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WO/2003/020199A1 |
The invention relates to the use of C2-substituted indan-1-ol systems, and to the physiologically tolerable salts and the physiologically functional derivatives of the same, for producing medicaments used to reduce the weight of mammals,...
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WO/2003/020704A1 |
Compounds of Formula I (I) wherein the substituents are as defined in claim 1, and the agrochemically tolerable salts and all stereoisomers and tautomers of the compounds of formula I, are suitable for use as herbicides.
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WO/2003/020690A1 |
Aryl sulfamate derivatives represented by the general formula (&Verbar ) or pharmacologically acceptable salts thereof: (&Verbar ) wherein Rr and Rs are each independently hydrogen or lower alkyl&semi R1, R2, R3, and R4 are each independ...
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WO/2003/020255A1 |
The invention relates to the use of polysubstituted indan-1-ol systems and the physiologically acceptable salts and physiologically functional derivatives thereof for producing drugs used in the prophylaxis or treatment of obesity. The i...
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WO/2003/020695A1 |
The invention relates to C2-disubstituted indane-1-ol systems and to their physiologically compatible salts and physiologically functional derivatives. The invention also relates to compounds of formula (I), wherein the groups are define...
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WO/2003/020693A1 |
The invention relates to polysubstituted indan-1-ol systems, the physiologically acceptable salts and physiologically functional derivatives thereof. The invention relates to the compounds of formula (I), wherein the groups are defined a...
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WO/2003/018535A2 |
The invention relates to a novel class of aminobenzophenones derivatives, to pharmaceutical preparations comprising said compounds, to dosage units of such preparations, to methods of treating patients comprising administering said compo...
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WO/2003/018070A1 |
This invention relates to a method of imaging amyloid deposits and to labeled compounds, and methods of making labeled compounds useful in imaging amyloid deposits. This invention also relates to compounds, and methods of making compound...
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WO/2003/018543A1 |
Novel sulphones of formula I are disclosed: The compounds modulate the processing of amyloid precursor protein by gamma-secretase, and hence are useful in the treatment or prevention of Alzheimer's disease.
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WO/2003/019145A2 |
Bis-diazo,triaryl and aryldiazo-N-arylphenazonium quencher moieties, substituted with electron-withdrawing and electron-donating substituents which induce polarity in the delocalized aryl/diazo ring systems, are useful as labels when att...
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WO/2003/016254A1 |
Carboxylic acid derivatives represented by the following general formula (I) and nontoxic salts thereof: (I) wherein R1 represents COOH, COOR4 (wherein R4 represents alkyl, etc.), etc.&semi A represents alkylene, etc.&semi R2 represents ...
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WO/2003/014073A1 |
The invention concerns novel molecules, their preparation and their uses, in particular in the field of human and veterinary medicine and in cosmetics. The inventive compounds are partly fatty acid derivatives and exhibit advantageous ph...
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WO2002030882A9 |
The present invention relates to novel sulfoxide and bis-sulfoxide compounds, compositions comprising sulfoxide and bis-sulfoxide compounds, and methods useful for treating and preventing caridovascular diseases, dyslipidemias, dysprotei...
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WO/2003/014071A1 |
The invention relates to benzoylcyclohexenone derivatives of general formula (I) wherein the variables R?1¿ to R?10¿ and n have the designation cited in claim 1. The invention also relates to the salts of the same and the use of said d...
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WO/2003/011819A1 |
The present invention relates to a compound of the formula I: (Formula I) in which: A, B, R?1¿, Z, n and R?2¿ are as defined in Claim 1. These compounds are useful in the treatment of dyslipidaemia, atherosclerosis and diabetes.
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WO/2003/009807A2 |
Cytoprotective compounds, many of which are phenolic derivatives characterized by a substituded phenol having certain conjugated bonds, are useful in the treatment of certain ischemic or inflammatory conditions, including but not limited...
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WO/2003/010137A1 |
A dibromomethyl moiety is converted to a sulfonylmethyl moiety by treatment with a sulfinic acid salt. For example, (methyl-sulfonyl)methyl bromo-quinoline is prepared by the treatment of dibromomethyl bromo-quinoline with a sulfinic aci...
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WO/2003/010122A1 |
High yields of ester-substituted diary carbonates such as bis-methyl salicyl carbonate were obtained by the condensation of methyl salicylate with phosgene in the presence of a phase transfer catalyst (PTC) in an interfacial reaction sys...
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WO/2003/007931A1 |
Drugs for potentiating the effect of cancer therapy based on the function mechanism of injuring DNA which contain compounds represented by the general formula (I) or physiologically acceptable salts thereof as the active ingredient: (I) ...
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WO/2003/008372A1 |
A bactericide which contains as the active ingredient a diamine derivative represented by the formula (1): (1) wherein R1 to R7 each represents a specific substituent, e.g., C1−6 alkyl&semi and R8 represents optionally substituted aryl...
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WO/2003/007954A2 |
The invention is directed to sulfonyl aromatic hydroxamic acid compounds and salts thereof that, inter alia, inhibit matrix metalloprotease (MMP) activity and/or aggrecanase activity. In some particularly preferred embodiments, the compo...
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WO/2003/006424A1 |
The present invention relates to compounds of the general formula (I), wherein A is a non-aromatic ring system containing 4 to 8 carbon atoms, wherein the ring system comprises at least one double bond and wherein one or more of the carb...
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WO/2003/006021A1 |
The present invention relates to compounds of formula (I): Useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's...
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WO2002070467B1 |
The invention relates to new diphenylurea having the formula (I) or a salt thereof, where Y is CO=O, C=S, C=NH, (C=O)2 or SO2; and to processes for the preparation of these compounds and to their use in the treatment of protozoal disease...
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WO/2003/002526A1 |
A method of oxidizing primary and secondary alcohols to an aldehyde or ketone using a fluorous sulfoxide or a fluorous sulfide is disclosed. The method includes regenerating and recycling the fluorous sulfoxide which has the structure, w...
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WO/2003/002524A2 |
The present invention relates to compounds of the formula I, in which R?1¿, R?2¿, R?4¿, R?5¿, D¿1?, D¿2?, X¿1?, X¿2?, X¿3?, A and B have the meanings indicated in the claims. The compounds of the formula I are valuable pharmacol...
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WO/2003/002519A1 |
The invention relates to novel phenol derivatives, a method for the production of said derivatives and their use in medicaments.
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WO/2002/100339A2 |
The present invention relates to a new process for the synthesis of racemic and optically active bicalutamide starting from ethyl pyruvate and methyl methacrylate. The present invention discloses processes of preparing bicalutamide inter...
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WO/2002/100812A1 |
A medicine containing as the active ingredient a novel carboxylic acid derivative useful as an insulin resistance ameliorant. The carboxylic acid derivative is represented by the following general formula (I). Also provided are a salt or...
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WO/2002/100344A2 |
This invention is directed to compounds that provide for sustained systemic concentrations of GABA analogs following administration to animals. This invention is also directed to pharmaceutical compositions including and methods using su...
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WO/2002/100172A1 |
The invention provides methods of screening agents, conjugates or conjugate moieties, linked or linkable to agents, for capacity to be transported as substrates through the PEPT2 transporter. The invention also provides methods of treatm...
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WO/2002/100846A1 |
the present invention provides novel compounds represented by formula I: or pharmaceutically acceptable salts thereof useful for treating Flaviviridae viral infection.
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WO/2002/098849A2 |
Disclosed are compounds of formula X, where R¿n?, R¿20?, R¿1?, R¿2?, R¿3?, and R¿c? are defined herein. These compounds are useful in treating Alzheimer's disease and other similar diseases. Pharmaceutical compositions comprising c...
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WO/2002/098850A2 |
The present invention relates to coumponds of formula (I) (in which X1 is−NHC(R1)(R2)X3 or −NHX4 and the other variables are as defined in the claims) and the pharmaceutically acceptable salts and N−oxides therof, useful as selecti...
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WO/2002/098406A1 |
The present invention relates to novel selective cathepsin S inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making
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WO/2002/096516A1 |
A method is provided for the prevention or inhibition of cardiovascular disease comprising the admiministration of a cyclooxygenase-2 selective inhibitor with a dose of radiation.
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WO/2002/096884A2 |
The invention relates to novel substituted benzoylketones of formula (I), in which Q = O (oxygen) or S (sulphur), R?1¿ - R?5¿ and Z have the meaning given in the description and several methods for production thereof and use thereof as...
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WO/2002/094770A2 |
The present invention relates to a compound formula wherein R?1¿ is phenyl, pyridyl, etc., each of which may be substituted with one or two substituent(s); R?2¿ is hydrogen, an amino protective group, etc.; R?3¿ and R?4¿ are each ind...
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WO/2002/095861A1 |
The present invention relates to a non-aqueous electrolyte addditive for improving safety and a lithium secondary battery comprising the same, and more particularly to a non-aqueous electrolyte additive taht can improve cycle life and sa...
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WO/2002/094766A1 |
A phthalamide derivative represented by the general formula (I): (I) (wherein R1 and R2 may be the same or different and each represents hydrogen, C1−6 alkyl, etc.&semi R3 represents halogeno, cyano, etc.&semi R4 represents halogeno, C...
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WO/2002/094765A2 |
The present invention provides a substituted anilide derivative of formula (I): (I) (II) (III) {wherein Z is a group of formula (II) or (III) (in these formulas, A is C¿1?-C¿6? alkylene, C¿2?-C¿6? alkenylene, etc., R?1¿ is H, haloge...
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WO/2002/092574A1 |
The invention relates to novel substituted benzoylcyclohexenones of formula (I), in which Q, R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, Y and Z are defined as per the description. The invention also relates to a method for their production and t...
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WO/2002/092553A1 |
This invention relates to new compounds, pharmaceutical compositions and diagnostic kits comprising such compounds, and methods of using such compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels a...
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WO/2002/090344A1 |
The invention relates to a amido-diphenyl derivatives of formula (I), whereby variables X, Z and R?1¿-R?7¿ have the meanings as cited in Claim No. 1, to a method for the production thereof, and to their use in medicaments.
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WO/2002/090336A1 |
The invention relates to novel arylketones of formula (I) wherein A?1¿, A?2¿, Q, R?1¿, R?2¿, X, Y and Z have the meaning cited in the description, the use thereof as herbicides and to methods and intermediate products for the product...
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WO/2002/088061A1 |
A novel compound which is highly effective in ameliorating the cellular disorders caused by radicals and in inhibiting the neurotoxicity induced by excitatory neurotransmitters such as glutamic acid. It is a compound represented by the f...
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WO/2002/088074A1 |
Phthalamide derivatives represented by the general formula (I)&semi insecticides for agricultural and horticultural use, containing the derivatives as the active ingredient&semi and a method for application thereof: (I) wherein R1, R2 an...
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WO/2002/088070A1 |
Methods of synthesizing an acylanilide include contacting a compound having the structure of Formula I with a compound having the structure of Formula II under conditions sufficient to provide a compound having the structure of Formula I...
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WO/2002/088075A1 |
Phthalamide derivatives represented by the general formula (I)&semi insecticides for agricultural and horticultural use, containing the derivatives as the active ingredient&semi and a method for application thereof: (I) wherein R1, R2 an...
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WO/2002/085843A2 |
The present invention relates to processes for the preparation of any of the intermediate 1,3-substituted indenes of formulae (Ia, Ib and Ic) or a mixture thereof, wherein R?1¿, R?2¿, R?3¿, R?4¿, and R?5¿ are defined herein. Compoun...
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