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Matches 651 - 700 out of 10,857

Document Document Title
WO2006040527A8
A process for making a compound of formula (I), said process comprising a) reaction of a compound of formula (II) with: i) a compound of formula (III) by nucleophilic aromatic substitution of X2 and ii) a compound of formula (IV) for exa...  
WO/2007/020381A3
A process for the preparation of a compound of formula (I) wherein: R is an alkynyl group; R1 is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkyl-alkyl, phenyl and phenylalkyl, it being possible in turn for all of the receding groups to c...  
WO/2007/046513A2
The present invention relates to a benzoylurea compound represented by formula (I), wherein X and Y represent a fluorine atom or a chlorine atom, R1 represents a lower alkyl group or the like, R2 represents a lower alkyl group, R3 repres...  
WO/2005/112921A3
The presently disclosed subject matter provides derivatives of non­steroidal anti-inflammatory drugs (NSAIDs) that are characterized by substantially reduced cyclooxygenase inhibiting activity, yet retain the ability to interact with an...  
WO/2007/010387A3
Methods and materials for preparing optically active 3,4-disubstituted cyclopentanones are disclosed. The method includes hydrolyzing one or more compounds represented by Formula (13), or removing an ester moiety from a compound represen...  
WO/2007/045572A1
The present invention provides for compounds useful for treating an HIV infection, or preventing an HIV infection, or treating AIDS or ARC. The compounds of the invention are of formula I wherein R1, R2, R3, R4, R5 and X are as herein de...  
WO/2007/041837A1
This invention relates to a novel class of compounds, represented by the formula (I) below, wherein the meanings of Rl, R2, R3, R4, R5, R6, R7, X and Y are indicated therein, which are cysteine protease inhibitors, including but not limi...  
WO/2007/042418A2
The instant invention discloses a process for preventing contact discoloration of substrates coming into contact with elastomers and stabilizing elastomers to prevent oxidative, thermal, dynamic, light-induced and/or ozone-induced degrad...  
WO/2007/043568A1
A drug, specifically, a novel arylamidrazone derivative having an antagonistic effect on an S1P3 receptor; and a medicine containing the drug as an active ingredient. The drug is an arylamidrazone derivative represented by the following ...  
WO/2007/039741A1
The invention relates to substituted phenoxyacetic acids as useful pharmaceutical compounds for treating respiratory disorders, pharmaceutical compositions containing them, and processes for their preparation.  
WO/2007/039127A1
The invention relates to a process for the preparation of bicalutamide (I) which comprises oxidizing N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)thi o]-2-hydroxy-2-methyl-propanamide (II) in a solution of peracetic acid in a...  
WO/2007/039736A1
The invention relates to substituted phenylacetic acids as useful pharmaceutical compounds for treating respiratory disorders, pharmaceutical compositions containing them, and processes for their preparation.  
WO/2006/136135A3
The invention relates to a method for decarboxylating C-C cross-linking by reacting carboxylic salts with carbon electrophiles in the presence of transition metal compounds as catalysts. The method represents a decarboxylating cross-coup...  
WO/2007/034755A1
Compounds exerting high activities against various destructive insects and/or mites in agricultural and horticultural field, particularly excellent miticidal activity against Panonychus citri which is a weighty pest to citrus fruits, nam...  
WO/2007/031608A1
The present invention relates to a refined and detailed molecular model of the α2β1 integrin l-domain, especially the MIDAS and to the use of such a model for designing novel integrin modulators, especially α2β1 integrin modulators. ...  
WO/2007/033266A2
Pharmaceutical compositions comprising 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4- dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile and pharmaceutically acceptable salts thereof are provided as well as kits and articles of m...  
WO/2007/030567A2
Compounds are described that are active on at least one of PPARα, PPARδ, and PPARγ, which are useful for therapeutic and/or prophylactic methods involving modulation of at least one of PPARα, PPARδ, and PPARγ.  
WO/2007/025575A1
A compound of Formula (I).  
WO/2006/108695A3
The invention relates to macrocyclic sulfoximines of the general Formula I : (I), wherein A, X, Y, R1, R2 and R3 have the meaning as given in the specification and the claims, and to salts thereof; to pharmaceutical compositions comprisi...  
WO/2005/089511A3
Crystalline salts, polymorphs, solvates, and hydrates of bicalutamide, 5-fluorouracil, donepezil, anastrozole, nelfinavir, mirtazapine, lansoprazole, and tamsulosin, or derivatives thereof are provided by the subject invention. Methods o...  
WO/2007/020381A2
A process for the preparation of a compound of formula (I) wherein: R is an alkynyl group; R1 is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkyl-alkyl, phenyl and phenylalkyl, it being possible in turn for all of the receding groups to c...  
WO/2006/138508A3
Benzamide derivatives of formulae I and II, and pharmaceutically acceptable salts, solvates, stereoisomers, and prodrugs thereof, and pharmaceutical compositions comprising the same, are described and have therapeutic utility, particular...  
WO/2007/012183A1
A process which includes the reacting of sodium perborate with N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)thi o]-2-hydroxy- 2-methylpropanamide to form bicalutamide. Said process may comprise the reaction of N-[4-cyano-3-(t...  
WO/2007/009250A1
The present invention relates to novel renin inhibitors of the general Formula (I), and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes fo...  
WO/2007/010387A2
Methods and materials for preparing optically active 3,4-disubstituted cyclopentanones are disclosed. The method includes hydrolyzing one or more compounds represented by Formula (13), or removing an ester moiety from a compound represen...  
WO/2006/124875A3
Compounds of Formula (I), or pharmaceutically acceptable salts thereof, are provided, which are modulators of secreted frizzled related protein-1. The compounds, and compositions containing the compounds, can be used to treat a variety o...  
WO/2005/079270A3
The present invention provides aryl nitrones, compositions comprising the same and methods of their use for the treatment or prevention of oxidative, ischemic, ischemia/reperfusion-related and chemokine mediated conditions.  
WO/2007/003965A1
The present invention relates to the compounds of formula (I): wherein A,B, n, X, Y, Z, R1, R2, R3, R4, R5, R6, R7 and R8 are defined herein, and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising them and ...  
WO/2007/001245A2
A method for improving the lubricating properties of a isomerized distillate base oil having a kinematic viscosity at 100 degrees C between about 2.5 cSt and about 8 cSt, the method comprising blending with said isomerized distillate bas...  
WO/2006/138660A2
The invention relates to substituted adamantane compounds of formula (I), pharmaceutical compositions thereof, processes for their preparation, and methods for inhibiting sphingosine kinase and for treating or preventing hyperproliferati...  
WO/2006/137395A1
Disclosed are a compound represented by the general formula (1) below which exhibits a high insecticidal effect, and a pesticide containing such a compound as an active ingredient. (1) (In the formula, A1, A2, A3 and A4 respectively repr...  
WO/2006/136135A2
The invention relates to a method for decarboxylating C-C cross-linking by reacting carboxylic salts with carbon electrophiles in the presence of transition metal compounds as catalysts. The method represents a decarboxylating cross-coup...  
WO/2006/137376A1
Disclosed is a compound having high pesticidal effects which is represented by the general formula (1) below. Also disclosed is a pesticide containing such a compound as an active ingredient. (1) (In the formula, A1, A2, A3 and A4 respec...  
WO2006112742A3
Invention relates to the process for preparation of 13,14-dihydro-PGF2a derivatives of R or S configuration at carbon atom in omega chain substituted by hydroxyl, represented by formula (I), wherein the meaning of substituents is defined...  
WO/2006/133823A1
Benzanilides of the formula: (I) in which X represents hydrogen, halogen, nitro, C1-6 alkylthio, C1-6 alkylsulfinyl, C1-6 alkylsulfonyl or C1-6 alkylsulfonyloxy; Y represents halogen or C1-6 alkyl; R1 represents C1-6 alkyl, C1-6 alkylthi...  
WO/2006/134040A1
The invention is concerned with novel anthranilic acid derivatives of formula (I) wherein R1 to R14, m and n are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compo...  
WO/2006/134341A1
A compound of the formula (I): wherein R1,R2,R3, R4,Ar, A, n and m are defined herein, is disclosed as a GlyT1 inhibitor; pharmaceutical compositions containing the compound of the formula (I) are also disclosed as are their use in medic...  
WO/2006/131713A1
The present invention provides compounds of formula (I): wherein R1 is an alkyl, phenyl, heterocyclyl, cycloalkyl, alkoxy, ester, amino or amide group; R2 is a phenyl, heterocyclyl, alkyl, cycloalkyl or cycloalkylalkyl group; R3 is an al...  
WO/2006/131465A1
The present invention pertains to a reversibly thermochromic system comprising a substituted or an unsubstituted 6,11-dihydroxy-naphthacene-5,12-dione and a base and to a reversibly thermochromic composition comprising the reversibly the...  
WO2005089269A3
Substituted phenol derivatives of Formula (I) are useful as antiproliferative agents including, for example, anticancer agents, and as radioprotective and chemoprotective agents.  
WO/2006/131711A1
The present invention provides compounds of formula I: wherein R1 is an alkyl, phenyl, heterocyclyl, cycloalkyl, alkoxy, ester, amino or amide group; R2 is a phenyl, heterocyclyl, alkyl, cycloalkyl or cycloalkylalkyl group; R3 is an alky...  
WO2006097817A9
This invention provides a compound of the formula (I) or a pharmaceutically acceptable salt or solvate thereof. These compounds are useful for the treatment of disease conditions caused by overactivation of VR1 receptor such of pain, or ...  
WO/2006/128287A1
The present invention provides compounds of formula I which are inhibitors of cathepsin S and as such are useful in the prevention and treatment of cathepsin S dependent diseases and conditions including, but not limited to, chronic obst...  
WO/2006/125593A1
A compound of formula (I); in free or pharmaceutically acceptable salt form, where R1, R2, R3, R4, R5, m, n, w, X, Y and Q have the meanings as indicated in the specification, are useful for treating conditions mediated by the CRTh2 rece...  
WO/2006/125688A1
The invention relates to benzoyl-substituted serine amides of formula (I), in which the variables R1 to R11 are defined as cited in the description and to their salts that can be used for agricultural purposes. The invention also relates...  
WO2006034004A3
The present invention is directed to a process for preparing certain cysteine protease inhibitors.  
WO/2006/124875A2
Compounds of Formula (I), or pharmaceutically acceptable salts thereof, are provided, which are modulators of secreted frizzled related protein-1. The compounds, and compositions containing the compounds, can be used to treat a variety o...  
WO/2006/120178A1
The present invention relates to compounds of formula I, in which at least one of R5, R6 and R7 is SR12, S(O)R12 or S(O)2R12 group where R12 is a C1-6haloalkyl group, that act, as chemical uncouplers. Compounds of the invention are usefu...  
WO2006059149A8
Compounds of formula (I) are potent and selective 5-HT2A antagonists, useful in treatment of a variety of adverse conditions of the CNS.  
WO2006093823A9
This invention provides aryl and heteroaryl compounds of formula (X). The compounds of the invention may be useful as antagonists, or partial antagonist of factor IX and/or factor Xl and thus, may be used to inhibit the intrinsic pathway...  

Matches 651 - 700 out of 10,857