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WO/2013/067646 |
The present application provides processes and intermediates useful in the production of β- aminocarbonyl- or β-aminothiocarbonyl-containing compounds. Provided herein is a process for synthesizing β-aminocarbonyl- or β-aminothiocarb...
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WO/2013/052727 |
The instant application describes novel compounds that modulate (in particular, inhibit) Sirt2, with structures according to Formulas (1) and (2) provided herein. The invention is also directed to pharmaceutical compositions thereof, met...
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WO/2013/037984 |
The present invention provides an anti-inflammatory agent/anti-oxidant agent conjugate of formula (I) where is selected from the groups of formula (i), (ii) or (iii), L is CH2CH2 and the other variables are as defined in the claims. Anot...
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WO/2013/029648 |
A compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof, wherein: - R' is H or F or trifluoromethyl; - R'' is OH or O-alkyl; - R''' is H or F or trifluoromethyl or phenyl or pyridyl; - R'''' is methylene or acy...
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WO/2013/016840 |
Disclosed is a novel intermediate used for preparing tapentadol and their analogues, wherein the structure of the intermediate is expressed by formula I or II, and the groups are defined as the description. Also disclosed are the process...
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WO/2013/007712 |
A process for the preparation of a compound of formula (I): which are useful as intermediates in the preparation of i.a. pharmaceutically active compounds.
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WO/2013/008835 |
An organic light-emitting element comprising a first electrode, a second electrode, and a light-emitting layer disposed between the first electrode and the second electrode; wherein the light-emitting layer includes a host material, a fi...
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WO/2012/117941 |
This electrode active material has general formula (I) or (II) in the constituent units thereof. In the formulas, X is C or Si; and Y1 and Y2, or Y3 and Y4 are mutually different substituent groups selected from S, O, Se, Te, NH, SR1'R2'...
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WO/2012/114926 |
Provided is the thioamide compound represented by general formula (1). In general formula (1): R1 represents -OR11 or -NR12R13; R2 and R3 each independently represent a protecting group of an amide group or a hydrogen atom; R11 represent...
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WO/2012/113829 |
The present invention relates to a heat-curable composition comprising (a) at least one compound which is capable of undergoing cationic polymerization; and (b) at least one sulfonium sulfate selected from compounds of the formulae Ia an...
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WO/2012/108542 |
A novel method for preparing a thiocarboxylic acid S-(fluoroalkyl) ester represented by formula (III) [wherein R1 is methyl, ethyl or phenyl; and R2 is C1-5 fluoroalkyl], characterized by reacting a thiocarboxylic acid represented by for...
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WO/2012/104415 |
A process for transforming a group >C=O (I) in a compound into a group >C=S (II) or into a tautomeric form of group (II) in a reaction giving a thionated reaction product, by use of crystalline P2S5·2 C5H5N as a thionating agent. A thio...
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WO/2012/101245 |
The present invention relates to a polymerizable composition comprising at least one ethylenically unsaturated, polymerizable compound and at least one oxime sulfonate compound of the formula (I) QAaBbCc where a is 0, 1, 2, 3, 4 or 6, b ...
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WO/2012/080178 |
The application relates to the preparation of thiophenols by reacting the corresponding disulfide with hydrogen in the presence of a heterogeneous transition metal hydrogenation catalyst. If the reaction is carried out in the presence of...
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WO/2012/060396 |
The purpose of the present invention is to provide a novel trans-2-decenoic acid derivative and a pharmaceutically acceptable salt thereof, and a medicament containing the compound described above as an active component and having a neur...
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WO/2012/035017 |
A process for the preparation of a compound of formula (I) which are useful as intermediates in the preparation of pharmaceutically active compounds.
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WO/2012/026931 |
Methods of synthesizing 4-alkyl resorcinols and other substituted phenol compounds, according to formula (IV): or salts thereof, are disclosed, wherein the variables are defined herein.
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WO/2012/017400 |
The present invention relates to a novel synthesis method for acyl-pantetheine derivatives. The present invention further relates to the use of said synthesized acyl-pantetheine derivatives as a starting material in the enzymatic synthes...
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WO/2011/150347 |
Methods and compounds for treating neurological and other disorders are provided. Included is the administering to a subject in need thereof an effective amount of a compound having binding and/or modulation specificity for a TrkB recept...
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WO/2011/146953 |
A compound of formula I wherein PROT is an amine protecting group and PROT' is hydrogen; or PROT and PROT' together with the nitrogen atom to which they are attached form a heterocyclic ring as an amine protecting group, and PROT" is a t...
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WO/2011/141705 |
The present invention provides compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel cationic lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic ...
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WO/2011/141705 |
The present invention provides compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel cationic lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic ...
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WO/2011/116490 |
A preparation method for racecadotril is disclosed, which includes reacting benzylacrylic acid with thioacetic acid, distilling off unreacted thioacetic acid by use of CH2Cl2, condensating the resulting product with benzyl glycinate para...
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WO/2011/114954 |
Disclosed are a diaryl sulfone compound represented by general formula (1), and a manufacturing method for the same. The present invention enables the high yield manufacturing of a novel compound using a simple manufacturing process whic...
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WO/2011/093401 |
Provided is a novel compound which has a surfactant ability and an ability to control polymerization. A compound represented by general formula (1) or (2). In the formulae, R1 and R3 represent an organic group having a hydrophobic/hydrop...
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WO/2011/075210 |
A family of covalent kinetic stabilizer compounds that selectively and covalently react with the prominent plasma protein transthyretin in preference to more than 4000 other human plasma proteins is disclosed. A contemplated compound cor...
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WO/2011/075210 |
A family of covalent kinetic stabilizer compounds that selectively and covalently react with the prominent plasma protein transthyretin in preference to more than 4000 other human plasma proteins is disclosed. A contemplated compound cor...
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WO/2011/070028 |
Whilst methodologies for the Kinetic Resolution of alcohols are well established, no analogous direct methods exist for the highly selective, direct catalytic Kinetic Resolution of thiols (i.e., R-SH). The present invention relates to a ...
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WO/2011/069143 |
The present invention provides bis-organosulfur compounds of formulae (I) and (II) and compositions comprising the compounds that are effective against animal pests, including parasites. The compounds and compositions may be used for com...
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WO/2011/050994 |
This invention relates to the field of biologically active compounds and specifically to closthioamides, pharmaceutical compositions comprising these compounds, and their use as antibiotic, antifungal, and/or cytotoxic agent.
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WO/2011/050994 |
This invention relates to the field of biologically active compounds and specifically to closthioamides of formula (I) wherein BA and E are as defined herein, pharmaceutical compositions comprising these compounds, and their use as antib...
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WO/2011/034364 |
The present invention provides a superior method which involves adding a reducing agent for removing side reaction products from polysulfide ester-amides when conducting a reaction between 3-mercaptopropion esters or 3,3'-dithiodipropion...
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WO/2011/034364 |
The present invention provides a superior method which involves adding a reducing agent for removing side reaction products from polysulfide ester-amides when conducting a reaction between 3-mercaptopropion esters or 3,3'-dithiodipropion...
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WO/2011/012319 |
The present invention relates to method for the preparation of an ω-amino-alkane(thio)amide having the general formula (6): Furthermore, novel intermediates and partial reaction steps of the claimed method are disclosed.
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WO/2011/000793 |
The present invention relates to a process for the preparation of S-[2-[1-(2-ethylbutyl)cyclohexylcarbonylamino]-phenyl] 2-methylthiopropionate which is a useful pharmaceutical active compound.
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WO/2011/000793 |
The present invention relates to a process for the preparation of S-[2-[1-(2-ethylbutyl)cyclohexylcarbonylamino]-phenyl] 2-methylthiopropionate which is a useful pharmaceutical active compound.
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WO/2010/149888 |
Compounds of formula (I) in which: R1 represents a hydrogen atom or a group of formula COR4, or else R1 represents a group of formula (A); R2 represents a group of formula NR5R6, or else R2 represents a nitrogen-containing heterocyclic, ...
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WO/2010/143735 |
Disclosed is a method appropriate for safely, economically and easily producing at a high yield a 4-substituted benzothioamide derivative which is useful as an intermediate in the production of a 2-(3-cyanophenyl)thiazole derivative usab...
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WO/2010/142956 |
The invention provides compounds according to formula (I): (wherein X, Y, Z1 R1, R2, R3, Ar and Ar' are as dedfined herein), and physiologically acceptable salts, solvates, esters or amides thereof, pharmaceutical compositions comprising...
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WO/2010/094992 |
The invention pertains to the field of life necessities and more particularly relates to the cosmetic and/or dermatological fields, in particular the field of weight loss. The invention more particularly relates to esters or amides of co...
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WO/2010/086429 |
(S)-(+)-3-(aminomethyl)-5-methyl-hexanoic acid or (S)-pregabalin is an anticonvulsive drug. In addition to its use as an anticonvulsive agent, pregabalin has also been indicated as a medicament in the treatment of anxiety, neuropathic pa...
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WO/2010/086429 |
(S)-(+)-3-(aminomethyl)-5-methyl-hexanoic acid or (S)-pregabalin is an anticonvulsive drug. In addition to its use as an anticonvulsive agent, pregabalin has also been indicated as a medicament in the treatment of anxiety, neuropathic pa...
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WO/2010/083307 |
The present invention relates to the use of mixtures containing hydrazone compounds and copper for controlling the growth of fungi.
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WO/2010/083307 |
The present invention relates to the use of mixtures containing hydrazone compounds and copper for controlling the growth of fungi.
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WO/2010/070132 |
The present invention relates to thioic acids according to formula (II) suitable as building block for polythioesters; Wherein X is O, N or S and whereby R1 is chosen from (-CH2-)2, -CH2-O-CH2- or (-CH2-)3, R2 is preferably chosen from a...
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WO/2010/069859 |
The invention is concerned with novel compound of formula (I) wherein R, R2 and Q are as defined in the description and in the claims, and pharmaceutically acceptable salts thereof, processes for their preparation, their use as pharmaceu...
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WO/2010/065512 |
The present invention is directed to compounds represented by structural formula (I), or a pharmaceutically acceptable salt or a transition metal chelate, coordinate or complex thereof or a transition metal chelate, coordinate or complex...
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WO/2010/065512 |
The present invention is directed to compounds represented by structural formula (I), or a pharmaceutically acceptable salt or a transition metal chelate, coordinate or complex thereof or a transition metal chelate, coordinate or complex...
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WO/2010/048191 |
The present invention relates to novel thioamide derivatives of formula (I) and formula (Ia): wherein, R3, R4, R5, R6, R7, P, Q, T, V, W, X, Y, Z, a, m and n are as defined in the description, compositions thereof, processes for their pr...
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WO/2010/048284 |
The present invention is directed to a compound comprising a bis[thiohydrazide amide] or a deprotonated form thereof, complexed to a transition metal cation, wherein the bis[thiohydrazide amide] is represented by Structural Formula (I):,...
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