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Patent Searching and Data


Matches 251 - 300 out of 2,565

Document Document Title
WO/1999/067211A1
The invention relates to a multifunctional vitamin D derivative of formula (I) wherein; O represents the oxygen atom of an ether group; X represents a spacer group having a length of 0.8 to 4.2 nm, for example, an amino carboxylic acid r...  
WO/1999/061417A2
The present invention provides a method for preparing a novel class of vitamin D compounds in which the C-25 or equivalent position has a double bond. In addition, the side chain is optionally extended by one or two methylene or methyne ...  
WO/1999/061398A2
The invention provides 24-hydroxyvitamin D compounds and their use in the treatment and prophylaxis of hyperparathyroidism and hyperproliferative diseases, and in the modulation of the immune and inflammatory responses as well as the tre...  
WO/1999/061418A2
The invention provides 1$g(a)-hydroxyvitamin D compounds in which the C-25 or equivalent position of the C-17 side chain has a double bond and their use in the treatment and prophylaxis of hyperparathyroidism and hyperproliferative disea...  
WO/1999/059966A1
A method of modifying or altering the structure of a 1$g(a)-hydroxylated vitamin D compound to increase its biological activity by altering the conformational equilibrium of the A-ring to favor a chair conformation that presents the 1$g(...  
WO/1999/052863A1
Vitamin D derivatives represented by general formula (I), intermediate compounds in the synthesis thereof, and medicinal compositions containing these vitamin D derivatives as the active ingredient wherein A represents linear or branched...  
WO/1999/043646A1
Compounds of formula (I) wherein X is C=CH¿2? or CH¿2?; Y and Z are independently of each other hydrogen, fluorine or hydroxy; A is -C$m(Z)C-, -CH=CH- or -CH¿2?-CH¿2?-; R?1¿ and R?2¿ are independently of each other alkyl or perfluo...  
WO/1999/043645A1
Vitamin D derivatives having general formula (1) which are hydroxylated at the 24-position and considered as one of metabolites of physiologically active vitamin D derivatives substituted at the 2$g(b)-position wherein R¿1?, R¿2?, R¿3...  
WO/1999/036400A1
A method of preparation of cholecalciferol derivatives, particularly 1$g(a),24-dihydroxycholecalciferol of formula (1), wherein substituents R¿1? and R¿2? are hydrogen, hydroxyl, or hydroxyl protecting group, R¿1? and R¿2? being the ...  
WO/1999/031112A1
The invention relates to novel vitamin D derivatives of general formula (I), a method for the production thereof, intermediate products of the method as well as the utilization thereof for producing medicaments.  
WO/1999/031055A1
The present invention relates to novel vitamin D derivatives of formula (I), wherein X is C=CH¿2? or CH¿2?; Y is hydrogen, fluorine or hydroxy; Z is hydroxy; n is 1 or 2; R?1¿ is lower alkyl; R?2¿ is a branched alkyl having 3 to 8 ca...  
WO/1999/018070A1
The present invention relates to compounds of formula (I), in which formula X is hydrogen or hydroxy or protected hydroxy; R?1¿ an R?2¿ stand for hydrogen, methyl or ethyl, or, when taken together with the carbon atom bearing the group...  
WO/1999/016745A1
The invention relates to novel vitamin D derivatives of general formula (I), a method for the production thereof, intermediate products of the method and the utilization of vitamin D derivatives for producing medicaments.  
WO/1999/015499A1
Novel 22-oxavitamin D derivatives having hydroxyl at each of the 1$g(a)- and 3$g(a)- positions and represented by general formula (I), wherein R¿1? represents linear or branched C¿4-10? alkyl having one to three hydroxyl groups; and RÂ...  
WO/1999/012894A1
This invention relates to 1,3-dihydroxy-20,20-dialkyl-vitamin D¿3? analogs of Formula (I), compositions comprising the analogs, methods of preparing the analogs and methods of treatment of osteoporosis, secondary hyperparathyroidism, ca...  
WO/1999/003828A1
Polyunsaturated 24a,24b-dihomo-9,10-secocholestane derivatives of formula (I) wherein A is a single or double bond, B?1¿ and B?2¿ are each independently CH=CH or C$m(0)C, T is CH¿2? or CH¿2?CH¿2?, X is -CH2- or > C=CH2, R?1¿ is H, ...  
WO/1999/003829A1
This invention provides a novel class of vitamin D compounds, namely, 13-ethyl and 13-vinyl-18,19-dinor-vitamin D derivatives, as well as a general method for their chemical synthesis. The compounds have formula (I): wherein Y¿1? and YÂ...  
WO/1998/058909A1
Vitamin D¿3? derivatives represented by general formula [1] and a process for producing the same: wherein R¿1? and R¿2? represent each hydrogen, trialkylsilyl, etc.; R¿3? and R¿4? represent each hydrogen, hydroxy, etc.; R¿5? to R¿...  
WO/1998/051664A1
Novel 3-epi vitamin D2 compounds having the orientation of the substituent attached to the carbon at position 3 of the A-ring of vitamin D2 inverted from a beta ($g(b)) to an alpha ($g(a)) configuration are described. These compounds wer...  
WO/1998/051678A1
Novel cyclic ether vitamin D3 compounds having a cyclic ether side chain are disclosed. These compounds were first identified as metabolites of 3-epi vitamin D3 produced via a tissue-specific metabolic pathway which catalyzes the formati...  
WO/1998/051663A2
Novel 3-epi vitamin D�3? compounds having the orientation of the substituent attached to the carbon at position 3 of the A-ring of vitamin D�3? inverted from a beta ($g(b)) to an alpha ($g(a)) configuration are described. These 3-epi...  
WO/1998/050353A1
1,25-Dihydroxy-2-methyl vitamin D�3? derivatives represented by general formula (I) wherein R�1? and R�2? each independently represents hydrogen or tri(C�1-7?alkyl)silyl; and the asymmetric carbon atoms at the 1-, 2- and 3-positi...  
WO/1998/049138A2
This invention provides Vitamin D�3? analogs of the Formula (I) wherein: X is H�2? or CH�2?; Y is hydrogen, hydroxy or fluorine; Z is hydroxy; R�1? and R�2? are a (C�1?-C�4?) alkyl or fluoroalkyl, or R�1? and R�2? toget...  
WO/1998/047866A2
24-Nor-secochola-5,7-diene derivatives of formula (I) wherein A is a single or double bond, B is a group CH�2?CH�2?, CH=CH or C$m(Z)C, T is a group CH�2? or CH�2?CH�2?, R?1� and R?3� are H or OH, C(R,R) is CH�2? or C=CHï¿...  
WO/1998/041500A1
This invention provides a novel class of vitamin D related compounds, namely, the 2-alkyl-19-nor-vitamin D derivatives, as well as a general method for their chemical synthesis. The compounds have formula (I), where Y�1? and Y�2?, wh...  
WO/1998/041501A1
The invention provides a novel class of vitamin D related compounds, namely, the 2-alkylidene-19-nor-vitamin D derivatives, as well as a general method for their chemical synthesis. The compounds have the formula (I) where Y�1? and Yï¿...  
WO/1998/039292A1
20-Epi-22(R)-lower alkyl-substituted vitamin D derivatives represented by general formula (I), wherein R?1�, R?2� and R?3� represent each hydrogen or a hydroxy-protective group; and R?4� represents lower (C�2-6?) alkyl.  
WO/1998/029123A1
The invention provides therapeutic methods for inhibiting, ameliorating or alleviating the hyperproliferative cellular activity of diseases of the prostate, e.g., prostatic cancer and prostatic hyperplasia, which includes administering t...  
WO/1998/028266A1
Vitamin D derivatives of general formula (1) wherein X represents oxygen or sulfur; R�11? represents saturated or unsaturated aliphatic hydrocarbyl which may be substituted by hydroxyl or protected hydroxyl, or -COR�12? (wherein R�...  
WO/1998/024762A1
A compound of formula (I) in which formula Q is a C�1?-C�6? hydrocarbylene diradical; Y is either a single bond, a carbonyl group or a methylene, ethylene, -CH(OH)-, -O-(C�6?H�4?)- (ortho, meta, para) or -S-(C�6?H�4?)- (ortho...  
WO/1998/021580A2
Compound comprising an analogue of 1,25-dihydroxy vitamin D, modified at the C?20� position, which is adapted to bind to at least an existing or readily produced antibody, wherein the analogue comprises a substituent adapted for quanti...  
WO/1998/018759A1
The present invention relates to compounds of formula (I) in which formula X is hydrogen or hydroxy; R?1� and R?2� which may be the same or different, stand for hydrogen or C�1?-C�5? hydrocarbyl; or R?1� and R?2�, taken toget...  
WO/1998/009935A1
A process for preparing a compound having structure (I) wherein n is an integer from 1-5; each of R�1? and R�2? independently is optionally substituted C�1?-C�6? alkyl; each of W and X is independently hydrogen or C�1?-C�6? a...  
WO/1998/008522A1
Multivitamin products targeted to specific groups.  
WO/1998/000397A1
A crystal of the compound of the structural formula (I); crystals of vitamin D derivatives prepared by purifying unpurified or roughly purified vitamin D derivatives by reversed phase chromatography and crystallizing the purified derivat...  
WO/1997/046522A1
The present invention relates to compounds of formula (I), in which formula X is hydrogen or hydroxy; R1 and R2, which may be the same or different, stand for hydrogen or a C1-C3 alkyl radical; or R1 and R2, taken together with the carbo...  
WO/1997/041096A1
The invention concerns new vitamin D derivatives of general formula (I) a process for their production, their use for production of medicaments, and intermediate products used in the process.  
WO/1997/037972A1
The present invention relates to compounds of formula (I) in which Q stands for a C1-C8 hydrocarbylene diradical, R stands for hydrogen or C1-C6 hydrocarbyl, or two R groups, taken together with the carbon atom bearing the hydroxy group ...  
WO/1997/024127A1
Biotin, fluorescent and chemiluminescent labeled vitamin D compounds are disclosed as well as their use in assays for the presence of vitamin D, its metabolites and vitamin D analogs in biological fluids.  
WO/1997/023453A1
1-Hydroxy pregnacalciferol derivatives of formula (I) and their corresponding 5,6-trans isomers wherein R1 is hydroxyl or lower alkoxy and R2 is optionally hydroxylated or lower alkoxylated lower alkynyl or R1 is C(RA) (RB)CH3 where RA i...  
WO/1997/020811A1
The present invention relates to compounds of formula (I) in which formula X is hydrogen or hydroxy; R1 and R2 stand for methyl or ethyl, or, when taken together with the carbon atom bearing the group X, can form a C3-C5 carbocyclic ring...  
WO/1997/019058A1
The invention relates to a compound of formula (I) wherein A is a carbon-carbon double bond having the E or Z stereochemical configuration, or A is a carbon-carbon triple bond, Et is ethyl, and R is hydroxy and R1 is hydrogen or =CH2, or...  
WO/1997/016423A1
The invention relates to a compound of formula (I) wherein A is a carbon double bond having the stereochemical configuration E or Z, i.e. of formula (a) or (b), respectively, R is hydroxy and R1 is hydrogen or =CH2 or R is hydrogen or fl...  
WO/1997/011053A1
A method of treating metabolic bone diseases such as osteoporosis, as well as other disease states treatable with vitamin D compounds, comprises administering an effective amount of one or more modified vitamin D compounds. The modified ...  
WO/1997/000242A1
The invention concerns novel vitamin D derivatives with C-25 substituents of general formula (I). The invention also concerns a process for their preparation and their use in preparing medicaments.  
WO/1996/040154A1
Novel 1'alpha'-hydroxy vitamin D4 and novel analogues, 1,25 dihydroxy vitamin D4 and 1,24 dihydroxy vitamin D4 which are useful as active compounds of pharmaceutical compositions for the treatment of disorders of calcium metabolism and v...  
WO/1996/040153A1
Novel 1'alpha'-hydroxy vitamin D4 and novel analogues, and preferably 1,24 dihydroxy vitamin D4, which are useful as active compounds of pharmaceutical compositions for the treatment of disorders of calcium metabolism and breast and colo...  
WO/1996/030338A1
Vitamine D3 analogues which include a hydroxyalkyl substituent in the 1-position and a modified D-ring side chain are described. These novel compounds are potent anti-proliferative substances with activity comparable to that of calcitrio...  
WO/1996/022776A1
Vitamin D derivatives of formula (I), wherein: X is =CH2 or H,H; Y is a moiety (a) -CH(CH3)-(A)n-C(O)-OR1, (b) -CH(CH3)-CH2-O-C(O)-R2 or (c) -C(O)-OR1; A is -CH=CH- or CH2-CH2-; R1 is lower alkyl, cycloalkyl, cycloalkylmethyl, -CH2R3 or ...  
WO/1996/022973A1
A compound represented by general formula (I), wherein R1 and R2 are the same or different and each represents C1-4 alkyl; and R3 represents C1-7 alkoxy optionally substituted by hydroxy, halogeno, cyano, C1-4 alkoxy, amino or acylamino;...  

Matches 251 - 300 out of 2,565