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WO/2002/068384A2 |
Compounds of formula (i) and of formula (ii), wherein the symbols have the meaning disclosed in the claims, specifically or selectively modulate $g(a)¿2A? adrenergic receptors and as such are useful for alleviating chronic pain and allo...
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WO/2002/068383A2 |
The present invention relates to biscarbodiimides, thiourea derivatives, urea derivatives, and cross-linked hyaluronan derivatives having at least one intramolecular disulfide bond, and methods of preparation thereof. The invention also ...
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WO/2002/064136A2 |
The present invention relates to novel compounds (I), their prodrugs, and the pharmaceutically acceptable salts as well as pharmaceutical compositions containing such compounds useful in treating certain metabolic diseases and diseases m...
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WO/2002/062762A2 |
Compounds of formula (I) are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.
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WO/2002/060388A2 |
A class of acyl sulfamides comprises compounds that are potent ligands for PPAR gamma and generally have antagonist or partial agonist activity. The compounds may be useful in the treatment, control or prevention of obesity, non-insulin ...
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WO/2002/058690A2 |
The present invention relates to methods for the prophylaxis, management and treatment of certain diseases modulated by the inhibition of the enzyme malonyl-coenzyme A decarboxylase (malonyl-CoA decarboxylase, MCD) by the administration ...
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WO/2002/059080A2 |
The present invention relates to novel, non-peptidic small organic compounds having an affinity for cyclophilin (CyP)-type immunophilin proteins, and to pharmaceutical compositions comprising one or more of the said compounds. The invent...
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WO2000064911A9 |
The present invention relates to novel compounds and formulations thereof which compounds are ligands, e.g., agonists or antagonists, for a metabotropic glutamate receptor or a NAALADase enzyme or both. The present invention also relates...
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WO/2002/046141A2 |
The present invention provides compounds that elevate cellular expression of the ABCA-1 gene, promoting cholesterol efflux from cells and increasing HDL levels in the plasma of a mammal, in particular humans. The compounds are useful for...
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WO1999059957A9 |
Compounds of formula (I) wherein the groups are as defined in the description are disclosed. The compounds of formula (I) are endowed with reversible inhibiting activity of carnitine palmitoyl-transferase and are useful in the preparatio...
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WO/2002/046172A2 |
The present invention provides compounds that elevate cellular expression of the ABCA-1 gene, promoting cholesterol efflux from cells and increasing HDL levels in the plasma of a mammal, in particular humans. The compounds are useful for...
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WO/2002/046181A2 |
The present invention provides compounds that elevate cellular expression of the ABCA-1 gene, promoting cholesterol efflux from cells and increasing HDL levels in the plasma of a mammal, in particular humans. The compounds are useful for...
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WO/2002/044126A2 |
The present invention relates to novel, non-peptidic small organic compounds having an affinity for cyclophilin (CyP)-type immunophilin proteins. In the compounds of this invention, at least two carbo-or heterocyclic groups are attached ...
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WO/2002/036556A2 |
The present invention relates to acylaminoalkyl-substituted benzenesulfonamide derivatives of formula (I), in which A, R(1), R(2), X, Y and Z have the meanings indicated in the claims. The compounds of formula (I) are valuable pharmaceut...
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WO2001002423A9 |
The present invention provides oligomers which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the nucleoside moieties of the oligomer is modified to include a guanidinium group. These oligome...
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WO/2002/034203A2 |
The present invention relates to novel antimycobacterial compounds and in particular to antimycobacterial compounds comprises of derivatives of phenyl 4-aminosalicylate. This invention further relates to methods for their preparation, to...
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WO/2002/033596A2 |
The invention provides a method of operating a computer system, and a corresponding computer system, for performing a discrete substructural analysis. First, a database of molecular structures is accessed. The database is searchable by m...
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WO/2002/026701A2 |
Ionic compounds with a freezing point of up to 100 °C are formed by the reaction of an one amine salt of formula (I) R?1¿ R?2¿ R?3¿ R?4¿ N?+¿ X?-¿, such as choline chloride with an organic compound (II) capable of forming a hydrog...
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WO/2002/022581A1 |
A method for the inhibition of high affinity glycine transporters, compounds that inhibit these transporters; pharmaceutically active compositions comprising such compounds; and the use of such compounds either as above, or in formulatio...
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WO/2002/022627A2 |
The present invention relates to novel compounds and formulations thereof which compounds are ligands, e.g., agonists or antagonists, for a metabotropic glutamate receptor or a NAALADase enzyme or both. The present invention also relates...
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WO/2002/018326A1 |
Propenohydroxamic acid derivatives represented by the following general formula (1) or salts thereof and drugs containing the same: (1) wherein R?1¿ represents hydrogen, alkyl or halogeno; R?2 ¿represents cycloalkyl, aryl, heteroaryl, ...
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WO/2002/016317A1 |
The present invention relates to an antagonist against vanilloid receptor and the pharmaceutical compositions containing the same.As diseases associated with the activity of vanilloid receptor, pain, acute pain, chronic pain, neuropathic...
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WO/2002/016318A1 |
The present invention relates to novel thiourea derivatives as a modulator for vanilloid receptor (VR) and the pharmaceutical compositions containing the same. As diseases associated with the activity of vanilloid receptor, pain acute pa...
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WO/2002/016319A1 |
The present invention relates to thiourea compounds and the pharmaceutical compositions containing the same, and particularly, to novel thiourea compounds as an antagonist against vanilloid receptor (VR) and the pharmaceutical compositio...
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WO/2002/014267A1 |
The present invention relates to compounds of formula (I) wherein U, V, W, A?1¿, A?2¿, A?3¿, A?4¿, A?5¿, A?6¿, m and n are as defined in the description and claims and pharmaceutically acceptable salts and/or pharmaceutically accep...
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WO/2002/012224A2 |
Substituted N-substituted alkoxyphenyl compounds, compositions containing them, and methods of making and using them.
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WO/2002/012190A2 |
Substituted non-imidazole aryloxypiperidine compounds, compositions containing them, and methods of making and using them to treat or prevent histamine-mediated conditions.
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WO/2002/012214A2 |
Substituted aryloxyalkylamines of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions.
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WO/2002/006189A2 |
The present invention relates to compounds of formula (I) and pharmaceutically acceptable salt and/or pharmaceutically acceptable esters thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associa...
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WO/2002/004406A2 |
The present invention pertains, at least in part, to novel 9- substituted minocycline compounds. These minocyline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms...
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WO/2002/000606A1 |
A novel biphenyl compound having GPR14 antagonism. It is a compound represented by the formula (I) or a salt thereof, wherein R?1¿ represents hydrogen, etc.; X represents 1 to 12 spacers; A represents amino, etc.; R?2¿ and R?3¿ each r...
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WO/2001/098256A1 |
This invention relates to compounds of the formula (I) which are thyroid receptor ligands, and are preferably selective for the thyroid hormone receptor $g(b), to methods of preparing such compounds and to methods for using such compound...
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WO/2001/098235A2 |
The invention relates to 3,4-dihydroxybenzyl-substituted carbonic acid derivatives, to their production, and to their use as antioxidants or free-radical scavengers, especially in cosmetic and pharmaceutical preparations and in foodstuff...
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WO/2001/094325A1 |
The invention concerns 2-aminithiazoline derivatives of formula (I) wherein: either R¿1? is a hydrogen atom or an alkyl radical and R¿2? is an alkyl, -alk-NH¿2?, -CH-R¿3?, -CH¿2?-S-R¿4? or phenyl radical substituted by a nitro or N...
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WO/2001/094357A1 |
New spisulosine derivatives of use in treating tumors are of the formula (I) wherein: each X is the same or different, and represents H, OH, OR', SH, SR', SOR', SO¿2?R', NO¿2?, NH¿2?, NHR', N(R')¿2?, CN, halogen, C(=O)H, C(=O)CH¿3?,...
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WO/2001/092213A2 |
Compounds of the formula (I) in which: R?1¿ is (CH¿2?)¿n?Y; n is 1 or 2; Y is NHSO¿2?R?2¿ or X?1¿-W-X?2¿-R?3¿; X?1¿ is O or NH; W is C=O, C=S, C=NH, or SO¿2?; X?2¿ is O or NH, provided that X?1¿ and X?2¿ are not both O; R?2Â...
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WO/2001/092207A1 |
A process of reacting a compound having an NH group with a thiocyanate, a cyanamide, a nitrile, or an ester in the presence of a silylating agent to thereby obtain the corresponding nitrogen-containing addition or substitution product. T...
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WO2000056681A9 |
This invention provides combinatorial chemistry libraries containing thiourea and urea compounds of formula (I), in which X is S or O; R and R1 are individually (CHR) -Ar; and the other variables are as defined in the claims. In addition...
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WO/2001/085681A2 |
1-(3-methoxybenzyl)-3-substituted thiourea antioxidant compounds and improved lipids compositions which are supplemented with amounts of such antioxidant compounds effective for augmenting oxidative stability of the base lipid are provid...
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WO/2001/083429A1 |
Compounds represented by the formular (A), tautomers thereof, or medicinally acceptable salts of both exhibit an NOS-inhibitory activity and are useful as drugs in the treatment of various diseases.
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WO/2001/083427A1 |
To provide PPAR$g(g) modulators seemingly usable in remedies for involutional osteoporosis which inhibit the accelerated differentiation of adipocytes and promote the formation and differentiation of osteoblasts from stem cells, or remed...
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WO/2001/078703A2 |
Methods and compositions for the treatment of pain. Particularly disclosed are new compositions for the treatment of chronic pain, and methods for their use.
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WO/2001/078702A2 |
Methods and compositions for the treatment of pain. Particularly disclosed are new compositions for the treatment of chronic pain, and methods for their use.
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WO/2001/079359A2 |
Anti-fouling agents comprising isothiouronium salts, guanidinium salts, and their conjugate base analogs are provided. Anti-fouling coating compositions that include these anti-fouling agents are also provided. Such anti-fouling agents a...
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WO/2001/074761A1 |
Substituted tetracycline compounds, methods of synthesis, and methods of use are discussed. Tetracyclines useful for treating tetracycline related disorders are also discussed. Intermediates useful for synthesizing other tetracycline com...
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WO/2001/070681A1 |
The invention relates to articles having an activated surface for immobilizing bioorganic macromolecules. Said articles comprise: a substrate with a surface; a dendritic skeleton linked to the substrate surface, and; a number of first co...
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WO2000071506A9 |
Compounds of formula (I), wherein R<1> and R<2> are substituents on the A rings and are, independently, -SO2NR<7>2, -C(O)NR<7>2, -NR<7>SO2R<7>, -NR<7>C(O)R<7>, -SO2OR<7>, -C(O)OR<7>, -OSO2R<7>, or -OC(O)R<7>, R<3> and R<4> are, independe...
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WO/2001/068033A2 |
This invention relates to novel compounds of Formula (I), and compositions thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
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WO/2001/058854A1 |
Compound (2-hydroxy-2-methyl-N-(4-X-3-(trifluoromethyl)phenyl)-3-(2,2
,2-perfluoroacylamino)propionamide) applied topically, specifically inhibits and/or eliminates cutaneous androgen receptors and thus finds cosmetic use in skin afflict...
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WO/2001/056975A1 |
The invention concerns novel substituted imide derivatives of general formula (I), wherein R?1¿ represents optionally substituted cycloalkyl; R?2¿ represents optionally substituted alkyl or optionally substituted cycloalkyl; R?3¿ repr...
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