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Patent Searching and Data


Matches 601 - 650 out of 10,865

Document Document Title
WO/2008/013791A2
Disclosed herein are compounds of formula (I) and formula (II), where R1-R4 are as defined in the claims, which are antagonists of the androgen receptor and androgen receptor mutations associated with clinical failure of.currently prescr...  
WO/2008/009815A2
The invention relates to aromatic sulfonates, the preparation thereof, and the use of the same as the salt of an electrolyte. The sulfonates have the formula [Ar-Z- (CF2)nCFRf-SO3 -] p Mp+ (I), wherein Z is a sulfide, sulfinyl or sulfony...  
WO/2007/103719A3
The present invention relates to inhibitors of 11-β hydroxyl steroid dehydrogenase type 1 and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with express...  
WO/2008/009816A2
The invention relates to aromatic sulfinates and sulfonyl halides, and to the preparation thereof. The halides and the sulfinates are respectively of formulae Ar-Z- (CF2) n-CFRf-SO2Y (I) and [Ar-Z- (CF2) n-CFRf-SO2] m M wherein Z is a su...  
WO/2008/009814A1
The invention relates to a process for preparing aromatic sulphonylimides, to the sulphonylimides obtained, and to the use thereof as salt of an electrolyte. The sulphonylimides correspond to the formula [R-SO2-N-SO2R']rM (I). R' is an A...  
WO/2008/007780A1
Disclosed is a pentadienamide derivative represented by the formula (I) or a pharmaceutically acceptable salt thereof or the like. (I) wherein R1 represents a substituted or unsubstituted aryl or a substituted or unsubstituted aromatic h...  
WO/2007/147771A2
Compounds of the formula (I), (II) or (III); or pharmaceutically acceptable salts thereof, wherein m, n, q, Ar, R1, R2, R3, R4 and R5 are as defined herein. Also provided are methods for preparing, compositions comprising, and methods fo...  
WO/2007/147763A1
The application relates to compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein: m is, from 0 to 3; q is from 0 to 3; Ar is optionally substituted aryl or optionally substituted heteroaryl; R1 and R7 each ind...  
WO/2007/142417A1
The novel C dialdehyde compound which can be efficiently utilized in the synthesis of carotenoid compounds based on the sulfone chemistry, the preparation method of the same, and the expeditious and practical synthetic processes for lyco...  
WO/2007/068894A3
The invention relates to substituted diphenylethers, -amines, -sulfides, and -methanes as useful pharmaceutical compounds for treating respiratory- disorders, pharmaceutical compositions containing them, and processes for their preparation.  
WO/2007/099450A3
The present invention relates to a process for the preparation of 2-nitro substituted benzoic acids of formula (I), wherein the (O)PSO2R1substituent(s) is in the 3-, 4- and/or 5-position, R1 represents a straight- or branched-chain alkyl...  
WO/2007/131680A1
Novel benzamidines of the formula (I) and a use thereof as insecticides  
WO/2006/074149A3
α,β-Unsaturated sulfones, sulfoxides and sulfonamides according to Formula I: wherein Ar1, Ar2, X, n, * and R are as defined herein are useful for the treatment of proliferative disorders which are resistant to treatment by ATP-competi...  
WO/2007/128137A1
A monomer of formula (I) may be used to prepare a poly(arylene ether) of formula (II) wherein k is 1 or 2, n is a non-zero number from 0 to 1, j is 0, 1 or 2, Q is O or S, L is a leaving group, Z is F or CI, Z' is F, CI or an organic gro...  
WO/2007/127639A2
This invention relates to novel homotopic prodrugs and medicaments and methods for their preparation, testing and use. In one embodiment, the homotopic prodrug has the general formula (I) wherein (II) is a biologically-active moiety comp...  
WO/2007/125952A1
Disclosed is a compound represented by the formula (I) below, a pharmaceutically acceptable salt thereof, or a solvate of any of them. (I) In the formula, R1 represents an optionally substituted lower alkyl group; Y represents -S(O)n- (w...  
WO/2007/117027A1
A process for the production of organic oxides, characterized by oxidizing a substrate with a hypohalous acid, a hypohalite, chlorine, bromine, or iodine in the presence of both a catalytic amount of a compound represented by the general...  
WO/2007/118041A1
Compounds are provided which bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, the compounds having the general formula (I) wherein R1, R2, R3, X and Ar have the meanings given in the specification, and the p...  
WO/2007/112844A1
The present invention relates to defined crystalline polymorphs of 3-chloro-N2-[(1S)-1-methyl-2-(methylsulfonyl)ethyl]-N1-{2-me thyl-4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]phenyl} phthalamide of the formula (A), to processes for...  
WO/2007/109175A1
The invention relates to N-hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive t...  
WO/2007/103221A2
The invention encompasses processes for preparing intermediates, such as (R)-modafinic acid and its C1-2 alkyl ester, and the conversion of the intermediates into armodafinil. In particular, the invention concerns: (i) a process for the ...  
WO/2007/103996A1
The present invention relates generally to novel 2-(aryloxy)acetamides of Formula (I) or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein the variables W, Y, Z, R7, R8, and R9 are as def...  
WO/2007/103719A2
The present invention relates to inhibitors of 11-β hydroxyl steroid dehydrogenase type 1 and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with express...  
WO/2006/041888A3
Selected compounds are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical...  
WO/2007/100074A1
Disclosed are a novel 1-fluoro-1,1-bis(arylsulfonyl)methane useful for monofluoromethylation, and a production method thereof. Specifically disclosed is a method for producing a fluorobis(arylsulfonyl)methane represented by the formula (...  
WO/2007/099450A2
The present invention relates to a process for the preparation of 2-nitro substituted benzoic acids of formula (I), wherein the (O)PSO2R1substituent(s) is in the 3-, 4- and/or 5-position, R1 represents a straight- or branched-chain alkyl...  
WO/2007/098273A2
The invention encompasses crystalline forms of armodafinil , processes for preparing the crystalline forms, and pharmaceutical formulation.  
WO/2007/070238A3
The present invention generally relates to an improved process for preparing modafinil and analogs thereof. The process minimizes impurities and improves the overall yield by oxidizing a modafinil intermediate compound in a reaction mixt...  
WO/2007/093772A1
The present invention relates to a method of making monomers of the formula X=C (H) -Y-S02-CH2-CH (R) -OH which comprises reacting a compound of the formula Q-Y-S02-CH2-CH (R) -OH with a vinyl-containing organometallic reagent comprising...  
WO/2007/079010A3
The invention relates to carbonate derivatives of fenicol compounds of formulae I and II, wherein the variables are as defined in the claims, having useful properties as antibiotic prodrugs, together with methods of making and using thes...  
WO/2007/093211A1
The invention relates to a process for the treatment of an aqueous mixture comprising a dipolar aprotic compound, comprising: a) an adsorption step, in which the aqueous mixture is brought into contact with a porous adsorbent, whereby th...  
WO/2007/046513A3
The present invention relates to a benzoylurea compound represented by formula (I), wherein X and Y represent a fluorine atom or a chlorine atom, R1 represents a lower alkyl group or the like, R2 represents a lower alkyl group, R3 repres...  
WO/2007/083242A1
The invention relates to a process for selectively controlling the crystallisation mesotrione [2-(4-methylsulphonyl-2-nitrobenzoyl)cyclohexane-1 ,3-dione] from aqueous solution in which the aqueous mesotrione solution is introduced to a ...  
WO/2007/081261A1
The present invention relates to a hydroxy- sulphureous acid, to a method for preparation of the hydroxysulphureous acid and to products based on said hydroxysulphureous acid, to methods for preparation of said products and to use of sai...  
WO/2006/138660A3
The invention relates to substituted adamantane compounds of formula (I), pharmaceutical compositions thereof, processes for their preparation, and methods for inhibiting sphingosine kinase and for treating or preventing hyperproliferati...  
WO2007010387B1
Methods and materials for preparing optically active 3,4-disubstituted cyclopentanones are disclosed. The method includes hydrolyzing one or more compounds represented by Formula (13), or removing an ester moiety from a compound represen...  
WO/2007/079010A2
The invention relates to carbonate derivatives of fenicol compounds of formulae I and II, wherein the variables are as defined in the claims, having useful properties as antibiotic prodrugs, together with methods of making and using thes...  
WO/2007/042418A3
The instant invention discloses a process for preventing contact discoloration of substrates coming into contact with elastomers and stabilizing elastomers to prevent oxidative, thermal, dynamic, light-induced and/or ozone-induced degrad...  
WO/2007/074473A1
A process for preparation of Bicalutamide of formula (I), comprising oxidation of compound of formula (II), with potassium permanganate in presence of water or a mixture of water and water miscible solvent and isolating Bicalutamide of f...  
WO/2007/071609A1
Compounds of formula I wherein X is O or S(=O)n; n is 0,1 or 2; R1 is optionally substituted alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, cycloalkyl, halocycloalkyl, cycloalkenyl, halocycloalkenyl, phenyl, hetaryl, pheny...  
WO/2007/071582A1
Disclosed are merocyanine derivatives of formula (1), wherein R1 and R2 independently from each other are branched C4-C22alkyl; or branched C4-C12 alkenyl; R3 and R4 independently from each other are cyano; COR7, COOR7; CONR7R8; SO2(C6- ...  
WO/2007/030567A3
Compounds are described that are active on at least one of PPARα, PPARδ, and PPARγ, which are useful for therapeutic and/or prophylactic methods involving modulation of at least one of PPARα, PPARδ, and PPARγ.  
WO/2007/069020A2
Described herein are N-hydroxyamlde antibacterial compounds, methods for making the compounds, pharmaceutical compositions containing the compounds and methods of treating bacterial infections utilizing the compounds and pharmaceutical c...  
WO/2007/068894A2
The invention relates to substituted diphenylethers, -amines, -sulfides, and -methanes as useful pharmaceutical compounds for treating respiratory- disorders, pharmaceutical compositions containing them, and processes for their preparation.  
WO/2007/070238A2
The present invention generally relates to an improved process for preparing modafinil and analogs thereof. The process minimizes impurities and improves the overall yield by oxidizing a modafinil intermediate compound in a reaction mixt...  
WO/2007/063789A1
Disclosed are a compound having a strong COMT inhibitory effect and represented by the general formula (I) below, a pharmacologically acceptable salt thereof, a pharmaceutical composition containing either of them, and uses of them. (I) ...  
WO/2007/060839A1
A compound given by the formula (I): has an excellent controlling activity against noxious arthropods.  
WO/2007/054668A1
The present invention relates to a process for the synthesis of l-substituted-2-fluoro-4- methylsulfonylphenyl compounds.  
WO/2007/054147A1
The present invention relates to the synthesis of antibacterial compounds such as Chloramphenicol and its analogues Thiamphenicol and Florfenicol and particularly to a new reaction for the preparation of the intermediate compound aminodi...  
WO/2007/033266A3
Pharmaceutical compositions comprising 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4- dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile and pharmaceutically acceptable salts thereof are provided as well as kits and articles of m...  

Matches 601 - 650 out of 10,865