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Matches 251 - 300 out of 10,857

Document Document Title
WO/2014/022879A1
The present invention relates to compounds for the treatment of mTOR (mammalian Target Of Rapamycin) pathway related diseases. Specifically, the present invention relates to the use of aminoactonitrile derivatives (AADs) in the treatment...  
WO/2014/023934A1
This invention relates to compounds and uses thereof in the treatment or prophylaxis of diseases associated with inflammation.  
WO/2014/020350A1
Compounds of formula (I) or pharmaceutically acceptable salts, solvates or hydrates thereof wherein P, Q, X, Y, R1, R2, R3, R10, R11, and R12 are as defined in the claims, and the use those compounds in medicine.  
WO/2013/171729A3
The present disclosure is directed to compounds of Formula (I), and pharmaceutically acceptable salts thereof, as modulator of retinoid-related orphan receptor gamma t (RORϒt). These compounds prevent, inhibit, or suppress the action of...  
WO/2014/020351A1
N-(4-carbamimidoylphenyl)-amide derivatives having utility in therapy as PAR2 receptor antagonists.  
WO/2014/016507A1
The present invention relates to novel compounds or to any of the salts thereof having the general formula (I), to the pharmaceutical and cosmetic compositions containing said compounds as well as to the use of said compounds and composi...  
WO/2013/191041A1
A fused heterocyclic compound represented by formula (1) has an excellent pest control effect. (In the formula, R1 represents a C1-C6 chain hydrocarbon group which may have one or more atoms or groups selected from group X, or the like; ...  
WO/2013/190482A1
The present invention relates to a compound of formula (I): in which: Rdenotes a hydrogen atom or an acetyl group; and Ydenotes a radical chosen from OR' or NAR''; and their salts, their solvates and their optical isomers, their racemate...  
WO/2013/185116A1
The description is directed to ionizable lipids useful for enhancing the delivery of therapeutic agents in liposomes.  
WO/2013/179153A1
Disclosed are compounds of formula (I) or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. Provided are also pharmaceutical compositions comprising an effective amount...  
WO/2013/178575A1
The present invention relates to compounds of general formula I, (I) wherein the groups R1, R2, R3, m and n are defined as in claim 1, which have valuable pharmacological properties, in particular bind to the GPR40 receptor and modulate ...  
WO/2013/175053A1
Compounds of formula (I), wherein R1 is as defined in the claims, exhibit COMT enzyme inhibiting activity and are thus useful as COMT inhibitors.  
WO/2013/165140A1
The present invention relates to: a benzyl derivative containing an activated vinyl group; a pharmaceutically acceptable salt thereof; and a pharmaceutical composition containing the compound as an active ingredient. The benzyl derivativ...  
WO/2013/161851A1
The present invention pertains to a benzamide derivative represented by formula (I), or a pharmaceutically acceptable salt thereof.  
WO/2013/161437A1
An organic light-emitting element, in which a compound represented by general formula (1) is contained in a light-emitting layer. The organic light-emitting element has high luminous efficiency. In the general formula, R1 to R10 independ...  
WO/2013/126360A3
Provided herein are new processes for the preparation of aminosulfone intermediates for the synthesis of 2-[l-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4- acetylaminoisoindoline-l,3-dione, which is useful for preventing or treati...  
WO/2013/126495A3
Processes for synthesizing aminosulfone compounds are provided. Aminosulfone compounds obtained using methods provided herein are useful in production or synthesis of sulfone group containing isoindoline based compounds.  
WO/2013/159026A1
This invention relates to novel substituted styryl benzylsulfones that are multikinase inhibitors and pharmaceutically acceptable acid addition salts thereof. The invention also provides compositions comprising a compound of this inventi...  
WO/2013/157229A1
[Problem] The present invention provides an alkylphenylsulphide derivative having excellent pest control effect or a salt thereof, a pest control agent containing the same as an active component and a production intermediate thereof. [So...  
WO/2013/153412A1
The invention relates to a process for the single step conversion of isomeric mixture of dichlorodipheriyi sulfones to chlorobenzene. The invention further relates a process of using dilute sulfuric acid and re-circulating the dilute sul...  
WO/2013/154080A1
The present invention provides: an aryloxyurea compound which can be industrially advantageously synthesized, while having excellent acaricidal activity and/or insecticidal activity and excellent safety, or a salt thereof; and a pest con...  
WO/2013/152170A1
Compounds having therapeutic potential as androgen receptor modulators, and methods of making such compounds, are provided. The compounds are structurally related to bicalutamide but bear at least one difluoromethyl or C2 to C5 perfluoro...  
WO/2013/138863A1
The present invention relates to kinase inhibitors for the treatment of cancer. Specifically, the present invention relates to the use of aminoactonitrile derivatives (AADs) in the treatment of cancer.  
WO/2013/130436A1
The present invention relates to processes for preparing 3-methylsulfonylpropionitrile. The processes provide a good yield and a good purity of the final product and provide a controllable reaction. The present invention also relates to ...  
WO/2013/127841A1
The invention is concerned with the compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, R3 and X are defined in the detailed description and claims. In addition, the present invention relates to method...  
WO/2013/126438A1
The present invention relates to novel thiobenzyl and sulfinylbenzyl derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.  
WO/2013/122028A1
The purpose of the present invention is to provide an aromatic ring compound exhibiting GPR40 agonist activity. The compound represented by formula (I) (refer to the description for information pertaining to each symbol in the formula) o...  
WO/2013/114987A1
The purpose of the present invention is to provide a method of consistently producing high-quality diallylbisphenols with high yields from bisphenols. This method involves steps (1) through (3) below, and enables the consistent productio...  
WO/2013/111864A1
Provided is a novel pest control agent. A compound represented by formula (I) or a salt thereof and a pest control agent comprising the same as the active ingredient. In formula (I): R1 and R2 independently represent a hydrogen atom, a h...  
WO/2013/104829A1
The invention relates to novel arylamide derivatives having formula (I), and stereoisomers and pharmaceutically acceptable salts thereof, where RA, RB, RC, R', R'', z and X are as defined in the claims. The arylamide derivatives of formu...  
WO/2013/104831A1
The invention relates to novel arylamide derivatives having formula (I) and stereoisomers and pharmaceutically acceptable salts thereof, where R2, R8, R9 and R11 are as defined in the claims. The arylamide derivatives of formula (I) have...  
WO/2013/104604A1
The invention relates to chiral imidodiphosphates and derivatives thereof having the general formula I, The compounds are suitable as chiral Brønsted acid catalysts, phase-transfer catalysts, chiral anions for organic salts, metal salts...  
WO/2013/104605A2
The present invention relates to a process for the asymmetric oxidation of nucleophilic organic compounds, particularly metal-free, with peroxide compounds in the presence of a chiral Bronsted acid catalyst. In one detail, the present in...  
WO/2013/103598A2
The present invention provides sulfoxide compounds comprising hydrophobic ester or amide moieties such that the compounds have surfactant properties. Also provided are methods for using the sulfoxide compounds or mixtures of the sulfoxid...  
WO/2013/092350A1
The present invention relates to novel N-arylamidine-substituted trifluoroethyl sulfide derivatives of the formula (I) in which X1, X2, X3, X4, R1, R2, R3, n are each defined as specified in the description, to the use thereof as acarici...  
WO/2013/083568A1
The invention relates to selective estrogen receptor modulators (SERMs), to methods for the production thereof, to the use thereof to treat and/or prevent diseases, and to the use thereof to produce drugs for the treatment and/or prevent...  
WO/2013/083488A1
A sulphur-comprising, fluorinated and sulphonated aromatic alkane monomer which can be used for the manufacture of a polymer membrane intended, for example, for a PEM (Polymer Electrolyte Membrane) fuel cell, said functionalized monomer ...  
WO/2012/031196A9
The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An embodiment of the invention is the provision of a compound of Formula IIIA.  
WO/2012/176856A3
The present invention provides a compound represented by the formula (I) or its salt, and a pesticide containing it as an active ingredient: (I) wherein each of R1 and R2 is a hydrogen atom, a halogen atom, alkyl, haloalkyl, alkoxy, halo...  
WO/2013/081031A1
Provided is an organic electronic material that can produce an organic electronic element that is capable of stable long-term driving and a reduction in driving voltage and that, when caused to be an ink composition, has superior low-tem...  
WO/2013/081052A1
Provided are: an organic electronics material that can, at a high yield, produce an organic electronics element that is capable of stable long-term driving and reduced driving voltage and that, when caused to be an ink composition, has s...  
WO/2013/067163A1
In one aspect, the invention relates to compounds having the formula: (I) where R1-R6, a, b, and Z are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. I...  
WO/2013/060653A1
This invention relates to novel 1-cycloalkyl- or l-heterocyclyl-hydroxyimino-3-phen propanes of the formula wherein R1 to R7 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These...  
WO/2012/137982A3
Provided is a compound having an AMPA receptor function enhancing action, and useful as a prophylactic or therapeutic drug for depression, Alzheimer's disease, schizophrenia, attention deficit hyperactivity disorder (ADHD) and the like. ...  
WO/2013/012665A3
Embodiment of the present disclosure can include a compound, a structure bonded to the compound, and the like. In an embodiment, the compound can be a linker between an agent and a structure, where the agent can be a dye or a pigment and...  
WO/2013/030205A1
The present application disclosed compounds of Formula I wherein variables R1 and R2 are defined as described herein, which are inhibitors of PARP and provides compounds and compositions containing the compounds of Formula I. The present...  
WO/2013/029338A1
Disclosed are novel retinoid-related orphan receptor gamma (RORy) modulators and their use in the treatment of diseases mediated by RORy.  
WO/2013/022919A1
A method for treating a p62-mediated disease (e.g., multiple myeloma) in a subject, the method comprising administering to the subject a therapeutically effective amount of at least one p62-ZZ inhibitor compound.  
WO/2013/012665A2
Embodiment of the present disclosure can include a compound, a structure bonded to the compound, and the like. In an embodiment, the compound can be a linker between an agent and a structure, where the agent can be a dye or a pigment and...  
WO/2013/010102A2
The present invention provides compositions and methods for the administration and targeted delivery, release and/or formation of a drug compound from a halogenated phenol starting compound of the present invention at site(s) within the ...  

Matches 251 - 300 out of 10,857