| Document |
Document Title |
|
JP2017057206A |
To provide a method of treating pain of mammalian.There is provided a novel compound having the general formula (I), where variable R, subscript n, ring A, X, L, subscript m, X, B, R, R, R, R, Rand Rhave meanings described in the specifi...
|
|
JP6058023B2 |
The present invention relates to sulfonamide derivatives, of formula (I): or a pharmaceutically acceptable salts thereof, wherein X, Z, R1a, R1b, R2, R3, R4 and R5 are as defined in the description, and to their use in medicine, to compo...
|
|
JP5992930B2 |
The present invention relates to a heat-curable composition comprising (a) at least one compound which is capable of undergoing cationic polymerization; and (b) at least one sulfonium sulfate selected from compounds of the formulae Ia an...
|
|
JP5947724B2 |
The present invention relates to a compound of formula (I): wherein: n is 0, 1 or 2; A is in particular CH or N; X is in particular CO, SO2, CS, and R1 is in particular H, R2 is a group of formula NR3R4 or OR5, R3 and R4 being in particu...
|
|
JP5944483B2 |
Provided is a sulfamide derivative having an adamantyl group represented by the following Formula 1, or a pharmaceutically acceptable salt thereof. The sulfamide derivative suppresses the activity of 11²-hydroxysteroid dehydrogenase typ...
|
|
JP5883135B2 |
Novel indansulfamide derivatives or a pharmaceutically acceptable salt thereof such as N -[(1 S )-2,2,5,7-tetrafluoro-2,3-dihydro-1 H -inden-1-yl]sulfamide, N -[(1S)-2,2,4,7-tetrafluoro-2,3-dihydro-1 H -inden-1-yl]sulfamide, (+)- N -(2,2...
|
|
JP5847088B2 |
The present invention relates to compounds of the formula I, wherein A, Y, Z, R20 to R22 and R50 have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. Specifically, they are inhibitors of the endo...
|
|
JP5801011B2 |
The problem to be solved is to provide a method for efficiently producing compounds (1) and (1a) that are important intermediate compounds in the production of FXa inhibitors (X) and (X-a). The solutions thereto are a method for producin...
|
|
JP2015529651A |
The present invention relates to compounds of formula (I) useful for positive regulation of the alpha 7 nicotinic acetylcholine receptor (α7 nAChR), the substituents are as described herein. The present invention also relates to the use...
|
|
JP2015044829A |
To provide a compound having biaryl phosphodiesterase-4 (PDE4) inhibitory action useful for treatment and prevention of stroke, myocardial infraction and cardiovascular inflammatory diseases.There is provided a biaryl compound having at ...
|
|
JP5667044B2 |
The present invention relates to substituted phenoxybenzamide compounds of general formula (I): in which R1, R2, R3, R4, R5, X, R6 and q are as defined in the claims, to methods of preparing said compounds, to pharmaceutical compositions...
|
|
JP5642995B2 |
New 1,2,3- or 1,2,3,4- or 1,2,3,4,5- substituted imidazolium salts and their uses as solvent in catalyzed organic reactions, as well as compositions containing them and a transition metal compound. They can be used in the following react...
|
|
JP5592253B2 |
This invention relates to novel substituted phenylamino-benzene compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and/or angiogenesis disorder...
|
|
JP5582634B2 |
Compounds of formula (I): in which R1, R2, R7, R8, R9, R10 and A have the meanings given in the specification, are DP2 receptor modulators useful in the treatment of immunologic diseases.
|
|
JP5555426B2 |
A process for preparing sulfonamides I where the variables are each as defined in the description, by reacting m-nitrobenzoyl chlorides II with amino sulfones III, under the influence of B equivalents of base IV, wherein, in step a), the...
|
|
JP2014516343A |
This invention relates to novel compounds suitable for labelling by 18F and the corresponding 18F labelled compounds themselves, 19F-fluorinated analogues thereof and their use as reference standards, methods of preparing such compounds,...
|
|
JP2014123105A |
To provide new photoresist compositions that comprise a component comprising a radiation-insensitive ionic compound.Photoresists of the invention may comprise: a resin that comprises photoacid-labile groups; a photoacid generator compoun...
|
|
JP2014515734A |
Triazene-substituted diphenyl derivatives are suitable as chemotherapeutic agents for treating carcinomas in humans and animals.
|
|
JP2014098008A |
To provide cholesteryl ester transfer protein inhibitors, pharmaceutical compositions containing the inhibitors, and to provide use of the inhibitors to elevate certain plasma lipid levels, including high density lipoprotein (HDL)-choles...
|
|
JP5498168B2 |
Compounds of formula Ia and Ib wherein A, B, C, R1 and R14 are described herein.
|
|
JP5465672B2 |
The present invention relates to a process for preparing sulfuric diamides of the general formula I R1R2N—S(O)2—NH2 (I) in which R1 and R2 are each independently a primary alkyl radical having from 1 to 8 carbon atoms, a seconda...
|
|
JP5422557B2 |
Compounds of formula (I) or formula (II) have dopaminergic activity: wherein: R1 is a carboxyl, carboxyl ester, or carboxamide group; R2 is a group —C(═O)—NR3R4, or —S(═O)2—NR3R4; R3 and R4 are independently selected from hyd...
|
|
JP5396279B2 |
The invention relates to compounds of the formula I as defined herein, which are inhibitors of activated thrombin-activatable fibrinolysis inhibitor. The compounds of the formula I are suitable for manufacturing medicaments for the proph...
|
|
JP5339028B2 |
To provide a new compound producing a resist achieving high sensitivity and high transparency in the case of using it as a photoacid generator in a resist composition. This aryl-substituted benzyl cyanide-based oximesulfonate compound is...
|
|
JP5289826B2 |
|
|
JP5268217B2 |
New sulfamide compounds and methods of forming those compounds are provided. The inventive methods comprise subjecting a template opened-ring sulfamide compound to a ring-closing metathesis reaction in the presence of a Grubbs catalyst t...
|
|
JP5208782B2 |
To provide a method for producing fluorosulfonylimides more safely, rapidly and efficiently while suppressing the formation of byproducts, and to provide the fluorosulfonylimides. The method for producing the fluorosulfonylimides include...
|
|
JP5208505B2 |
the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein Z represents O, S, NR6, SO or SO2; R1 represents hydrogen, cyano, hydroxy, or C1-4alkyl optionally substituted wit...
|
|
JP2013508318A |
The present invention relates to substituted benzosulphonamide compounds of general formula (I): in which R1, R2, R3, R4, R5 and A are as defined in the claims, to methods of preparing said compounds, to pharmaceutical compositions and c...
|
|
JP2013508320A |
The present invention relates to substituted halophenoxybenzamide derivative compounds of general formula (I) in which R1, R2, R3, R3a, R4, R5, R6, Ra, Rb, Rc, and X are as defined in the claims, to methods of preparing said compounds, t...
|
|
JP5148646B2 |
Novel cycloalkyl compounds useful as inhibitors of potassium channel function (especially inhibitors of the K v l subfamily of voltage gated K + channels, especially inhibitors K v 1.5 which has been linked to the ultra-rapidly activatin...
|
|
JP5146714B2 |
Methods, compounds, pharmaceutical compositions and kits are described for treating or preventing amyloid-related disease.
|
|
JP5127093B2 |
Compounds of formula (I) wherein the groups are as defined in the description are disclosed. The compounds of formula (I) are endowed with reversible inhibiting activity of carnitine palmitoyl-transferase and are useful in the prepar...
|
|
JP5113823B2 |
The present invention relates to novel compounds (I), their prodrugs, and the pharmaceutically acceptable salts as well as pharmaceutical compositions containing such compounds useful in treating certain metabolic diseases and diseases m...
|
|
JPWO2010122968A1 |
To provide a compound useful as an anti-obesity drug. The present inventors have investigated a compound having a DGAT1 inhibitory action, which is promising as an active ingredient of a pharmaceutical composition for treating obesity, t...
|
|
JP5048017B2 |
A compound represented by the formula (I) or a salt thereof wherein n represents an integer of 1 to 3, R represents an alkyl group having 3 to 8 carbon atoms, a group represented by the following formula: R<1>(CH2)k- (wherein k represent...
|
|
JP2012524106A |
Curcumin analogues and methods of making and using the same are disclosed.
|
|
JP2012185482A |
To provide a resist composition that can obtain a pattern having an excellent focus margin.A resist composition comprises: an iodonium salt having an anion represented by formula (IA); an acrylic resin which has an acid-labile group, and...
|
|
JP5000683B2 |
A compound represented by the formula (I) or a salt thereof wherein n represents an integer of 1 to 3, R represents an alkyl group having 3 to 8 carbon atoms, a group represented by the following formula: R<1>(CH2)k- (wherein k represent...
|
|
JP4912312B2 |
The present invention is directed to novel benzo-fused heteroaryl sulfamide derivatives, pharmaceutical compositions containing them and their use in the treatment of epilepsy and related disorders.
|
|
JP2012025702A |
To provide a new amphiphilic sulfamide compound which has excellent amphiphilicity, and with which a molecular recognition function and a biological cell conformity function, and furthermore demonstration of higher order functions, such ...
|
|
JP4860613B2 |
The present invention relates to a process for preparing 3-phenyl(thio)uracils and -dithiouracils of the formula I where the variables are each as defined in the description, and also intermediates for their preparation.
|
|
JP4855368B2 |
The present invention relates to novel compounds (I), their prodrugs, and the pharmaceutically acceptable salts as well as pharmaceutical compositions containing such compounds useful in treating certain metabolic diseases and diseases m...
|
|
JP2012006936A |
To provide a process for preparing 3-phenyl(thio)uracils and -dithiouracils.In the process for preparing 3-phenyl(thio)uracils and -dithiouracils, carbamates having X1, X3, Ar, and A in formula and enamines having X2, R1, R2, and R3 are ...
|
|
JP4833884B2 |
The invention concerns novel derivatives of 3,3-diphenylpropylamines, methods for their preparation, pharmaceutical compositions containing the novel compounds, and the use of the compounds for preparing drugs. More particularly, the inv...
|
|
JP4815566B2 |
The present invention provides non-steroidal compounds of formula I which are selective modulators (i.e., agonist and antagonists) of a steroid receptor, specifically, the glucocorticoid receptor. The present invention also provides phar...
|
|
JP4743382B2 |
A medicament having inhibitory activity against NF- kappa B activation which comprises as an active ingredient a substance selected from the group consisting of a compound represented by the following general formula (I) and a pharmacolo...
|
|
JP4738812B2 |
Bifunctional phenyl iso(thio)cyanate derivatives (I) are new. Also new are aniline and nitrobenzene derivative intermediates (II) and (V). Bifunctional phenyl iso(thio)cyanate derivatives of formula W=C=N-Ar-CO-NH-SO 2-A (I) are new. W :...
|
|
JP2011111545A |
To provide a gelling agent that has a gelling ability for various kinds of solvents.The gelling agent has a dialkylsulfamide derivative represented by formula I [wherein R1 and R2 each independently represent a group selected from the gr...
|
|
JP4683801B2 |
|
