 wt.% of a fraction of normal paraffin having from 14 to 18 ...  
WO/2018/072024A1
The invention relates to methods for the production of sulphamic acid derivatives, for example, halogenated derivatives and the salts thereof, metallic or organic, are described. The present application also relates to the resulting sulp...  
WO/2018/058534A1
The present invention relates to the field of medicinal chemistry. Disclosed are a pleuromutilin derivative having a 2-amino phenyl mercaptan side chain, a preparation method therefor, and uses thereof. The compound has the structures re...  
WO/2018/059889A1
The invention comprises a process for preparing mixtures of DEFI and amide taurate (ATA) having excellent yields of ATA and substantial absence of browning of final ATA and DEFI mixtures. The process permits much greater flexibility in r...  
WO/2018/062799A1
Disclosed in the present specification is a method capable of preparing N-[4-[(1R)-1-[[(R)-(1,1-dimethylethyl)sulfinyl]amino]ethyl]- 2,6-difluorophenyl]-methanesulfonamide (INT028-2) with high optical purity, through the selection of Ell...  
WO/2018/052680A1
There is disclosed a process for producing taurine from ammonium isethionate by the ammonolysis of alkali isethionate in the presence of alkali ditaurinate or alkali tritaurinate, or their mixture, to inhibit the formation of byproducts ...  
WO/2018/043400A1
A compound represented by formula (I) or a salt thereof. In formula (I), each of R1 and R4 independently represents a hydrogen atom, an unsubstituted or substituted C1-6 alkyl group or the like; R2 represents a hydrogen atom, an unsubsti...  
WO/2018/038742A1
Compositions comprising bridged bicyclic-based compounds such as iptycene-based compounds and methods for mechanochemically synthesizing them are generally provided. In some cases, two or more polycyclic aromatic hydrocarbons may be mech...  
WO/2018/034696A1
There is disclosed a process for producing taurine by the ammonolysis of alkali isethionate in the presence of alkali ditaurinate or alkali tritaurinate, or their mixture, to inhibit the formation of byproducts and to continuously conver...  
WO/2018/029699A1
The Present invention relates to solid state forms of (2E)-N-hydroxy-3-[3-(N-phenyl sulfamoyl)phenyl]prop-2-enamide represented by the following structural formula-1 and process for the preparation thereof.  
WO/2018/026396A1
There is disclosed a process for producing taurine by the ammonolysis of alkali isethionate in the presence of alkali ditaurinate or alkali tritaurinate, or their mixture, to inhibit the formation of byproducts and to continuously conver...  
WO/2018/018863A1
Disclosed are a mild and efficient preparation method for an α-acyloxy alkenyl amide compound and a use thereof in the synthesis of an amide and a polypeptide. The α-acyloxy alkenyl amide compound is obtained by an addition reaction of...  
WO/2018/021185A1
[Problem] To provide a morphology for storage and the like of a sulfonimide which was difficult to produce by conventional methods, which has a reduced content of halide, and which has polymerizable functional groups having improved spon...  
WO/2018/015191A1
The present invention relates to methods for adding an aqueous solution of alkane sulfonic acids to a reactor via a pipe or container, wherein a condensation reaction takes place after addition of the aqueous solution of alkane sulfonic ...  
WO/2018/008040A1
The invention relates to an improved process for the preparation N-[4-[[4-(diethyl amino) phenyl] (2,5-disulfophenyl)methylene]-2,5-cyclohexadien-1-ylidene]-N - ethylethanaminium inner salt sodium salt (Isosulfan blue) of formula I. The ...  
WO/2018/004606A1
Complexation of metal ions using chelating agents within a subterranean formation can often be desirable, such as to temper the formation of metal-containing precipitates. However, many chelating agents are produced commercially in an al...  
WO/2018/000404A1
Provided in the present application is a method for preparing taurine, characterized in comprising the following steps: (a) mixing isethionate with a taurine salt solution so that the system pH reaches a certain value between 5.0 and 9.5...  
WO/2017/220512A1
The present invention relates to a compound according to Formula (3), wherein the compound comprises from 28 wt.% to 100 wt.% bio-based carbon content, relative to the total mass of carbon in the compound, measured according to standard ...  

Matches 1 - 50 out of 9,469