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Matches 551 - 600 out of 10,785

Document Document Title
WO/2008/041140A3
This invention is directed to substituted aryl compounds, which are linked to a substituted indole moiety by various linkers, and the kynurenine/kynuramine-like metabolites of these agents, their preparation and pharmaceutical compositio...  
WO/2008/041140A2
This invention is directed to substituted aryl compounds, which are linked to a substituted indole moiety by various linkers, and the kynurenine/kynuramine-like metabolites of these agents, their preparation and pharmaceutical compositio...  
WO/2008/041140A8
This invention is directed to substituted aryl compounds, which are linked to a substituted indole moiety by various linkers, and the kynurenine/kynuramine-like metabolites of these agents, their preparation and pharmaceutical compositio...  
WO/2008/037072A1
Compounds of formula ( I ) : are found to be selective inhibitors of cathepsin B, and hence useful in treating a variety of pathological conditions.  
WO/2008/039645A1
Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are ...  
WO/2008/039999A1
Disclosed are sulfone compounds and compositions that inhibit soluble epoxide hydrolase (sEH), methods for preparing the compounds and compositions, and methods for treating patients with such compounds and compositions. The compounds, c...  
WO/2008/032453A1
Disclosed is a commercially advantageous method for producing a hydrazone represented by the formula (4) below. Specifically disclosed is a method for producing a hydrazone according to the following reaction formula.  
WO/2008/027604A2
RF-compositions including surfactants, foam stabilizers, monomers, polymers, urethanes, intermediates, metal complexes, phosphate esters as well as telomerization methods are provided.  
WO/2008/027604A3
RF-compositions including surfactants, foam stabilizers, monomers, polymers, urethanes, intermediates, metal complexes, phosphate esters as well as telomerization methods are provided.  
WO/2008/024746A1
Compounds of Formula (I): in which R1, R2, R7, R8, R9, R10 and A have the meanings given in the specification, are DP2 receptor modulators useful in the treatment of immunologic diseases.  
WO/2008/015139A2
There are described compounds having the general formula (I) below and their pharmaceutically acceptable salts thereof, wherein E, X, m, q, R1, R2, n and ZBG have the meanings reported in the description useful, in therapy, as inhibitors...  
WO/2008/015139A3
There are described compounds having the general formula (I) below and their pharmaceutically acceptable salts thereof, wherein E, X, m, q, R1, R2, n and ZBG have the meanings reported in the description useful, in therapy, as inhibitors...  
WO/2008/013791A2
Disclosed herein are compounds of formula (I) and formula (II), where R1-R4 are as defined in the claims, which are antagonists of the androgen receptor and androgen receptor mutations associated with clinical failure of.currently prescr...  
WO/2008/013791A3
Disclosed herein are compounds of formula (I) and formula (II), where R1-R4 are as defined in the claims, which are antagonists of the androgen receptor and androgen receptor mutations associated with clinical failure of.currently prescr...  
WO/2008/009815A2
The invention relates to aromatic sulfonates, the preparation thereof, and the use of the same as the salt of an electrolyte. The sulfonates have the formula [Ar-Z- (CF2)nCFRf-SO3 -] p Mp+ (I), wherein Z is a sulfide, sulfinyl or sulfony...  
WO/2008/009816A3
The invention relates to aromatic sulfinates and sulfonyl halides, and to the preparation thereof. The halides and the sulfinates are respectively of formulae Ar-Z- (CF2) n-CFRf-SO2Y (I) and [Ar-Z- (CF2) n-CFRf-SO2] m M wherein Z is a su...  
WO/2008/009816A2
The invention relates to aromatic sulfinates and sulfonyl halides, and to the preparation thereof. The halides and the sulfinates are respectively of formulae Ar-Z- (CF2) n-CFRf-SO2Y (I) and [Ar-Z- (CF2) n-CFRf-SO2] m M wherein Z is a su...  
WO/2008/009815A9
The invention relates to aromatic sulfonates, the preparation thereof, and the use of the same as the salt of an electrolyte. The sulfonates have the formula [Ar-Z- (CF2)nCFRf-SO3 -] p Mp+ (I), wherein Z is a sulfide, sulfinyl or sulfony...  
WO/2008/009814A1
The invention relates to a process for preparing aromatic sulphonylimides, to the sulphonylimides obtained, and to the use thereof as salt of an electrolyte. The sulphonylimides correspond to the formula [R-SO2-N-SO2R']rM (I). R' is an A...  
WO/2008/009815A3
The invention relates to aromatic sulfonates, the preparation thereof, and the use of the same as the salt of an electrolyte. The sulfonates have the formula [Ar-Z- (CF2)nCFRf-SO3 -] p Mp+ (I), wherein Z is a sulfide, sulfinyl or sulfony...  
WO/2008/007780A1
Disclosed is a pentadienamide derivative represented by the formula (I) or a pharmaceutically acceptable salt thereof or the like. (I) wherein R1 represents a substituted or unsubstituted aryl or a substituted or unsubstituted aromatic h...  
WO/2007/147771A2
Compounds of the formula (I), (II) or (III); or pharmaceutically acceptable salts thereof, wherein m, n, q, Ar, R1, R2, R3, R4 and R5 are as defined herein. Also provided are methods for preparing, compositions comprising, and methods fo...  
WO/2007/147771A3
Compounds of the formula (I), (II) or (III); or pharmaceutically acceptable salts thereof, wherein m, n, q, Ar, R1, R2, R3, R4 and R5 are as defined herein. Also provided are methods for preparing, compositions comprising, and methods fo...  
WO/2007/147763A1
The application relates to compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein: m is, from 0 to 3; q is from 0 to 3; Ar is optionally substituted aryl or optionally substituted heteroaryl; R1 and R7 each ind...  
WO/2007/142417A1
The novel C dialdehyde compound which can be efficiently utilized in the synthesis of carotenoid compounds based on the sulfone chemistry, the preparation method of the same, and the expeditious and practical synthetic processes for lyco...  
WO/2007/131680A1
Novel benzamidines of the formula (I) and a use thereof as insecticides  
WO/2007/128137A1
A monomer of formula (I) may be used to prepare a poly(arylene ether) of formula (II) wherein k is 1 or 2, n is a non-zero number from 0 to 1, j is 0, 1 or 2, Q is O or S, L is a leaving group, Z is F or CI, Z' is F, CI or an organic gro...  
WO/2007/127639A3
This invention relates to novel homotopic prodrugs and medicaments and methods for their preparation, testing and use. In one embodiment, the homotopic prodrug has the general formula (I) wherein (II) is a biologically-active moiety comp...  
WO/2007/127639A2
This invention relates to novel homotopic prodrugs and medicaments and methods for their preparation, testing and use. In one embodiment, the homotopic prodrug has the general formula (I) wherein (II) is a biologically-active moiety comp...  
WO/2007/125952A1
Disclosed is a compound represented by the formula (I) below, a pharmaceutically acceptable salt thereof, or a solvate of any of them. (I) In the formula, R1 represents an optionally substituted lower alkyl group; Y represents -S(O)n- (w...  
WO/2007/117027A1
A process for the production of organic oxides, characterized by oxidizing a substrate with a hypohalous acid, a hypohalite, chlorine, bromine, or iodine in the presence of both a catalytic amount of a compound represented by the general...  
WO/2007/118041A1
Compounds are provided which bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, the compounds having the general formula (I) wherein R1, R2, R3, X and Ar have the meanings given in the specification, and the p...  
WO/2007/112844A1
The present invention relates to defined crystalline polymorphs of 3-chloro-N2-[(1S)-1-methyl-2-(methylsulfonyl)ethyl]-N1-{2-me thyl-4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]phenyl} phthalamide of the formula (A), to processes for...  
WO/2007/109175A1
The invention relates to N-hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive t...  
WO/2007/103221A2
The invention encompasses processes for preparing intermediates, such as (R)-modafinic acid and its C1-2 alkyl ester, and the conversion of the intermediates into armodafinil. In particular, the invention concerns: (i) a process for the ...  
WO/2007/103996A1
The present invention relates generally to novel 2-(aryloxy)acetamides of Formula (I) or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein the variables W, Y, Z, R7, R8, and R9 are as def...  
WO/2007/103719A3
The present invention relates to inhibitors of 11-β hydroxyl steroid dehydrogenase type 1 and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with express...  
WO/2007/103719A2
The present invention relates to inhibitors of 11-β hydroxyl steroid dehydrogenase type 1 and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with express...  
WO/2007/103221A3
The invention encompasses processes for preparing intermediates, such as (R)-modafinic acid and its C1-2 alkyl ester, and the conversion of the intermediates into armodafinil. In particular, the invention concerns: (i) a process for the ...  
WO/2007/100074A1
Disclosed are a novel 1-fluoro-1,1-bis(arylsulfonyl)methane useful for monofluoromethylation, and a production method thereof. Specifically disclosed is a method for producing a fluorobis(arylsulfonyl)methane represented by the formula (...  
WO/2007/099450A2
The present invention relates to a process for the preparation of 2-nitro substituted benzoic acids of formula (I), wherein the (O)PSO2R1substituent(s) is in the 3-, 4- and/or 5-position, R1 represents a straight- or branched-chain alkyl...  
WO/2007/099450A3
The present invention relates to a process for the preparation of 2-nitro substituted benzoic acids of formula (I), wherein the (O)PSO2R1substituent(s) is in the 3-, 4- and/or 5-position, R1 represents a straight- or branched-chain alkyl...  
WO/2007/098273A2
The invention encompasses crystalline forms of armodafinil , processes for preparing the crystalline forms, and pharmaceutical formulation.  
WO/2007/098273A3
The invention encompasses crystalline forms of armodafinil , processes for preparing the crystalline forms, and pharmaceutical formulation.  
WO/2007/093772A1
The present invention relates to a method of making monomers of the formula X=C (H) -Y-S02-CH2-CH (R) -OH which comprises reacting a compound of the formula Q-Y-S02-CH2-CH (R) -OH with a vinyl-containing organometallic reagent comprising...  
WO/2007/093211A1
The invention relates to a process for the treatment of an aqueous mixture comprising a dipolar aprotic compound, comprising: a) an adsorption step, in which the aqueous mixture is brought into contact with a porous adsorbent, whereby th...  
WO/2007/083242A1
The invention relates to a process for selectively controlling the crystallisation mesotrione [2-(4-methylsulphonyl-2-nitrobenzoyl)cyclohexane-1 ,3-dione] from aqueous solution in which the aqueous mesotrione solution is introduced to a ...  
WO/2007/081261A1
The present invention relates to a hydroxy- sulphureous acid, to a method for preparation of the hydroxysulphureous acid and to products based on said hydroxysulphureous acid, to methods for preparation of said products and to use of sai...  
WO2007010387B1
Methods and materials for preparing optically active 3,4-disubstituted cyclopentanones are disclosed. The method includes hydrolyzing one or more compounds represented by Formula (13), or removing an ester moiety from a compound represen...  
WO/2007/079010A2
The invention relates to carbonate derivatives of fenicol compounds of formulae I and II, wherein the variables are as defined in the claims, having useful properties as antibiotic prodrugs, together with methods of making and using thes...  

Matches 551 - 600 out of 10,785