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Matches 201 - 250 out of 10,865

Document Document Title
WO/2015/072463A1
In the production of crops in agriculture, horticulture, and the like, damage by destructive insects is still great, and the development of novel agricultural/horticultural insecticides is desired due to the occurrence of destructive ins...  
WO/2015/026990A3
The present disclosure is generally directed to compositions and methods for treating diseases that are ameliorated by the inhibition of CYP26 mediated retinoic acid metabolism. The compositions comprise compounds of formula (I). A repre...  
WO/2015/064584A1
The present invention produces various triarylmethane compounds at a high yield and by means of few steps by means of reacting a diaryl methyl aryl sulfone compound represented by the formula CHAr1Ar2SO2Ar (where Ar1, Ar2, and Ar are sub...  
WO/2015/062103A1
Disclosed are a refining method for 2-nitro-4-methylsulfonyl benzoic acid and an intermediate thereof. The method comprises the following steps of: synthesizing an intermediate organic ammonium salt (III) in an organic solvent using a cr...  
WO/2015/054008A1
The present invention is directed to 4-methylsulfonyl-2-butenenitrile, or a pharmaceutically acceptable salt, an isomer, or isomers thereof. The present invention is also directed to a pharmaceutical composition comprising a pharmaceutic...  
WO/2015/050878A1
The present invention is directed to a pharmaceutical composition comprising a pharmaceutically acceptable carrier and 3-benzylsulfonylpropionitrile, or a pharmaceutically acceptable salt thereof. The present invention is directed to a m...  
WO/2015/051141A1
Methods for preparing fluorinated sulfides and fluorinated sulfones are described. To prepare a fluorinated sulfides, a sulfur-containing reactant represented by the formula: R1SM or M2S, wherein R1 is a C1 to C10 alkyl or fluoroalkyl, S...  
WO/2015/032328A1
The present invention relates to an indane derivative, a preparation method therefor, and a pharmaceutical application thereof. Specifically, the present invention relates to a compound shown in formula (I), or a stereoisomer thereof, an...  
WO/2015/033936A1
The present invention relates to a polyarylene sulfide resin manufacturing method comprising: a process for obtaining a poly(arylene sulfonium salt) having specified constituent units by reacting a sulfoxide represented by general formul...  
WO/2015/006728A3
The present invention relates to methods and reagents for use in site-selective modification of proteins having lysine residues with functionalized peptides using a chemoenzymatic microbial transglutaminase-mediated reaction. The functio...  
WO/2015/028938A1
The invention relates to naphthalene compounds of Formula (I) and their pharmaceutically acceptable salts, wherein the substituents are as described herein, and their use in medicine for the treatment of diseases, disorders associated wi...  
WO/2015/025960A1
Provided are: a compound having high activity against harmful organisms; a harmful organism control agent comprising the compound; and a method for controlling harmful organisms by applying the compound. A phenoxyalkylbenzamide-type comp...  
WO/2015/025826A1
The purpose of the present invention is to provide: a novel substituted phenyl ether compound which has a control effect against pests; and a pest control agent which contains this substituted phenyl ether compound as an active ingredien...  
WO/2015/022631A1
The invention relates to compounds of Formula (I) and their pharmaceutically acceptable salts, wherein the substituents are as described herein, and their use in medicine for the treatment of diseases, disorders associated with the modul...  
WO/2015/010655A1
Triadic fused cyclic carboxylic acids derivatives, preparation method therefor and pharmaceutical use thereof, particularly relating to compounds represented by general formula (I), stereoisomers, hydrates, solvates, metabolites, eutecti...  
WO/2015/013187A1
The present invention relates to hydroxamate compounds and pharmaceutical compositions that are useful for treating and/or preventing metabolic inflammation mediated diseases such as diabetes, obesity, hypertension, dyslipidemia, a neuro...  
WO/2015/011334A1
The invention relates to the use of compounds comprising a molecule of lipid origin and a vinyl sulfone group as an immunological adjuvant. The lipid molecule binds to an antigen in order to form a lipopeptide that acts as a vaccine. The...  
WO/2003/063762A3
The present invention discloses a process for the synthesis of reverse hydroxamate matrix metalloproteinase (MMP) inhibitors.  
WO/2014/205091A1
The use of Michael addition curing chemistries in compositions comprising sulfur-containing polymers such as polythioethers and polysulfides useful in aerospace sealant applications are disclosed. Sulfur-containing adducts comprising ter...  
WO/2014/147182A3
The present invention relates to substituted N-biphenyl-3-acetylamino-benzamides and N-[3-(acetylamino)phenyl]-biphenyl-carboxamides of general formula (I) as described and defined herein, to methods of preparing said compounds, to inter...  
WO/2014/138518A3
Disclosed herein are bisarylmethylthioacetamides and bisarylmethylthioethylamines useful as inhibitors of monoamine transporters. The compounds are potent and/or selective inhibitors of dopamine (DA), serotonin (5-HT), and/or norepinephr...  
WO/2014/178309A1
 The present invention provides a method for purifying dimethyl sulfoxide economically and at good yield so as to satisfy the specifications of the United States Pharmacopoeia and reduce odor. The method is characterized in that a solu...  
WO/2014/178389A1
Provided is a new compound having glycogen synthase activation potency, high muscular transition, minimal activation of receptor PPAR, and a high degree of safety. Provided is a compound represented by the following general formula, or a...  
WO/2014/175187A1
Provided is a method for preparing, in an economical manner and with favorable yield, a dimethylsulfoxide having a reduction in malodor and satisfying the stipulations of the United States Pharmacopoeia. The present invention is characte...  
WO/2014/134005A3
Methods of preparing carbamate prodrugs of amine-containing drugs are provided. Carbonates useful in the synthesis of the carbamate prodrugs are also provided.  
WO/2014/168297A1
A sulfone-based compound of the present invention is characterized by being represented by chemical formula 1 in the specification. The sulfone-based compound has a hydrocarbon core and an ether sulfone unit, wherein the properties of th...  
WO/2014/113700A9
The present disclosure provides nitroxyl donating pharmaceutical compositions comprising N-substituted hydroxylamine derivatives. The compositions are highly efficacious in treating cardiovascular diseases (e.g., heart failure), have a s...  
WO/2014/144669A2
Machines, apparatuses, systems and methods for providing adjustable tension to a cable system using a pivotally mounted leverage mechanism that employs an adjustably positionable weight. Embodiments are used in exercise and other muscle ...  
WO/2014/138720A1
A thio-selective radioactive labeling agent has the following general formula: *R-L-VS, wherein said *R is a radioisotope, L is a linking group, and VS is a vinylsulfone functional group, wherein said labeling agent is capable of covalen...  
WO/2014/138518A2
Disclosed herein are bisarylmethylthioacetamides and bisarylmethylthioethylamines useful as inhibitors of monoamine transporters. The compounds are potent and/or selective inhibitors of dopamine (DA), serotonin (5-HT), and/or norepinephr...  
WO/2014/129971A1
The present invention is compositions and methods of synthesis of polyamide single-ion conducting polymer electrolytes and polyamide single-ion conducting polymer electrolyte composite films. In additional embodiments, the invention also...  
WO/2014/124234A1
The present invention relates to alkene derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.  
WO/2014/112646A1
The present invention addresses the problem of providing a compound having a selective inhibitory activity on LAT-1 that can be expressed in a tumor cell at a high level. The present invention provides: a compound represented by formula ...  
WO/2014/113700A1
The present disclosure provides nitroxyl donating pharmaceutical compositions comprising N-substituted hydroxylamine derivatives. The compositions are highly efficacious in treating cardiovascular diseases (e.g., heart failure), have a s...  
WO/2014/113696A1
The disclosed subject matter provides N-substituted hydroxylamine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, th...  
WO/2014/104400A1
Provided is an actinic-ray- or radiation-sensitive resin composition including a resin (A) and any of compounds (B) of general formula (I) below. (In general formula (I), Rf represents a fluorine atom or a monovalent organic group contai...  
WO/2014/095103A1
The invention relates to an ester having at least one sulphonic group on the acid chain, a method for the production thereof and the use of the ester as a plasticizer for polymers.  
WO/2014/097881A1
[Problem] The purpose of the present invention is to provide a thermal recording body that has both excellent color development performance and thermal discoloration resistance in blank sections, and that offers excellent barcode readabi...  
WO/2014/058330A3
Process for preparation of MK-7 type of vitamin K2 is characterized by attaching hexaprenyl chain of „all-trans" configuration to monoprenyl derivative of menadiol following „1 + 6" synthetic strategy. According to the invention, a-s...  
WO/2014/082581A1
Disclosed is an α-(3, 5-dimethoxy benzylidene)-α'-hydrocarbyl methylene cyclic ketone, having a structure as represented by (I) or (II), wherein R is an aryl or alkyl; a preparation method is: mixing cyclic ketone and morpholine, and a...  
WO/2014/080251A1
Cell binding agent-drug conjugates comprising hydrophilic linkers, and methods of using such linkers and conjugates are provided.  
WO/2014/075754A1
Compounds of the formula (I) in which R1, R4, R, X1, X2, X3, X4, q and W have the meanings indicated in Claim 1, are inhibitors of fatty acid synthase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardio...  
WO/2014/074778A1
The present invention relates to the antimalarial compounds of formula (l)and their use against protozoa of the genus Plasmodium, including drug-resistant Plasmodia strains. This invention further relates to compositions containing such ...  
WO/2014/067235A1
Provided is a dimethylsulfoxide preparation method, the method comprising the following steps: 1) bringing hydrogen sulfide in contact with methanol to obtain a mixture containing dimethyl sulfide, and separating the dimethyl sulfide fro...  
WO/2014/062044A1
Invention is related to novel compounds - fluorinated benzenesulfonamides of general formula (I). The compounds can be used in biomedicine as active ingredients in pharmaceutical formulations, because they inhibit enzymes which participa...  
WO/2014/048958A1
The present invention relates to a method for the preparation of optionally substituted aryl and pyridyl pyrrolidines which are useful intermediates for the preparation of certain biologically active compounds.  
WO/2014/050814A1
[Problem] To provide a method for producing a compound having a bis(trifluoroalkanesulfonyl)methyl group, which is a compound having a high acidity degree and hydrophobicity and useful as a raw material compound for a resin, and a salt t...  
WO/2014/047110A2
Compounds according to Formula I are provided: and salts thereof, wherein Q1, Q2, R3, R4, X, and Y are as defined herein. Methods for preparing compounds of Formula I are also provided, as well as methods of treating cellular proliferati...  
WO/2014/038763A1
The sulfone-based compound of the present invention is characterized by having an activating group for radical polymerization, and an ether-sulfone unit. Preferably, the activating group for radical polymerization can be a compound compr...  
WO/2014/028669A1
The present invention relates to aryl sulfones and related compounds that are modulators of ROR-gamma receptors. The invention also provides pharmaceutical compositions comprising these modulators, and methods of modulating ROR-gamma rec...  

Matches 201 - 250 out of 10,865