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WO/2024/077386A1 |
The present application relates to amorphous otenaproxesul and to amorphous solid dispersions and compositions comprising amorphous solid dispersions of amorphous otenaproxesul or a pharmaceutically acceptable salt thereof and a polymer,...
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WO/2023/240156A9 |
Provided are ionizable cationic lipids and lipid nanoparticles for the delivery of nucleic acids to cells (e.g., immune cells), and methods of making and using such lipids and targeted lipid nanoparticles.
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WO/2024/034746A1 |
The present invention relates to a method for producing a chiral carbonyl derivative using an (R,R)-1,2-diphenylethylenediamine (DPEN)-based thiourea catalyst compound. According to the production method, a chiral carbonyl derivative hav...
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WO/2024/031002A1 |
This disclosure includes pesticidal compounds, compositions, and related agricultural methods.
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WO/2024/017150A1 |
Provided in the present application is a method for synthesizing deucravacitinib. The method comprises: subjecting the compound of formula (I) to chlorination and to electrophilic substitution with the compound of formula (VI) to synthes...
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WO/2024/004755A1 |
A compound according to the present invention is represented by general formula (1).　General formula (1): (In formula (1), A represents an n-valent organic group that contains a sulfur atom; n represents an integer of 3 or more; S repr...
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WO/2023/240156A1 |
Provided are ionizable cationic lipids and lipid nanoparticles for the delivery of nucleic acids to cells (e.g., immune cells), and methods of making and using such lipids and targeted lipid nanoparticles.
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WO/2023/200916A1 |
An acid medium is provided comprising one or more water-soluble oxidized disulfide oil ODSO compounds. The use of such an acid medium is disclosed as a replacement for conventional acids. Embodiments of the present disclosure are directe...
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WO/2023/188968A1 |
[1] A polyfunctional (meth)acrylate thioester composition containing a polyfunctional (meth)acrylate thioester compound (A) represented by formula (1); [2] a curable composition containing the polyfunctional (meth)acrylate thioester comp...
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WO/2023/190410A1 |
The present invention provides a compound which is represented by formula (A). In the formula, n represents an integer of 1 to 4; each of R3 and R4 independently represents a C1-C20 alkyl group, a C3-C20 cycloalkyl group, a C6-C20 aryl g...
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WO/2023/178795A1 |
Provided in the present invention are cationic lipid compounds used for nucleic acid delivery, a composition and the use. The compounds are represented by the following formula (I). Further provided in the present invention are the use o...
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WO/2023/179497A1 |
The present invention belongs to the field of gene drug delivery, and particularly relates to a lipid compound, a lipid carrier based on the lipid compound, a nucleic acid lipid nanoparticle composition and a pharmaceutical formulation. ...
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WO/2023/159296A1 |
The present application relates to methods of treating urologic chronic pelvic pain syndrome (UCPPS) or pain associated with UCPPS using a compound of Formula I, or a pharmaceutically acceptable salt, prodrug and/or solvate thereof. UCPP...
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WO/2023/162777A1 |
Provided are: a compound represented by general formula (1); a curable resin composition containing this compound; a cured product obtained using this curable resin composition; a diffraction optical element; and augmented reality glasse...
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WO/2023/127808A1 |
There is still a great amount of damage by pests or the like in production of agricultural crops, horticultural crops, and the like, and the development of novel pest control agents is desired due to factors such as the emergence of pest...
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WO/2023/092242A1 |
The present application includes dendrons of Formula I, compositions comprising these dendrons and uses thereof, in particular for the delivery of agents such as nucleic acids and drugs to cells and subjects. (I) wherein each Repeating G...
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WO/2023/083465A1 |
A P2S5·2C5H5N stock formulation comprising a solution of P2S5·2C5H5N in sulfolane, a process for preparing the formulation, and the use of the formulation in a thionating reaction.
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WO/2023/079545A1 |
The present invention discloses an isolated substantially pure trans isomer of 3-(2- bromo-3,4-dihydroxy-phenyl)-N-(3,4,5-trihydroxy-benzyl)-thio
acrylamide, methods for its preparation, pharmaceutical compositions comprising same, and u...
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WO/2023/080243A1 |
One purpose of the present invention is to provide a novel thioester derivative and a method for producing the same, a novel ketone derivative and a method for producing the same, a novel method for producing a C-arylhydroxyglucoside der...
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WO/2023/065802A1 |
The present invention belongs to the field of polythiol compounds and uses thereof, relating in particular to a polythiol compound and a preparation method therefor, a curing agent, a resin composition, an adhesive, and a sealant. The po...
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WO/2023/058449A1 |
Provided are: a naphthalene dithiol capable of achieving both high refractive index and high solubility (compatibility) or a derivative thereof; and a production method and a use for the same.　A naphthalene compound according to the pr...
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WO/2023/043039A1 |
The present invention provides a novel compound for a light-emitting device, and an organic light-emitting device comprising same.
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WO/2023/036945A1 |
The invention relates to a compound of formula (I) wherein A is NH or CH2; G1 is a linear or a cyclic alkyl; Y1 is CH or N; Y2 is O, N or CH, W is O, N or CH; Z is NH or O; X1 and X2 and R, and R1 to R8 are functional groups.
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WO/2023/017400A1 |
Novel compounds of general Formula (I) derived from the conjugation of the native metformin drug to molecular moieties endowed with the property of releasing hydrogen sulfide are described. The compounds forming the object of the present...
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WO/2023/277606A1 |
The present invention provides a novel compound for a capping layer, and an organic light-emitting device comprising same.
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WO/2022/115645A9 |
The present disclosure provides for improved compositions of ionizable lipid nanoparticles for the delivery of therapeutic nucleic acids to cells. Cationic ionizable lipids are engineered with improved stability to oxidative degradation ...
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WO/2022/186305A1 |
The present invention provides a production method by which an arylthiol ester compound can be quickly synthesized at a high yield under mild conditions. The present invention pertains to a production method of an arylthiol ester compoun...
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WO/2022/175660A1 |
There are provided compounds of formula (I): [hyaluronan production inhibitor]—[labile linker]—X (I), which compounds are useful in the treatment of diseases associated with hyaluronan overproduction.
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WO/2022/099374A1 |
The present invention relates to a compound of formula (I): or a salt or solvate thereof, combinations comprising same, uses and methods thereof, and kits comprising same.
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WO/2022/079637A1 |
Analogues of oleuropein and oleacein and pharmaceutically acceptable salts thereof and processes for the preparation of these compounds are disclosed. The invention further relates to use of oleuropein and oleacein analogues for the trea...
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WO/2022/061365A1 |
The disclosure relates generally novel sulfur containing glycerol mono- ester derivatives and methods useful for treating gram positive, gram negative, fungal and envelope viral infections in a patient.
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WO/2022/038224A1 |
A method for the preparation of an alpha-substituted carbonyl compound or an alpha- substituted nitrile compound carrying an aryl or heteroaryl group as an alpha-substituent, said method comprising reacting a sulfoxide compound S1 compri...
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WO/2021/153720A1 |
The present invention provides: a 3-alkoxy benzoic acid amide derivative having an excellent pest control effect, or a salt thereof; and a pest control agent and a production intermediate which contain the same as an active ingredient.ã€...
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WO/2021/019071A1 |
The present invention relates to novel aminoesters compounds or its pharmaceutically acceptable salts or optical isomers, racemates, diastereoisomers, enantiomers or tautomers. The present invention also relates to their process of prepa...
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WO/2021/014368A1 |
According to one embodiment, there is provided a method of producing a gene modification T cell (CAR-T cells) which expresses a chimeric antigen receptor (CAR). This method includes stimulating a cell population containing a T cell with ...
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WO/2020/262603A1 |
The purpose of the present invention is to provide a drug for the prevention and/or treatment of a disease associated with the activation of an EP2 receptor, the drug containing, as an active ingredient, a compound having an antagonistic...
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WO/2020/254484A1 |
The present invention provides a novel isolated succinate prodrug as the free com- pound or a salt, hydrate, solvate or complex thereof being cell permeable and aimed for increasing the ATP-production in mitochondria. The compound is use...
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WO/2020/227085A1 |
The present invention provides, in part, di-thioester cationic lipid compounds or a pharmaceutically acceptable salt thereof. The compounds provided herein can be useful for delivery and expression of mRNA and encoded protein, e.g., as a...
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WO/2020/219427A1 |
The present invention provides, in part, thioester cationic lipid compounds of formula A, and sub-formulas thereof: or a pharmaceutically acceptable salt thereof. The compounds provided herein can be useful for delivery and expression of...
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WO/2020/215726A1 |
A recycling process of waste generated in synthesis of thioacetic acid, comprising: in a thioacetic acid synthesis process, pretreating a thioacetic acid synthesis reaction solution, transferring the reaction solution to a filter device,...
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WO/2020/217710A1 |
Provided is a compound having at least one characteristic proprety selected from high chemical stability, high ability to horizontally align liquid crystal molecules, high alignability over a broad range of addition concentrations, prope...
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WO/2020/212543A1 |
The present invention relates to novel ophthalmic devices comprising polymerized compounds comprising a photoactive unit, said polymerized compounds, and special monomer compounds being particularly suitable for compositions and ophthalm...
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WO/2020/165601A1 |
Methods are provided for the synthesis of a compound of formula (X). R2 is selected from -H, -C1-C4-alkyl,-C2-C4-alkenyl and C1-C4-aryl; R3 is selected from -C(O)H and -C(O)C1-C4-alkyl; and A is a pharmaceutically acceptable anion (e.g.a...
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WO/2020/147704A1 |
Disclosed is a method for synthesizing a S-(-)-benzoylmercapto-2-methylpropanoic acid compound, comprising hydrolyzing the S-(-)-3-acetylmercapto-2-methylpropanoic acid represented by formula (II) as a raw material in a reaction solvent ...
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WO/2020/142865A1 |
Disclosed in the present invention are a Benzamide compound, intermediates, a preparation method, and an application. The present invention provides a Benzamide compound as represented by formula I, and pharmaceutically acceptable salts,...
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WO/2020/129899A1 |
In order to provide a method for the economical and efficient industrial production of C-aryl hydroxy glycoxide derivatives, the present invention provides a method for producing a C-aryl hydroxy glycoxide derivative represented by formu...
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WO/2020/117608A1 |
Oxidized disulfide oil (ODSO) solvent compositions are derived from by-product disulfide oil (DSO) compounds produced as by-products from the generalized mercaptan oxidation (MEROX) processing of a refinery feedstock. The oxidized disulf...
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WO/2020/102348A1 |
Provided herein are compositions and methods for preparing albumin-targeting moieties that feature a thioamide linkage. Methods to use the albumin targeting molecules to generate drugs with improved in vivo pharmacodynamics and biodistri...
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WO/2020/059790A1 |
The the present invention addresses the problem of providing a DP receptor antagonist. Compounds represented by general formula (I): (in the formula, all of the symbols are as defined in the specification) and pharmacologically acceptabl...
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WO/2019/234651A1 |
A process is described for the preparation of thiadiazole derivatives and more specifically a new synthetic process of compounds having general formula (I) and intermediate compounds having general formula (XVI).
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