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WO/1998/037074A1 |
A process for preparing 2-mercaptothiazole by reacting a water soluble salt of dithiocarbamic acid with 2-haloacetaldehyde characterised in that either the 2-haloacetaldehyde is added to a slurry of the salt of dithiocarbamic acid in sol...
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WO/1998/035937A1 |
CETP activity inhitors containing as the active ingredient compounds represented by general formula (I), prodrug compounds thereof, pharmaceutically acceptable salts thereof, or hydrates or solvates of these, (wherein R represents linear...
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WO/1998/035935A1 |
Novel compounds useful as active ingredients of pesticides are disclosed. Acrylonitrile compounds of formula (I) or their salts, wherein Q is Qa, Qb, Qc or Qd, Y is =C(R�4?)- or =N-, R�1? is alkyl, haloalkyl, etc., each of R�2? and...
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WO/1998/030660A1 |
Dithiocarbamyl carboxylic acids, useful as multifunctional additives for lubricating oils, possess general formula (I), wherein R?1� and R?2� each independently is a hydrocarbyl group of from 1 to about 60 carbon atoms and R?3� is ...
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WO/1998/030539A1 |
Thiocarbamic acid derivatives which have a higher safety and a more excellent cholesterol resistance than those of conventional drugs and are characterized by being represented by general formula (1) or salts thereof (for example: O-(4-t...
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WO/1998/026775A1 |
This invention is directed to compounds of formula (I) wherein m is from 0-4; X is O or S; Y is halogeno; R�1? is hydrogen or C�1-4? alkyl; R�2? is hydrogen, C�1-4? alkyl or optionally substituted propargyl; and R�3? and R�4?...
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WO/1998/027055A1 |
This invention is directed to compounds of formula (I) wherein when a is 0, b is 1 or 2; when a is 1, b is 1, m is from 0-3, X is O or S, Y is halogeno, R�1? is hydrogen or C�1-4? alkyl, R�2? is hydrogen, C�1-4? alkyl, or optiona...
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WO/1998/026030A1 |
A lubricating oil composition is provided comprising a major amount of an oil of lubricating viscosity and a minor amount of, as an additive, at least one compound comprising a trinuclear molybdenum core and bonded thereto ligands capabl...
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WO/1998/025886A1 |
Novel pro-drugs and assay reagents are provided which are useful as therapeutic agents especially for delivery and targetting therapeutically active agents to melanoma cells. The pro-drugs and assay reagents are substrates for tyrosinase...
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WO/1998/011066A1 |
In accordance with the present invention, there is provided a new class of drugs for therapeutic treatment of such indications as cerebral stroke and other ischemia/reperfusion injury. Thus, in accordance with the present invention, dith...
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WO/1997/045016A1 |
Protectors against phytotoxic side-effects of pesticides in culture plants are compounds of formula (I) and their salts, in which R1 is hydrogen, a hydrocarbon, a hydrocarbon thio radical or a heterocyclyl radical, in which each of the f...
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WO/1997/042154A1 |
The present invention provides compounds which inhibit an envelope virus by inhibiting the fusion of the virus with the host cell. The virus may be inhibited in an infected cell, a cell susceptible of infection or a mammal in need thereof.
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WO/1997/041846A1 |
The present invention provides compounds which inhibit an envelope virus by inhibiting the fusion of the virus with the host cell. The virus may be inhibited in an infected cell, a cell susceptible of infection or a mammal in need thereof.
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WO/1997/032844A1 |
The current invention discloses hydroxyamidino derivatives useful as nitric oxide synthase inhibitors.
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WO/1997/023469A1 |
The invention relates to a process for the preparation of 2-chloro-5-chloromethyl-thiazole, which is employed as intermediate in the preparation of compounds having a pesticidal action, which process comprises reacting a compound of form...
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WO/1997/020580A1 |
A therapeutic system comprising: (a) a compound comprising a target cell-specific portion and a portion capable of converting a substance into another substance; and (b) a molecule capable of substantially inhibiting the conversion of sa...
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WO/1997/019671A1 |
The invention relates to novel UVB/UVA-absorbing chromophores that are present in the natural products of a marine hydroid, and derivatives thereof, useful as sunscreening agents. Furthermore, the present invention relates to methods for...
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WO/1997/008140A1 |
N-sulfonyliminodithio compounds have the formula (I), in which R1 and R2 stand for optionally substituted alkyl, alkenyl or alkinyl, and Ar stands for optionally substituted aryl; also disclosed are processes for preparing these compound...
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WO/1997/007093A1 |
The use is disclosed of didepsipeptides having the general formula (I) and their salts, as well as new didepsipeptides and a process for preparing the same. In the formula (I), the rests have the meanings given in the description.
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WO/1997/005103A1 |
Phenyl acetic acid derivatives of formula (I) in which: X is NOCH3, CHOCH3 and CHCH3; Y is NMR and O; R, R1 are hydrogen and C1-4 alkyl; R2 is hydrogen, C1-C6 alkyl, C1-C4 alkyl halide and C3-C6 cycloalkyl; R3 is C4-C6 alkyl, substituted...
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WO/1997/001533A1 |
Thiocarbamic acid derivatives represented by general formula (I) and salts thereof, wherein m is 0 or 1; A is 4,4-dimethyl-2-pentynyl or the like; R1 and R3 are each hydrogen, formyl or lower alkyl; Z is nitrogen or CH; R2 is hydrogen, l...
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WO/1997/000854A1 |
An amide compound represented by general formula (I), a process for producing the same, and an insecticidal/miticidal drug which works without fail and is safely usable, wherein X represents hydrogen, halogen, alkyl, alkoxy, phenyl, phen...
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WO/1996/040672A1 |
Combinatorial libraries are constructed to include aminodiol monomer subunits connected by phosphodiester, phosphorothioate, or phosphoramidate linking moieties. Combinatorial libraries of the invention feature a plurality of functional ...
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WO/1996/038457A1 |
In accordance with the present invention, there are provided methods for the in vivo reduction of nitric oxide levels in a mammalian subject. In contrast to the inhibitory approach described in the prior art (i.e., wherein the function o...
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WO/1996/034851A1 |
The present invention provides a compound of formula (I), (II), (III) or (IV), processes for the preparation of the compounds of the invention, intermediates useful in these processes, a pharmaceutical composition, and methods of using t...
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WO/1996/033164A1 |
Hydroximic acid derivatives of general formula (I), wherein G is either G1 or G2 or G3 or G4 of the formula: R5OC=C(COOR4)-, R5ON=C(COOR4)-, R5ON=C(CONR6R7)-, R5OC=C(CONR6R7)-, X1, X2, X3 are H, halo, HO, mercapto, nitro, SCN, azido, CN,...
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WO/1996/032378A1 |
There is disclosed 3-N-substituted thiocarbamoyl-2-phenyl-1,3-propanediol carbamate, represented by structural formula (I), that is very effective for prophylaxis and treatment of central nervous system disorders including nervous muscul...
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WO/1996/022970A1 |
The invention concerns substituted amino acid amides of general formula (I), a process for their preparation and their use as pesticides. In formula (I): A stands for a single bond or optionally substituted alkylene; Q1, Q2 Q3 are identi...
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WO/1996/020922A1 |
There are disclosed 3-thiocarbamoyl-2-phenyl-1,3-propandiol carbamate racemate, represented by structural formula (I), and its (R)- and (S)- optical isomers and intermediates thereof, which are very effective for prophylaxis and treatmen...
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WO/1996/018372A2 |
Novel cationic amphiphiles are provided that facilitate transport of biologically active (therapeutic) molecules into cells. The amphiphiles contain lipophilic groups derived from steroids, from mono or dialkylamines, or from alkyl or ac...
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WO/1996/016020A1 |
The present invention relates to a method of synthesizing a 2-substituted nitrogen containing compound having formula (I), by reacting a hydroxylamine of formula (II); or a nitrone of formula (III); with a compound of formula (IV); there...
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WO/1996/015107A1 |
The invention relates to compounds of the general formula (I) D.M.G.Y, wherein D stands for one or more moieties comprising dithiocarbamic functional groups of the formula R1R2NCS2, where R1 and R2 are alkyl or together form alkylene whi...
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WO/1996/014289A1 |
Fluorobutenyl esters have the formula (I), in which R1 stands for hydrogen or a halogen, and R2 stands for one of the groups (a), (b) or (c), in which V, Y, Z, R3 and R5 have the meanings given in the description. Also disclosed are a pr...
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WO/1996/013481A1 |
An amino acid amide derivative represented by general formula (I), and an agrohorticultural bactericide containing the same as the active ingredient. In said formula, R1 represents lower alkyl which may be the same or different and may b...
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WO/1996/013482A1 |
An amino acid amide derivative represented by general formula (I), and an agrohorticultural bactericide containing the same as the active ingredient. In said Formula R1 represents lower alkyl which may be the same or different and may be...
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WO/1996/005215A1 |
The present invention is directed toward a polynucleotide synthesis support for use in automated polynucleotide synthesis of 3'-nitrogen functionalized polynucleotides. The invention includes, in one aspect, a polynucleotide synthesis re...
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WO/1996/000061A1 |
A compound of formula (I) with R being hydrogen, alkyl, cycloalkyl or aryl, which may be substituted with halogen or alkyl, and R' being hydroxyl, or -O-alkyl, pharmaceutically acceptable salts thereof; or mixtures thereof. An anti-neopl...
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WO/1995/030415A1 |
Dithiocarboxylates, including dithiocarbamates, block the induced expression of the endothelial cell surface adhesion molecule VCAM-1, and are therefore useful in the treatment of cardiovascular disease, including atherosclerosis, as wel...
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WO/1995/029889A1 |
Compounds of formula (I) in which X is (a) or (b), n is 0, 1, 2, 3, 4 or 5, where if n is greater than 1, the radicals R2 are identical or different; o is 0, 1, 2, 3 or 4, where if o is greater than 1, the radicals R3 are identical or di...
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WO/1995/027710A1 |
A compound represented by general formula (I) or a medicinally acceptable salt thereof (wherein R1 represents hydrogen, lower alkyl or acyl; R2 and R3 may be the same or different from each other and each represents hydrogen, optionally ...
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WO/1995/026337A1 |
The present invention relates to compounds as represented by formula (I) that can maintain, increase, or restore sensitivity of cells to therapeutic or prophylatic agents. This comprising these compounds. The compounds and pharmaceutical...
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WO/1995/019167A1 |
A composition suitable for administration to a warm-blooded animal comprising an antisense oligonucleotide to the C-C chemokine family typified by MCP-1 and MIP-1-Alpha which may or may not be labeled with a radionuclide by means of a ch...
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WO/1995/018820A1 |
Novel ethylene glycol compounds bearing various functional groups are used to prepare oligomeric structures. The ethylene glycol monomers can be joined via standard phosphate linkages including phosphorothioate, phosphodiester, and phosp...
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WO/1995/018100A1 |
A novel basic metal salt of a dithiocarbamic acid represented by general formula (1) and having a basic component content (=ax3x100) of 30-100 mol %. In formula (1) R1 to R4 represent each independently a C1-C30 lipophilic group; M repre...
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WO/1995/011226A1 |
A substituted benzene derivative of formula (I), wherein A is an aryloxy group which may be substituted, an arylthio group which may be substituted or -ON=C(R1)R2, each of R1 and R2 which are independent of each other is an alkyl group w...
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WO/1995/005362A1 |
A sulfonylsemicarbazide derivative represented by general formula (I) and a chemical for keeping cut flower freshness containing the same as the active ingredient, wherein R1 represents C3-C4 alkyl, optionally substituted phenyl pyridyl ...
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WO/1994/026705A1 |
The invention concerns 3-methoxy-2-phenylacrylic acid esters of formula (I) in which R is optionally substituted alkyl, cycloalkyl or aryl and n is 0 or 1, a method for the preparation of such esters and their use as pest-control agents.
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WO/1994/026724A2 |
Group 1 or 2 metal salts of N-cyanodithioiminocarbonate are prepared by reacting cyanamide, carbon disulfide and a Group 1 or 2 metal hydroxide, preferably in a methanolic solvent. These salts can be converted to metal salts of S-substit...
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WO/1994/026706A1 |
A process which involves the step of contacting, in a methanolic solvent system, a metal salt, preferably a Group 1 or 2 metal salt, of the anion of formula (II) with at least one compound containing an R-group under conditions sufficien...
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WO/1994/025432A1 |
An amino acid amide derivative represented by general formula (I) and an agrohorticultural bactericide containing the same as the active ingredient. In said formula (I) R1 represents lower alkyl which may be substituted by one or more su...
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