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Matches 1 - 50 out of 10,761

Document Document Title
WO/2018/234232A1
The present invention relates to new biphenylsulfoximine compounds and, in particular, to their activity as positive allosteric modulators of the dopamine D1 receptor and to their use for the treatment of pathological states for which a ...  
WO/2018/234957A1
The invention provides mesotrione copper chelate form I and mesotrione copper chelate form II. A process for preparing mesotrione copper chelate form I and mesotrione copper chelate form II is also disclosed. Further, the present inventi...  
WO/2018/228079A1
The present invention discloses a fluorescent probe for detecting a sulfenated protein, having the following structural general formula (I). The fluorescent probe has good stability and can be preserved for long-term use. The fluorescent...  
WO/2018/229083A1
The present invention relates to compounds, in particular those of formula (I) and formula (II) described herein, or pharmaceutically acceptable salts or solvates thereof, which may be used as radioligands in in vitro, ex vivo and in viv...  
WO/2018/228857A1
The invention relates to novel laser markable compositions comprising developing agent precursors according to formula (I).  
WO/2018/227053A1
The disclosure is directed to compounds and methods for preparing purified macrocyclic peptide using "catch-release" methods. These methods comprise reacting a free amino group of a resin-bound linear peptide with an azide- or alkyne-fun...  
WO/2018/218281A1
A process for inhibiting the formation of gas hydrates in a hydrocarbon fluid comprising adding to the hydrocarbon fluid, a gas hydrate anti-agglomerate which is a biodegradable anti-agglomerant derived from a naturally occurring substance.  
WO/2018/219204A1
The present invention relates to a novel phenoxyacetic acid derivative represented by general formula (I), a preparation method for the derivative and uses of drug compositions containing the derivative in drug preparation for treatment ...  
WO/2018/215070A1
The present invention pertains to novel dual modulators of farnesoid X receptor (FXR) and soluble epoxide hydrolase (sEH). The modulators of the invention were designed to provide compounds which harbor a dual activity as agonists of FXR...  
WO/2018/215610A1
The present invention pertains to novel dual modulators of farnesoid X receptor (FXR) and soluble epoxide hydrolase (sEH). The modulators of the invention were designed to provide compounds which harbor a dual activity as agonists of FXR...  
WO/2018/211896A1
The purpose of the present invention is to provide a vinyl sulfone compound and the like which exhibits excellent storage stability when stored long-term in a non-aqueous solvent and, when used in a lithium ion battery, exhibits less dec...  
WO/2018/213813A2
The R enantiomer of amisulpride and amisulpride derivative disclosed herein or a pharmaceutical composition thereof may be used for antagonizing serotonin (e.g., 5-HT2a, 5-HT7) receptor in a subject, either individually or in combination...  
WO/2018/210633A1
The present invention relates to a method for the production of phenylguanidines or the salts thereof by reacting an aniline that has electronegative substituents with a cyanamide-containing mixture.  
WO/2018/203192A1
An alternative and improved process for the preparation of Apremilast (Formula I) and Apremilast form B or a pharmaceutically acceptable salt thereof is provided. The novel process includes hydrogenation in acetone, Cyclization and acety...  
WO/2018/197156A1
The present disclosure relates to method of making three-dimensional (3D) objects using an additive manufacturing system wherein the part material comprises a polymeric component comprising a poly(biphenyl ether sulfone) polymer (PPSU) h...  
WO/2018/201000A1
Compounds and methods are provided for one-step functionalization of disulfide bonds in proteins.  
WO/2018/189969A1
The present invention is a method for distilling a liquid containing dimethylsulfoxide using a distillation apparatus, wherein: (1) assuming the total of the liquid containing dimethylsulfoxide at the bottom of the distillation apparatus...  
WO/2018/188942A1
Described herein are pastilles comprising a dicholorodiphenyl sulfone ("DCDPS"), corresponding formation methods and methods of synthesizing poly(aryl ether sulfone)s incorporating the DCDPS pastilles. It was surprisingly discovered that...  
WO/2018/184936A1
It is described an industrially viable and advantageous process for the preparation of (S)-beta-aminosulfone (1) starting from the corresponding racemic compound, said (S)-beta-aminosulfone being a useful intermediate for the preparation...  
WO/2018/184933A1
It is described an industrially viable and advantageous process for the preparation of racemic beta-aminosulfone (1), an useful intermediate for the preparation of N-(2-((1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)et hyl)-2,3-dih...  
WO/2018/178860A1
The present disclosure relates to a method for the synthesis of mesotrione. The method comprises reacting p-toluene sulfonyl chloride with alkali metal sulphite and alkali metal bicarbonate to obtain p-toluene alkali metal sulfinate. The...  
WO/2018/177865A1
The present invention relates to the use of compounds having an anti- heparanase activity of formu la [R - L1- Ar1- L - Ar]2- X, wherein X is selected from the group consisting of SO2, C1 -C4 a lkylene, linear or branched, and wherein Ζ...  
WO/2018/174253A1
[Problem] To provide a fluorescent probe with which it is possible to selectively detect GSTP1 activity. [Solution] A nitrobenzene derivative represented by general formula (1) [in the formula, the symbols are defined as in the specifica...  
WO/2018/172503A2
A liquid laundry detergent comprising the adduct of a) a vinyl sulfone monomer of formula (I) wherein R is an organic radical with up to 500 carbon atoms and R may comprise heteroatoms selected from O, N or S and b) a saccharide having a...  
WO/2018/165257A1
Disclosed are dendritic anionic lipids which are compounds of Formula (I) : wherein R and R1 are non-polar groups, L is a linking moiety, and Dm is a dendritic moiety of m generations, each as defined herein. These dendritic anionic lipi...  
WO/2018/157240A1
The disclosure relates to a compound of formula: (I) Several different uses of this compound are described for preparing different compounds. For example, this compound makes it possible to graft a fluorosulfonyl group on a molecule. A m...  
WO/2018/149991A1
The present invention relates to particular sulfonamide derivatives, the pharmaceutically acceptable addition salts thereof, the hydrates thereof and/or the solvates thereof, and also the use thereof as inverse agonists of retinoid-relat...  
WO/2018/145653A1
The present invention relates to the technical field of chemical medicine and relates to a compound represented by formula (I) or formula (II) and a preparation method therefor, the compound being a biaryl derivative and having retinoid-...  
WO/2018/144869A1
Disclosed herein, inter alia, are compositions and methods useful for inhibiting ubiquitin-like modifier activating enzyme 5.  
WO/2018/144870A1
Disclosed herein, inter alia, are compositions and methods useful for inhibiting reticulon 4(RTN4).  
WO/2018/143923A1
The present disclosure is drawn to an amine synergist including a tertiary benzylamine with a substituted benzene ring attached to a tertiary amine. The tertiary amine can be modified with multiple water soluble groups.  
WO/2018/139607A1
[Problem] To provide a complex which contains a tin ion (Sn2+) or a bismuth ion (Bi3+) with a high purity and is suitable for the production of a lead-free perovskite compound. [Solution] A complex which is represented by general formula...  
WO/2018/135373A1
The present invention addresses the problem of providing a novel alkoxymethyl-substituted bisphenol compound having exceptional storage stability and exceptional solvent solubility, heat resistance, and optical properties when used as a ...  
WO/2018/104288A1
The present application relates to compounds according to (Formula IA) or (Formula IB): (Formula IA) (Formula IB) or a pharmaceutically acceptable salt thereof. The compounds can be used as inhibitors of RORγ and are useful for the trea...  
WO/2018/096066A1
This invention is directed at a mechanochemical process using at least one solid catalytically active compound for simulating or capturing the transformation over time of a solid pharmaceutical composition in a shortened time span and th...  
WO/2018/091430A1
Compounds of the formula (I), wherein R1, R2, R3, R4 and R5 are as defined in claim 1. Furthermore, the present invention relates to agrochemical compositions which comprise compounds of formula (I), to preparation of these compositions,...  
WO/2018/089402A1
There are described RORγ Gamma modulators of the formula (I), (I) or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein all substituents are defined herein. Also provided are pharmaceutic...  
WO/2018/083110A1
The invention relates to novel compounds having fluoridated terminal groups, to the use thereof as surface-active substances, and to agents containing said compounds.  
WO/2018/083933A1
This secondary battery is provided with a positive electrode, a negative electrode and an electrolyte solution which contains at least one sulfonyl compound selected from among those represented by R1(-O-C(=O)-R2-S(=O)2-Rf1)n1 or the lik...  
WO/2018/071741A1
The invention provides sulfoxyalkyl organonitro and related compounds, compositions containing such compounds, and methods for using such compounds and compositions to treat medical disorders, such as a neurodegenerative disorder, autoim...  
WO/2018/070303A1
Provided is a resist underlayer film-forming composition which is capable of providing a resist underlayer film, said resist underlayer film exerting a sufficient anti-reflection function particularly in a KrF process, a high solvent res...  
WO/2018/061034A1
The present invention relates to a process for the preparation of 1-(3-ethoxy-4-methoxy-phenyl)-2-methylsulfonyl-ethanamine, an intermediate for the preparation of apremilast via a compound of Formula (V) wherein R is (C1-C4)alkyl, (C1-C...  
WO/2018/064559A1
The present invention is directed to tablets for oral administration to a subject, comprising a therapeutically effective amount of SYN120 or a pharmaceutically acceptable salt thereof, wherein the tablet is substantially free of lactose...  
WO/2018/054877A1
The invention relates to a method for producing bistolanes which are substituted in the 1,1 '-position with halogen and to products from said compounds. The C-C-triple bonds of the bistolanes are produced by elimination reactions.  
WO/2018/048856A1
A method of radiolabeling a biomolecule using a microfluidic device includes loading one or more droplets containing a 18F-labeled prosthetic group on or into the microfluidic device and evaporating the droplet(s) containing the 18F-labe...  
WO/2018/047888A1
The present invention provides a compound that has an exceptional TLR4 signal-inhibiting action and can be useful as a drug for the prevention or treatment of autoimmune diseases and/or inflammatory diseases or diseases such as chemother...  
WO/2018/016657A1
The invention provides a compound of ethyl 6- [ (2-chloro- 4-fluorophenyl)methanesulfonyl] -3-methylcyclohex-1-ene-1- carboxylate. The compound possesses an advantageous combination of TLR4 antagonist properties and brain permeability, a...  
WO/2018/012947A1
The present invention relates to a novel organic sulfur compound, a method for preparing the same, and a pharmaceutical composition for preventing or treating cancer or an inflammatory disease, containing the same as an active ingredient...  
WO/2018/007481A1
A process for preparing polyaryl ethers in which a polycondensation of the monomer building blocks is carried out using microwave irradiation leads to thermoplastic molding compositions having improved color properties.  
WO/2018/001353A1
Provided is a method for preparing apremilast of formula I. Method one: (S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethylamin e N-acetyl-L-leucine salt of formula II is reacted with 3-acetylaminophthalic anhydride of formula III i...  

Matches 1 - 50 out of 10,761