Document |
Document Title |
WO/2001/062939A1 |
22,23-Dihydroavermectin B1a, which is useful in drugs, veterinary drugs and pesticides, can be produced by direct fermentation. Thus, the troublesome and difficult industrial steps of purifying avermectin B1a and chemically modifying ave...
|
WO/2001/058865A1 |
Method for the preparation of (S)-2-acetylthio-3-phenylpropionic acid, wherein (R)-2-bromo-3-phenylpropionic acid is contacted with thioacetic acid and an organic base, for example triethylamine. Preferably the base is metered to a mixtu...
|
WO/2001/058837A2 |
Process for the preparation of (R)-2-bromo-3-phenylpropionic acid starting from D-phenylalanine, sodium nitrite and HBr in an aqueous solution, the reaction being carried out in the presence of a bromide salt, at a temperature between -1...
|
WO/2001/056976A1 |
The invention relates to novel compounds of general formula (I). Paracyclophane-based hydroxamic acids/hydroxamic acid derivatives of this type are suitable for use in enantioselective expoxidation. The invention also relates to a method...
|
WO/2001/055074A1 |
A nitrous acid salt is added at a temperature of 10 to 80°C to an aqueous solution which contains an optically active 2-aminocarboxylic acid (4) and a protonic acid, the amount of the latter acid being 1 to 3 equivalents to the former, ...
|
WO/2001/049275A2 |
Methods and therapeutic compounds for treating pain, mitigating inflammation, effecting analgesia and/or effecting sedation in a subject are described. A subject is administered an effective amount of a therapeutic compound which is a ni...
|
WO/2001/047876A1 |
The subject invention provides a method for the efficient production of high purity xanthates. The method comprises (a) mixing aluminium with an alkali metal salt; (b) heating said mixture until an exothermic reaction is achieved, whereb...
|
WO/2001/044175A1 |
Disclosed are 'acid-thioamide' calixarenes of formula (I), wherein: L is [-CH¿2?-] or [-O-CH¿2?-O-] and is the same or different between each aryl group; R?5¿ is H, NO¿2?, halogen, or C¿1?-C¿10?aliphatic hydrocarbyl group, C¿6?-cÂ...
|
WO/2001/040175A1 |
A process for producing a sulfur compound bearing at least one thio group in the molecule by reacting a thiol compound with an organic compound bearing at least one functional group capable of reacting with a mercapto group to thereby fo...
|
WO/2001/036095A1 |
A novel polymer-supported Lewis acid catalyst which has high activity in reactions in an aqueous medium, can be easily recovered, and is highly reusable. The catalyst comprises a polymer film and Lewis acid groups represented by general ...
|
WO/2001/034594A1 |
The present invention provides the inhibitors of dipeptidyl peptidase IV based upon or including proline or similar moieties. The inhibitors are useful for treating various disorders, including those of the central nervous system and the...
|
WO/2001/030745A1 |
This invention relates to a compound of formula (I): wherein R?1¿ is nitro group, amino group, cyano group, a halo(lower)alkyl group, a halogen atom, etc., R?2¿ is an optionally substituted aryl group, A is a lower alkylene group, and ...
|
WO/2001/028991A1 |
N-Cycloalkyl thiooxamide derivatives represented by general formula (I) wherein R?1¿ represents alkyl, alkenyl, cycloalkyl, alkylcycloalkyl, cycloalkylalkyl, cycloalkenylalkyl, alkoxyalkyl, dialkoxyalkyl, phenoxyalkyl, piperidinylalkyl,...
|
WO/2001/018171A2 |
The present invention provides the compound having formula (I), wherein each of R¿1? and R¿2? is, substituted or unsubstituted, aryl, cycloalkyl, cycloalkylamino, naphtha, pyridineamino, piperidino, t-butyl, aryloxy, arylalkyloxy, or p...
|
WO/2001/010825A1 |
Novel bactericides having an excellent controlling effect on plant disease injury (in particular, wheat powdery mildew and cucumber gray mold) without exerting any undesirable effect on crops. Carbamate derivatives represented by general...
|
WO/2001/008685A1 |
The present invention relates to acyclic and cyclic amine derivatives for treating or preventing neuronal damage associated with neurological diseases. The invention also provides compositions comprising the compounds of the present inve...
|
WO/2001/005742A1 |
The invention concerns drug precursors with antimalarial effect, characterised in that it consists in quaternary bis-ammonium salts of general formula (I) wherein A and A', identical or different, are respectively either a group A¿1? an...
|
WO/2001/000566A2 |
Disclosed are substituted phenoxyacetic acids useful in the treatment of chronic complications arising from diabetes mellitus. Also disclosed are pharmaceutical compositions containing the compounds, alone or in combination with other th...
|
WO/2000/076962A1 |
Thiol derivative compounds, pharmaceutically acceptable salts, and biolabile esters thereof, useful for inhibiting metallo-$g(b)-lactamases, bacterial enzymes which confer resistance to clinically relevant ß-lactam antibiotics, characte...
|
WO/2000/073266A1 |
The invention concerns compounds of general formula (I) (wherein R and R' represent an alkyl radical or an aryl group and R'' is hydrogen or a CO-R?1¿ group wherein R?1¿ is an alkyl radical or an aryl group; and the dimers formed by th...
|
WO/2000/068190A2 |
Compounds of Formula (1) and Formula (2) where the symbols have the meaning defined in the specification, have retinoid, retinoid antagonist or retinoid negative hormone like biological activity.
|
WO/2000/065913A1 |
Microbicides for agricultural and horticultural use, containing sulfonamide derivatives such as compounds of general formula (I) or salts thereof; some of the derivatives; and processes for the preparation of the same. In said formula, A...
|
WO/2000/063165A1 |
The compound of the present invention is useful as a medicament for prophylactic and therapeutic treatment of MMP- or TNF $g(a)-mediated diseases.
|
WO/2000/061537A2 |
Compounds or their salts having general formulas (I) and (II): wherein s is and integer equal to 1 or 2, preferably s = 2; A is the radical of a drug and is such as to meet the pharmacological tests reported in the description, C and C¿...
|
WO/2000/061548A1 |
The N-substituted-N'-substituted urea derivative of formula (a), analogues of the same, or medicinally acceptable salts of both, having a TNF-production inhibiting effect.
|
WO/2000/061549A2 |
Compounds or their salts of general formula (I): A-(B) wherein A = R-T¿1?-, wherein R is the drug radical and T¿1? = (CO)¿t? or (X)¿t'?, wherein X = O, S, NR¿1C?, R¿1C? is H or an alkyl having from 1 to 5 carbon atoms, or a free va...
|
WO/2000/054756A2 |
Compounds and methods for mitigating neurodegeneration, effecting neuroprotection and/or effecting cognition enhancement in a subject are described. Neurological or cognitive conditions are treated by administering to a subject an effect...
|
WO/2000/051979A1 |
The invention provides novel PGF analogs. In particular, the present invention relates to compounds having a structure according to formula (I) wherein R¿1?, X, and Z are defined below. This invention also includes optical isomers, dias...
|
WO/2000/050392A1 |
2-Mercaptocarboxylic acid derivatives represented by general formula (I), pharmacologically acceptable esters of the same, or pharmacologically acceptable salts of both, which exhibit excellent antihyperglycemic and PPAR-activating effec...
|
WO/2000/048994A1 |
Compounds of formula (1): and the pharmaceutically acceptable salts and esters thereof wherein X and Y are as defined in the specification, inhibit the binding of VCAM-1 to VLA-4 and are useful in treating inflammation associated with ch...
|
WO/2000/046189A1 |
Sulfonamide derivatives having matrix metalloprotease inhibiting effects, which are compounds represented by general formula (I), optical isomers of the same, pharmaceutically acceptable salts of both, or hydrates of them: wherein A is a...
|
WO/2000/044716A1 |
Compounds of formula (B): (1a), or (1b), (1c) are provided wherein the variables are as defined herein which are useful in disease conditions mediated by TNF-$g(a), such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative c...
|
WO/2000/044717A2 |
Facile methods for preparing diketide and triketide thioesters are disclosed. The resulting thioesters may be used as intermediates in the synthesis of desired polyketides, and may contain functional groups which ultimately reside in sid...
|
WO/2000/043000A1 |
Proteasome inhibitors containing as the active ingredient carboxylic acid derivatives represented by general formula (I) or pharmacologically acceptable salts thereof: wherein m and n are each independently an integer of 0 to 10; p is 0 ...
|
WO/2000/040210A2 |
This invention relates to a topical composition for treating amino acid based substrates comprising a protected thiol compound having the formula R—(S—Pr)¿m? where R is a functional group, S is sulfur, and Pr is a heterocyclic prote...
|
WO/2000/039070A1 |
This invention relates to compounds, pharmaceutical compositions, and methods of using compounds of formula (I); A is O or S; R is C¿1?-C¿10? straight or branched chain alkyl, C¿2?-C¿10? straight or branched chain alkenyl, C¿2?-C¿1...
|
WO/2000/032563A1 |
The invention relates to novel substituted oximes, to a method for their production and to their use as fungicides.
|
WO/2000/025776A1 |
The present invention describes novel nitrosated and/or nitrosylated nonsteroidal antiinflammatory compounds, and novel compositions comprising at least one nitrosated and/or nitrosylated nonsteroidal antiinflammatory compound, and, opti...
|
WO/2000/024734A1 |
This invention relates to the identification of a novel class of therapeutic agents which selectively target and kill tumor cells and certain other types of diseased cells, and to compositions comprising lipoic acid derivatives which poi...
|
WO/2000/024738A1 |
New synthetic procedures for preparing insecticidal 3-(substituted phenyl)-5-(thienyl or furyl)-1,2,4-triazoles utilizing thioimidate intermediate.
|
WO/2000/024720A1 |
3-(Substituted phenyl)-5-(substituted cyclopropyl)-1,2,4-triazole compounds are useful as insecticides and acaricides. New synthetic procedures and intermediates for preparing the compounds, pesticide compositions containing the compound...
|
WO/2000/016766A1 |
A medical composition containing, as an active constituent, a nitroetheneamine derivative represented by formula (I) wherein R?1¿ is a hydrogen atom, an optionally substituted alkyl, alkenyl, alkinyl, cycloalkyl, cycloalkenyl, aryl or h...
|
WO/2000/017133A2 |
The invention concerns LTA¿4? hydrolase inhibiting compounds of formula (I). It also concerns their therapeutic, in particular anti-inflammatory, applications.
|
WO/2000/005198A1 |
Anthranilic acid derivatives represented by general formulae (1) or (2) (wherein Y?1¿ and Y?2¿ are each a group represented by general formula (3)-1, (3)-2 or the like; X?1¿ is O, S or the like; X?2¿ is O or S; and R?1¿ to R?4¿ are...
|
WO/2000/003979A1 |
The invention relates to novel benzocycloheptenes of general formula (I), wherein R?1¿, R?2¿ and SK have the meanings cited in the description. The novel compounds exhibit a selective estrogenic activity on bones and are suitable for p...
|
WO1999048897B1 |
The present invention provides a system for the production of chemical compounds and libraries of compounds that are complex, stereochemically and regioselectively pure, and may mimic the structural or functional properties of a peptide....
|
WO/2000/002866A1 |
The invention relates to novel substituted phenyl uracils of general formula (I) wherein n, Q, R?1¿, R?2¿, R?3¿, R?4¿, R?5¿ and X have the meanings given in the description, to methods and novel intermediate products for producing s...
|
WO/2000/001668A2 |
The present invention relates to N-Acetylated $g(a)-Linked Acidic Dipeptidase (NAALADase) inhibitors enzyme activity, pharmaceutical compositions comprising such inhibitors, and methods of their use to inhibit NAALADase enzyme activity, ...
|
WO/2000/001838A2 |
The stereochemical centers of a polyketide can be changed by replacement of ketosynthase domains in the polyketide synthase (PKS) enzyme that produces the polyketide. The specificity of the AT domains of a PKS is determined by a hypervar...
|
WO/1999/065871A2 |
This invention pertains to the discovery of a novel family of thiolesters and uses thereof. Also provided for are viricidal compounds and pharmaceutical formulations comprising these novel thiolesters. The invention also provides thioles...
|