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JP6407950B2 |
where R1, R2, R3, R4a, R4b, R5, R6 and R7 are defined herein, or stereoisomers or pharmaceutically acceptable salts thereof, are described herein. Such compounds have activity as SHIP1 modulators, and thus may be used to treat any of a v...
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JP6407951B2 |
R1, R2, R5 and R13 are described herein, or a stereoisomer, enantiomer or tautomer thereof or mixtures thereof, or a pharmaceutically acceptable salt or solvate thereof, are described herein, as well as other compounds. These compounds h...
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JP6408353B2 |
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JP2018020989A |
To provide a urea compound or thiourea compound with pharmacological action.One aspect of the present invention relates to a pharmaceutical component comprising a urea compound or thiourea compound represented by the general formula (I),...
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JP2017178962A |
To provide a novel 4-dedimethylamino tetracycline compounds that can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms.The present invention pertains to substituted tetracycline...
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JP2017039725A |
To provide methods of treating a cancer.Methods of treating a cancer characterized by the presence of a mutant allele of IDH1 comprise administering a compound represented by formula I. A method for inhibiting a mutant IDH1 activity comp...
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JP6081354B2 |
Provided are methods of treating a cancer characterized by the presence of a mutant allele of IDH1 comprising administering to a subject in need thereof a compound described here.
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JP6037396B2 |
A novel serine racemase inhibitor exhibits sufficient activity and specificity. The serine racemase inhibitor includes one or more compounds selected from compounds respectively represented by the following general formulas [MM_1], [DR_1...
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JP5976733B2 |
In its many embodiments, the present invention provides provides certain iminothiadiazine dioxide compounds, including compounds Formula (I): and include stereoisomers thereof, and pharmaceutically acceptable salts of said compounds ster...
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JP5955221B2 |
An object of the present invention is to provide a novel fungicide having an excellent fungicidal activity. The compound used as the fungicide of the present invention is an ethynylphenylamidine compound or a salt thereof, the compound b...
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JP2016510320A |
Equation (I):Compounds or pharmaceutically acceptable salts thereof are described herein. In equation (I), N, R1, R4a, R4b, R5, R7And R8Is as defined herein. The compounds of the present disclosure have activity as SHIP1 modulators and c...
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JP5829520B2 |
Provided are 4-modified colchicine compounds and medicines using the same. Specifically provided are colchicine derivatives represented by general formula (1), salts thereof, and solvates of the same. In general formula (1), R1 is a halo...
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JP5819188B2 |
The present invention relates to the use of acylthiourea or acylurea derivatives for the treatment of pathologies involving a tissue dysfunction associated with a deregulation of the Hedgehog protein signalling pathway, and also to novel...
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JP5810097B2 |
The invention relates to a process for the preparation of salts having perfluoroalkyltricyano- or perfluoroalkylcyanofluoroborate anions, ((per)fluoro)phenyltricyano- or ((per)fluoro)phenylcyanofluoroborate anions, phenyltricyanoborate a...
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JP5773877B2 |
Provided are compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions.
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JP2015145392A |
To provide compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using the compounds and compositions.This invention r...
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JP2015063557A |
To provide novel 4-dedimethylamino tetracycline compounds which can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms.The present invention provides substituted tetracycline com...
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JP5587987B2 |
Disclosed are nitrile derivatives and pharmaceutical compositions comprising nitrile derivatives. The pharmaceutical compositions comprise compounds of the formula I and the pharmaceutically acceptable salts of such compounds. Also discl...
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JP5576411B2 |
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JPWO2012117941A1 |
The electrode active material has the general formula (I) or (II) in its constituent units. X is C or Si, Y1And Y2, Or Y3And Y4Are different substituents, S, O, Se, Te, NH or SR1 R2, SR3 R4 Is selected. R1~ R4, R1 ~ R4 Is a predetermined...
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JPWO2012105438A1 |
The electrode active material has a dithionic structure as shown in the following general formula. In the dithion structure, the linking group Z is interposed between the X = S groups (X: C or Si). Connecting group Z is CH2, CF2, O, S, S...
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JP5523695B2 |
The present invention discloses a composition containing a conjugate comprising two moieties covalently linked by a thiourea linker and thiourea or a derivative thereof in free form. It also relates to a method for stabilizing a conjugat...
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JP5523838B2 |
The present invention relates to crystalline complexes comprising at least one agriculturally active organic compound A having at least one functional moiety which is capable as serving as a hydrogen acceptor in a hydrogen bond and thiop...
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JP5506386B2 |
The present invention relates to compounds which activate the p53 response, and find use in, for example, hyperproliferative diseases such as cancer treatment and potentially other diseases/conditions involving sirtuin function.
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JP5485838B2 |
A compound of formula wherein R 2 is arylene or heterocyclene and the other residues have various meanings, useful as pharmaceuticals, e.g. antimicrobials.
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JP5426560B2 |
The present invention relates to compounds represented by formula (I) or composition comprising at least one of such compounds, which are inhibitors of histone deacetylase. The detailed description of these compounds is disclosed in the ...
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JP5365176B2 |
To provide a new material high in piezoelectricity as an organic piezoelectric material and excelling in heat resistance by adding ferroelectricity to a discotic liquid crystal. This organic piezoelectric material includes a compound rep...
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JP5346307B2 |
To provide a polyion dendrimer capable of intracellularly transporting a protein by such a simple operation as to merely make mixing through utilizing intermolecular interaction via no covalent bond, thus useful as a highly versatile pro...
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JP2013202606A |
To improve efficiency of concentrating and recovering thiourea from thiourea-containing water.A sulfide of an alkali metal or an alkaline earth metal is added to thiourea-containing water which includes a metal, the metal included in the...
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JP5279161B2 |
Substituted aryloxyalkylamines of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions.
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JP5277213B2 |
Antibacterial compounds of formula (I) are provided: As well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds; treating bacterial infections by the a...
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JP2013533266A |
A method for synthesizing an isothiocyanate of general formula (I) SCN-R1-R4-R2(I) wherein R1 and R2 represent independently of each other an alkyl-aryl or aryl group, R4 represents a carbonyl, sulfinyl, sulfonyl group or a sulfide group...
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JP5270600B2 |
The present invention is concerned with novel compounds derived from polyquinonic ionic compounds and their use in electrochemical generators.
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JP5250422B2 |
Indanyl- and Tetrahydronaphtyl-amino-thiourea compounds for combating animal pests The present invention relates to Indanyl- and Tetrahydronaphtyl-amino-thiourea compounds of formula I wherein the variables R1 to R4 are as in the descrip...
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JP2013530182A |
Disclosed are novel thiourea or urea derivatives inhibitory of HIV activity. Also provided are a method for preparing the thiourea or urea derivatives, and a pharmaceutical composition for the prophylaxis or therapy of AIDS comprising th...
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JP5240398B2 |
A composition containing a compound represented by General Formula (I) below (see the definition in the specification for the symbols in the formula) or a salt thereof has an excellent CaSR agonistic effect and provides a pharmaceutical ...
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JP5232841B2 |
This invention provides compounds of Formula (I), wherein B, G, A, E, R 1 , R 2 , R 3 , m and n are as defined herein, which are useful as type I receptor tyrosine kinase inhibitors, and methods of use thereof in the treatment of hyperpr...
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JP5235683B2 |
The present invention concerns a process for the manufacture of an adamantanamine of formula wherein R, R' and X are as defined in the claims, which comprises (i) reacting a compound of formula with thiourea; (ii) subjecting the resultin...
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JP2013116121A |
To discover ligands using combined technique.There are provided new methods for ligand discovery. The inventive methods rely on a process termed "tethering" where potential ligands are covalently bonded or "tethered" to a target and subs...
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JP5173914B2 |
The invention provides a method for preparing an aqueous dispersion of polymer particles comprising the following steps: (i) preparing a dispersion having a continuous aqueous phase, a dispersed organic phase comprising one or more ethyl...
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JP5166668B2 |
Ionic compounds with a freezing point of up to 100° C. are formed by the reaction of an one amine salt of formula (I) R1R2R3R4N+X-, such as choline chloride with an organic compound (II) capable of forming a hydrogen bond with X; such a...
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JP5164236B2 |
To provide a new compound for an electrode material of high capacity as an electrode of an electrochemical element of a battery, a method for manufacturing the same and an electrode using the compound. A redox-active polymer in which a p...
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JP5146714B2 |
Methods, compounds, pharmaceutical compositions and kits are described for treating or preventing amyloid-related disease.
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JP5127093B2 |
Compounds of formula (I) wherein the groups are as defined in the description are disclosed. The compounds of formula (I) are endowed with reversible inhibiting activity of carnitine palmitoyl-transferase and are useful in the prepar...
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JP5095050B2 |
The present invention relates to novel compounds and formulations thereof which compounds are ligands, e.g., agonists or antagonists, for a metabotropic glutamate receptor or a NAALADase enzyme or both. The present invention also relates...
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JP5086635B2 |
Antibacterial compounds of formula (I) are provided: As well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds; treating bacterial infections by the a...
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JP5080260B2 |
The invention relates to sulfonamido derivatives of formula (I) wherein R1-R7 are as defined in the description. Compounds (I) antagonize the vanilloid receptor and can be used for the preparation of medicaments for the treatment of infl...
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JP5047777B2 |
The invention provides N,N'-disubstituted monothiourea or bis-thiourea-Pd(0) complexes that are useful as catalysts for palladium-catalyzed Heck reaction of aryl iodides and bromides with olefins, and as catalysts for palladium catalyzed...
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JP5037436B2 |
The present invention pertains, at least in part, to novel 9- substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasm...
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JP5013236B2 |
To provide a new insecticide for horticulture, and the application. The new insecticide is the aromatic diamide derivative or its salt of formula I, and the medicine for horticulture. A1 shows a 1-8C alkylene group, 3-8C alkenylene group...
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