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Matches 1 - 50 out of 409

Document Document Title
WO/2018/092085A1
The technical solution relates to the field of medicine, and particularly to means for treating tuberculosis. A pharmaceutical composition for treating tuberculosis contains an active ingredient and at least one pharmaceutically acceptab...  
WO/2018/092077A1
The technical solution relates to the field of medicine, and particularly to means for treating tuberculosis. A pharmaceutical composition for treating tuberculosis contains an active ingredient and at least one pharmaceutically acceptab...  
WO/2018/043399A1
[Problem] To provide a novel therapeutic agent for diabetes which can be less apt to produce side effects such as persistent hypoglycemia. [Solution] A compound characterized by containing a derivative of 1,1-diphenylsemicarbazide or 1,1...  
WO/2017/214680A1
The present invention relates to new multi-functional compounds that are useful in the treatment of neurodegenerative diseases, such as Alzheimer's disease, to the preparation of the compounds, and to compositions including the compounds...  
WO/2017/099695A1
N-[(aminosulfonyl)phenyl]-2-(1,2-dihydro-2-oxo-3H-indol-3-yl idene)-hydrazinecarbothioamide derivatives of the following formula (III) for treating cancer and immunological disorders. R5, R6 and R7 are each independently selected from hy...  
WO/2017/070752A1
The present invention provides certain thiosemicarbazone metal complexes which have advantageous properties in medical imaging. The thiosemicarbazone metal complexes can be safely and easily produced in real time, administered quickly af...  
WO/2017/030983A1
This present disclosure is directed to compound of Formula I and methods of using these compounds in the treatment of conditions in which modulation of a cathepsin, particularly cathepsin L, cathepsin K, and/or cathepsin B, will be thera...  
WO/2016/111658A1
The present invention relates to the synthesis method of thiosemicarbazone derivatives comprising sulphonamide group and having high anticonvulsant/antiepileptic activity.  
WO/2016/041972A1
The present invention relates to benzothiophene, benzyloxybenzylidene and indoline-2-one derivatives and the use of said derivatives in the treatment and/or prevention of tuberculosis.  
WO/2016/033635A1
The invention provides compounds of Formula (I), and their use in methods for treating or preventing a protozoan infection in a subject using a compound of Formula (I). The invention also provides the use of a compound of Formula (I) in ...  
WO/2015/070177A3
In one embodiment, the present application discloses compounds that are selective neuroactive agents for the treatment of diseases of the central nervous system (CNS). In one aspect, the neuroactive agents are NCDs of metal chelates, inc...  
WO/2014/198241A1
Provided is a process for preparing a compound shown as formula (I), comprising a step of contacting a compound shown as formula (II) or a salt thereof with a brominating agent, wherein R1is OR2 or NR3R4; R2 is C1-C6 alkyl or phenyl; eac...  
WO/2014/176636A1
The invention provides compounds of Formula (I), and methods of treating or preventing a bacterial infection in a subject using a compound of Formula (I). The invention also provides the use of a compound of Formula (I) in the manufactur...  
WO/2014/176636A9
The invention provides compounds of Formula (I), and methods of treating or preventing a bacterial infection in a subject using a compound of Formula (I). The invention also provides the use of a compound of Formula (I) in the manufactur...  
WO/2013/169361A1
The present invention relates to chelator compounds for chelating metal ions. In particular, the present invention relates to (thio)semicarbazone compounds and (thio)hydrazone compounds, such as PpYeT and PpYaT, which are chelators for m...  
WO/2013/158803A1
The present invention relates to a novel composition useful in targeted diagnostic and/or therapy of a target site, such as cancerous tissue. The composition and methods disclosed herein find particular use in diagnosing and imaging canc...  
WO/2013/142038A2
This invention is directed to compound of Formula I and methods of using these compounds in the treatment of conditions in which modulation of a cathepsin, particularly cathepsin K or cathepsin L, will be therapeutically useful.  
WO/2013/111798A1
[Problem] To provide a novel serine racemase inhibitor having a satisfactory activity and satisfactory specificity. [Solution] A serine racemase inhibitor comprising at least one compound selected from a compound group consisting of comp...  
WO/2012/105438A1
An electrode active material having a dithionic structure indicated in general formula. The dithionic structure has a linking group (Z) interposed between X=S groups (X: C or Si). The linking group (Z) is CH2, CF2, O, S, SO2, Se, or N-R'...  
WO/2012/018757A1
The present invention discloses processes for forming polythiol compositions from olefinic hydrocarbons such as cyclooctadiene, cyclododecatriene, and trivinylcyclohexane. The polythiol compositions produced from these processes, includi...  
WO/2011/026193A1
The present invention relates to a compound of general formula (I) or a pharmaceutically acceptable salt or solvate or thereof. In particular, the present invention relates to a method treating diseases involving cell proliferation, migr...  
WO/2011/026193A8
The present invention relates to a compound of general formula (I) or a pharmaceutically acceptable salt or solvate or thereof. In particular, the present invention relates to a method treating diseases involving cell proliferation, migr...  
WO/2010/066010A1
The present invention relates to a method of making asymmetrical bis(thiosemicarbazones), compounds useful as synthetic intermediates in the method, new bis(thiosemicarbazones) that can be readily accessed by use of the method and method...  
WO/2009/096039A1
A compound useful as an intermediate for obtaining a thiadiazole-based acaricide having a high purity in a high yield. This intermediate is obtained, for example, by reacting a 2-(4-hydroxyphenoxy)propionic acid ester represented by the ...  
WO/2008/025941A3
The invention provides metal complexes of formula (I), wherein M is a transition metal or a p-block metal, and a, b, c, n, L, X, X', Y, Y', L1, L1', R1, R1', R2 and R2' are defined herein. Such complexes are useful in medical imaging and...  
WO/2008/025941A2
The invention provides metal complexes of formula (I), wherein M is a transition metal or a p-block metal, and a, b, c, n, L, X, X', Y, Y', L1, L1', R1, R1', R2 and R2' are defined herein. Such complexes are useful in medical imaging and...  
WO/2008/024304A3
Disclosed are compounds of formula (IA), formula (IV) or formula (V), wherein the variables are as defined herein, and pharmaceutical compositions containing them which are useful for treating a subject with a proliferative disorder, suc...  
WO/2008/024304A2
Disclosed are compounds of formula (IA), formula (IV) or formula (V), wherein the variables are as defined herein, and pharmaceutical compositions containing them which are useful for treating a subject with a proliferative disorder, suc...  
WO/2008/024303A3
Disclosed are compounds of formulae (I), (III), (IV), (VII), (X), (XI), (XII), (XIII) and (XIV), wherein the variabables are as defined in the claims, and methods of using compounds of the invention for treating a subject with a prolifer...  
WO/2007/088545A3
The present invention provides a novel montelukast intermediate and a simple and straightforward process for preparing it. According to the present invention, by using this intermediate and the process, essentially as described herein, m...  
WO/2006/116816A1
The present invention relates to a storage stable dithizone preparation, whereby the dithizone preparation is in a form that is ready for use to detect the presence of transition metal ions in a sample. The present invention also relates...  
WO/2006/093124A1
It is intended to provide a novel free radical scavenger for removing active oxygen which is causative for various diseases in vivo and results in degradation and color fade-out in commercial products. A free radical scavenger which cont...  
WO2006019955A3
Disclosed herein are antiviral compounds, such as anti-human cytomegalovirus antiviral compounds, pharmaceutical compositions and antiviral methods.  
WO/2006/041119A1
Compounds represented by the general formula (1) or salts thereof, or hydrates of both, which are safe and have moderate physicochemical stability and which are useful as preventive or therapeutic agents for diseases caused by thrombus f...  
WO/2006/019955A2
Disclosed herein are antiviral compounds, such as anti-human cytomegalovirus antiviral compounds, pharmaceutical compositions and antiviral methods.  
WO/2005/087211A1
The present invention provides a novel class of compounds that disrupt the parasitic infectious life cycle and serve as promising agents for anti-parasitic therapy.  
WO2004062601A3
Antibacterial compounds of formula (I) are provided: As well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infectio...  
WO/2005/009940A1
The invention provides novel compounds according to formula I relates to compounds with the general formula I said compounds being useful, e.g. in the treatment of inflammatory, ophthalmic diseases or cancer.  
WO/2004/062601A2
Antibacterial compounds of formula (I) are provided: As well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infectio...  
WO2002096867A3
The present invention is directed in part towards methods of modulating the function of protein kinases with phenol- and hydroxynaphthalene-based compounds. The methods incorporate cells that express a protein kinase. In addition, the in...  
WO/2003/078386A1
The present invention relates to novel naphthyl semicarbazone, naphthylhydrazone, naphthyl thiosemicarbazone, and naphthyl thiohydrazone compounds. The invention also relates to therapeutic uses of such compounds and&sol or their iron co...  
WO2002092019A3
Halogenated derivatives of two synthetic anti-tuberculosis agents, thioacetazone and p-aminosalicylic acid, have been synthesized. In general, the halogenated compound has the structure of Structure (I), wherein X1 is a halogen and X2 is...  
WO2002049413A3
Invented are non-peptide TPO mimetics. also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected substituted thi...  
WO/2003/000647A1
The invention relates to a novel class of ligands, complexes comprising such ligands and a metal ion, and adducts of these metal complexes and a macromolecule. Pharmaceutical compositions and methods of making and using the ligand-metal ...  
WO2002059080A3
The present invention relates to novel, non-peptidic small organic compounds having an affinity for cyclophilin (CyP)-type immunophilin proteins, and to pharmaceutical compositions comprising one or more of the said compounds. The invent...  
WO/2002/098420A1
The present invention is directed to optionally substituted 4-substituted-1-(arylmethylidene)thiosemicarbazide, 4-substituted-1-(arylcarbonyl)thiosemicarbazide and analogs thereof, represented by the Formulae (I) and (II), wherein A¿1,?...  
WO/2002/096867A2
The present invention is directed in part towards methods of modulating the function of protein kinases with phenol- and hydroxynaphthalene-based compounds. The methods incorporate cells that express a protein kinase. In addition, the in...  
WO2002081438A3
A process is provided for producing a thiosemicarbazide which includes the steps of reacting an alkylamine with carbon disulphide in the presence of a base selected from N,N-diisopropylethylamine and N,N,-diisopropyl-methylamine to produ...  
WO/2002/092019A2
Halogenated derivatives of two synthetic anti-tuberculosis agents, thioacetazone and $i(p)-aminosalicylic acid, have been synthesized. In general, the halogenated compound has the structure of Structure (I), wherein X¿1? is a halogen an...  
WO/2002/081438A2
A process is provided for producing a thiosemicarbazide which includes the steps of reacting an alkylamine with carbon disulphide in the presence of a base selected from N,N-diisopropylethylamine and N,N,-diisopropyl-methylamine to produ...  

Matches 1 - 50 out of 409