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JP3773824B2 |
To provide a solid acid catalyst which can improve the efficiency of a reaction proceeding in the presence of a Broensted acid or a Lewis acid catalyst, for example, facilitates the benzoylation of an alcohol, can easily be recovered or ...
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JP2006511445A |
Where Y, R1-R8 and R101-R108 are as defined in the specification. Compounds of formula (II) and methods of inhibiting the cytokine or biological activity of Macrophage Migrating Inhibitory Factor (MIF) comprising contacting MIF with a co...
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JP2006504693A |
Treatment of central nervous system disorders with (1R,4S)-trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-napthal
enamine and with (1S,4R)-trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-napthal
enamine is disclose...
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JP3739654B2 |
A process for producing a compound of the formula (II): wherein Hal<1> represents halogen and R<1> and R<2> each independently represents halogen, alkyl, alkoxy, nitro or cyano, which comprises allowing a halogenating agent to react with...
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JP2006500407A |
The invention is a process for the preparation of compounds of the Formula I: where R1, R2, R3, R4 and R5 are defined in the specification, which are intermediates useful for the preparation of tubulin inhibitors which are useful in the ...
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JP2005537223A |
The invention describes novel nitric oxide donors and novel compositions comprising at least one nitric oxide donor. The invention also provides novel compositions comprising at least one nitric oxide donor, and, optionally, at least one...
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JP2005314354A |
To provide a new axially asymmetric compound capable of being used as an asymmetric group-introducing assistant compound.This optically active sulfinic acid compound is expressed by formula (1) [wherein, R1 is a 1-4C alkoxy or group expr...
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JP3711581B2 |
PURPOSE: To obtain a new semicarbazone derivative, having excellent insecticidal and acaricidal activities against agricultural insect pests and tetranychids in a small dose, hardly exerting adverse influences upon mammals, fishes and be...
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JP3706904B2 |
To provide an industrially advantageous method for producing sulfene amide compound which is useful of a rubber vulcanizing agent and a physiological activity, in safety, in a good yield and without using any harmful reagent. When sulfen...
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JP3704166B2 |
PURPOSE: To prepare 4-alkyl-3-chloroalkylsulfonylbenzene by successively subjecting p-alkylbenzenesulfonylchloride used as a starting material to chlorination, reduction, condensation with an α-halocarboxylic acid or its salt and decarb...
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JP3701044B2 |
PURPOSE: To industrially advantageously, efficiently and economically obtain a new compound useful as an intermediate of a 3-substituted benzoisothiazole derivative important as an intermediate for producing a medicine. CONSTITUTION: The...
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JP2005523920A |
The present invention relates to novel compounds of formula (I), or a salt, solvate, or physiologically functional derivative thereof, to a process for their manufacture, to pharmaceutical compositions containing them, and to their use i...
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JP2005522525A |
This invention provides intermediates useful in a method of preparing amine stereoisomers. It also provides a method of preparing sulfoxide and sulfinylamine stereoisomers using certain of the intermediates.
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JP3671110B2 |
To obtain the subject new compound useful as an active ingredient for pest-controlling agents such as insecticides, acaricides and nematicides. An acrylonitrile compound of formula I {Q is a group of formula II-V [R3 groups are each a ha...
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JP2005170948A |
To provide a new compound having pesticidal activity, to provide a method for producing the compound, and to provide applications of the compound.The pest control agent includes a compound represented by formula (I) [wherein, Q is a grou...
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JP2005154438A |
To provide a method for manufacturing sulfinate without producing a large amount of unnecessary salt.The invention relates to the method for manufacturing sulfinate with few unnecessary salt comprising reduction of dithionite of alkali m...
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JP3660941B2 |
To obtain a decomposable polymer compound and to provide its decomposing method, and to obtain a new sulfinic acid having excellent water solubility. This decomposable polymer compound is a polysulfone characterized by containing in the ...
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JP3657002B2 |
The present invention provides retroviral protease inhibitor compounds represented by the Formula I: Such compounds are urseful for preparing medicaments for inhibiting proteases, especially for inhibiting HIV protease and for treating a...
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JP2005132816A |
To provide a compound that can be used as an optical resolution reagent selected from the group of axially asymmetry compounds that can more easily be produced through an uncomplicated process.The optical resolution reagent is mainly com...
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JP2005511730A |
This invention is directed to functionalized higher diamondoids having at least one functional group. These derivatives have a higher diamondoid nucleus and up to six independently selected functional groups. The functionalized higher di...
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JP3640962B2 |
The present invention relates to a process for the preparation of a compound of formula (I) or a sodium salt thereofwherein HET is 7-chloroquinolin-2-yl or 6,7-difluoroquinolin-2-yl, which comprises: reacting the dilithium dianion of 1-(...
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JP3630101B2 |
Novel sulfur-containing analogs of 1±,25-dihydroxyvitamin D 3 are provided. These analogs are synthesized in a convergent manner by joining A-ring and C,D ring fragments. Each analog with 1±,3²-substituent stereochemistry shows a phar...
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JP2005503446A |
This invention relates to new cyclodextrin derivatives, processes for producing these cyclodextrin derivatives, and inclusion complexes comprised of the new cyclodextrin derivatives and guest molecules, as well as methods of making such ...
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JP2005502620A |
Novel sulfenate derivatives and their bioconjugates for phototherapy of tumors and other lesions. The sulfenates of the present invention are designed to absorb low-energy ultraviolet, visible, or near-infrared (NIR) region of the electr...
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JP2004359695A |
To provide a new compound useful as an active ingredient of a pesticide.The acrylonitrile compounds expressed by formula (I) and salts thereof. [wherein Q is a group of formula Qd, Y is =C(R4)- or =N-, R1 is an alkyl, a haloalkyl, etc., ...
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JP3598131B2 |
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JP2004536082A |
A positron emission tomography (PET)-ready library of candidate pharmaceutical agents is provided which can be prepared by a multistep process wherein the final or penultimate step is a reaction using a PET-ready reagent or a plurality o...
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JP2004536073A |
A method is provided for the prevention or inhibition of cardiovascular disease by a method comprising the administration of a cyclooxygenase-2 selective inhibitor and a dose of radiation.
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JP3592348B2 |
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JP2004307387A |
To obtain a sulfonic acid compound which has a ≥8C hydrocarbon part and a difluoroalkylsulfonic acid part having proper acidity.The 2-(bicyclo[2.2.1]hept-2-yl)-1,1-difluoroethylsulfinate or 2-(bicyclo[2.2.1]hept-2-yl)-1,1-difluoroethyl...
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JP2004529982A5 |
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JP2004529982A |
Novel compounds of formula (I) wherein R1 represents hydrogen; R2 represents hydroxy, fluoro, or an oxo group; R3 represents hydrogen; R4 represents hydrogen; and pharmaceutically acceptable salts, solvates, and the stereoisomers thereof...
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JP2004223451A |
To largely heighten industrial production efficiency and to obtain a target substance as a homogeneous crystal.The separating/refining apparatus 1 uses a separating/refining method for an organic compound for separating the organic compo...
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JP2004523495A |
The invention relates, in part, to making of making and using, and compositions comprising, racemic and stereomerically pure cyclobutylalkylamines, including hydroxylated sibutramine and hydroxylated metabolites of sibutramine. Methods o...
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JP2004520397A |
PPAR alpha activators, pharmaceutical compositions containing such compounds and the use of such compounds to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma lipid lev...
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JP2004168684A |
To provide a new hydroxy-group-protecting group easily introduced into the 5'-hydroxy group of a nucleoside and removable under a mild oxidative condition, a reagent for the introduction thereof, and a nucleoside phosphoramidite compound...
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JP2004513906A |
The invention relates to a reducing composition for the permanent deformation of the hair comprising an N-substituted formamidinesulphinic acid derivative as reducing agent and to a process for the permanent deformation of the hair emplo...
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JP2004508857A |
The present invention provides a method of contrast enhanced magnetic resonance imaging of a sample, said method comprising: a) administering a hyperpolarised MR contrast agent comprising non-zero nuclear spin nuclei into said sample for...
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JP3506768B2 |
PURPOSE: To provide a method for efficiently synthesizing a triphenylene ring useful as a mother nucleus for discotic liquid crystal. CONSTITUTION: (1) The characteristic of this method for synthesizing a 2,3,6,7,10,11-hexaalkoxy-substit...
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JP3499175B2 |
To provide a halogen free substantially colorless flame retardant polyolefin resin composition having a high practicability capable of replacing a polyvinyl chloride based resin and its laminated sheet, excellent in processability, flexi...
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JP2004051614A |
To provide a new vermin-controlling agent, especially an insecticide or acaricide.This vermin-controlling agent contains a substituted amide compound expressed by general formula (1) [wherein, A is carbon atom or the like; G is G-1 or G-...
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JP2003531134A |
The invention relates to novel pesticidally active alpha-sulfin- and alpha-sulfonamino acid amides of the general formula (I) including the optical isomers thereof and mixtures of such isomers, wherein n is a number zero or one; R1-R9 ha...
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JP2003531135A |
The invention relates to novel pesticidally active alpha-sulfin and alpha-sulfonamino acid amides of the general formula (I) including the optical isomers thereof and mixtures of such isomers, wherein n is a number zero or one; R1, R2, R...
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JP2003531136A |
The invention relates to novel pesticidally active alpha-sulfin- and alpha-sulfonamino acid amides of the general formula (I) including the optical isomers thereof and mixtures of such isomers, wherein n is a number zero or one, R1-R7 ha...
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JP3448635B2 |
To obtain a new sulfenamide useful for profitably producing benzoisothiazolinone compounds by aminating the thiol group of a thiosalicylic acid ester compound without using a poisonous chlorine gas and a starting raw material which is di...
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JP2003523983A |
This invention is directed to novel and known sulfur containing compounds and pharmaceutically acceptable salts thereof that have utility as antifungals and as antiproliferative agents against mammalian cells, in particular cancer cells ...
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JP3426252B2 |
The sulfonamide or carboamide derivatives of the formula (I) and a pharmaceutical composition which comprise them as an active ingredient: (wherein A ring, B ring is carbocyclic ring, heterocyclic ring; Z<1> is -COR<1>, -CH=CH-COR<1> etc...
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JP3421350B2 |
The invention provides methods and compositions relating to novel pentafluorophenylsulfonamide derivatives and analogs and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in th...
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JP2003048875A |
To provide a method for manufacturing a new imidazoline compound acting as an NPY receptor antagonist and useful as a treating agent for various circulatory system diseases, central nervous system diseases, or metabolic system diseases. ...
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JP2003506311A |
A process for preparing novel compounds useful in the preparation of 1H-indole-3-glyoxamides.
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