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Patent Searching and Data


Matches 1 - 50 out of 10,878

Document Document Title
WO/2019/232245A1
Disclosed herein, inter alia, are methods useful for making a fluoroalkyl amine and methods useful for making an α-oxygenated cyclic amine.  
WO/2019/207484A3
A foamable composition includes a blowing agent, a foamable polymer or a precursor composition thereof, and a nucleating agent. The nucleating agent includes a compound having structural formula (I) R1SO2R2(SO2R3)n (I) where R1, R2, and ...  
WO/2019/226490A1
Provided is a compound of Formula (I), wherein the variable groups are defined herein.  
WO/2018/213813A8
The R enantiomer of amisulpride and amisulpride derivative disclosed herein or a pharmaceutical composition thereof may be used for antagonizing serotonin (e.g., 5-HT2a, 5-HT7) receptor in a subject, either individually or in combination...  
WO/2019/204375A1
Disclosed herein are small molecule inhibitors of 12(S)-Lipoxygenase (12-LOX), and methods of using the small molecules to inhibit 12-LOX activation and to treat diseases, such as platelet hemostasis and thrombosis. In particular, disclo...  
WO/2019/200185A1
Among other things, the present disclosure provides designed oligonucleotides, compositions, and methods of use thereof. In some embodiments, the present disclosure provides technologies useful for reducing levels of transcripts. In some...  
WO/2019/197468A1
The present invention relates to N-(cyclopropylmethyl)-5-(methylsulfonyl)-N-{1-[1-(pyrimidin- 2-yl)-1H-1,2,4-triazol-5-yl]ethyl}benzamide derivatives and the corresponding pyridine-carboxamide derivatives as well as related compounds of ...  
WO/2019/194690A1
Provided is an improved process of vitamin K2 derivatives preparation, represented by formula (I) wherein n is an integer from 3 to 13.  
WO/2019/192058A1
A biochip substrate, a preparation method therefor, and an application thereof. The surface of the biochip substrate contains an active vinyl sulfone group. The preparation method involves a one-step reaction of a compound containing vin...  
WO/2019/194982A1
This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Moll usca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions co...  
WO/2019/191227A1
The present disclosure provides methods of reducing inflammation of the digestive system in a subject in need thereof, including subjects suffering from inflammatory bowel disease. Compositions for use in these methods are also provided.  
WO/2019/187445A1
Provided are: an active-ray-sensitive or radiation-sensitive resin composition which can be prevented from the change in line width of a pattern due to post-exposure delay; a resist film using the active-ray-sensitive or radiation-sensit...  
WO/2019/180627A1
The present invention relates to an improved asymmetric synthesis of alpha- (diarylmethyl) alkyl amines (hereafter referred to as the compound (1)) or its pharmaceutically acceptable salt and derivatives. The process comprises an unusual...  
WO/2018/144870A8
Disclosed herein, inter alia, are compositions and methods useful for inhibiting reticulon 4(RTN4).  
WO/2019/161917A1
The invention relates to compounds of formula I able to inhibit α- synuclein aggregation, their use in the treatment or prophylaxis of a synucleinopathy and to pharmaceutical compositions comprising said compounds of formula I : wherein...  
WO/2019/088800A3
The present invention relates to a polyethylene glycol derivative and a preparation method thereof. A preparation process of a polyethylene glycol derivative, according to the present invention, may provide a novel polyethylene glycol de...  
WO/2019/136025A1
Described herein are compounds, including pharmaceutically acceptable salts and solvates thereof, methods of making such compounds, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat non-a...  
WO/2019/088800A9
The present invention relates to a polyethylene glycol derivative and a preparation method thereof. A preparation process of a polyethylene glycol derivative, according to the present invention, may provide a novel polyethylene glycol de...  
WO/2019/112426A1
This invention relates to compounds that are useful as inhibitors, in particular as inhibitors of Cathepsin K (CatK), and to a method of inhibiting cathepsin activity, comprising administering a compound or formulation comprising a compo...  
WO/2019/108824A1
The present disclosure provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.  
WO/2019/102054A1
Non-glycosidic analogues of alpha-galactosylceramide of formula (I), wherein A, Z, Ra, Rb and Rc have the meaning indicated in the description, as NKT cell activators.  
WO/2019/101132A1
Disclosed in the present invention are a fluorosulfonyl-containing compound, an intermediate thereof, a preparation method therefor and use thereof. The fluorosulfonyl-containing compound disclosed in the present invention comprises a ca...  
WO/2018/071741A8
The invention provides sulfoxyalkyl organonitro and related compounds, compositions containing such compounds, and methods for using such compounds and compositions to treat medical disorders, such as a neurodegenerative disorder, autoim...  
WO/2019/091179A1
Disclosed is a method for preparing florfenicol intermediate V, which belongs to the technical field of the preparation of veterinary medicines. The method comprises an addition reaction, a ring-closing reaction, a hydrolysis reaction an...  
WO/2019/088800A2
The present invention relates to a polyethylene glycol derivative and a preparation method thereof. A preparation process of a polyethylene glycol derivative, according to the present invention, may provide a novel polyethylene glycol de...  
WO/2019/089478A1
The present disclosure relates to substituted phenyl sulfonyl phenyl triazole thiones, pharmaceutical compositions containing them, and methods of using them.  
WO/2019/079541A1
Provided herein are compositions and methods for treating eye disorders. In particular, provided herein are neuroprotective compositions and methods for treating vision loss and related disorders.  
WO/2019/060998A1
The present disclosure relates to reagents and method for performing trifluoromethylation, difluoromethylation or alkylation of aromatic or heteroaromatic rings in a redox-neutral manner without any catalyst which are enabled by light. I...  
WO/2019/062561A1
Provided herein the synthesis methods of firocoxib and an intermediate thereof. The synthesis of the first intermediate is performed through methylation of p-bromopropiophenone or through Friedel-Crafts acylation of bromobenzene, avoidin...  
WO/2019/055951A1
Among other things, the present disclosure provides technologies for oligonucleotide preparation, particularly chirally controlled oligonucleotide preparation, which technologies provide greatly improved crude purity and yield, and signi...  
WO/2019/051222A1
The present disclosure provides a benzene fused heterocyclic derivative of Formula (I): --̅-̅-̅ is a single or double bond; n is an integer of 0 or 1; A is -CH2-, -CH(OH)-, or - C(O)-; G is C or N; X is -CH2-, O, or -C(O)-; Y is alkyl...  
WO/2019/048450A1
The present invention relates to sulfoxide-based reagents suitable in the mass spectrometric determination of analyte molecules such as peptides as well as adducts of such reagents and analyte molecules and applications of said reagents ...  
WO/2018/172503A3
A liquid laundry detergent comprising the adduct of a) a vinyl sulfone monomer of formula (I) wherein R is an organic radical with up to 500 carbon atoms and R may comprise heteroatoms selected from O, N or S and b) a saccharide having a...  
WO/2019/043289A1
The present invention relates to a process for the preparation of arylsulfonylpro- penenitriles. The reaction starting from arylsulfonyl iodides is catalyzed by light. The process is scalable, environmentally benign and provides the prod...  
WO/2019/039705A1
The present invention relates to a method for separating 5-hydroxymethyl-2-furfural (HMF) and dimethyl sulfoxide (DMSO), the method comprising the steps of: (a) preparing a mixture solution comprising HMF and DMSO; and (b) mixing an orga...  
WO/2019/035479A1
A cyclopropanation method includes reacting an alcohol, an ester, or an aldehyde with a sulfone in an organic solvent containing a base providing a counter cation to form a cyclopropane; and isolating the cyclopropane. When using the a...  
WO/2019/030184A1
The invention relates to new compounds of formula (I) wherein X represents a halogen atom selected from the group consisting of fluorine, chlorine, bromine and iodine, which are useful for the preparation of 4,4'dihalodiphenylsulfones of...  
WO/2019/026479A1
In one or more embodiments, the present invention pertains to a method for purifying dimethyl sulfoxide, the method including a step for adding an alkaline earth metal hydroxide to a material to be distilled that contains dimethyl sulfox...  
WO/2019/026868A1
A method for recovering dimethyl sulfoxide, which comprises a step wherein water and a recovered resist remover that contains dimethyl sulfoxide and at least one compound selected from the group consisting of glycol ethers, glycols and t...  
WO/2018/234232A1
The present invention relates to new biphenylsulfoximine compounds and, in particular, to their activity as positive allosteric modulators of the dopamine D1 receptor and to their use for the treatment of pathological states for which a ...  
WO/2018/234957A1
The invention provides mesotrione copper chelate form I and mesotrione copper chelate form II. A process for preparing mesotrione copper chelate form I and mesotrione copper chelate form II is also disclosed. Further, the present inventi...  
WO/2018/228079A1
The present invention discloses a fluorescent probe for detecting a sulfenated protein, having the following structural general formula (I). The fluorescent probe has good stability and can be preserved for long-term use. The fluorescent...  
WO/2018/229083A1
The present invention relates to compounds, in particular those of formula (I) and formula (II) described herein, or pharmaceutically acceptable salts or solvates thereof, which may be used as radioligands in in vitro, ex vivo and in viv...  
WO/2018/228857A1
The invention relates to novel laser markable compositions comprising developing agent precursors according to formula (I).  
WO/2018/227053A1
The disclosure is directed to compounds and methods for preparing purified macrocyclic peptide using "catch-release" methods. These methods comprise reacting a free amino group of a resin-bound linear peptide with an azide- or alkyne-fun...  
WO/2018/218281A1
A process for inhibiting the formation of gas hydrates in a hydrocarbon fluid comprising adding to the hydrocarbon fluid, a gas hydrate anti-agglomerate which is a biodegradable anti-agglomerant derived from a naturally occurring substance.  
WO/2018/219204A1
The present invention relates to a novel phenoxyacetic acid derivative represented by general formula (I), a preparation method for the derivative and uses of drug compositions containing the derivative in drug preparation for treatment ...  
WO/2018/215070A1
The present invention pertains to novel dual modulators of farnesoid X receptor (FXR) and soluble epoxide hydrolase (sEH). The modulators of the invention were designed to provide compounds which harbor a dual activity as agonists of FXR...  
WO/2018/215610A1
The present invention pertains to novel dual modulators of farnesoid X receptor (FXR) and soluble epoxide hydrolase (sEH). The modulators of the invention were designed to provide compounds which harbor a dual activity as agonists of FXR...  
WO/2018/211896A1
The purpose of the present invention is to provide a vinyl sulfone compound and the like which exhibits excellent storage stability when stored long-term in a non-aqueous solvent and, when used in a lithium ion battery, exhibits less dec...  

Matches 1 - 50 out of 10,878