Acyclic or Carbocyclic Compounds

Matches 301 - 350 out of 1,417	< 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >

Document	Document Title
WO/1999/062871A1	NEW 3-ARYL PROPIONIC ACID DERIVATIVES AND ANALOGS Novel 3-aryl proprionic acid derivatives and analogs, having general formula (I) and stereo- and optical isomers and racemates thereof as well as pharmaceutically acceptable salts, solvates and crystalline forms thereof, process for thei...
WO1999051546A9	PARALLEL COMBINATORIAL APPROACH TO THE DISCOVERY AND OPTIMIZATION OF CATALYSTS AND USES THEREOF The present invention provides methods and compositions, i.e. synthetic libraries of candidate compounds, useful in the discovery and optimization of compounds which catalyze at least one chemical transformation. In certain instances, th...
WO/1999/051570A1	ANION-COMPLEXING COMPOUND, METHOD OF PREPARING THE SAME, AN ION-SELECTIVE MEMBRANE AND A SENSOR PROVIDED WITH SUCH A COMPOUND OR MEMBRANE Disclosed is an anion-complexing compound (I) wherein R1 and A represent an aromatic 6-ring, Y' represents a -NHC(X)NH-group, and Y' represents a rest selected from the group -NHC(X')-, -C(X')NH- and -NHC(X')NH-, wherein X and X', indepe...
WO/1999/036393A1	INHIBITORS OF $g(a)4 MEDIATED CELL ADHESION The present invention relates to a pharmaceutical composition comprising as an active ingredient a compound of formula (I), wherein Ring A is an aromatic or a heterocyclic ring; Q is a bond, carbonyl, lower alkylene, lower alkenylene, -O...
WO/1999/033790A1	INSECTICIDAL FLUORO-SUBSTITUTED BENZOYLUREAS Fluoro-substituted benzoylureas of formula (I) wherein R?1¿, R?2¿ and R?3¿ each independently represent a hydrogen atom, nitro, cyano, halogen, C¿1-3?-alkyl, C¿1-3?-haloalkyl, C¿1-3?-alkoxy, C¿1-3?-haloalkoxy, C¿1-3?-alkylthio or...
WO/1999/032463A1	INHIBITION OF p38 KINASE USING SYMMETRICAL AND UNSYMMETRICAL DIPHENYL UREAS This invention relates to the use of a group of aryl ureas in treating cytokine mediated diseases and proteolytic enzyme mediated diseases, and pharmaceutical compositions for use in such therapy.
WO/1999/032433A1	THIOUREA AND BENZAMIDE COMPOUNDS, COMPOSITIONS AND METHODS OF TREATING OR PREVENTING INFLAMMATORY DISEASES AND ATHEROSCLEROSIS The present invention provides compounds of formula (I). The present invention also provides methods of treating or preventing inflammation or atherosclerosis, and a pharmaceutical composition that contains a compound of formula (I).
WO/1999/029655A1	NOVEL ANTIARRHYTHMIC COMPOUNDS The invention relates to compounds of formula (I), wherein R?1¿ and R?2¿, independently from each other, mean hydrogen, halogen or C¿1-4? alkyl group; R?3¿, R?4¿ and R?5¿, independently from each other, stand for hydrogen or C¿1-4...
WO/1999/028984A1	NOVEL ELECTRODE MATERIALS DERIVED FROM POLYQUINOID IONIC COMPOUNDS AND THEIR USES IN ELECTROCHEMICAL GENERATORS The invention concerns novel electrode materials derived from polyquinoid ionic compounds and their uses such as in electrochemical generators. It concerns in particular compounds such as a rhodizonic acid salt; a rufigallic acid salt; a...
WO/1999/010313A1	N-AROYLPHENYLALANINE DERIVATIVES Compounds of formula (I) are disclosed which have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4. Such compounds are useful for treating diseases whose symptoms and /or damage are related to the binding of VC...
WO/1999/008992A1	2,4-PENTADIENOIC ACID DERIVATIVES HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY Enantiomerically substantially pure compounds of formula (I) where R is H or lower alkyl of 1 to 6 carbons, or pharmaceutically acceptable salts thereof have retinoid-like biological activity. The enantiomerically pure or substantially p...
WO/1999/007672A1	DERIVATIVES OF 2,5- AND 3,5-DISUBSTITUTED ANILINES, THEIR PREPARATION AND USE Substituted anilines of general formula (I) wherein R?1¿, R?2¿, R?3¿, R?4¿ and X are defined in the description, compositions thereof and methods for preparing the compounds are described. The compounds are useful for the treatment o...
WO/1998/053688A1	FUNGICIDAL MIXTURES, The invention relates to a fungicidal mixture containing a synergistically effective amount of a.1) a phenyl-benzyl ether derivative of formula (I.a), (I.b) or (I.c) or a.1) a carbamate of formula (I.d), wherein X = CH and N, n = 0, 1 or...
WO/1998/052552A1	PROCESS FOR THE PREPARATION OF POLYAMINES AND POLYAMINE DERIVATIVES Disclosed are processes for the preparation of compounds of the formula (I): H�2?N-(CH�2?)�n?-A-(CH�2?)�m?-NH�2?, or (II): H�2?N-(CH�2?)�n?-NH-C(=NR?1�)-NH-(CH�2?)�m?-NH� �2?, wherein n and m are each independent...
WO/1998/049152A1	PROTEASE INHIBITORS Compounds of formula (I), wherein R?l� is an aromatic or a heteroaromatic ring; R?2� and R?3� are H, C�1?-C�8?alkyl, aryl, arylC�1?-C�8?alkyl, or heteroaryl; R?4� is an aromatic or a heteroaromatic ring or an amine; W, X,...
WO/1998/047879A1	SUBSTITUTED PHENYL DERIVATIVES, THEIR PREPARATION AND USE A compound having formula (I) or a pharmaceutically acceptable salt thereof wherein one of R?1�, R?2� and R?3� is a cyclic or heterocyclic acidic functional group having a pKa value below 8 or a group which is convertible in vivo t...
WO/1998/046551A1	SYNTHESIS AND USE OF BIASED ARRAYS The invention provides methods for making a new type of library of compounds, referred to herein as a 'biased array'. The biased array is based on the premise that by preparing compounds that include (i) a common molecular core that is t...
WO/1998/046559A1	SYNTHESIS AND USE OF $g(a)-KETOAMIDE DERIVATIVES AND ARRAYS The invention is based on new methods for making and using compounds and arrays of novel $g(a)-ketoamides, and the arrays and compounds made by these methods. These novel compounds are potential inhibitors of proteolytic enzymes, particu...
WO/1998/045259A2	POLYAROMATIC ANTIVIRAL COMPOSITIONS The present invention relates to polyaromatic compounds having useful antiviral activity against viruses of the herpes family, to a composition containing them, and to a method of using them for the treatment of herpes viruses infections.
WO/1998/038180A1	PROCESS FOR THE PREPARATION OF BENZOTHIAZOLONE COMPOUNDS There are described processes for the preparation of a compound of formula (I), and novel intermediates in the preparative process.
WO/1998/031665A1	N-PHENYLTHIOURA DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF, FUNGICIDES FOR AGRICULTURAL AND HORTICULTURAL USE CONTAINING THE SAME AS THE ACTIVE INGREDIENT, AND INTERMEDIATES FOR THE PREPARATION THEREOF N-phenylthiourea derivatives useful as fungicides for agricultural and horticultural use which exhibit excellent activities particularly even at low concentrations. The derivatives are represented by general formula (I) with compounds re...
WO/1998/024760A1	AMINOBENZENEDICARBOXYLIC ACID-BASED COMBINATORIAL LIBRARIES The present invention provides a library of compounds, each comprised of a common animobenzenedicarboxylic acid core structure (scaffold) that serves as a template for synthesizing approximately 10?1�-10?6� compounds which are analog...
WO/1998/013036A1	PHARMACEUTICAL COMPOSITIONS COMPRISING S-ALKYLISOTHIOURONIUM DERIVATIVES S-alkylisothiouronium salts with phosphorus containing acids, including several new such compounds which are for use as medicaments for increasing arterial blood pressure or for protecting against hyperoxia. These compounds can be used f...
WO/1998/006262A1	IL-8 RECEPTOR ANTAGONISTS This invention relates to the use of compounds of formula (I) in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8). The variables of (I) are defined herein.
WO/1998/004521A1	POTASSIUM CHANNEL INHIBITORS Compounds of general formula (I) wherein R?1� is H, alkyl or is selected from the group consisting of an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted heterocyclyl and an optionally substi...
WO/1997/049680A1	IL-8 RECEPTOR ANTAGONISTS This invention relates to the use of phenyl ureas of formulas (I) and (II) in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8). The variables of (I) and (II) are defined herein.
WO/1997/045400A1	PHENYL DERIVATIVES CONTAINING AN ACIDIC GROUP, THEIR PREPARATION AND THEIR USE AS CHLORIDE CHANNEL BLOCKERS The present patent application relates to compounds having formula (I) or a pharmaceutically acceptable salt thereof wherein one of R1, R2 and R3 is a non-cyclic acidic group having a pKa value below 8 or a group which is in vivo convert...
WO/1997/045111A1	PHENYL DERIVATIVES USEFUL AS BLOCKERS OF CHLORIDE CHANNELS The present invention relates to a method for the treatment of a disorder or disease of a living animal body, including a human, which disorder or disease is responsive to the blockade of chloride channels, comprising administering to a ...
WO/1997/042166A1	AMIDINE DERIVATIVES AND DRUG CARRIERS COMPRISING THEM Novel amidine derivatives of general formula (1); and drug carriers (such as liposomes or emulsions) comprising the derivatives, which can enclose genetic materials or drugs and transfer them to cells or affected sites efficiently and sa...
WO/1997/041846A1	ANTI-VIRAL COMPOUNDS The present invention provides compounds which inhibit an envelope virus by inhibiting the fusion of the virus with the host cell. The virus may be inhibited in an infected cell, a cell susceptible of infection or a mammal in need thereof.
WO/1997/036862A1	META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS The present invention relates to a class of compounds represented by Formula (I), or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula (I), and methods of selectively inhibiting o...
WO/1997/029743A1	IL-8 RECEPTOR ANTAGONISTS This invention relates to novel compounds and a novel use of phenyl ureas in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
WO/1997/023508A1	COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES Compounds of peptide mimetic nature having general formula (I), wherein a and b are independently 1 or 2, R1 and R2 are independently H or C1-6alkyl, G and J are independently, inter alia, aromats, and D and E are independently several d...
WO/1997/009297A2	SYNTHESIS AND USE OF RETINOID COMPOUNDS HAVING NEGATIVE HORMONE AND/OR ANTAGONIST ACTIVITIES Aryl-substituted and aryl and (3-oxo-1-propenyl)-substituted benzopyran, benzothiopyran, 1,2-dihydroquinoline, and 5,6-dihydronaphthalene derivatives have retinoid negative hormone and/or antagonist-like biological activities. The invent...
WO/1997/009306A1	NOVEL ISOTHIOUREA DERIVATIVES Isothiourea derivatives represented by general formula (I) or pharmacologically acceptable salts thereof, wherein R1, R2 and R3 independently represent each hydrogen, halogeno, nitro, lower alkyl or lower alkoxy; R4 and R5 independently ...
WO/1997/008145A1	META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS The present invention relates to a class of compounds represented by formula (I) or a pharmaceutically acceptable salt thereof, wherein A is (a) or (b) or (c) or (d) pharmaceutical compositions thereof and methods of using such compounds...
WO/1997/002255A1	TRIAZOLINE AND ISOXAZOLINE BIS-OXIME DERIVATIVES AND THEIR USE AS PESTICIDES Bis-oxime derivatives of formula (I) in which A is (a) or (b), where W is oxygen or sulfur, and the other substituents defined as follows: R1 = hydrogen, C1-C4alkyl; cyclopropyl; R2 = hydrogen, C1-C6alkyl; halo(C1-C6) alkyl; C2-C6alkoxya...
WO/1996/040743A2	INHIBITORS OF FACTOR Xa Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
WO/1996/040641A1	SULFONAMIDE DERIVATIVES AS CELL ADHESION MODULATORS There are disclosed novel substituted naphthyl-, quinolyl- and isoquinolyl- sulfonamide derivatives that are useful in a method of treating immuno-inflammatory diseases in a mammalian patient suffering therefrom. Pharmaceutical compositi...
WO/1996/039374A1	2,4-PENTADIENOIC ACID DERIVATIVES HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY Compounds of Formula (1), wherein Z is selected from the group consisting of the radicals shown in Formula (2) and in Formula (3), Y is cycloalkyl or cycloalkenyl of 3 to 8 carbons optionally substituted with one or two R4 groups, or Y i...
WO/1996/033164A1	NEW HYDROXIMIC ACID DERIVATIVES Hydroximic acid derivatives of general formula (I), wherein G is either G1 or G2 or G3 or G4 of the formula: R5OC=C(COOR4)-, R5ON=C(COOR4)-, R5ON=C(CONR6R7)-, R5OC=C(CONR6R7)-, X1, X2, X3 are H, halo, HO, mercapto, nitro, SCN, azido, CN,...
WO/1996/030329A1	SUBSTITUTED BENZENE DERIVATIVES USEFUL AS NEURAMINIDASE INHIBITORS The invention relates to substituted benzenes and derivatives thereof, useful as neuraminidase inhibitors, to pharmaceutical compositions comprising such compounds, and to methods of using these compounds for treating viral and other inf...
WO/1996/025157A1	IL-8 RECEPTOR ANTAGONISTS This invention relates to the novel use of phenyl ureas in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
WO/1996/024580A1	COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES There are disclosed novel compounds of general formula (I) which compounds of formula (I) promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the prod...
WO/1996/024588A1	BICYCLIC ISOTHIOUREA DERIVATIVES USEFUL IN THERAPY There are provided novel compounds of formula (I) wherein D represents alkyl C1 to 6; T represents a C3-5 saturated or unsaturated alkylene chain substituted by -(CH2)m-NXY; -O-(CH2)2-NH- substituted by -(CH2)m-NXY; or -U-(CH2)a-N(X)-(CH...
WO/1996/019440A1	ACETAMIDINE DERIVATIVES AND THEIR USE AS INHIBITORS FOR THE NITRIC OXIDE SYNTHASE A class of acetamidine derivatives of general formula (I), methods for the manufacture thereof in therapy, particularly as inhibitors of nitric oxide synthase, is disclosed or a salt thereof, wherein R1 is hydrogen, a C1-6 hydrocarbyl gr...
WO/1996/018607A1	ANILINE DERIVATIVE HAVING THE EFFECT OF INHIBITING NITROGEN MONOXIDE SYNTHASE A compound represented by general formula (1) or possible stereoisomers and optical isomers thereof, and medicinally acceptable salts of these compounds, wherein R1 represents SR6 or NHR7; R6 represents C1-C6 alkyl, etc.; R7 represents h...
WO/1996/018608A1	ANILINE DERIVATIVES HAVING NITROGEN MONOXIDE SYNTHASE INHIBITORY ACTIVITY A compound represented by general formula (1),zor possible stereoisomers and optical isomers thereof, and medicinally acceptable salts of these, (wherein R1 represents SR6 or NR7R8; R6 represents C1-C6 alkyl, etc.; R7 represents hydrogen...
WO/1996/009286A1	ISOTHIOUREA DERIVATIVES AS NO SYNTHASE INHIBITORS There are provided novel compounds of formula (I), wherein D, R1, R2, R3, X and p are as defined in the specification together with processes for their preparation, compositions containing them and their use in therapy. Compounds of form...
WO/1996/006076A1	AMINO ACID DERIVATIVE HAVING NITROGEN MONOXIDE SYNTHETASE INHIBITOR ACTIVITY A compound represented by general formula (I) or a medicinally acceptable salt thereof, (wherein R1 represents hydrogen, C1-C6 alkoxycarbonyl or C1-C9 acyl; R2 represents hydrogen or C1-C6 alkyl; R3 represents C1-C6 alkyl or C2-C6 alkeny...

Matches 301 - 350 out of 1,417	< 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >