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Matches 1 - 50 out of 3,823

Document Document Title
WO/2019/194690A1
Provided is an improved process of vitamin K2 derivatives preparation, represented by formula (I) wherein n is an integer from 3 to 13.  
WO/2019/192058A1
A biochip substrate, a preparation method therefor, and an application thereof. The surface of the biochip substrate contains an active vinyl sulfone group. The preparation method involves a one-step reaction of a compound containing vin...  
WO/2019/180627A1
The present invention relates to an improved asymmetric synthesis of alpha- (diarylmethyl) alkyl amines (hereafter referred to as the compound (1)) or its pharmaceutically acceptable salt and derivatives. The process comprises an unusual...  
WO/2019/175149A1
The present invention relates to compounds of the formula (1) which are suitable for use in electronic devices, in particular organic electroluminescent devices, and to electronic devices which comprise these compounds.  
WO/2019/088800A3
The present invention relates to a polyethylene glycol derivative and a preparation method thereof. A preparation process of a polyethylene glycol derivative, according to the present invention, may provide a novel polyethylene glycol de...  
WO/2019/088800A9
The present invention relates to a polyethylene glycol derivative and a preparation method thereof. A preparation process of a polyethylene glycol derivative, according to the present invention, may provide a novel polyethylene glycol de...  
WO/2019/091179A1
Disclosed is a method for preparing florfenicol intermediate V, which belongs to the technical field of the preparation of veterinary medicines. The method comprises an addition reaction, a ring-closing reaction, a hydrolysis reaction an...  
WO/2019/088800A2
The present invention relates to a polyethylene glycol derivative and a preparation method thereof. A preparation process of a polyethylene glycol derivative, according to the present invention, may provide a novel polyethylene glycol de...  
WO/2019/062561A1
Provided herein the synthesis methods of firocoxib and an intermediate thereof. The synthesis of the first intermediate is performed through methylation of p-bromopropiophenone or through Friedel-Crafts acylation of bromobenzene, avoidin...  
WO/2019/043289A1
The present invention relates to a process for the preparation of arylsulfonylpro- penenitriles. The reaction starting from arylsulfonyl iodides is catalyzed by light. The process is scalable, environmentally benign and provides the prod...  
WO/2019/039705A1
The present invention relates to a method for separating 5-hydroxymethyl-2-furfural (HMF) and dimethyl sulfoxide (DMSO), the method comprising the steps of: (a) preparing a mixture solution comprising HMF and DMSO; and (b) mixing an orga...  
WO/2019/035479A1
A cyclopropanation method includes reacting an alcohol, an ester, or an aldehyde with a sulfone in an organic solvent containing a base providing a counter cation to form a cyclopropane; and isolating the cyclopropane. When using the a...  
WO/2019/030184A1
The invention relates to new compounds of formula (I) wherein X represents a halogen atom selected from the group consisting of fluorine, chlorine, bromine and iodine, which are useful for the preparation of 4,4'dihalodiphenylsulfones of...  
WO/2019/026479A1
In one or more embodiments, the present invention pertains to a method for purifying dimethyl sulfoxide, the method including a step for adding an alkaline earth metal hydroxide to a material to be distilled that contains dimethyl sulfox...  
WO/2019/026868A1
A method for recovering dimethyl sulfoxide, which comprises a step wherein water and a recovered resist remover that contains dimethyl sulfoxide and at least one compound selected from the group consisting of glycol ethers, glycols and t...  
WO/2018/228079A1
The present invention discloses a fluorescent probe for detecting a sulfenated protein, having the following structural general formula (I). The fluorescent probe has good stability and can be preserved for long-term use. The fluorescent...  
WO/2018/210633A1
The present invention relates to a method for the production of phenylguanidines or the salts thereof by reacting an aniline that has electronegative substituents with a cyanamide-containing mixture.  
WO/2018/189969A1
The present invention is a method for distilling a liquid containing dimethylsulfoxide using a distillation apparatus, wherein: (1) assuming the total of the liquid containing dimethylsulfoxide at the bottom of the distillation apparatus...  
WO/2018/114914A1
The present invention relates to a method for producing (functionalized) biaryls by employing a visible-light-driven, gold-catalyzed C-C cross-coupling reaction system involving boron- and silicon-containing aryl compounds and aryldiazon...  
WO/2018/096066A1
This invention is directed at a mechanochemical process using at least one solid catalytically active compound for simulating or capturing the transformation over time of a solid pharmaceutical composition in a shortened time span and th...  
WO/2018/067401A1
Eflornithine is an agent that can be used to treat glioma, especially glioma of WHO Grade II or Grade III such as anaplastic glioma. Eflornithine can suppress or prevent mutations in glioma which can cause the glioma to progress to a hig...  
WO/2018/061034A1
The present invention relates to a process for the preparation of 1-(3-ethoxy-4-methoxy-phenyl)-2-methylsulfonyl-ethanamine, an intermediate for the preparation of apremilast via a compound of Formula (V) wherein R is (C1-C4)alkyl, (C1-C...  
WO/2018/054877A1
The invention relates to a method for producing bistolanes which are substituted in the 1,1 '-position with halogen and to products from said compounds. The C-C-triple bonds of the bistolanes are produced by elimination reactions.  
WO/2018/012947A1
The present invention relates to a novel organic sulfur compound, a method for preparing the same, and a pharmaceutical composition for preventing or treating cancer or an inflammatory disease, containing the same as an active ingredient...  
WO/2018/007481A1
A process for preparing polyaryl ethers in which a polycondensation of the monomer building blocks is carried out using microwave irradiation leads to thermoplastic molding compositions having improved color properties.  
WO/2018/001353A1
Provided is a method for preparing apremilast of formula I. Method one: (S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethylamin e N-acetyl-L-leucine salt of formula II is reacted with 3-acetylaminophthalic anhydride of formula III i...  
WO/2017/208501A1
Provided are: a surface-modified sodium hypochlorite pentahydrate crystal, an aqueous solution of which has a pH which can be significantly lowered safely and simply and at low cost without performing risky, high-cost pH adjustment that ...  
WO/2017/164813A1
D The present invention relates to ion pair catalysts (I) comprising the cationic bisguanidinium ligand (A) and diperoxomolybdate anion (B). The present invention also relates to ion pair catalysts (III) comprising the cationic bisguanid...  
WO/2017/150478A1
[Problem] To provide an industrially preferred method for producing a sulfoxide derivative. [Solution] A method for producing a sulfoxide derivative represented by general formula (1), the method being characterized in that a sulfide der...  
WO/2017/137147A1
The present invention relates to novel crystalline modifications of N-(4,5- bismethanesulfonyl-2-methylbenzoyl)guanidine hydrochloride, novel N-(4,5- bismethanesulfonyl-2-methylbenzoyl)guanidine salts and their crystalline modifications ...  
WO/2017/130798A1
Disclosed is a polyarylene sulfide resin having a main chain including a structural unit represented by general formula (1.1). No absorption peak derived from the S=O stretching vibration of a sulfonyl group is observed in the infrared a...  
WO/2017/094031A3
The present invention related to a novel compound of Formula II, its enantiomers or acid addition salts thereof and process for its preparation. The compound of Formula II can be used for preparation of N-[2-[(1S)-1-(3-ethoxy-4-methoxyph...  
WO/2017/098900A1
The present invention is a method for purifying dimethyl sulfoxide, comprising distilling a dimethyl sulfoxide-containing liquid in an inert gas atmosphere in the presence of sodium carbonate to distil out dimethyl sulfoxide, wherein the...  
WO/2017/093172A1
Disclosed is a method for producing 2-alkyl-4-trifluoromethyl-3-alkyl sulfonyl benzoic acids of formula (I). In said formula, the substituents represent groups such as alkyl and substituted phenyl.  
WO/2017/095119A1
A polythiol compound of an embodiment, which is obtained by reacting a sulfide compound having two or more triple bonds with an alcohol compound having a mercapto group to prepare a tetrafunctional or higher functional polyol compound co...  
WO/2017/073468A1
A compound represented by formula (3) (wherein R1 represents a C1-C6 alkyl group which may have at least one halogen atom; R2 represents a C1-C6 alkyl group; and m represents an integer of 0 to 3) can be produced by reacting a C1-C6 alka...  
WO/2017/072038A1
A method for synthesizing 2-alkyl-4-trifluoromethyl-3-alkylsulfonyl-benzoic acids of formula (I) is described. In said formula (I), the substituents represent groups such as alkyl and substituted phenyl (formulae (II)-(V), (V)-(I)).  
WO/2017/064723A1
The present invention relates to and an improved process for the preparation of Armodafinil with high purity and high yield. The present invention also related to preparation of Armodafinil polymorphic Form-1 with a particle size of abov...  
WO/2017/064910A1
The present invention is a method for preventing the decomposition of dimethyl sulfoxide, said method comprising adding sodium carbonate in an amount of 0.0005 to 2 g relative to 100 g of dimethyl sulfoxide contained in a dimethyl sulfox...  
WO/2017/057460A1
Provided is a method for producing an organic compound, wherein the organic compound is an industrially useful compound, and a deodorization step, for removing from a reaction solution odorants that are generated in or remaining after a ...  
WO/2017/046319A1
The present invention relates to an asymmetric process for providing N-{2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)et hyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide (apremilast) or a pharmaceutically acceptable salt or...  
WO/2017/014214A1
A compound represented by formula (4) can be produced by adding a heterogeneous transition metal catalyst to a solution containing a compound represented by formula (3) and then subjecting the resultant mixture to a reduction reaction, w...  
WO/2016/202806A1
The present invention relates to a process for providing a chiral β-hydroxysulfone compound, an intermediate useful in the synthesis of the isoindoline-based compound apremilast.  
WO/2016/197900A1
A process for the preparation of mesotrione enolate is provided, the process comprising providing a solution of mesotrione in an organic solvent and contacting the solution with a moderate base in the presence of water at a pH of from 6 ...  
WO/2016/199031A1
Present application relates to the process for the preparation of 1-(3-Ethoxy-4-methoxy-phenyl)-2-methanesulfonyl-ethylamine of the formula (II), its resolution and its use in preparation of Apremilast of formula (I), process for the pre...  
WO/2016/201039A1
A process for preparing diaryl sulfones, such as 4,4'-dichlorodiphenylsulfone is disclosed. The process comprises contacting an aryl compound with sulfur trioxide to provide a benzene sulfonic acid. The benzene sulfonic acid is coupled t...  
WO/2016/192694A1
The invention relates to a preparation method of (S)-l-(3-ethoxy-4-methoxyphenyl)- 2-(methylsulfonyl)-ethyl-amine (S)-l, or its N-acyl derivatives of general formula (S)-2. The amine (S)-l is the key intermediate in the synthesis of (S)-...  
WO/2016/194929A1
Compounds shown by formula (3): (in the formula, R1 represents a C1-C6 perfluoroalkyl group, R2 represents a C1-C6 alkyl group, and m represents any integer of 0-3) or salts thereof which are useful as production intermediates of pharmac...  
WO/2016/196664A1
The invention provides methods and agents that modulate RelA activity. These methods and modulators of RelA acitivity can be used to treat cancer progression of basal-like breast cancer, such as triple-negative breast cancer.  
WO/2016/189486A1
The present invention provides an improved process for preparation of an intermediate of apremilast. The present invention also provides an improved process for preparation of apremilast. This invention also provides novel polymorphs of ...  

Matches 1 - 50 out of 3,823