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WO/2006/045554A1 |
The present invention relates to compounds having the general formula (I) with the definitions of A, X, R1-R6 given below, and/or a salt or ester thereof. Furthermore the invention relates to the use of said compounds for the treatment o...
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WO/2006/043635A1 |
A novel 3-triazolylphenyl sulfide derivative which has excellent soil treatment activity when used as an insecticide/acaricide/nematicide for agricultural or horticultural plants. It is a 3-triazolylphenyl sulfide derivative represented ...
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WO/2006/041888A2 |
Selected compounds are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical...
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WO/2006/040180A1 |
The present invention relates to an aminomethyl substituted bicyclic aromatic compound of the formula (I) wherein Ar is a cyclic radical selected from the group consisting of phenyl, a 5- or 6-membered C-bound heteroaromatic radical comp...
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WO/2006/041119A1 |
Compounds represented by the general formula (1) or salts thereof, or hydrates of both, which are safe and have moderate physicochemical stability and which are useful as preventive or therapeutic agents for diseases caused by thrombus f...
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WO/2006/040179A1 |
The present invention relates to aromatic compounds of the formula (I) wherein Ar is phenyl or an aromatic 5- or 6-membered C-bound heteroaromatic radical, wherein Ar may carry 1 radical Ra and wherein Ar may also carry 1 or 2 radicals R...
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WO/2006/040527A1 |
A process for making a compound of formula (I), said process comprising a) reaction of a compound of formula (II) with: i) a compound of formula (III) by nucleophilic aromatic substitution of X2 and ii) a compound of formula (IV) for exa...
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WO/2006/035157A2 |
The invention relates to poly-substituted N-(benzyl)phenylacetamide-type derivatives having formula (I), pharmaceutical compositions containing same and the therapeutic use thereof as PPAR ligands, such as in the human and animal health ...
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WO/2006/035891A1 |
Isonitriles represented by the general formula (1) and antifouling agents against the adhesion of aquatics containing the same: (1) wherein R1 is CH2X (wherein X is hydroxy, halogeno, isocyano, amino, substituted amino, or optionally sub...
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WO/2006/034006A1 |
The present invention is directed to polymorphs of N-(1-cyanocyclopropyl)-3-cyclopropylmethanesulfonyl-2(R)-(2,
2,2-trifluoro-1(S)-4-fluorophenylethylamino)-propionamide, methods of using them to treat a disease mediated by cathepsin S, ...
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WO/2006/033446A1 |
The present invention relates to a compound of the formula [I]: wherein (a), in which -Y-, R4, R5 and R6 are4 R5 each as defined in the description, etc., R1 is hydrogen, halogen, lower alkyl, hydroxy, etc., R2 is hydrogen, lower alkyl o...
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WO/2006/032386A1 |
The invention relates to a lyophilisate containing N-diaminomethylene-2-methyl-4,5-di-(methylsulfonyl)-benzamid
e as an active ingredient. The preparation has a longer storage stability even at higher temperatures and can be applied as a...
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WO/2006/034004A2 |
The present invention is directed to a process for preparing certain cysteine protease inhibitors.
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WO/2006/030278A1 |
The present invention is directed to a process for the isolation of the enantiomeric forms of modafinil with high enantiomeric purity and high overall yields by means of a continuous chromatographic process.
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WO/2006/029436A1 |
The invention relates to the compounds of the general formula (I), wherein X = -CH- or -N=, n = 0 or 1, R1 = -H, -F, -OCH3 or -COOCH3, R2 = -H or -F, R3 = -H, or R2 and R3 together represent -CH2-CH2-, R4 = -H or -OCH3, R5 = -H, -OCH3 or...
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WO/2006/029532A1 |
Nitrate esters and methods for mitigating neurodegeneration, affecting neuroprotection, affecting cognition enhancement, and/or preventing or mitigating tissue and/or cellular damage in a subject are described. Neurological or cognitive ...
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WO/2006/024402A1 |
The invention relates to novel salts of chiral 3-halophthalic acid derivatives of formula (I) from 3-halophthalic acid anhydrides of formula (II), amines of formula (III), a method for the production thereof, the use thereof for producin...
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WO/2006/024412A2 |
Novel optically active phthalamides of the formula (I) in which A, q, R1, R2, E1, E2, X, m, Y, n and Z are as defined in the description, processes for preparing these compounds and their use for controlling pests.
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WO/2006/021806A1 |
Compounds of formula (I) are useful in treatment of sleep disorders and other conditions mediated by 5-HT2A receptor activity.
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WO/2006/021759A1 |
The invention relates to substituted phenoxyacetic acids of formula (I), where the variables are as defined in claim 1, as useful pharmaceutical compounds for treating respiratory disorders, pharmaceutical compositions containing them, a...
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WO/2006/021805A1 |
Compounds of formula (I) are potent and selective antagonists of the human 5-HT2A receptor, and hence useful in treatment of a variety of adverse conditions of the CNS.
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WO/2006/021743A1 |
A process for selectively controlling the crystallisation of thermodynamically stable Form (1) or kinetically stable Form (2) polymorphs of mesotrione from an aqueous mesotrione solution, said method comprising adjusting the pH of the me...
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WO/2006/023778A2 |
The invention relates to small molecules which function as inhibitors of anti-apoptotic Bcl-2 family member proteins (e.g., Bcl-2 and Bcl-xL). The invention also relates to the use of these compounds for inducing apoptotic cell death and...
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WO/2006/022225A1 |
An optically active phthalamide derivative represented by the general formula (I): (wherein R1 and R2 each represents H or optionally substituted C1-6 alkyl or C1-6 alkoxycarbonyl; R3 represents C1-6 alkyl; A represents H, C1-6 alkyl, C3...
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WO/2006/015829A1 |
Compounds of formula (I), a pharmaceutically acceptable salt, solvate or prodrug thereof are disclosed: wherein R1 is C1-6alkyl, haloC1-6alkyl, C2-6alkenyl, amino, monoC1-4alkylamino or diC1 4alkylamino; R2 and R3, which may be the same ...
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WO/2006/016194A1 |
Compounds of Formula (I) wherein R1 is a cycloalkylsulphonyl group, or pharmaceutically acceptable salts thereof, are useful in the prophylactic and therapeutic treatment of hyperglycemia and diabetes.
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WO/2006/013085A1 |
The invention relates to compounds of formula (I), in which R, R' and R' are as defined in the disclosure and the pharmaceutically acceptable esters thereof. The compounds of the invention reduce the synthesis of kynurenic acid thus inhi...
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WO/2006/013193A2 |
Described herein are derivatives of arylsulfonamido-substituted hydroxamic acid of formula (I) having good solubility in water and inhibitory activity of matrix metalloproteinases, useful for the preparation of pharmaceutical composition...
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WO/2006/012227A2 |
The present invention relates to inhibitors of 11-β hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor MR, and pharmaceutical compositions thereof. The compounds of the invention can be useful in the tr...
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WO/2006/011669A1 |
Novel cinnamic acid-related compounds and salts thereof which are useful as drugs, specifically, compounds represented by the general formula [1] and salts thereof: [1] wherein A is a six-membered hydrocarbon ring or a six-membered heter...
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WO/2006/011469A1 |
A cyclohexane derivative having the function of reducing a blood sugar level and having preferable properties required of medicines, such as long-lasting drug activity, metabolic stability, and safety; and a medicinal composition for use...
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WO/2006/011466A1 |
Disclosed are a compound and pharmaceutically acceptable salts thereof represented by the general formula (1) below. (In the formula (1), R1, R2, R3, R4 and X are the same as R1, R2, R3, R4 and X defined in the description.)
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WO/2006/009134A1 |
A novel fungicide that exhibits a wide disease control spectrum against pathogenic fungi acting on various crops and helps resolve worsening resistant strain problems. There are provided diamine derivatives of the formula (1), a process ...
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WO/2006/005909A1 |
The invention relates to substituted acids of formula (I), where T,W,X,Y,Z,R1 and R2 as defined in the claims, as useful pharmaceutical compounds for treating asthma and rhinitis, pharmaceutical compositions containing them, and a proces...
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WO/2006/006736A1 |
A method of crystallizing bicalutamide, comprising adding an acetone solution containing bicalutamide to water. There is provided a crystal of bicalutamide obtained by the above method and having a particle size distribution of Dp10=1 to...
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WO/2006/003923A1 |
Disclosed is an excellent LXR modulator. Specifically disclosed are compounds represented by the following general formula (I). (In the formula, R1 represents -COR9 (wherein R9 represents an alkyl, an optionally substituted alkoxy or an ...
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WO/2005/123667A1 |
Compounds of formula (I) wherein the substituents are as defined in claim 1, are suitable for use as herbicides.
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WO/2005/121078A2 |
The invention relates to substituted cyclopentene compounds of general formula (I), to a method for the production thereof, medicaments containing said compounds, in addition to the use thereof in the production of medicaments.
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WO/2005/121077A1 |
This invention provides a general method for the synthesis of polymer-supported benzoquinones described by the following generic structure I: wherein: •, X, R1, R2 and R3 are described in the main text. The general concept of the metho...
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WO/2005/119315A2 |
In one aspect, the present invention provides a hyperpolarizable organic chromophore. The chromophore is a nonlinear optically active compound that includes a &pgr -donor conjugated to a &pgr -acceptor through a &pgr -electron conjugated...
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WO/2005/118530A1 |
Disclosed are novel triketone compounds, a method for producing those, and an excellent herbicide containing those. Specifically disclosed are triketone compound represented by the formula (I) below or salts thereof. (I) [In the formula,...
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WO/2005/113491A1 |
A monomer comprising the structure (1a) or (1b) wherein Z comprises S, SO2, or POR wherein R comprises a linear or branched perfluoroalkyl group of 1 to 14 carbon atoms optionally containing oxygen or chlorine, an aryl or substituted ary...
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WO/2005/113506A1 |
The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated R...
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WO/2005/110981A1 |
The present invention relates to a compound formula[I]: wherein X is bond or -O-, R1 is formula[A] or formula [B] in which R5, R6 and R7 are each as defined in the description, R2 is hydrogen or lower alkyl, R3 is hydrogen or an amino pr...
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WO/2005/110980A2 |
Aryl sulfone compounds of formula (I) and (II) are described and have therapeutic utility, particularly in the treatment of diabetes, obesity and related conditions and disorders.
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WO/2005/110955A1 |
The invention provides reagents and kits for introducing a fixed charge to the side-chain of methionine, and peptides and proteins containing methionine, for selective identification by tandem mass spectrometry. The reagents are based on...
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WO/2005/105718A2 |
The present invention relates to a process for the preparation of compounds of formula (I), wherein the substituents are as defined in claim 1, by reacting a compound of formula (II), with a bromine or chlorine source to form a compound ...
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WO/2005/105717A1 |
The present invention relates to the preparation of compounds of formula (I); wherein the substituents are as defined in claim 1, by reacting a compound of formula (II); with a bromine or chlorine source to form a compound of formula (II...
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WO/2005/105764A1 |
Compounds of the formula (I): in which R, R1 and R2 are as defined in the description, the use thereof for the treatment of dyslipidaemia, atherosclerosis and diabetes, pharmaceutical compositions comprising them, and . processes for the...
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WO/2005/105712A1 |
Novel sulfon amide derivatives are chemical uncouplers useful e.g. for the treatment of obesity.
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