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Matches 451 - 500 out of 10,959

Document Document Title
WO/2010/116342A2
The present invention concerns compounds of general Formula (I) : method of preparation and uses thereof.  
WO/2010/107807A2
The present invention is directed to a compound of 2-N halo-4-methylsulfonyl-butyric acid, such as 2-N chloro-4-methylsulfonyl-butyric acid, or a pharmaceutically acceptable salt or solvate thereof. The present invention is also directed...  
WO/2010/059004A3
The present invention relates to a chemical inhibitor of p53-Snail binding and to a pharmaceutical composition for treating cancer diseases containing the same as its active ingredient. The chemical inhibitor of p53-Snail binding induces...  
WO/2010/074332A3
There is provided a sulfur-containing compound having a controlling effect on arthropod pests represented by the formula (I): wherein m represents 1, 2 or 3; n represents 0, 1 or 2; A represents an optionally substituted C2-C10 fluoroalk...  
WO/2010/094659A1
The invention relates to the use of compounds of formula (I), wherein the substituents are described in the description and claims, for the preparation of medicaments for the treatment of psychoses, dysfunction in memory and learning, sc...  
WO/2010/092180A1
The present invention relates to aminotetraline derivatives of the formula (I) or a physiologically tolerated salt thereof. The invention relates to pharmaceutical compositions comprising such aminotetraline derivatives, and the use of s...  
WO/2010/090305A1
Disclosed is an excellent agent for treatment or prevention of dementia, schizophrenia and the like, which has a serotonin 5-HT5A receptor modulating activity. An acylguanidine derivative represented by formula (I), wherein guanidine is ...  
WO/2010/090954A1
The present invention is directed to a novel trifluoromethylsulfonamide derivative which inhibits the processing of APP by the putative γ-secretase and thus is useful in the treatment or prevention of Alzheimer's disease. This compound ...  
WO/2006/013193A8
Described herein are derivatives of arylsulfonamido-substituted hydroxamic acid of formula (I) having good solubility in water and inhibitory activity of matrix metalloproteinases, useful for the preparation of pharmaceutical composition...  
WO/2010/056877A3
The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these proteases. The present invention is dir...  
WO/2010/084975A1
Disclosed is a method for producing a conjugated aromatic compound, which is characterized in that an aromatic compound (A) represented by formula (1) is reacted with another aromatic compound (A) which has the same structure as the arom...  
WO/2010/049946A3
The present invention relates to novel compounds of general formula (I) which are thyroid receptor ligands and are preferably selective for the thyroid hormone receptor beta (TR-Beta). Further, the present invention relates to processes ...  
WO/2010/084976A1
Disclosed is a method for manufacturing a conjugated aromatic compound, which is characterized in that an aromatic compound (A), wherein one or two leaving groups selected from a group comprised of an iodine atom, bromine atom and chlori...  
WO/2010/059004A9
The present invention relates to a chemical inhibitor of p53-Snail binding and to a pharmaceutical composition for treating cancer diseases containing the same as its active ingredient. The chemical inhibitor of p53-Snail binding induces...  
WO/2010/056527A3
The present invention relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the co...  
WO/2010/074332A2
There is provided a sulfur-containing compound having a controlling effect on arthropod pests represented by the formula (I): wherein m represents 1, 2 or 3; n represents 0, 1 or 2; A represents an optionally substituted C2-C10 fluoroalk...  
WO/2010/069150A1
The para-hydrobenzene acrylic acid derivatives of formula (I) and pharmaceutically acceptable salts, preparation methods, their pharmaceutical compositions and uses for preparing drugs for treating and preventing inflammations or disease...  
WO/2010/069778A1
Methods for producing a compound of formula (k1) or (k2) by reducing a dihydronapthalene amide compound of formula (i); with hydrogen gas in the presence of a ruthenium catalyst of formula (j1) or (j2); Ru(Z)2(L) = (j1), Ru(E)(E')(L)(D) ...  
WO/2010/028088A3
Provided are sulphur-linked compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions.  
WO/2010/068371A2
Embodiments of this disclosure, among others, encompass methods for generating alkenes under mild thermolytic conditions that can provide almost total conversion of a precursor compound to an alkene without isomerization or the need to c...  
WO/2010/063767A1
The invention relates to compounds of the general formula (I) wherein the variable have the meanings as indicated in the claims, and optionally the enantiomers thereof. The active ingredients have advantageous pesticidal properties. They...  
WO/2010/059004A2
The present invention relates to a chemical inhibitor of p53-Snail binding and to a pharmaceutical composition for treating cancer diseases containing the same as its active ingredient. The chemical inhibitor of p53-Snail binding induces...  
WO/2010/056877A2
The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these proteases. The present invention is dir...  
WO/2010/055911A1
A compound represented by formula (I) or a salt thereof, which is useful as an agent for treatment or prevention of various epileptic seizures, namely partial seizures and/or generalized seizures. (In the formula, R1, R2 and R3 may be th...  
WO/2010/056527A2
The present invention relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the co...  
WO/2010/055005A1
The invention is concerned with the compounds of formula (I) and pharmaceutically acceptable salts and esters thereof, wherein X, Q, and R1-R6 are defined in the detailed description and claims. In addition, the present invention relates...  
WO/2010/055004A1
The invention is concerned with the compounds of formula I, and pharmaceutically acceptable salts and esters thereof, wherein W, X, Y, and R1- R7 are defined in the detailed description and claims. In addition, the present invention rela...  
WO/2010/054565A1
The present invention provides the water-soluble prodrug of (R)-(-)-bicalutamide as follows of formula (I), its pharmaceutically acceptable salts, its preparation method and uses thereof. The compound of formula (I) is useful for treatme...  
WO/2010/055744A1
An aprotic polar solvent having a relatively low melting point and excellent thermal stability, which is chiefly useful as solvents for electrochemical devices and the like. Specifically disclosed is a sulfone compound represented by for...  
WO/2010/014566A3
Processes for preparing oxazoline compounds are disclosed. These oxazoline compounds are useful intermediates in the preparation of Florfenicol and related compounds.  
WO/2010/030345A3
Processes for synthesizing aminosulfone compounds are provided. Aminosulfone compounds obtained using methods provided herein are useful in production or synthesis of isoindoline based PDE 4 modulators.  
WO/2009/132832A3
The invention relates to a method for producing 1,4-benzothiepin-1,1-dioxide derivatives substituted with benzyl groups.  
WO/2010/049946A2
The present invention relates to novel compounds of general formula (I) which are thyroid receptor ligands and are preferably selective for the thyroid hormone receptor beta (TR-Beta). Further, the present invention relates to processes ...  
WO/2010/047257A1
An aprotic polar solvent having a relatively low melting point and excellent thermal stability, which is chiefly useful as solvents for electrochemical devices and the like. Specifically disclosed is a sulfone compound represented by for...  
WO/2010/003127A3
Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the compounds described herein that are antagonists Of PGD2 receptors. Also described here...  
WO/2010/041748A1
Disclosed is a prophylactic or therapeutic agent for diabetes, diabetic complications, insulin resistance syndrome, metabolic syndrome, hyperglycemia, dyslipidemia, atherosclerosis, heart failure, cardiomyopathy, myocardial ischemia, cer...  
WO/2010/038550A1
A method for producing a specific amine wherein an extraction/separation step, in which the specific amine is extracted and separated as an organic layer in the co-presence of at least one kind of organic solvent (A) having a dielectric ...  
WO/2010/034999A1
A compound of formula (I) in solid form, preferably crystalline form.  
WO/2010/035000A1
Using a combination of Kumada, Suzuki and Biellmann chemistry, various menaquinones can synthesised rapidly and with stereochemical integrity offering a new way of preparing these vitamin K2 components for the pharmaceutical market. In o...  
WO/2010/029950A1
Disclosed are: a process for producing an optically active epoxy compound and an optically active sulfoxide compound; a ligand and a complex for use in the process; and a process for producing the complex. Specifically disclosed are: an ...  
WO/2010/030345A2
Processes for synthesizing aminosulfone compounds are provided. Aminosulfone compounds obtained using methods provided herein are useful in production or synthesis of isoindoline based PDE 4 modulators.  
WO/2009/147632A3
The invention provides a method of preparing the stereoisomers of 1,11-diamino-6-aza- undecane-2,4,8,10-tetraol.  
WO/2010/028088A2
Provided are sulphur-linked compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions.  
WO/2010/027051A1
Disclosed is a novel intermediate for producing a substituted isoxazoline compound that is useful as a harmful organism control agent. Specifically disclosed are: a substituted acetophenone compound represented by general formula (1) or ...  
WO/2009/144344A3
Compound for labelling biomolecules based on vinylsulphone, preparation and uses, comprising a labelling molecule and a vinylsulphone group. In addition it relates to the use of the compounds as labelling agents, to the procedure of obta...  
WO/2010/018858A1
Disclosed is an organic sulfur compound represented by general formula (a1) [wherein A represents –S-, -S(O)- or –S(O)2-; Z1 and Z4 independently represent a trivalent aromatic hydrocarbon group, or the like; Z2 and Z3 independently ...  
WO/2010/014566A2
Processes for preparing oxazoline compounds are disclosed. These oxazoline compounds are useful intermediates in the preparation of Florfenicol and related compounds.  
WO/2010/013352A1
Diphenylsulfone crosslinked compounds of the general formula: (1) wherein n is an integer of 1 to 10. Further, there is disclosed a thermal recording material comprising a support and, superimposed thereon, a thermosensitive color formin...  
WO/2010/013567A1
Disclosed is a pest control agent having an excellent effect, which contains, as an active ingredient, a compound represented by general formula (1). (In the formula, A represents a carbon atom, a nitrogen atom or the like; K represents...  
WO/2010/009508A1
A compound of Formula (A) wherein Z is an aryl, substituted aryl, heteroaryl, or substituted heteroaryl, wherein the heteroaryl or substituted heteroaryl connected to a 2,4-dinito-6-(trifluoromethyl)phenyl ring via a carbon-carbon bond.  

Matches 451 - 500 out of 10,959