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WO/1996/019448A1 |
A process for producing a bis(4-alkylthiophenyl) disulfide comprising: (a) directly reducing a 4-alkylthiobenzenesulfonyl chloride or (b) reducing a 4-alkylthiobenzenesulfonyl chloride and oxidizing the obtained 4-alkylthiobenzenethiol, ...
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WO/1996/016034A1 |
A process for producing an aromatic or heteroaromatic thiol represented by the following general formula (2): Ar-(-SH)n by hydrolyzing an aromatic or heteroaromatic halomethyl sulfide represented by the following general formula (1): Ar-...
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WO/1996/006144A1 |
Low-molecular or polymer organic compounds available in a column-shaped helical phase with liquid crystal properties are useful as photoconductors or in electronic components. Also disclosed are photoconductive layers containing the same...
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WO/1996/004297A1 |
The present invention is directed to the process of preparing a peptide comprising reacting a first amino acid or peptide with an amino acid fluoride of formula (I) or the acid fluoride salts thereof wherein BLK is an N-amino protecting ...
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WO/1995/029925A1 |
A compound consisting essentially of a multidentade ligand including at least two thioether groups for being complexed to Rhodium-105 in specific activities that are sufficiently high for use in formulating therapeutic 105Rh-radiopharmac...
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WO/1995/027696A1 |
Described are preferred processes which produce methyl mercaptan from methyl bromide and aqueous mediums of metal hydrosulfide. The processes can be used to simultaneously consume methyl bromide byproduct and aqueous NaSH byproduct while...
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WO/1995/025089A1 |
A process for producing an alkali metal salt of an arylmercaptan compound represented by general formula (3), by the reaction of a disulfide compound represented by general formula (1) with a hydroxide of an alkali metal M1 in the presen...
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WO/1995/014011A2 |
The present invention relates to novel 5,6-dihydropyrone derivatives and related structures which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The 5,6-dihydropyrone derivatives are useful in the development of the...
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WO/1995/009564A1 |
The present invention provides methods and compositions for improved magnetic resonance imaging and spectroscopy. The compositions are of the general formula: Cn-Lx-Gy, wherein n is about 60 to about 1,000; L is a bifunctional linker; x ...
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WO/1995/005375A1 |
Compounds of formula (I) and pharmaceutically acceptable salts thereof, where R is CO2R12 and R12 is H or a biolabile ester-forming group or R is tetrazol-5-yl and either (a) R1 is (Ia) and R2 is F, Cl, Br, I, CH3 or CF3 or (b) R1 is C3-...
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WO/1994/029262A1 |
Compounds having the active site of natural lipoxins, but a longer tissue half-life are disclosed. These small molecules are useful for treating vasoconstrictive, inflammatory, myeloid suppressive, cardiovascular, and gastrointestinal di...
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WO/1994/029253A1 |
A method for preparing difunctional compounds, e.g. diols, having high enantiomeric purity (compound If) from alpha-hydroxycarboxylic acid esters (compound Id) in an anhydrous medium by a) reducing compound (Id) into compound (If) in an ...
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WO/1994/026704A1 |
Compounds of formula (I) and pharmaceutically acceptable salts thereof in which m is 0, 1 or 2; n is 2, 3, 4 or 5; X is carbonyl or a group of formula (II) in which R5 is H or alkyl; Y is an alkylene chain optionally substituted by one o...
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WO/1994/022845A1 |
A benzothiazole compound represented by general formula (I) and a pharmaceutically acceptable salt thereof wherein, R1 represents halogen; R2 and R3 represent each independently hydrogen or halogen; R4 represents hydrogen, halogen, lower...
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WO/1994/015927A1 |
Catalytic oxidation of thiols or thiol salts or dithiocarbamic acids or their salts using oxygen, optionally in the presence of a primary or secondary amine, is accomplished with a carbon catalyst which contains no metal complex of porph...
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WO/1994/012910A1 |
Compounds having non-linear optical activity of general formula (I), wherein D and A are electron donor and acceptor groups, respectively, R1 and R2 are aromatic bridging groups, X and Y are preferably groups capable of partaking in poly...
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WO/1994/012450A1 |
The invention relates to a method of preparing sulfur-containing compounds, comprising reacting a sulfur compound with a compound containing unsaturated carbon-carbon bonds, wherein in a solvent one or more compounds containing non-activ...
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WO/1994/008978A1 |
Compounds having the structural formula (I), wherein R can be the same or different and is halogen, hydrogen, C1-C8 alkyl, C1-C8 haloalkyl, C3-C6 cycloalkyl, C7-C9 aralkyl, phenyl, nitro, C1-C6 alkoxy, C1-C6 alkylthio, C1-C6 alkylsulfiny...
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WO/1994/003149A2 |
Aging of the human skin is caused primarily by the biochemical action of free radicals, peroxides and derived products. Lipid-soluble thioethers and dithioethers in cosmetic preparations inactivate the peroxides formed in the skin and th...
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WO/1994/002456A1 |
Hydroxyphenylthioalkyl amines represented by formula (I), wherein R1 is H or C1-C8 alkyl; R2 is H or C1-C8 alkyl; R3 is H, C1-C8 alkyl or C1-C8 alkanoyl; R4 is H or C1-C8 alkanoyl; Ra is a radioactive material useful in radioimaging and/...
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WO/1994/002465A1 |
This invention is directed to the pharmaceutical use of phenyl compounds, which are linked to an aryl moiety by various linkages, for inhibiting tumor necrosis factor. The invention is also directed to the compounds, their preparation an...
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WO/1994/000426A1 |
A method for preparing organic compounds or polymers containing one or more sulphur atoms and having one or more double bonds in a hydrocarbon chain. An acyclic olefin or a cyclic unsaturated hydrocarbon, containing sulphur, is metathesi...
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WO/1994/000423A1 |
A process is disclosed for preparing compounds having general formula (I) by cross-coupling boric acids, borine acids or boric anhydrides derived therefrom having general formula (II), in which x1, x2, x3 and x4 represent independently f...
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WO/1993/025530A2 |
A process and pharmaceutical compositions for treating several diseases and conditions which are normally treatable with retinoid-like compounds are disclosed where the compounds used for the treatment are substantially non-teratogenic a...
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WO/1993/023371A1 |
A method and composition for decreasing the viscosity of mercaptan terminated polymers. The method involves adding thiol terminated trithio-orthoformate polycondensates to the mercaptan terminated polymer to achieve desired decreases in ...
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WO/1993/023369A1 |
Disclosed is a process for preparation of an aromatic thiol corresponding to the structure A-(SH)n wherein A is a substituted or unsubstituted aromatic radical and n is 1, 2, 3, 4, 5 or 6 comprising contacting at a temperature of at leas...
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WO/1993/019033A1 |
Processes for preparing 2-substituted benzaldehydes of general formula (I), wherein: R1 is CH2CH2-(L1)p-(CH2)q-(L2)r-CH2-(T)s-Z; L1 and L2 are independently CH2CH2, CH=CH or C=C; q is 0 to 8; p, r and s are independently 0 or 1; T is O, ...
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WO/1993/016037A1 |
There are provided compounds of formula (1) wherein R1 is a substituted or unsubstituted divalent aliphatic group of 1 to 16 carbon atoms; wherein the substituents are mono or poly and are selected from the group consisting of lower alky...
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WO/1993/015046A1 |
Carbamate having the formula (I), its plant-compatible acid addition and basic addition products, and fungicides containing the same are disclosed.
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WO/1992/021653A1 |
Compounds of formula (I) wherein X is CH or N; n is 0, 1, 2 or 3; R?1� and R?3�, which may be the same or different, are alkyl, alkoxy or alkylthio, each of which is optionally substituted, halogen, nitro, cyano, COOR?4�, -NR?5�R...
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WO/1992/020643A1 |
Bi-aromatic compounds characterized in that they comply with general formula (I), where: R1 is -CH3, -CH2OH, -COR8, or -CH2OCOR9, R8 is H, OH, -OR10, -N(rr'), or alkyl, R10 is alkyl, alkenyl, aryl or aralkyl, r and r' being H, alkyl, ary...
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WO/1992/016483A1 |
Methylene cyclobutane derivates are disclosed having formula (I), in which R?1�, A?1�, A?2�, Z?1�, Z?2�, L?1�, L?2�, X, Y and m have the meanings given in claim 1. Also disclosed is their use as components of liquid-crystal...
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WO/1992/012222A1 |
Alkylated diphenyl ethers, alkylated diphenyl methanes, alkylated phenoxathins and alkylated diphenyl sulfides are high-temperature stable lubricant fluids having excellent low temperature viscometrics, and excellent additive solubility....
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WO/1992/012126A1 |
Novel sulphurized compounds, their preparation and use. The compounds are based on the general formula {[R-Sx-(CH2)n-]z CH3-z-(CH2)p-}2 Sy, in which R is a monovalent hydrocarbon radical having 1 to 30 carbon atoms, optionally functional...
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WO/1992/008700A1 |
Compounds represented by formula (I) or a pharmaceutically acceptable salt, prodrug or ester thereof, wherein A represents radicals represented by formulae (A1, A2, A3) (values for the variables given herein), are effective as retroviral...
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WO/1992/007824A1 |
A process for preparing a compound of formula (IV) comprising: a) contacting an oxazoline compound of formula (I) wherein Z is as defined hereinbefore, with a reagent capable of causing an equilibrium between oxazoline compound (I) and a...
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WO/1992/002495A1 |
The invention relates to cyclopentane derivatives of formula (I) and their salts with physiologically tolerables bases and the $g(a), $g(b) or $g(g)-cyclodextrin clathrates and the liposome-encapsulated compounds of formula (I), a proces...
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WO/1991/019695A2 |
Compounds of formula (I) where R is C1-15 alkyl, X is hydrogen, fluorine or chlorine, m and n are independently selected 1 or 0, W is C1-15 alkyl or alkoxy, CN or halogen, rings A and B are independently selected from phenyl, laterally f...
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WO/1991/016320A1 |
Derivatives and analogues of 2-deoxy-2,3-didehydro-N-acetyl neuraminic acid, pharmaceutical formulations thereof, methods for their preparation and their use in the treatment of viral infections, in particular influenza, are described.
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WO/1991/014685A1 |
Technetium-99m complexes of crown thioethers having 3 to 6 donor sulphur atoms joined into a macrocyclic ring by C2 or C3 groups, for example 1,4,7-trithiacyclononane (9S3); and of tripodal ligands having more than 3 donor sulphur atoms ...
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WO/1991/005541A1 |
A deodorant composition comprising a body odor suppressing effective amount of an inhibitor of an amino acid beta-lyase enzyme which catalyzes the formation of human body malodor in a dermatologically acceptable vehicle.
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WO/1991/005564A1 |
A compound of formula (I) or the acid fluoride salts thereof, wherein BLK is an N-amino protecting group or hydrogen; AA is an amino acid residue and X is H or a protecting group, is useful as a coupling agent in peptide synthesis.
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WO/1991/002715A2 |
Disclosed are certain poly-methine compounds having formula (I), wherein each R1 is independently selected from cyano; carboxy; alkenyloxycarbonyl; an unsubstituted or substituted alkoxycarbonyl, cycloalkoxycarbonyl or aryloxycarbonyl ra...
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WO/1990/012073A1 |
The invention concerns trifluoromethylcyclohexane derivatives of the formula (I) in which R, A?1¿, A?2¿, (a), Z?1¿, Z?2¿ and o are as defined in claim 1. These compounds can be used as components of liquid-crystal media for electro-o...
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WO/1990/012019A1 |
A bis(1,2-diaryl-1,2-ethylenedithiolato) nickel complex is produced by reacting a benzil or benzoin compound with phosphorus pentasulfide in 1,2-dimethyl-2-imidazolidinone and reacting the reaction product with nickel chloride.
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WO/1989/012670A1 |
Sulfur derivatives of unsaturated oligomers formed from alpha-olefins of 2 to 20 carbon atoms which oligomer has a branch ratio of less than 0.19. Such derivatives are useful as additives for lubricants.
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WO/1989/012085A1 |
Molecular building beams, liquid crystals, and surfactants in the form of compounds based on [1.1.1]propellane, including poly[1.1.1]propellanes. Molecular building beams having a telomeric or polymeric chain staff, and linking groups fu...
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WO/1989/009050A1 |
This invention is therapeutically useful tetralins and pharmaceutically acceptable acid addition salts thereof of formula (I), wherein -YR1 is one substituent on the 5, 6, 7 or 8 position of the aromatic ring, and is -S(C1-C3) alkyl or O...
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WO/1989/005796A1 |
Novel mercapto-acylamino acids useful in the treatment of hypertension and combinations of mercapto-acylamino acids and atrial natriuretic factors or angiotensin converting enzyme inhibitors useful for treating hypertension are disclosed.
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WO/1989/003416A1 |
Compounds having the formula (I): R1-(CO)m-S-aryl-Z1-(A1-Z2)n-A2-R2, in which R1, R2, aryl, Z1, Z2, A1, A2, m and n have the meaning defined in claim 1 are used as components of ferroelectric liquid crystalline phases. The invention also...
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