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Matches 151 - 200 out of 10,644

Document Document Title
WO/2014/144669A2
Machines, apparatuses, systems and methods for providing adjustable tension to a cable system using a pivotally mounted leverage mechanism that employs an adjustably positionable weight. Embodiments are used in exercise and other muscle ...  
WO/2014/138518A3
Disclosed herein are bisarylmethylthioacetamides and bisarylmethylthioethylamines useful as inhibitors of monoamine transporters. The compounds are potent and/or selective inhibitors of dopamine (DA), serotonin (5-HT), and/or norepinephr...  
WO/2014/138720A1
A thio-selective radioactive labeling agent has the following general formula: *R-L-VS, wherein said *R is a radioisotope, L is a linking group, and VS is a vinylsulfone functional group, wherein said labeling agent is capable of covalen...  
WO/2014/138518A2
Disclosed herein are bisarylmethylthioacetamides and bisarylmethylthioethylamines useful as inhibitors of monoamine transporters. The compounds are potent and/or selective inhibitors of dopamine (DA), serotonin (5-HT), and/or norepinephr...  
WO/2014/134005A3
Methods of preparing carbamate prodrugs of amine-containing drugs are provided. Carbonates useful in the synthesis of the carbamate prodrugs are also provided.  
WO/2014/129971A1
The present invention is compositions and methods of synthesis of polyamide single-ion conducting polymer electrolytes and polyamide single-ion conducting polymer electrolyte composite films. In additional embodiments, the invention also...  
WO/2014/124234A1
The present invention relates to alkene derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.  
WO/2014/112646A1
The present invention addresses the problem of providing a compound having a selective inhibitory activity on LAT-1 that can be expressed in a tumor cell at a high level. The present invention provides: a compound represented by formula ...  
WO/2014/113700A9
The present disclosure provides nitroxyl donating pharmaceutical compositions comprising N-substituted hydroxylamine derivatives. The compositions are highly efficacious in treating cardiovascular diseases (e.g., heart failure), have a s...  
WO/2014/113700A1
The present disclosure provides nitroxyl donating pharmaceutical compositions comprising N-substituted hydroxylamine derivatives. The compositions are highly efficacious in treating cardiovascular diseases (e.g., heart failure), have a s...  
WO/2014/113696A1
The disclosed subject matter provides N-substituted hydroxylamine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, th...  
WO/2014/106804A3
The invention relates to the compounds of formula I and formula II or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an ef...  
WO/2014/104400A1
Provided is an actinic-ray- or radiation-sensitive resin composition including a resin (A) and any of compounds (B) of general formula (I) below. (In general formula (I), Rf represents a fluorine atom or a monovalent organic group contai...  
WO/2014/095103A1
The invention relates to an ester having at least one sulphonic group on the acid chain, a method for the production thereof and the use of the ester as a plasticizer for polymers.  
WO/2014/097881A1
[Problem] The purpose of the present invention is to provide a thermal recording body that has both excellent color development performance and thermal discoloration resistance in blank sections, and that offers excellent barcode readabi...  
WO/2014/082581A1
Disclosed is an α-(3, 5-dimethoxy benzylidene)-α'-hydrocarbyl methylene cyclic ketone, having a structure as represented by (I) or (II), wherein R is an aryl or alkyl; a preparation method is: mixing cyclic ketone and morpholine, and a...  
WO/2014/080251A1
Cell binding agent-drug conjugates comprising hydrophilic linkers, and methods of using such linkers and conjugates are provided.  
WO/2014/075754A1
Compounds of the formula (I) in which R1, R4, R, X1, X2, X3, X4, q and W have the meanings indicated in Claim 1, are inhibitors of fatty acid synthase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardio...  
WO/2014/074778A1
The present invention relates to the antimalarial compounds of formula (l)and their use against protozoa of the genus Plasmodium, including drug-resistant Plasmodia strains. This invention further relates to compositions containing such ...  
WO/2014/067235A1
Provided is a dimethylsulfoxide preparation method, the method comprising the following steps: 1) bringing hydrogen sulfide in contact with methanol to obtain a mixture containing dimethyl sulfide, and separating the dimethyl sulfide fro...  
WO/2014/062044A1
Invention is related to novel compounds - fluorinated benzenesulfonamides of general formula (I). The compounds can be used in biomedicine as active ingredients in pharmaceutical formulations, because they inhibit enzymes which participa...  
WO/2014/058330A3
Process for preparation of MK-7 type of vitamin K2 is characterized by attaching hexaprenyl chain of „all-trans" configuration to monoprenyl derivative of menadiol following „1 + 6" synthetic strategy. According to the invention, a-s...  
WO/2014/048958A1
The present invention relates to a method for the preparation of optionally substituted aryl and pyridyl pyrrolidines which are useful intermediates for the preparation of certain biologically active compounds.  
WO/2014/050814A1
[Problem] To provide a method for producing a compound having a bis(trifluoroalkanesulfonyl)methyl group, which is a compound having a high acidity degree and hydrophobicity and useful as a raw material compound for a resin, and a salt t...  
WO/2014/047110A2
Compounds according to Formula I are provided: and salts thereof, wherein Q1, Q2, R3, R4, X, and Y are as defined herein. Methods for preparing compounds of Formula I are also provided, as well as methods of treating cellular proliferati...  
WO/2014/038763A1
The sulfone-based compound of the present invention is characterized by having an activating group for radical polymerization, and an ether-sulfone unit. Preferably, the activating group for radical polymerization can be a compound compr...  
WO/2014/028669A1
The present invention relates to aryl sulfones and related compounds that are modulators of ROR-gamma receptors. The invention also provides pharmaceutical compositions comprising these modulators, and methods of modulating ROR-gamma rec...  
WO/2014/022879A1
The present invention relates to compounds for the treatment of mTOR (mammalian Target Of Rapamycin) pathway related diseases. Specifically, the present invention relates to the use of aminoactonitrile derivatives (AADs) in the treatment...  
WO/2014/023934A1
This invention relates to compounds and uses thereof in the treatment or prophylaxis of diseases associated with inflammation.  
WO/2014/020350A1
Compounds of formula (I) or pharmaceutically acceptable salts, solvates or hydrates thereof wherein P, Q, X, Y, R1, R2, R3, R10, R11, and R12 are as defined in the claims, and the use those compounds in medicine.  
WO/2014/020351A1
N-(4-carbamimidoylphenyl)-amide derivatives having utility in therapy as PAR2 receptor antagonists.  
WO/2014/016507A1
The present invention relates to novel compounds or to any of the salts thereof having the general formula (I), to the pharmaceutical and cosmetic compositions containing said compounds as well as to the use of said compounds and composi...  
WO/2013/191041A1
A fused heterocyclic compound represented by formula (1) has an excellent pest control effect. (In the formula, R1 represents a C1-C6 chain hydrocarbon group which may have one or more atoms or groups selected from group X, or the like; ...  
WO/2013/190482A1
The present invention relates to a compound of formula (I): in which: Rdenotes a hydrogen atom or an acetyl group; and Ydenotes a radical chosen from OR' or NAR''; and their salts, their solvates and their optical isomers, their racemate...  
WO/2013/185116A1
The description is directed to ionizable lipids useful for enhancing the delivery of therapeutic agents in liposomes.  
WO/2013/179153A1
Disclosed are compounds of formula (I) or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. Provided are also pharmaceutical compositions comprising an effective amount...  
WO/2013/178575A1
The present invention relates to compounds of general formula I, (I) wherein the groups R1, R2, R3, m and n are defined as in claim 1, which have valuable pharmacological properties, in particular bind to the GPR40 receptor and modulate ...  
WO/2013/175053A1
Compounds of formula (I), wherein R1 is as defined in the claims, exhibit COMT enzyme inhibiting activity and are thus useful as COMT inhibitors.  
WO/2013/171729A3
The present disclosure is directed to compounds of Formula (I), and pharmaceutically acceptable salts thereof, as modulator of retinoid-related orphan receptor gamma t (RORϒt). These compounds prevent, inhibit, or suppress the action of...  
WO/2013/165140A1
The present invention relates to: a benzyl derivative containing an activated vinyl group; a pharmaceutically acceptable salt thereof; and a pharmaceutical composition containing the compound as an active ingredient. The benzyl derivativ...  
WO/2013/161851A1
The present invention pertains to a benzamide derivative represented by formula (I), or a pharmaceutically acceptable salt thereof.  
WO/2013/161437A1
An organic light-emitting element, in which a compound represented by general formula (1) is contained in a light-emitting layer. The organic light-emitting element has high luminous efficiency. In the general formula, R1 to R10 independ...  
WO/2013/159026A1
This invention relates to novel substituted styryl benzylsulfones that are multikinase inhibitors and pharmaceutically acceptable acid addition salts thereof. The invention also provides compositions comprising a compound of this inventi...  
WO/2013/157229A1
[Problem] The present invention provides an alkylphenylsulphide derivative having excellent pest control effect or a salt thereof, a pest control agent containing the same as an active component and a production intermediate thereof. [So...  
WO/2013/153412A1
The invention relates to a process for the single step conversion of isomeric mixture of dichlorodipheriyi sulfones to chlorobenzene. The invention further relates a process of using dilute sulfuric acid and re-circulating the dilute sul...  
WO/2013/154080A1
The present invention provides: an aryloxyurea compound which can be industrially advantageously synthesized, while having excellent acaricidal activity and/or insecticidal activity and excellent safety, or a salt thereof; and a pest con...  
WO/2013/152170A1
Compounds having therapeutic potential as androgen receptor modulators, and methods of making such compounds, are provided. The compounds are structurally related to bicalutamide but bear at least one difluoromethyl or C2 to C5 perfluoro...  
WO/2013/138863A1
The present invention relates to kinase inhibitors for the treatment of cancer. Specifically, the present invention relates to the use of aminoactonitrile derivatives (AADs) in the treatment of cancer.  
WO/2013/130436A1
The present invention relates to processes for preparing 3-methylsulfonylpropionitrile. The processes provide a good yield and a good purity of the final product and provide a controllable reaction. The present invention also relates to ...  
WO/2013/127841A1
The invention is concerned with the compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, R3 and X are defined in the detailed description and claims. In addition, the present invention relates to method...  

Matches 151 - 200 out of 10,644