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WO/2013/067646 |
The present application provides processes and intermediates useful in the production of β- aminocarbonyl- or β-aminothiocarbonyl-containing compounds. Provided herein is a process for synthesizing β-aminocarbonyl- or β-aminothiocarb...
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WO/2013/041204 |
The invention relates to novel isocyanate and isothiocyanate compounds, pharmaceutical compositions comprising same, and the use thereof for the treatment of cancer in humans and animals. Compared with previously known isocyanate and iso...
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WO/2013/031603 |
Provided are: a liquid-crystal compound that can combine characteristics such as chemical stability, excellent compatibility with other liquid-crystal materials or non-liquid-crystal materials, fast response, low viscosity, a wide liquid...
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WO/2012/158008 |
Sulforaphane is an isothiocyanate having anti-microbial and anti-carcinogenic properties, found in a broad range of vegetables of the Brassica oleracea genus, of which broccoli and cabbage are considered to be the most important types. T...
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WO/2012/146569 |
The invention relates to a method for producing 2-chloroallyl isothiocyanate from 2,3-dichloro-1-propene, wherein the 2,3-dichloro-1-propene is reacted with a thiocyanate in the presence of a phase-transfer catalyst, without diluent or i...
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WO/2012/073314 |
The purpose of the invention is to provide a novel production method for producing a corresponding isothiocyanate compound having a carboxyl group at high purity in one step by a reaction of an amino compound having a carboxyl group, thi...
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WO/2012/010644 |
Process for the synthesis of an isothiocyanate of general formula (I) SCN‑R1-R4-R2 in which R1 and R2 represent, independently of one another, an alkyl, aryl or alkylaryl group, R4 represents a carbonyl, sulphinyl or sulphonyl group or...
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WO/2011/073143 |
Substituted cyanobutyrates of the formula I in which the variables are defined according to the description, processes and intermediates for preparing the compounds of the formula I and their N-oxides, their agriculturally suitable salts...
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WO/2010/140271 |
Disclosed is a substance which can potentiate the power of α brain waves produced from the cerebrum of a human to exhibit a relaxing activity, an concentration-enhancing activity and an anti-stress activity. Specifically disclosed is a ...
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WO/2010/140902 |
The invention provides the use of isothiocyanate and isoselenocyanate compounds for treating diseases and conditions mediated by MIF.
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WO/2010/125414 |
The subject of the present invention is a novel process for the preparation of the [4-(2-chloro-4-methoxy-5-methylphenyl)-5-methyl-thiazolo-2-y
l]-[2-cyclopropyl-1-(3-fluoro-4-methylphenyl)-ethyl]-amine of formula (I) and the new interme...
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WO/2010/125414 |
The subject of the present invention is a novel process for the preparation of the [4-(2-chloro-4-methoxy-5-methylphenyl)-5-methyl-thiazolo-2-y
l]-[2-cyclopropyl-1-(3-fluoro-4-methylphenyl)-ethyl]-amine of formula (I) and the new interme...
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WO/2009/145816 |
A first aspect of the invention is a compound (sometimes also referred to herein as an "active agent" or "active compound") of Formula (I) or ( Ia): or a pharmaceutically acceptable salt or prodrug thereof. Compositions thereof and metho...
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WO/2009/145816 |
A first aspect of the invention is a compound (sometimes also referred to herein as an "active agent" or "active compound") of Formula (I) or ( Ia): or a pharmaceutically acceptable salt or prodrug thereof. Compositions thereof and metho...
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WO/2009/114409 |
New fluorination processes for introducing one or more fluorine atoms into target substrate compounds with arylsulfur halotetrafluorides are disclosed. Also disclosed are methods for preparation of arylsulfur trifluorides.
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WO/2009/107796 |
Disclosed is a novel method for producing a corresponding isothiocyanate compound having a carboxyl group from an amino compound having a carboxyl group. Specifically disclosed is a method for producing an isothiocyanate compound having ...
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WO/2009/073592 |
The present invention provides fluoroalkyl amines represented by the formula R1-Q-S(O)x-C(H),(CH3)r(CH2)z+(1-1)-NHR and fluoroalkyl isocyanates and isothiocyanates represented by the formula RrQ-S(O)x-C(H)l(CH3)r(CH2)Z+(1-1)-N=C=X1, wher...
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WO/2009/073592 |
The present invention provides fluoroalkyl amines represented by the formula R1-Q-S(O)x-C(H),(CH3)r(CH2)z+(1-1)-NHR and fluoroalkyl isocyanates and isothiocyanates represented by the formula RrQ-S(O)x-C(H)l(CH3)r(CH2)Z+(1-1)-N=C=X1, wher...
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WO/2009/030457 |
The invention relates to methods of using certain compounds of formula (I), (II) and (III) in the synthesis of an insecticide intermediate of formula (IV), wherein the substituents are as defined in claim 1, to processes for preparing th...
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WO/2008/009127 |
The present invention relates to derivatives of non-steroidal anti-inflammatory drugs (NSAIDs) having improved anti-inflammatory properties useful in the treatment of inflammation, pain and fever. More particularly, NSAIDs are derivatize...
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WO/2008/008954 |
The present invention provides glucosinolate and isothiocyante compounds and related methods for synthesizing these compounds and analogs. In certain embodiments, these glucosinolate and isothiocyanate compounds are useful and chemopreve...
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WO/2008/008954 |
The present invention provides glucosinolate and isothiocyante compounds and related methods for synthesizing these compounds and analogs. In certain embodiments, these glucosinolate and isothiocyanate compounds are useful and chemopreve...
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WO/2007/122488 |
The present invention provides a process for [18F]-fluorination of biomolecules containing a primary amino group such as proteins and peptides and in particular of peptides. The invention further provides reagents for this process, in pa...
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WO/2007/122488 |
The present invention provides a process for [18F]-fluorination of biomolecules containing a primary amino group such as proteins and peptides and in particular of peptides. The invention further provides reagents for this process, in pa...
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WO/2007/121269 |
This invention concerns N-(ortho phenylaminoaryl), N'-alkyl sulfamides which are inhibitors of MEK and are useful in the treatment of cancer and other hyperproliferative diseases.
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WO/2007/082996 |
This invention concerns novel neutral labeling reactants. The novel reactants are deri- vatives of diethylenetriaminepentaacetic acid (DTPA) diamides, wherein a suitable group is linked to the molecule allowing introduction of the said n...
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WO/2007/026373 |
An improved process for the preparation of Rivastigmine is disclosed.
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WO/2007/009798 |
A process of producing a compound of formula (3), wherein R1 is a C1-5alkyl group, R2 is a halogen atom, a C1-5 alkyl group, a C2-5 alkenyl group, a C2-5 alkynyl group, a C1-5 alkyl group, a C1-5 alkoxy group, a nitro group, or a hydroxy...
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WO/2007/009798 |
A process of producing a compound of formula (3), wherein R1 is a C1-5alkyl group, R2 is a halogen atom, a C1-5 alkyl group, a C2-5 alkenyl group, a C2-5 alkynyl group, a C1-5 alkyl group, a C1-5 alkoxy group, a nitro group, or a hydroxy...
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WO/2006/029532 |
Nitrate esters and methods for mitigating neurodegeneration, affecting neuroprotection, affecting cognition enhancement, and/or preventing or mitigating tissue and/or cellular damage in a subject are described. Neurological or cognitive ...
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WO/2005/118527 |
Aspects of the present invention relate to compounds for preparing fluorocarbon compounds, methods for preparing fluorocarbon compounds, and methods for purifying a mixture of compounds. One aspect of the present invention relates to a t...
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WO/2005/112915 |
The present invention provides compositions, methods, and kits for reducing oxidative stress thereby extending life span. The compositions, methods, and kits of the present invention can also be used to treat diseases of aging resulting ...
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WO/2005/068488 |
The invention relates to a solid phase synthesis method for synthesising compounds of general formula (I) on a resin, wherein Z is, in particular a hydrogen atom or a fluorogenic or chromogenic group, m and p are, in particular equal to ...
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WO/2005/060569 |
New bifunctional chelation complexes are described. These are based on the structure of the so-called 'TAME-HexA' molecule. The compounds are especially useful for forming chelation complexes with metal ions, including radioisotopes.
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WO/2005/057207 |
The present invention provides a method of forming an ion of formula (I) comprising the steps of: (i) reacting a compound of the formula (IIa); with a biopolymer, BP, having at least one group capable of reacting with M to form a covalen...
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WO/2005/054174 |
The invention relates to compounds for modulating the glycolysis enzyme complex and the transaminase complex, pharmaceutical compositions containing said compounds, and to the uses of said compounds for the production of pharmaceutical c...
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WO/2004/105929 |
A method and system for reactively destroying alkyl halides in volume or stream of gas. The method and device employ nucleophilic reaction of the alkyl halide under phase transfer catalysis conditions. The method and system are useful fo...
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WO/2004/089539 |
A catalyst composition comprising a support having a surface area of at least 500 m2/kg, and deposited on the support: - silver metal, - a metal or component comprising rhenium, tungsten, molybdenum or a nitrate- or nitrite-forming compo...
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WO/2004/039768 |
The invention relates to a method for producing phenyliso(thio)cyanates of general formula (I) according to which a compound of general formula (II) or the HCl adduct thereof is reacted with a phosgenating agent, wherein W represents oxy...
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WO/2004/031137 |
Compounds of formula (I) inhibit the processing of APP by gamma-secretase, and hence are useful in treatment of Alzheimer's disease.
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WO/2004/027388 |
The present invention provides novel fluorescent compounds and covalent attachment chemistries which facilitate the use of these compounds as labels for ultrasensitive and quantitative fluorescent detection of low levels of biomolecules....
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WO/2004/018414 |
The present invention relates to compounds of formula I or a pharmaceutically acceptable salt thereof, wherein X=NH Y=CO, CS, -C(=N-CN) or X and Y together form an alkene, or C3-C5 cycloalkyl; R1 is -COOH; R2 is an electron withdrawing g...
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WO/2003/082946 |
Disclosed is a method for activating a composition comprising monomer units (TCM and/or SCM) which contain thiocyanate and/or selenocyanate, particularly vinylbenzyl thiocyanate and/or vinylbenzyl selenocyanate, according to which said c...
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WO/2003/074473 |
In one embodiment, this invention provides a class of androgen receptor targeting agents (ARTA). The agents define a new subclass of compounds, which are selective androgen receptor modulators (SARM). The SARM compounds have unexpected a...
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WO/2003/074449 |
This invention provides androgen receptor targeting agents (ARTA). The agents define a new subclass of compounds, which are selective androgen receptor modulators (SARM). Several of the SARM compounds have been found to have an unexpecte...
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WO/2003/070666 |
A method for preparing organic products from aqueous solutions, such as waste or byproduct liquid streams and waste or byproduct gas or vapor streams, uses phase transfer catalysis to transfer a chemical species in low concentration from...
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WO/2003/059896 |
The invention relates to a method for producing compounds of formula (I), wherein R represents H or F. Said method is characterised in that a compound of formula (II), wherein X represents halogen, mesylate or tosylate, is reacted with a...
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WO/2003/000647 |
The invention relates to a novel class of ligands, complexes comprising such ligands and a metal ion, and adducts of these metal complexes and a macromolecule. Pharmaceutical compositions and methods of making and using the ligand-metal ...
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WO/2002/076928 |
The invention relates to methods for preventing the attachment of aquatic organisms to surfaces that are submerged for extensive periods of time in water. More particularly, this invention relates to the protection of submerged surfaces ...
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WO/2002/057739 |
This invention relates to novel tracers and their synthesis and use in an immunoassay for the detection of controlled drugs such as amphetamine (APM), methamphetamine (MAPM) and their derivatives, in a biological or aqueous sample. In pa...
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