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JP2002521360A |
A compound of formula (I) or a pharmaceutically acceptable salt thereof; or an enantiomer thereof. Compounds of formula (I) are useful as inhibitors or microsomal triglyceride transfer protein (MTP) and apolipoprotein B (ApoB) secretion ...
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JP2002515860A |
The present invention is directed to (D)-amino acid containing inhibitors of cysteine or serine proteases. Methods for the use of the protease inhibitors are also described.
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JP2002512999A |
The present invention provides a method of converting a hydroxy group in alcohols containing an electron withdrawing group into perfluoroalkane sulfonate and fluorosulfonate esters, which are good leaving groups, with inversion of config...
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JP2002512639A |
The application relates to the use of a beta 3 adrenergic receptor agonist selected from the group consisting of formulas (IV),(V),(VI),(VII) and (VIII) for the manufacture of a medicament for the prophylactic and/or the therapeutic trea...
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JP2002512633A |
This application relates to a compound of formula (I), a pharmaceutically acceptable salt of the compound, or a prodrug thereof, as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as...
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JP3256541B2 |
The present invention provides pharmaceutically useful compounds which are aminosulfonyl urea compounds which are ACAT inhibitors rendering them useful in controlling blood cholesterol levels, pharmaceutical compositions and methods of u...
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JP2002504536A |
Novel alpha-amino acid amides of formula (I) as well as possible isomers and mixtures of isomers thereof, wherein the substituents are defined as follows: n is the number zero or one; R1 is optionally substituted alkyl, alkenyl, alkynyl,...
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JP2002030063A |
To provide a method for producing a sulfamate compound, which can be applied to various hydroxyl group-containing compounds having various functional groups and by which the sulfamate compound can be produced from necessary minimal amoun...
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JP3250777B2 |
PURPOSE: To obtain an imide compound or its salt useful as a catalyst on the synthesis of organic compounds, and to provide the method for producing the same. CONSTITUTION: An imide compound having a fluorocarbon sulfonate ester group of...
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JP2002020362A |
To provide a new biphenyl derivative effective as a steroid sulfatase inhibitor, for treating estrone diseases such as breast cancer, endometrial cancer, endometriosis or hysteromyoma.This new biphenyl derivative is shown by the formula ...
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JP3238512B2 |
PURPOSE: To obtain the subject compounds useful as an intermediate for producing a medicine, a medicine for animals or plants, a stereoisomeric alcohol, etc., under mild neutral conditions in a shortened process according to a new method...
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JP3220582B2 |
PURPOSE: To provide an imide compd. which contains specific fluoroalkyl, fluoroaryl and polyether units, can be produced simply at a low cost, and is useful as a surfactant such as a detergent excellent in rinsing and wetting properties....
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JP3219408B2 |
The present invention provides a pharmaceutical composition comprising a compound admixed with a pharmaceutically acceptable diluent or carrier; wherein the compound has the the formula wherein each of R1 and R2 is independently selected...
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JP2001515474A |
The invention relates to novel pesticidally active compounds of the general formula Ias well as possible isomers and isomeric mixtures thereof,whereinn is a number zero or one; andR1 is C1-C12alkyl that is unsubstituted or may be substit...
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JP2001513095A |
alpha-Amino acid amides of formula (I) wherein the substituents are defined as follows: n is a number zero or one; R1 to R7 are as defined herein; R8 is C1-C6alkyl, C3-C6alkenyl or C3-C6alkynyl; R9 is C3-C8cycloalkyl; a C1-C6alkyl, C3-C6...
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JP2001511781A |
The present invention provides compounds of the formula: wherein R14 represents a phenyl group which is unsubstituted or substituted by one or two of halogen; nitro; cyano; (1-10C) alkyl; (2-10C)alkenyl; (2-10C)alkynyl; (3-8C)cycloalkyl;...
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JP3199295B2 |
PURPOSE: To provide a production method for obtaining a 5-acyl-2- amidohydroquinone, forming a small amount of by-products, excellent handleability and capable of readily isolating the reaction product. CONSTITUTION: Friedel-Crafts acyla...
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JP3190340B2 |
There are disclosed cardiovascularly active compounds possessing antihypertensive properties, and pharmaceutical compositions containing these agents and a method of treating cardiovascular disorders with the compounds. The active compon...
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JP3189279B2 |
The invention aims at providing a device comprising lipids that act like the so-called cationic liposome and are reduced in toxicity and the lipids as the constituent of the device. The invention compounds are exemplified by 3-0-(4- dime...
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JP3177245B2 |
Compounds of the formula wherein R is hydrogen, a straight or branched alkyl group having from 1 to 8 carbon atoms or benzyl; wherein each of R1 and R2 is hydrogen, an aralkyl group, a straight or branched hydrocarbon group having from 1...
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JP3174410B2 |
PURPOSE: To obtain a sulfamate showing antispasmodic activity and useful for the treatment for symptoms such as epilepsy from an easily available source material under safe conditions. CONSTITUTION: A compd. expressed by RCH2OH (R is for...
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JP3167029B2 |
PCT No. PCT/US92/02232 Sec. 371 Date Dec. 6, 1993 Sec. 102(e) Date Dec. 6, 1993 PCT Filed Mar. 27, 1992 PCT Pub. No. WO93/00324 PCT Pub. Date Jan. 7, 1993.A method of producing 4-ADPA is disclosed wherein aniline or substituted aniline d...
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JP2001097944A |
To provide an additive which has low volatility and a relatively high ignition point, is physically and chemically stable, can sufficiently be mixed with the other kind of proper solvents, and has good conductive behaviors. A group of fl...
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JP2001501922A |
This invention is directed to methods for stereospecifically preparing [(1-optionally substituted aryl)- or (1-optionally substituted heteroaryl)]-2-substituted ethyl-2-amines, having chirality at the 2-position, and to intermediates to ...
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JP2001026574A |
To obtain a novel aminosulfonylurea derivative that inhibits cholesterol acyl transferase as an acyl-coenzyme A and is useful as a therapeutic agent for hypercholesterolemia and atherosclerosis.This is an aminosulfonylurea derivative rep...
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JP3124242B2 |
To obtain a new tricyclic compound having β3 operation activity, blood sugar lowering action and lipolytic activity, useful for treating and preventing diseases related to β3, such as diabetes, obesity and hyperlipemia. This compound i...
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JP2000351684A |
To use a specific dicarboxylic acid diureide as a slow-acting fertilizer for nitrogenous fertilizers through combination with other commonly used fertilizers or additives so as to effect delayed release of a plurality of nutrients contai...
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JP3117780B2 |
The process according to the invention for the preparation of compounds of the formula (I) or salts thereof in which X = -O-, -O-NR<2>- or -SO2-NR<2>-, Y is N or CH, R<1> is a (substituted) alkyl, (substituted) alkenyl or (substituted) a...
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JP2000513323A |
alpha-Amino acid amides of formula (I) wherein the substituents are defined as follows: n is the number zero or one; R1 to R7 are as herein defined; R8 is C1-C6alkyl, C3-C6alkenyl or C3-C6alkynyl; R9 is C3-C8cycloalkyl; a C1-C6alkyl, C3-...
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JP2000239255A |
To obtain the subject composition, showing β3-agonistic activity and hypoglycemic and lipolysis functions, and useful for treatment and prevention of the β3-related diseases, e.g. diabetes, obesity and hyperlipidemia, by including a sp...
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JP3082243B2 |
PCT No. PCT/JP92/01414 Sec. 371 Date May 3, 1994 Sec. 102(e) Date May 3, 1994 PCT Filed Nov. 2, 1992 PCT Pub. No. WO93/10097 PCT Pub. Date May 27, 1993.A new nitro compound of the formula: wherein R1 and R2 are each lower alkyl or lower ...
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JP3071448B2 |
Sulphonylureas of the formula where A is a bond or a C1-C10-hydrocarbon radical, R<1> is a saturated or unsaturated hydrocarbon radical which is optionally substituted by halogen, saturated or unsaturated alkoxy, alkylthio, alkylsulp...
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JP2000509092A |
Novel bleaches, a method for bleaching substrates using these materials and detergent compositions containing same are reported. The bleaches are sulfanimines. Substrates such as fabrics may be bleached in an aqueous solution containing ...
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JP3054875B2 |
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JP2000154174A |
To efficiently produce the subject hydrazines without using a metal reducing agent such as tin chloride by reacting a specific diazonium salt with (hydrogen)sulfurous salts.A derivative represented by formula I [X is H or a halogen; Y is...
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JP2000504722A |
This invention relates to the novel use of phenyl ureas in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
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JP2000053630A |
To provide a method for producing chlorosulfonyl isocyanate from a sulfur trioxide and cyanogen chloride in good operability and in high yield. This method comprises feeding cyanogen chloride to a mixture of a sulfur trioxide and chloros...
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JP3012002B2 |
The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors, of formula (I). In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors characterized by specif...
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JP2000501390A |
The invention relates to new amino acid derivatives of general formula (I), wherein B, T, Z, Y, V and n are defined as in claim 1, the tautomers, diastereomers and enantiomers thereof, the mixtures thereof and the salts thereof, particul...
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JP2000034271A |
To obtain in good operability and in a high yield the subject compound useful as an organic product such as medicament or agrochemical, or as an intermediate therefor by reaction a specified N-chlorosulfonyl-β-lactam with a metal alkoxi...
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JP2000500758A |
The present invention relates to novel geranylgeranyl derivatives and the pharmaceutically acceptable salts thereof having antiproliferative activity in eukaryotic cells with respect to the inhibition of protein geranygeranylation. The i...
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JP2977137B2 |
The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases.The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated disease...
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JPH11510184A |
PCT No. PCT/US96/11366 Sec. 371 Date Jan. 26, 1998 Sec. 102(e) Date Jan. 26, 1998 PCT Filed Jul. 8, 1996 PCT Pub. No. WO97/05868 PCT Pub. Date Feb. 20, 1997The present invention is directed to new therapeutic uses of compounds of formula...
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JPH11507379A |
There are disclosed N-substituted piperazine NONOate compounds having the structure: (I) wherein M is a pharmaceutically acceptable cation, x is the valence of the cation, and R is selected from the group consisting of: an unsubstituted ...
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JPH11503110A |
This invention relates to the novel use of phenyl ureas in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
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JP2857742B2 |
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JPH1121276A |
To obtain a new compound as a color developing main agent derivative includable in a heat-developable photosensitive material affording sufficient color development and gradation in heat developing process. This new compound is shown by ...
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JPH1112213A |
To obtain a new compound having excellent antimicrobial activities against wide ranges of bacteria, yeasts and fungi, low in toxicity and having preferable properties for environmental problems. A trihaloallyl derivative of the formula (...
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JPH10316648A |
To obtain a new derivative and a pharmacological permissible salt, having excellent inhibitory actions on acylcoenzyme/cholesterol/acryltransferase (hereinafter abbreviated as ACAT). An amide derivative or urea derivative is shown by the...
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JP2768505B2 |
The preparation is described of compounds of the structure in which the substituents have the meanings indicated in the description. The compounds, which are in part new, are used as intermediate products for dyestuffs.
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