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Matches 1 - 50 out of 3,766

Document Document Title
WO/2018/067401A1
Eflornithine is an agent that can be used to treat glioma, especially glioma of WHO Grade II or Grade III such as anaplastic glioma. Eflornithine can suppress or prevent mutations in glioma which can cause the glioma to progress to a hig...  
WO/2018/061034A1
The present invention relates to a process for the preparation of 1-(3-ethoxy-4-methoxy-phenyl)-2-methylsulfonyl-ethanamine, an intermediate for the preparation of apremilast via a compound of Formula (V) wherein R is (C1-C4)alkyl, (C1-C...  
WO/2018/054877A1
The invention relates to a method for producing bistolanes which are substituted in the 1,1 '-position with halogen and to products from said compounds. The C-C-triple bonds of the bistolanes are produced by elimination reactions.  
WO/2018/012947A1
The present invention relates to a novel organic sulfur compound, a method for preparing the same, and a pharmaceutical composition for preventing or treating cancer or an inflammatory disease, containing the same as an active ingredient...  
WO/2018/007481A1
A process for preparing polyaryl ethers in which a polycondensation of the monomer building blocks is carried out using microwave irradiation leads to thermoplastic molding compositions having improved color properties.  
WO/2018/001353A1
Provided is a method for preparing apremilast of formula I. Method one: (S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethylamin e N-acetyl-L-leucine salt of formula II is reacted with 3-acetylaminophthalic anhydride of formula III i...  
WO/2017/208501A1
Provided are: a surface-modified sodium hypochlorite pentahydrate crystal, an aqueous solution of which has a pH which can be significantly lowered safely and simply and at low cost without performing risky, high-cost pH adjustment that ...  
WO/2017/164813A1
D The present invention relates to ion pair catalysts (I) comprising the cationic bisguanidinium ligand (A) and diperoxomolybdate anion (B). The present invention also relates to ion pair catalysts (III) comprising the cationic bisguanid...  
WO/2017/150478A1
[Problem] To provide an industrially preferred method for producing a sulfoxide derivative. [Solution] A method for producing a sulfoxide derivative represented by general formula (1), the method being characterized in that a sulfide der...  
WO/2017/137147A1
The present invention relates to novel crystalline modifications of N-(4,5- bismethanesulfonyl-2-methylbenzoyl)guanidine hydrochloride, novel N-(4,5- bismethanesulfonyl-2-methylbenzoyl)guanidine salts and their crystalline modifications ...  
WO/2017/130798A1
Disclosed is a polyarylene sulfide resin having a main chain including a structural unit represented by general formula (1.1). No absorption peak derived from the S=O stretching vibration of a sulfonyl group is observed in the infrared a...  
WO/2017/098900A1
The present invention is a method for purifying dimethyl sulfoxide, comprising distilling a dimethyl sulfoxide-containing liquid in an inert gas atmosphere in the presence of sodium carbonate to distil out dimethyl sulfoxide, wherein the...  
WO/2017/093172A1
Disclosed is a method for producing 2-alkyl-4-trifluoromethyl-3-alkyl sulfonyl benzoic acids of formula (I). In said formula, the substituents represent groups such as alkyl and substituted phenyl.  
WO/2017/095119A1
A polythiol compound of an embodiment, which is obtained by reacting a sulfide compound having two or more triple bonds with an alcohol compound having a mercapto group to prepare a tetrafunctional or higher functional polyol compound co...  
WO/2017/094031A3
The present invention related to a novel compound of Formula II, its enantiomers or acid addition salts thereof and process for its preparation. The compound of Formula II can be used for preparation of N-[2-[(1S)-1-(3-ethoxy-4-methoxyph...  
WO/2017/073468A1
A compound represented by formula (3) (wherein R1 represents a C1-C6 alkyl group which may have at least one halogen atom; R2 represents a C1-C6 alkyl group; and m represents an integer of 0 to 3) can be produced by reacting a C1-C6 alka...  
WO/2017/072038A1
A method for synthesizing 2-alkyl-4-trifluoromethyl-3-alkylsulfonyl-benzoic acids of formula (I) is described. In said formula (I), the substituents represent groups such as alkyl and substituted phenyl (formulae (II)-(V), (V)-(I)).  
WO/2017/064723A1
The present invention relates to and an improved process for the preparation of Armodafinil with high purity and high yield. The present invention also related to preparation of Armodafinil polymorphic Form-1 with a particle size of abov...  
WO/2017/064910A1
The present invention is a method for preventing the decomposition of dimethyl sulfoxide, said method comprising adding sodium carbonate in an amount of 0.0005 to 2 g relative to 100 g of dimethyl sulfoxide contained in a dimethyl sulfox...  
WO/2017/057460A1
Provided is a method for producing an organic compound, wherein the organic compound is an industrially useful compound, and a deodorization step, for removing from a reaction solution odorants that are generated in or remaining after a ...  
WO/2017/046319A1
The present invention relates to an asymmetric process for providing N-{2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)et hyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide (apremilast) or a pharmaceutically acceptable salt or...  
WO/2017/014214A1
A compound represented by formula (4) can be produced by adding a heterogeneous transition metal catalyst to a solution containing a compound represented by formula (3) and then subjecting the resultant mixture to a reduction reaction, w...  
WO/2016/202806A1
The present invention relates to a process for providing a chiral β-hydroxysulfone compound, an intermediate useful in the synthesis of the isoindoline-based compound apremilast.  
WO/2016/197900A1
A process for the preparation of mesotrione enolate is provided, the process comprising providing a solution of mesotrione in an organic solvent and contacting the solution with a moderate base in the presence of water at a pH of from 6 ...  
WO/2016/199031A1
Present application relates to the process for the preparation of 1-(3-Ethoxy-4-methoxy-phenyl)-2-methanesulfonyl-ethylamine of the formula (II), its resolution and its use in preparation of Apremilast of formula (I), process for the pre...  
WO/2016/201039A1
A process for preparing diaryl sulfones, such as 4,4'-dichlorodiphenylsulfone is disclosed. The process comprises contacting an aryl compound with sulfur trioxide to provide a benzene sulfonic acid. The benzene sulfonic acid is coupled t...  
WO/2016/192694A1
The invention relates to a preparation method of (S)-l-(3-ethoxy-4-methoxyphenyl)- 2-(methylsulfonyl)-ethyl-amine (S)-l, or its N-acyl derivatives of general formula (S)-2. The amine (S)-l is the key intermediate in the synthesis of (S)-...  
WO/2016/194929A1
Compounds shown by formula (3): (in the formula, R1 represents a C1-C6 perfluoroalkyl group, R2 represents a C1-C6 alkyl group, and m represents any integer of 0-3) or salts thereof which are useful as production intermediates of pharmac...  
WO/2016/196664A1
The invention provides methods and agents that modulate RelA activity. These methods and modulators of RelA acitivity can be used to treat cancer progression of basal-like breast cancer, such as triple-negative breast cancer.  
WO/2016/189486A1
The present invention provides an improved process for preparation of an intermediate of apremilast. The present invention also provides an improved process for preparation of apremilast. This invention also provides novel polymorphs of ...  
WO/2016/175128A1
The present invention relates to a process for producing an allyl-substituted bisphenol compound, the process including a step in which a diallyl-etherified bisphenol compound represented by general formula (I) is caused to undergo therm...  
WO/2016/173020A1
A conjugated compound containing a diphenyl sulfone phenyl structure, a method for preparing same, and use for fabricating a light emitting layer or an electronic transmission layer of an organic electroluminescent diode. The compound ha...  
WO/2016/174685A1
A process for the resolution of racemic 2-(3-ethoxy-4-methoxyphenyl)-1-(methylsulphonyl)-eth-2-ylami ne using novel chiral salts is disclosed. An L-phenylalanine p-toluene-sulfonamide salt of (S)-2-(3-ethoxy-4-methoxyphenyl)-1-(methylsul...  
WO/2016/161996A1
The present invention provides a method of chiral resolution of racemic amines of the benzyl type by means of salts formed with tartaric acid of formula (3) and intermediate of formula (2), and their use in the synthesis of Apremilast of...  
WO/2016/086710A1
Disclosed is a carboxylic acid preparation method. The method is characterized in that: a compound (II) reacts in the presence of hydrogen peroxide and a base to produce a target product (I) represented by the following equation: R1 is a...  
WO/2016/076160A1
[Problem] To provide a method for producing an industrially preferred optically active sulfoxide derivative. [Solution] A method for producing an optically active sulfoxide derivative represented by general formula (1), the method charac...  
WO/2016/039691A1
Compounds of formula (I): wherein R and A- are defined herein as a catalyst for making chiral heterocyclic sulfoxides and a method of producing enantioenriched sulfoxide in the presence of the said compounds.  
WO/2015/198850A1
Provided is a method for producing a compound represented by formula (2-b), which is useful as an intermediate for producing agricultural chemicals. The method includes a step for obtaining a compound represented by formula (2-a) by oxid...  
WO/2015/196086A1
The present invention is directed to novel inhibitors of system Xc _, also known as the cystine/glutamate antiporter. The present invention is further directed to methods of treating and detecting cancer that overexpresses system Xc _ wh...  
WO/2015/181249A1
The present invention relates to processes for preparing β-aminosulfone compounds. The provided compounds are useful intermediates in the preparation of sulfone group containing isoindoline-based compounds, in particular apremilast.  
WO/2015/157927A1
Disclosed is a new florfenicol synthesizing method. The method synthesizes florfenicol products meeting requirements of the Drug Administration by a series of combinations of cyclization, selective reduction, fluorinated open ring, depro...  
WO/2015/087352A1
The present patent discloses a novel, efficient and transition-metal-free room temperature single step process for synthesis of aryl sulfones and substituted aryl sulfones starting from aryl substrates.  
WO/2015/062103A1
Disclosed are a refining method for 2-nitro-4-methylsulfonyl benzoic acid and an intermediate thereof. The method comprises the following steps of: synthesizing an intermediate organic ammonium salt (III) in an organic solvent using a cr...  
WO/2015/051141A1
Methods for preparing fluorinated sulfides and fluorinated sulfones are described. To prepare a fluorinated sulfides, a sulfur-containing reactant represented by the formula: R1SM or M2S, wherein R1 is a C1 to C10 alkyl or fluoroalkyl, S...  
WO/2015/048328A1
The present invention is directed to 3, 4-bis-benzylsulfonylbutanenitrile, or a pharmaceutically acceptable salt, an enantiomer, or enantiomers thereof. The present invention is also directed to a pharmaceutical composition comprising a ...  
WO/2015/032328A1
The present invention relates to an indane derivative, a preparation method therefor, and a pharmaceutical application thereof. Specifically, the present invention relates to a compound shown in formula (I), or a stereoisomer thereof, an...  
WO/2015/010655A1
Triadic fused cyclic carboxylic acids derivatives, preparation method therefor and pharmaceutical use thereof, particularly relating to compounds represented by general formula (I), stereoisomers, hydrates, solvates, metabolites, eutecti...  
WO/2014/191475A1
The present invention relates to a process for oxidizing a sulfoxide to the respective sulfone, said process comprising reacting the sulfoxide with hydrogen peroxide in the presence of a catalyst, obtaining a mixture (M) comprising the s...  
WO/2014/178309A1
 The present invention provides a method for purifying dimethyl sulfoxide economically and at good yield so as to satisfy the specifications of the United States Pharmacopoeia and reduce odor. The method is characterized in that a solu...  
WO/2014/175187A1
Provided is a method for preparing, in an economical manner and with favorable yield, a dimethylsulfoxide having a reduction in malodor and satisfying the stipulations of the United States Pharmacopoeia. The present invention is characte...  

Matches 1 - 50 out of 3,766