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Patent Searching and Data


Matches 851 - 900 out of 10,878

Document Document Title
WO/2005/068415A1
Disclosed is a phenylalanine derivative having excellent VLA-4 inhibitory activity which is represented by the following general formula (1) or a salt thereof. (1) (In the formula, R1 represents an aromatic hydrocarbon group having 6-10 ...  
WO2005042478A3
The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR delta modulators to treat or inhibit the progression of, for example, dyslipidemia.  
WO/2005/066119A2
Novel florfenicol compounds having the chemical structure: Or a pharmaceutically-acceptable salt thereof or a solvate thereof,or prodrug thereof, wherein R1 is CHCl2, CHClF, CHF2, CHBrCl, CH3, CH2N3, CH2CN, CH(R2)NH2 or CH X1X2; where R2...  
WO/2005/063665A1
The invention provides para substituted dialkylphenol derivatives of propofol. The invention further provides pharmaceutical compositions comprising such analogs, methods for preparing such analogs, and methods of using such analogs to i...  
WO/2005/063703A1
A novel process for producing a 2-halogenobenzamide compound useful as a raw material or active ingredient for medicines and agricultural chemicals. The process, which is for producing a 2-halogenobenzamide compound represented by the ge...  
WO/2005/063729A1
The present invention provides a novel compound represented by the formula (I) wherein each symbol is as defined in the specification, a salt thereof and a prodrug thereof having a superior GPR40 receptor function modulating action, whic...  
WO/2005/063018A1
Present invention relates to a haloalkene compound of the formula (I)or its salt: wherein each of X1 and X2 is halogen; Y is alkyl, haloalkyl or phenyl; n is 0 to 5; L is -C(=B)Q, -C(=B)B’Q, -C(=B)N(D)Q, -N(D)Q, -N(D)C(=B)Q, -N(D)C(=B)...  
WO2005023198A3
Co-crystals and solvates of racemic, enantiomerically pure, and enantiomerically mixed modafinil are formed and several important physical properties are modulated. The solubility, dissolution, bioavailability, dose response, and stabili...  
WO2004098516A3
The present application describes modulators of MCP-1 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of rheumatoid arthritis, multiple sclerosis, artherosclerosis and asthma.  
WO/2005/060692A2
Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.  
WO/2005/058269A1
Described are merocyanine derivatives of formula (1a) or (1b) wherein n and o are integers from 2 to 4 and aminocyclohexenone intermediates. They are used in protecting human and animal hair and skin from UV radiation.  
WO/2005/056519A1
The present invention provides a compound represented by the formula (I): (INSERT CHEMICAL FORMULA) (wherein R1 is a lower alkyl substituted by a lower alkoxy or a heterocyclic group, or a heterocyclic group; R2 is a lower alkyl optional...  
WO/2005/057714A1
It is aimed to obtain a lithium secondary battery with excellent characteristics such as energy density and electromotive force, which is also excellent in cycle life and shelf life stability. Disclosed is an electrolyte solution for sec...  
WO/2005/056518A1
This invention discloses a series of sulfur- or oxygen-containing oxime ether compounds represented by the general formula (I), in which R, R,, X, n, Ar and F, are as defined in the specification, and their preparation methods. The compo...  
WO2004046094A9
The present invention provides histone deacetylase inhibitors of general formula (I), process for the preparation of such compounds and uses of the compounds in medicine.  
WO/2005/056510A2
The present invention relates to novel compounds corresponding to the general formula (I) below: to compounds containing them, and to their use in pharmaceutical compositions intended for use in human or veterinary medicine, or alternati...  
WO/2005/054181A1
It is intended to provide a medicinal composition containing, as the active ingredient, a compound specifically binding to KSRP or a functional fragment thereof and a method of screening this compound. A composition capable of regulating...  
WO/2005/054176A1
The present invention is directed to a compound of formula (I), or a pharmaceutically acceptable salt, solvate hydrate or stereoisomer thereof, which is useful in treating or preventing disorders mediated by a peroxisome proliferator act...  
WO/2005/051898A2
The present invention relates to novel, non-secosteroidal, sulfonate and sulfonamide functional diaryl compounds with vitamin D receptor (VDR) modulating activity that are less hypercalcemic than 1&agr ,25 dihydroxy vitamin D3. These com...  
WO/2005/051947A1
The invention relates to novel macrocycles of general formula (I) and to the use thereof for treating cancerous diseases.  
WO/2005/051896A1
The invention relates to a compound of the formula (I) in which: - R1 represents, independently of each other, a halogen atom; an aliphatic hydrocarbon-based group optionally substituted and/or optionally interrupted by one or more oxyge...  
WO/2005/051900A1
A compound according to formula (I) wherein R1 and R2 independently represent hydrogen, nitro, cyano, halogen, alkyl, alkenyl, alkynyl, haloalkyl, aralkyl, heteroaralkyl, alkoxy, alkylamino, -C(O)O-R4, -C(O)NR5R6, -S(O)2OR4, S(O)2NR5R6 o...  
WO2005042476A3
The invention encompasses the novel compounds of Formula (I) and Formula (II), which are prodrugs that convert in vivo to diaryl-2-(5H)-furanones useful in the treatment of cyclooxygenase-2 mediated diseases. These prodrugs are far more ...  
WO/2005/051888A2
The invention relates to compounds of the formula (I) in which: i and j=1; R1 is in position 3 or 4 on the phenyl ring and represents a cyano group, an alkoxy group substituted by halogen, a thioalkyl group, an alkylcarbonyl group or an ...  
WO/2005/051899A2
A novel polymer electrolyte is provided that enables a solid polymer electrolyte used in fuel cells, for example, to have sufficient proton conductivity even in a low-water-content state or a zero-water-content state by using a monomer c...  
WO/2005/051941A1
A 1,2,4-triazole derivative of formula (1) or a non-toxic salt thereof, a preparation method thereof, and a pharmaceutical composition containing the derivative or the salt as an active ingredient are provided.  
WO/2005/046599A2
&agr β-Unsaturated sulfoxides of Formula I: (I) are useful as antiproliferative agents including, for example, anticancer agents, and as radioprotective and chemoprotective agents.  
WO/2005/047271A1
Disclosed is a process for preparing a 6-chloro-2,5-dicarbonamido phenol compounds comprising a step employing a 2-alkyl-6-aminobenzoxazole to form a 2-alkyl-6-amino-7-chlorobenzoxazole in which the 2-alkyl group is unbranched at the &ag...  
WO/2005/046854A2
A process for the preparation of Diphenylmethylsulfinyl derivatives of formula (I) comprising (wherein R1 is selected from hydrogen, C1-12 linear, branched or cyclic alkyl & hydroxy) reacting compound fo formula (V) with compound of form...  
WO/2005/047236A1
The present invention relates to sulfoxide and bis-sulfoxide compounds of formula (I), formula (II), or formula (III), compositions comprising sulfoxide and bis-sulfoxide compounds, and methods useful for treating and preventing cardiova...  
WO2005028429A3
The application is directed to haloalkyl-substituted compounds of formula (I) wherein R<7> represents haloalkyl; and R<1>, R<2>, R<3>, R<4>, R<5>, R<6> and R<8> are as defined in the claims. The compounds are inhibitors of cysteine prote...  
WO/2005/044785A1
Novel compounds of the structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds...  
WO/2005/044787A1
Compounds of formula (I) and salts, solvates, and physiologically functional derivatives thereof, useful for the prophylaxis or treatment of a clinical condition for which a selective β2-adrenoreceptor agonist is indicated, for example ...  
WO2004078924A3
The present invention relates to non-steroidal ligands for use in nuclear receptor-based inducible gene expression system, and a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding...  
WO/2005/044780A1
An aminocarboxylic acid derivative represented by the general formula (1) (example: 3-amino-6-[4-(3-benzyloxyphenylsulfanyl)-2-chlorophenyl]-3-h ydroxymethylhexanoic acid). It is highly effective in controlling a sphingosine-1-phosphoric...  
WO2005012220A9
The present invention relates to novel compounds with a variety of therapeutic uses, more particularly novel substituted cyclic alkylidene compounds that are particularly useful for selective estrogen receptor modulation. Formula (I) inc...  
WO/2005/044007A1
A pesticide having stabilized high pesticidal effects for crop plants infected with plant diseases, is presented. The pesticide contains a biphenyl derivative represented by the formula (I) or its salt, as an active ingredient: wherein X...  
WO/2005/042476A2
The invention encompasses the novel compounds of Formula (I) and Formula (II), which are prodrugs that convert in vivo to diaryl-2-(5H)-furanones useful in the treatment of cyclooxygenase-2 mediated diseases. These prodrugs are far more ...  
WO/2005/042478A2
The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR delta modulators to treat or inhibit the progression of, for example, dyslipidemia.  
WO/2005/042479A1
The present invention is directed to an improved process for preparing modafinil wherein benzhydrylthioacetate is prepared in high yield and purity by the reaction of a haloacetate with the reaction product of thiourea and benzhydrol. Th...  
WO/2005/042471A1
The present invention relates to novel nitrophenyl mustard and nitrophenylaziridine alcohols, to their corresponding phosphates, to their use as targeted cytotoxic agents; as bioreductive drugs in hypoxic tumours, and to their use in cel...  
WO2004092145A8
Alpha substituted carboxylic acids of formula (I): wherein R' and R2 are as defined in the specification and R3 is A) formula (II); B) formula (III); C) formula (IV); and D) formula (V); wherein Y, Art, Are, AP, R4, R5, R6, R7, R6, R9, R...  
WO/2005/042464A1
Treatment of Diseases caused by Disturbances of the Activity of the Androgen Receptor uses of compounds of Formula (I): (as defined herein), for the treatment of diseases caused by disturbances of the activity of androgen receptor are pr...  
WO2004048318A8
An improved process for the preparation of 1,3 substituted indenes which are useful intermediates in the synthesis of aryl fused azapolycyclic compounds as agents for the treatment of neurological and psychological disorders.  
WO2004048321A8
The invention relates to phenylsulfoxide and phenylsulfone derivatives and to a method for producing them. The invention also relates to their use in the production of medicaments for the treatment and/or prophylaxis of diseases, especia...  
WO/2005/040127A1
The present invention relates to novel compounds accelerating the activity of Peroxisome proliferator-activated receptor gamma (PPAR&gammad ) and alpha (PPAR&agr ), processes of preparing the same, and pharmaceutical compositions contain...  
WO2004002939A3
The present invention relates to a compound formula [I]: Y is bond, -0-(CH2)n- (in which n is 1, 2, 3 or 4), etc., Z is cyano, tetrazolyl, etc., R<1> is hydrogen, lower alkyl, etc., R<2> is hydrogen or an amino protective group, R<3> is ...  
WO/2005/040095A1
The invention relates to compounds of the formula (I) or pharmaceutically-acceptable salts thereof wherein Ar, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 have any of the meanings defined in the description, which possess dipeptidyl ...  
WO/2005/037777A1
A process for producing bicalutamide, which is represented by the formula (4), (4) which comprises: a step (A) in which the compound represented by the formula (1) is reacted with a peroxycarboxylic acid to obtain the compound (2) repres...  
WO2004014844A3
This invention provides certain compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, and their use in treating human or animal disorders. The compounds of the invention are useful as antagonists,...  

Matches 851 - 900 out of 10,878