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WO/2018/219204A1 |
The present invention relates to a novel phenoxyacetic acid derivative represented by general formula (I), a preparation method for the derivative and uses of drug compositions containing the derivative in drug preparation for treatment ...
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WO/2018/215070A1 |
The present invention pertains to novel dual modulators of farnesoid X receptor (FXR) and soluble epoxide hydrolase (sEH). The modulators of the invention were designed to provide compounds which harbor a dual activity as agonists of FXR...
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WO/2018/215610A1 |
The present invention pertains to novel dual modulators of farnesoid X receptor (FXR) and soluble epoxide hydrolase (sEH). The modulators of the invention were designed to provide compounds which harbor a dual activity as agonists of FXR...
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WO/2018/211896A1 |
The purpose of the present invention is to provide a vinyl sulfone compound and the like which exhibits excellent storage stability when stored long-term in a non-aqueous solvent and, when used in a lithium ion battery, exhibits less dec...
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WO/2018/213813A2 |
The R enantiomer of amisulpride and amisulpride derivative disclosed herein or a pharmaceutical composition thereof may be used for antagonizing serotonin (e.g., 5-HT2a, 5-HT7) receptor in a subject, either individually or in combination...
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WO/2018/210633A1 |
The present invention relates to a method for the production of phenylguanidines or the salts thereof by reacting an aniline that has electronegative substituents with a cyanamide-containing mixture.
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WO/2018/203192A1 |
An alternative and improved process for the preparation of Apremilast (Formula I) and Apremilast form B or a pharmaceutically acceptable salt thereof is provided. The novel process includes hydrogenation in acetone, Cyclization and acety...
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WO/2018/197156A1 |
The present disclosure relates to method of making three-dimensional (3D) objects using an additive manufacturing system wherein the part material comprises a polymeric component comprising a poly(biphenyl ether sulfone) polymer (PPSU) h...
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WO/2018/201000A1 |
Compounds and methods are provided for one-step functionalization of disulfide bonds in proteins.
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WO/2018/189969A1 |
The present invention is a method for distilling a liquid containing dimethylsulfoxide using a distillation apparatus, wherein: (1) assuming the total of the liquid containing dimethylsulfoxide at the bottom of the distillation apparatus...
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WO/2018/188942A1 |
Described herein are pastilles comprising a dicholorodiphenyl sulfone ("DCDPS"), corresponding formation methods and methods of synthesizing poly(aryl ether sulfone)s incorporating the DCDPS pastilles. It was surprisingly discovered that...
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WO/2018/184936A1 |
It is described an industrially viable and advantageous process for the preparation of (S)-beta-aminosulfone (1) starting from the corresponding racemic compound, said (S)-beta-aminosulfone being a useful intermediate for the preparation...
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WO/2018/184933A1 |
It is described an industrially viable and advantageous process for the preparation of racemic beta-aminosulfone (1), an useful intermediate for the preparation of N-(2-((1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)et
hyl)-2,3-dih...
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WO/2018/178860A1 |
The present disclosure relates to a method for the synthesis of mesotrione. The method comprises reacting p-toluene sulfonyl chloride with alkali metal sulphite and alkali metal bicarbonate to obtain p-toluene alkali metal sulfinate. The...
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WO/2018/177865A1 |
The present invention relates to the use of compounds having an anti- heparanase activity of formu la [R - L1- Ar1- L - Ar]2- X, wherein X is selected from the group consisting of SO2, C1 -C4 a lkylene, linear or branched, and wherein Ζ...
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WO/2018/174253A1 |
[Problem] To provide a fluorescent probe with which it is possible to selectively detect GSTP1 activity. [Solution] A nitrobenzene derivative represented by general formula (1) [in the formula, the symbols are defined as in the specifica...
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WO/2018/172503A2 |
A liquid laundry detergent comprising the adduct of a) a vinyl sulfone monomer of formula (I) wherein R is an organic radical with up to 500 carbon atoms and R may comprise heteroatoms selected from O, N or S and b) a saccharide having a...
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WO/2018/165257A1 |
Disclosed are dendritic anionic lipids which are compounds of Formula (I) : wherein R and R1 are non-polar groups, L is a linking moiety, and Dm is a dendritic moiety of m generations, each as defined herein. These dendritic anionic lipi...
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WO/2018/157240A1 |
The disclosure relates to a compound of formula: (I) Several different uses of this compound are described for preparing different compounds. For example, this compound makes it possible to graft a fluorosulfonyl group on a molecule. A m...
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WO/2018/149991A1 |
The present invention relates to particular sulfonamide derivatives, the pharmaceutically acceptable addition salts thereof, the hydrates thereof and/or the solvates thereof, and also the use thereof as inverse agonists of retinoid-relat...
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WO/2018/145653A1 |
The present invention relates to the technical field of chemical medicine and relates to a compound represented by formula (I) or formula (II) and a preparation method therefor, the compound being a biaryl derivative and having retinoid-...
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WO/2018/144869A1 |
Disclosed herein, inter alia, are compositions and methods useful for inhibiting ubiquitin-like modifier activating enzyme 5.
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WO/2018/144870A1 |
Disclosed herein, inter alia, are compositions and methods useful for inhibiting reticulon 4(RTN4).
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WO/2018/143923A1 |
The present disclosure is drawn to an amine synergist including a tertiary benzylamine with a substituted benzene ring attached to a tertiary amine. The tertiary amine can be modified with multiple water soluble groups.
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WO/2018/139607A1 |
[Problem] To provide a complex which contains a tin ion (Sn2+) or a bismuth ion (Bi3+) with a high purity and is suitable for the production of a lead-free perovskite compound. [Solution] A complex which is represented by general formula...
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WO/2018/135373A1 |
The present invention addresses the problem of providing a novel alkoxymethyl-substituted bisphenol compound having exceptional storage stability and exceptional solvent solubility, heat resistance, and optical properties when used as a ...
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WO/2018/104288A1 |
The present application relates to compounds according to (Formula IA) or (Formula IB): (Formula IA) (Formula IB) or a pharmaceutically acceptable salt thereof. The compounds can be used as inhibitors of RORγ and are useful for the trea...
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WO/2018/096066A1 |
This invention is directed at a mechanochemical process using at least one solid catalytically active compound for simulating or capturing the transformation over time of a solid pharmaceutical composition in a shortened time span and th...
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WO/2018/091430A1 |
Compounds of the formula (I), wherein R1, R2, R3, R4 and R5 are as defined in claim 1. Furthermore, the present invention relates to agrochemical compositions which comprise compounds of formula (I), to preparation of these compositions,...
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WO/2018/089402A1 |
There are described RORγ Gamma modulators of the formula (I), (I) or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein all substituents are defined herein. Also provided are pharmaceutic...
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WO/2018/083110A1 |
The invention relates to novel compounds having fluoridated terminal groups, to the use thereof as surface-active substances, and to agents containing said compounds.
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WO/2018/083933A1 |
This secondary battery is provided with a positive electrode, a negative electrode and an electrolyte solution which contains at least one sulfonyl compound selected from among those represented by R1(-O-C(=O)-R2-S(=O)2-Rf1)n1 or the lik...
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WO/2018/071741A1 |
The invention provides sulfoxyalkyl organonitro and related compounds, compositions containing such compounds, and methods for using such compounds and compositions to treat medical disorders, such as a neurodegenerative disorder, autoim...
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WO/2018/070303A1 |
Provided is a resist underlayer film-forming composition which is capable of providing a resist underlayer film, said resist underlayer film exerting a sufficient anti-reflection function particularly in a KrF process, a high solvent res...
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WO/2018/061034A1 |
The present invention relates to a process for the preparation of 1-(3-ethoxy-4-methoxy-phenyl)-2-methylsulfonyl-ethanamine, an intermediate for the preparation of apremilast via a compound of Formula (V) wherein R is (C1-C4)alkyl, (C1-C...
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WO/2018/064559A1 |
The present invention is directed to tablets for oral administration to a subject, comprising a therapeutically effective amount of SYN120 or a pharmaceutically acceptable salt thereof, wherein the tablet is substantially free of lactose...
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WO/2018/054877A1 |
The invention relates to a method for producing bistolanes which are substituted in the 1,1 '-position with halogen and to products from said compounds. The C-C-triple bonds of the bistolanes are produced by elimination reactions.
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WO/2018/048856A1 |
A method of radiolabeling a biomolecule using a microfluidic device includes loading one or more droplets containing a 18F-labeled prosthetic group on or into the microfluidic device and evaporating the droplet(s) containing the 18F-labe...
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WO/2018/047888A1 |
The present invention provides a compound that has an exceptional TLR4 signal-inhibiting action and can be useful as a drug for the prevention or treatment of autoimmune diseases and/or inflammatory diseases or diseases such as chemother...
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WO/2018/016657A1 |
The invention provides a compound of ethyl 6- [ (2-chloro- 4-fluorophenyl)methanesulfonyl] -3-methylcyclohex-1-ene-1- carboxylate. The compound possesses an advantageous combination of TLR4 antagonist properties and brain permeability, a...
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WO/2018/012947A1 |
The present invention relates to a novel organic sulfur compound, a method for preparing the same, and a pharmaceutical composition for preventing or treating cancer or an inflammatory disease, containing the same as an active ingredient...
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WO/2018/007481A1 |
A process for preparing polyaryl ethers in which a polycondensation of the monomer building blocks is carried out using microwave irradiation leads to thermoplastic molding compositions having improved color properties.
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WO/2018/001353A1 |
Provided is a method for preparing apremilast of formula I. Method one: (S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethylamin
e N-acetyl-L-leucine salt of formula II is reacted with 3-acetylaminophthalic anhydride of formula III i...
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WO/2017/219935A1 |
The present invention discloses a biaryl urea RORγt inhibitor, and specifically relates to a biaryl urea derivative, as represented by formula I, with an RORγt inhibiting activity, and a manufacturing method thereof, and a pharmaceutic...
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WO/2017/208501A1 |
Provided are: a surface-modified sodium hypochlorite pentahydrate crystal, an aqueous solution of which has a pH which can be significantly lowered safely and simply and at low cost without performing risky, high-cost pH adjustment that ...
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WO/2017/209762A1 |
Disclosed herein are electrolyte compositions comprising a fluorinated solvent, a fluorinated sulfone, at least one component selected from a borate salt, and/or an oxalate salt, and/or a fluorinated cyclic carbonate, and at least one el...
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WO/2017/199103A1 |
The present disclosure is directed to compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein ring A, R1, R2, R3, R4, R5, n and p are as defined herein, which are active as modulators of retinoid-related orphan re...
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WO/2017/177307A1 |
Compounds having a structure of Formula I or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1, R2, R3, R11a, R11b, R11c, R11d, and X, are as defined herein, are provided. Uses of such compounds for modulat...
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WO/2017/164813A1 |
D The present invention relates to ion pair catalysts (I) comprising the cationic bisguanidinium ligand (A) and diperoxomolybdate anion (B). The present invention also relates to ion pair catalysts (III) comprising the cationic bisguanid...
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WO/2017/162390A1 |
New benzenesulfonyl asymmetric ureas are herein disclosed, corresponding to the general formulas (I) –(IV) and pharmaceutically acceptable salts thereof, whose structure and substituents are detailed in the specification. Procedures fo...
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