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WO/1994/020455A1 |
Compounds of general formula (1) are described wherein Y is a halogen atom or a group -OR1, wherein R1 is an optionally substituted alkyl group; X is -O-, -S-, or -N(R6), wherein R6 is a hydrogen atom or an optionally substituted alkyl g...
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WO/1994/019314A1 |
The invention aims at providing a device comprising lipids that act like the so-called cationic liposome and are reduced in toxicity and the lipids as the constituent of the device. The invention compounds are exemplified by 3-0-(4-dimet...
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WO/1994/018987A1 |
The invention aims at effectively utilizing a single-stranded nucleic acid copolymer, in particular, poly(adenylic acid-uridylic acid) and providing a drug composition having an antitumor effect. An example of the drug composition of the...
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WO/1994/015927A1 |
Catalytic oxidation of thiols or thiol salts or dithiocarbamic acids or their salts using oxygen, optionally in the presence of a primary or secondary amine, is accomplished with a carbon catalyst which contains no metal complex of porph...
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WO/1994/015599A1 |
Taxane derivatives substituted on the C10 position with novel substituents are disclosed. The novel compounds have utility as antileukemia and antitumor agents.
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WO/1994/013629A1 |
The present invention relates to a class of compounds which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of mannitol-derived HIV aspartyl protease inhibitors characterized by specific struc...
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WO/1994/011468A1 |
This invention relates to perfluoroalkyl group terminated urethanes, thiourethanes and ureas of the general formula: (R-X-CONH)mA where m is 1, 2, or 3, R is Rf-E and optionally R1 with the proviso that at least one R is Rf-E, Rf is a pe...
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WO/1994/009772A1 |
Dithiocarboxylates, and in particular, dithiocarbamates, block the induced expression of the endothelial cell surface adhesion molecule VCAM-1, and are therefor useful in the treatment of cardiovascular disease, including atherosclerosis...
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WO/1994/003149A2 |
Aging of the human skin is caused primarily by the biochemical action of free radicals, peroxides and derived products. Lipid-soluble thioethers and dithioethers in cosmetic preparations inactivate the peroxides formed in the skin and th...
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WO/1993/021772A2 |
Herbicidal composition comprising N-[2-(3,3,3-trifluoropropyl)-phenylsulfonyl]-N'-(4-methoxy-6
-methyl-1,3,5-triazin-2-yl)-urea of formula (I) or agrochemically tolerated salts thereof, and a synergistic amount of one or more further her...
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WO/1993/016992A1 |
Sulfonic acid stilbenes of formula (I) wherein B is -CH=CH- (cis or trans), -CH2CH2- or a bond; X is NH or oxygen; Y is oxygen or sulfur; Z is NH, CH2, oxygen or sulfur; R1 is hydrogen, C1-C4 alkyl, -CH2-Ar, or -Ar wherein Ar is a phenyl...
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WO/1993/014772A1 |
The invention relates to a new utilization of niobium derivatives in the 4 or 5 oxidation status as active principle for the production of medicaments useful in the treatment and/or prevention of glucid and/or lipid metabolism troubles. ...
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WO/1993/010086A1 |
An improved process is disclosed for preparing known N-(arylsulphonyl)-carbamic acid derivates (carbamide, carbamate and thiocarbamate) having the formula (I), in which Ar can be an aryl group, Z can be N, S or O and R?4¿ and R?5¿ can ...
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WO/1993/009084A1 |
A novel class of compounds are disclosed which may be used as novel crosslinking agents for acrylic-containing, vinyl-containing and/or styrene-containing hydrophilic monomers to prepare novel UV-curable hydrophilic copolymers suitable f...
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WO/1993/009132A1 |
Compounds of formula (I) wherein R1 and A are amino terminal groups: Z is O or N-R2; M is a dipeptide isostere; and D1 and D2 are optionally absent or amino acids; and pharmaceutically acceptable salts thereof, are potent inhibitors of t...
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WO/1993/009085A1 |
Constitution: a nitroxyalkylamide derivative represented by the general formula (I): R1-(A)n-COHN-B-ONO2, wherein R1 represents optionally substituted heterocyclic, heterocyclic oxy, aryloxy or arylthio; A represents C1-C4 alkylene; B re...
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WO/1993/007116A1 |
Fungicidal compounds having formula (I), wherein W is CH3O.CH=CCO2CH3, CH3ON=CCONR3R4 or CH3ON=CCO2CH3 and stereoisomers thereof; n is 0 or 1; X is oxygen or sulphur; Z is oxygen, sulphur or NR1; R1 is hydrogen or alkyl optionally substi...
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WO/1993/004032A1 |
A compound having a high insecticidal activity, represented by general formula (I), or a salt thereof wherein R¿1? represents optionally substituted alkyl; R¿2? represents hydrogen, optionally substituted alkyl or COR¿3? wherein R¿3?...
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WO/1993/000355A1 |
A method is described for the generation of phenylthiocarbamyl. (PTC) amino acids from phenylthiohydantoin (PTH) or anilinothiozolinone (ATZ) amino acids. The method involves a base-catalyzed ring opening of the PTH or ATZ in the presenc...
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WO/1992/017025A2 |
Peptides which include unnatural amino acids and which inhibit the secretion of gonadotropins by the pituitary gland and inhibit the release of steroids by the gonads. The peptides are analogs of the decapeptide GnRH wherein there is at ...
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WO/1992/015595A1 |
A dihydrocarbyl dithiophosphate or dithiocarbamate suitable for use as a lubricating oil additive is prepared from reactants in different phases by reacting the reactants in a reaction region defined by adjacent surfaces between which th...
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WO/1992/013835A1 |
Salts of dithiocarbamic acid which can be converted into isothiocyanates, which are suitable intermediates for producing thiazabicyclononane derivatives and monothiourazole derivatives, in a remarkably high yield; a process for producing...
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WO/1992/008698A1 |
Compounds represented by formula (I) wherein A represents R, R?13¿ and radicals represented by formula (II), B represents R?5¿ and radicals represented by formula (III) (values for the variables given herein) are effective as retrovira...
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WO/1992/008700A1 |
Compounds represented by formula (I) or a pharmaceutically acceptable salt, prodrug or ester thereof, wherein A represents radicals represented by formulae (A1, A2, A3) (values for the variables given herein), are effective as retroviral...
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WO/1992/007826A1 |
The present invention is directed to compounds of general formula (I), methods for using the compounds of formula (I), pharmaceutical compositions thereof, and processes for preparing the compounds. Formula (I) wherein X is oxygen or sul...
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WO/1992/003410A1 |
Novel N-(mercaptoalkyl)urea or carbamates of formulae (I) and (II) wherein A is a monocyclic or bicyclic arylene or heteroarylene; Q is hydrogen or R9CO-; Y is -O-, -S- or -NR8-; R1 is lower alkyl, cyclolower alkyl, aryl or heteroaryl; R...
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WO/1992/002484A1 |
Compounds having anti-inflammatory and other activities are disclosed. The compounds are derived from diterpenes, aromatic heterocyclic compounds of the indole, indene, benzofuran and benzothiophene class and from polyacetates, diaminobe...
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WO/1992/001682A1 |
Compounds of the structure (I) where p and q are zero or one, but cannot both be the same, M is a pharmaceutically acceptable cation or a metabolically cleavable group, B is a valence bond or a straight or branched alkylene group, R is a...
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WO/1991/016299A1 |
A method for control of plant disease, especially fungus, using compounds of formula (I) and novel compounds within the class, wherein: A is C(=O)R, C(=O)OR1, C(=O)SR1, P(=O)QR2Q1R3; C(=O)NHR, SO2R5, SO2NR6R7; Q and Q1 are independently ...
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WO/1991/005761A1 |
A method of inhibiting the growth or replication of viruses of the HIV group is disclosed. Also disclosed are compounds useful in the method and pharmaceutical formulations incorporating such compounds. The method involves the use of com...
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WO/1991/005767A1 |
Said polyurethanes contain patterns of the type (Ia) or (Ib) with A = alkyl, cycloalkyl, aryl, arylalkyl or alkylaryl, or polyoxyalkylene or polyester; D = alkylene, cycloalkylene, arylene, alkylarylene or arylalkylene, and can contain a...
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WO/1990/012784A1 |
A method for control of plant disease, especially fungus, using compounds of formula (I) and novel compounds within the class (I), wherein: A is C(=O)R, C(=O)OR?1¿, C(=O)SR?1¿, P(=O)QR?2¿Q?1¿R?3¿; C(=O)NHR, SO¿2?R?5¿, SO¿2?NR?6¿...
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WO/1990/006916A1 |
Compounds which improve extreme pressure and anti-wear propertiesof lubricating compositions are described. The compounds include the compounds of formula (I) as well as statistical mixtures of those compounds, wherein R1 is hydrogen or ...
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WO/1990/005135A2 |
Process for the specific synthesis of dithiocarbamic acid esters by substituting hydroxylated sites on mono- or polyhydroxylated molecules; products obtained by this process and their applications. Process for preparing esters of dithioc...
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WO/1989/010917A2 |
Compound of formula (I), wherein R1, W, R2, Z, A and B have the meaning given in claim 1, process for producing it, and its use as a renin inhibitor in the treatment of hypertension and chronic cardiac insufficiency and in the treatment ...
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WO/1989/010956A1 |
Quaternary ammonium dithiocarbamate compounds having formula (I) or (II) and methods of preparing same by mixing in water a quaternary ammonium compound having formula (III) and a dithiocarbamate salt having formula (i) or a bis-dithioca...
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WO/1989/009765A1 |
This invention relates to novel compositions of matter and their methods of preparation, which compositions are esters with enhanced water solubility, for use in aqueous enzymatic resolution reactions of racemic mixtures of these esters....
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WO/1989/009207A1 |
A substituted 1-(2-chlorethyl)-3-acyl-3-alkyltriazene of formula (I), in which R1 is 1-oxoalkyl containing from two to eight carbon atoms, fluorinated 1-oxoalkyls containing from two to eight carbon atoms and substituted with up to three...
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WO/1989/009208A1 |
A preparation for treatment of addiction to alcohol, containing a carbamic acid ester having general formula (I), wherein X is -CH3 or -CH2CH3, R and R1 which may be the same of different, are hydrogen, C1-5 alkyl or a group of formula (...
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WO/1989/007890A1 |
Useful as antimicrobial agents are beta-substituted alpha-halo-acrylonitriles of formula (I), wherein X represents chlorine, bromine or iodine and R represents a lower alkyl, aryl, aralkyl, heterocyclyl, or thiocarbonyl group. These comp...
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WO/1989/007622A1 |
Composition useful for molding into articles such as food containers, beverage bottles, cured structural plastics and the like comprising molding grade linear or unsaturated polyester or polycarbonate (a) containing a mono-4-acyloxystyry...
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WO/1989/006126A1 |
Disclosed are novel substituted 3-aralkyl-imidazolines of structure (I), processes for their preparation, intermediates useful in their preparation, pharmaceutical compositions containing them and their use in therapy in particular as do...
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WO/1989/003822A1 |
Anthralin analogues containing a thio-substituent, especially in one or more of the positions 2-, 7- and 10- of the anthralin ring. They may be made by reacting an anthralin derivative (e.g. 10-bromoanthralin) with a thiol or a compound ...
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WO/1989/002430A1 |
The invention relates to diethyl-dithiocarbamate of choline having the developed formula (I), as well as a method for preparing it from choline chloride and trihydrated sodium diethyl-dithio-carbamate. This compound is useful for the tre...
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WO/1988/008441A1 |
An electro-optical liquid crystal display element comprises a dielectric with at least two liquid crystal components. In order to shorten the switching time, the dielectric contains at least one fluorine compound of formula (I): R1-(A1-Z...
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WO/1988/005050A1 |
A renin inhibiting compound of formula (I), wherein A is a substituent; W is C=O or CHOH; U is CH2 or NR2, provided that when W is CHOH then U is CH2; R1 is loweralkyl, cycloalkylmethyl, benzyl, 4-methoxybenzyl, halobenzyl, (1-naphthyl-m...
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WO/1988/002363A1 |
The derivatives have the general formula (I) wherein R1 is an optionally mono or polyhalogenated aliphatic acyl group, a benzoyl or phenacetyl group which may carry on the phenyl residue one to three halogeno or alkyl substituents, an al...
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WO/1987/005622A1 |
A phosphorus free or a low phosphorus containing lubricant composition is provided by formulating the composition with an additive of the formula (I), wherein R1 and R2 are independently alkyl of 1 to about 7 carbons, aryl, aralkyl or to...
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WO/1987/005045A1 |
Novel molybdenum or tungsten thiocarbamate additives for functional fluids, e.g., lubricating oils, automatic transmission fluids (ATF), as well as fuel compositions, have been developed. The molybdenum or tungsten carbamate compositions...
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WO/1987/004156A1 |
Salts of N-(vinyloxiethyl)dithiocarbamic acid have the following formula: ADCH2=CHOCH2CH2NHC(S)S BDnM, where M is K, Na, Zn, Cu; n is equal to 1.2. Potassium and sodium salts of N-(vinyloxiethyl)dithiocarbamic acid are obtained by reacti...
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