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Matches 401 - 450 out of 4,808

Document Document Title
WO/2009/038204
It is intended to provide a novel long-chain fatty acid derivative compound having an agonistic activity to GPR120 and GPR40. The long-chain fatty acid derivative compound of the invention is represented by the following general formula ...  
WO/2009/037416
The present invention relates to a process for preparing a class of sulphonamides which are aspartyl protease inhibitors. These compounds find therapeutic use in the treatment of the human immunodeficiency virus (HIV). This virus is the ...  
WO/2009/034432
The invention relates to compounds of formula: (I) processes and intermediates for their preparation, their use as muscarinic antagonists and pharmaceutical compositions containing them.  
WO/2009/035928
Disclosed are amide, thoiamide, urea and thiourea compounds and compositions that inhibit soluble epoxide hydrolase (sEH), methods for preparing the compounds and compositions, and methods for treating patients with such compounds and co...  
WO/2009/034432
The invention relates to compounds of formula: (I) processes and intermediates for their preparation, their use as muscarinic antagonists and pharmaceutical compositions containing them.  
WO/2009/034432
The invention relates to compounds of formula: (I) processes and intermediates for their preparation, their use as muscarinic antagonists and pharmaceutical compositions containing them.  
WO/2009/035855
The present invention relates to methods of treating disorders relating to mood, anxiety, stress, sleep, cognitive impairment/dysfunction, substance dependency/abuse, metabolism, eating and chronic pain comprising administering a therape...  
WO/2009/021944
The present invention relates to compounds of the general formula (I), wherein A, B, D, Y, R1, R2, R3, R4 and R5 are defined as mentioned in the description, the enantiomers, diastereomers, mixtures, and salts thereof, particularly physi...  
WO/2009/021945
The present invention relates to compounds of the general formula (I), wherein A1, A2, B, D, Y, R1, R2, R3, R4 and R5 are defined as mentioned in the description, the enantiomers, diastereomers, mixtures, and salts thereof, particularly ...  
WO/2009/022721
Disclosed is a compound represented by the general formula (I) below, which has retinoid action and is useful as an active ingredient of pharmaceutical products. (In the formula, R1 represents a hydrogen atom or a C1-6 alkyl group; A and...  
WO/2009/022681
Disclosed is a positive resist composition which is good in pattern shape, line-edge roughness, pattern collapse, sensitivity and resolution in conventional exposure (dry exposure), liquid immersion exposure and double exposure. Also dis...  
WO/2009/016083
Disclosed are a method for improving the degradation of natural and/or synthetic polymers or a polymer article made from such polymer(s) by light and/or heat and/or humidity, comprising the incorporation of a compound of formula (I) into...  
WO/2009/013915
An inhibitor of plasminogen activator inhibitor-1 (PAI-1). A medicinal composition having an effect of inhibiting the PAI-1 activity and being efficacious in preventing or treating various diseases for the onset of which the PAI-1 activi...  
WO/2009/013915
An inhibitor of plasminogen activator inhibitor-1 (PAI-1). A medicinal composition having an effect of inhibiting the PAI-1 activity and being efficacious in preventing or treating various diseases for the onset of which the PAI-1 activi...  
WO/2009/012954
The invention provides a compound of formula (I) or a pharmaceutically acceptable ester, amide, solvate or salt thereof, including a salt of such an ester or amide, and a solvate of such an ester, amide or salt, wherein W, X, Y, Z, R1, R...  
WO/2009/015028
Disclosed herein are deuterated derivatives of TAK-242 of Formula (I) which are modulators of TLR4 signalling pathway, pharmaceutical compositions thereof and methods of use thereof. Formula (I)  
WO/2009/012203
Methods for preparing compound of Formula (I) are described, wherein R1-R3 are defined herein, as are methods for preparing the intermediates formed therein. Formula (I) Also described are methods for enantioselectively preparing a chira...  
WO/2009/012205
Novel sulfonamide compounds useful in the treatment of conditions related to the production of beta-amyloid are described, as are routes to their preparation. The sulfonamide compounds are of the following structure, wherein R4-R3 are de...  
WO/2009/006267
The present invention provides N'-(2-halobenzylidene)sulfonylhydrazides of formula (I). Compounds of formula (I) are useful for the manufacture of 1-arylsulfonylindazole 5-HT6 ligands.  
WO/2009/006267
The present invention provides N'-(2-halobenzylidene)sulfonylhydrazides of formula (I). Compounds of formula (I) are useful for the manufacture of 1-arylsulfonylindazole 5-HT6 ligands.  
WO/2009/005024
Disclosed is a method for producing a chiral amine, which is characterized in that an imine compound is subjected to a hydrogen transfer-type asymmetric reduction in the presence of an iridium (III) complex having a chiral proline amide ...  
WO/2008/157272
The present application describes deuterium-enriched tamsulosin, pharmaceutically acceptable salt forms thereof, and methods of treating using the same.  
WO/2008/156142
It is intended to provide a novel compound which has AT2 receptor agonism and is capable of being expected as a pharmaceutical and to provide a therapeutic or preventive method for various diseases. A novel malonic acid sulfonamide deriv...  
WO/2008/152334
The invention relates to novel derivatives of 3-phenyl acrylic acid of the following general formula (I), to a method for preparing the same, and to the use thereof in pharmaceutical compositions used in human or veterinary medicine (in ...  
WO/2008/152334
The invention relates to novel derivatives of 3-phenyl acrylic acid of the following general formula (I), to a method for preparing the same, and to the use thereof in pharmaceutical compositions used in human or veterinary medicine (in ...  
WO/2008/152333
The invention relates to novel derivatives of 3-phenyl propanoic acid of the following general formula (I), to a method for preparing the same, and to the use thereof in pharmaceutical compositions used in human or veterinary medicine (i...  
WO/2008/152333
The invention relates to novel derivatives of 3-phenyl propanoic acid of the following general formula (I), to a method for preparing the same, and to the use thereof in pharmaceutical compositions used in human or veterinary medicine (i...  
WO/2008/154414
Fluorochemical ester compositions comprising one or more compounds or oligomers having at least one long chain fluorine-containing repeatable unit and at least one fluorine-containing terminal group are described. The compositions are us...  
WO/2008/154372
Mutual prodrugs comprising retinoids and histone deacetylase inhibitors, methods for production of the mutual prodnigs, and methods of treatment comprising administration of the mutual prodrugs. The retinoids include all-trans retinoic a...  
WO/2008/152653
The invention relates an improved process for preparing the (R)-(-)5-[2-[[2-(2-ethoxyphenoxyethyl]amino]propyl]-2-methox ybenzenesulfonamide of Formula (I): and its pharmaceutically acceptable salts.  
WO/2008/154414
Fluorochemical ester compositions comprising one or more compounds or oligomers having at least one long chain fluorine-containing repeatable unit and at least one fluorine-containing terminal group are described. The compositions are us...  
WO/2008/152333
The invention relates to novel derivatives of 3-phenyl propanoic acid of the following general formula (I), to a method for preparing the same, and to the use thereof in pharmaceutical compositions used in human or veterinary medicine (i...  
WO/2008/152653
The invention relates an improved process for preparing the (R)-(-)5-[2-[[2-(2-ethoxyphenoxyethyl]amino]propyl]-2-methox ybenzenesulfonamide of Formula (I): and its pharmaceutically acceptable salts.  
WO/2008/151211
The present invention relates to A compound of the formula Ia wherein in any of its stereoisomers forms or a mixture of stereoisomeric forms in any ratio, or a physiologically acceptable salt thereof, wherein the substituents are as desc...  
WO/2008/147797
In general, the invention relates to compounds useful as ion channel modulators. It has now been found that compounds of this invention, and pharmaceutically acceptable compositions thereof, are useful as inhibitors of voltage-gated sodi...  
WO/2008/147797
In general, the invention relates to compounds useful as ion channel modulators. It has now been found that compounds of this invention, and pharmaceutically acceptable compositions thereof, are useful as inhibitors of voltage-gated sodi...  
WO/2008/144660
The invention provides cross-linked polymer electrolyte membranes (PEM's), catalyst coated proton exchange membranes (CCM's) and membrane electrode assemblies (MEA' s) that are useful in fuel cells and their application In electronic dev...  
WO/2008/144660
The invention provides cross-linked polymer electrolyte membranes (PEM's), catalyst coated proton exchange membranes (CCM's) and membrane electrode assemblies (MEA' s) that are useful in fuel cells and their application In electronic dev...  
WO/2008/139152
The invention provides a method of preparing a therapeutically active compound having reduced hERG activity, which method comprises: (a) selecting a non-N-oxide drug compound containing a basic tertiary amino group, wherein said non-N-ox...  
WO/2008/139987
Disclosed is a novel aralkyl carboxylic acid compound which has an agonistic activity on GPR-120 and/or GPR-40, particularly GPR-120, and is therefore useful as an appetite regulator, an anti-obesity agent, a therapeutic agent for diabet...  
WO/2008/136378
Disclosed is a compound represented by the following general formula: (wherein R1 represents a hydrogen atom or the like; R2 represents an optionally substituted alkyl or aryl group or the like; R3 and R4 may be the same or different and...  
WO/2008/131946
The invention relates to substituted amide derivatives of formula (I), methods for the production thereof, medicaments containing said compounds, and the use thereof as B1R bradykinin antagonists and especially for the treatment of pain ...  
WO/2008/132154
A process for the preparation of N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzen esulfonylamide derivatives (I) in which a 1-benzyl-2-hydroxy-3-isobutylamine derivative (II) is reacted with a p-nitrophenylsulfonyl halide (II...  
WO/2008/129276
There is provided compounds of formula (I), wherein the A ring, X1, X2, R1, R2, Cx, Qy, T1 and T2 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of disea...  
WO/2008/130332
Substituted sulphonamides having the general formula (I) and salts, hydrates and solvates thereof were prepared and described, wherein R1 isCO or SO2 and R2 is NH or O and where R represents linear or cyclic aliphatic chain and n represe...  
WO/2008/129288
There is provided compounds of formula (I), wherein Y1, Y2, Y3, Y4, T1, T2, W1, W2, R1 and R2 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases ...  
WO/2008/129288
There is provided compounds of formula (I), wherein Y1, Y2, Y3, Y4, T1, T2, W1, W2, R1 and R2 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases ...  
WO/2008/131047
The invention relates to plasminogen activator- 1 (PAl-1I) inhibitor compounds and uses thereof in the treatment of any disease or condition associated with elevated PAI-1. The invention includes, but is not limited to, the use of such c...  
WO/2008/131047
The invention relates to plasminogen activator- 1 (PAl-1I) inhibitor compounds and uses thereof in the treatment of any disease or condition associated with elevated PAI-1. The invention includes, but is not limited to, the use of such c...  
WO/2008/131219
Disclosed herein are substituted anthranilic acids, pharmaceutically acceptable salts and prodrugs thereof, the chemical synthesis thereof, and medical use of such compounds for the treatment and/or management of hypertension, edema asso...  

Matches 401 - 450 out of 4,808