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WO/2000/001650A1 |
The invention provides a method of producing $g(a)-tocopherol and $g(a)-tocopheryl esters and a method of producing vitamin A or $g(b)-carotene. The methods comprise using a biological system to produce farnesol or geranylgeraniol. Then,...
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WO/1999/061417A2 |
The present invention provides a method for preparing a novel class of vitamin D compounds in which the C-25 or equivalent position has a double bond. In addition, the side chain is optionally extended by one or two methylene or methyne ...
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WO/1999/059966A1 |
A method of modifying or altering the structure of a 1$g(a)-hydroxylated vitamin D compound to increase its biological activity by altering the conformational equilibrium of the A-ring to favor a chair conformation that presents the 1$g(...
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WO/1999/055897A1 |
The invention relates to a method for oxidising substituted trimethylcyclohexenyl compounds in the presence of microorganisms of the actinomycetal order and to the use of microorganisms in oxidation reactions.
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WO/1999/054408A1 |
Trans-xanthophyll ester concentrates having a trans-xanthophyll ester content of at least four times greater and preferably at least nine times greater than the cis-xanthophyll ester content are obtained. Xanthophyll ester concentrates h...
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WO/1999/050240A1 |
The present invention relates to a polyethoxylated retinamide derivative represented by formula (I), which is useful as an agent for inhibiting skin aging: in which R represents hydrogen or C¿1-6?-lower alkyl and n denotes the number of...
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WO/1999/048866A1 |
The process of the present invention relates to a process for producing 13-cis retinoic acid. The process of the present invention involves reacting a Wittig salt in a solvent with a butenolide in the presence of a weak base and optional...
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WO/1999/043646A1 |
Compounds of formula (I) wherein X is C=CH¿2? or CH¿2?; Y and Z are independently of each other hydrogen, fluorine or hydroxy; A is -C$m(Z)C-, -CH=CH- or -CH¿2?-CH¿2?-; R?1¿ and R?2¿ are independently of each other alkyl or perfluo...
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WO/1999/038826A1 |
Trimethylcyclohexane derivatives represented by general formula (1): wherein A represents C=O or CH-OH; n is 2; R?1¿ represents hydrogen or methyl; R?2¿ represents linear or branched and optionally saturated C¿3-10? hydrocarbyl; and t...
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WO/1999/035144A1 |
7-[3-[4-(6-Fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl]propox
y]-chromen-4-one derivatives having formula (I) wherein R is hydrogen, CHO, CH¿2?OR¿2? or COOH; R¿1? is hydrogen or CH¿2?OH; and R¿2? is alkyl having 1 to 4 carbon atoms w...
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WO/1999/029315A1 |
Compositions, syntheses, formulations and methods for treating or protecting the retina of a mammalian eye by contacting, with the retinal tissue, a therapeutically effective amount of retinyliden tauret (3,7-dimethyl-9-(2,6,6-trimehyl-1...
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WO/1999/026914A1 |
Process for producing a product which has a high content of zeaxanthine, luteine or a mixture of both, such as short chain organic acid diesters of zeaxanthine, luteine or a mixture of both, usable essentially for the pigmentation of chi...
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WO/1999/023067A1 |
The invention relates to a lutein to zeaxanthin isomerisation process which includes a step of saponification or alkali treatment of a plant extract which contains lutein, followed by a step of heating under control conditions and in the...
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WO/1999/020587A1 |
A process for simultaneously extracting, saponifying, and isolating lutein and zeaxanthin, and a mixture of several rare carotenoids in high purity from plants without the use of harmful organic solvents. Lutein crystals containing 5 % z...
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WO/1999/008992A1 |
Enantiomerically substantially pure compounds of formula (I) where R is H or lower alkyl of 1 to 6 carbons, or pharmaceutically acceptable salts thereof have retinoid-like biological activity. The enantiomerically pure or substantially p...
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WO/1999/008987A1 |
Described is a cyclohexenone long-chain alcohol represented by formula (1), wherein R1, R2 and R3 each independently represents a hydrogen atom or a methyl group and X represents a C10-18 alkylene or alkenylene group. The cyclohexenone l...
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WO/1999/007238A2 |
Oil-in-water dispersions of $g(b)-carotene and other carotenoids that are stable against oxidation, even in the presence of polyphosphates, especially sodium hexametaphosphate. These oil-in-water dispersions are typically prepared by con...
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WO/1999/004821A2 |
The invention relates to mesomorphic complexes composed of vitamin A acid and cationic polyelectrolytes. The invention also relates to their production and use.
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WO/1999/003810A1 |
The invention relates to a method for producing oxo products by hydroformylation of substrates with C=C double bonds, using unmodified rhodium catalysts in a reaction mixture consisting essentially of the substrates, the catalyst and car...
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WO/1999/003830A1 |
A method of isomerizing lutein to yield a mixture of epimers of zeaxanthin includes the following steps: mixing a lutein-containing extract in a glycol solution to obtain a mixture, treating the mixture with alkali to obtain an alkali-co...
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WO/1998/052914A1 |
The invention relates to leukotriene B�4? derivatives of general formula (I) in which R�1? stands for CH�2?OH, CH�3?, CF�3?, COOR�4?, CONR�5?R�6?; R�2? stands for H or an organic acid radical with 1-15 C atoms; R�3? s...
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WO/1998/052912A2 |
The invention relates to leukotriene B�4? antagonists of formula (I), a method for the production and the pharmaceutical use thereof.
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WO/1998/052915A2 |
The invention relates to leukotriene B�4? derivatives of general formula (I) in which R�1? stands for H, CF�3?, CH�2?OH; R�2? stands for an organic acid radical; R�3? stands for H, C�1?-C�14?-alkyl, C�3?-C�10?-cycloal...
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WO/1998/052916A1 |
The invention relates to leukotriene B�4? derivatives of general formula (I), wherein R�1? = CH�2?OH, CH�3?, CF�3?, COOR�4?, CONR�5?R�6? and R�2? = H or an organic acid radical with 1-15 C atoms, R�3? = H, C�1?-C�...
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WO/1998/050574A1 |
The present invention describes a process for the direct isolation of a crystalline carotenoid compound from microbial biomass. With the process of the invention, the use of large amounts of solvent necessary to solubilize the carotenoid...
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WO/1998/049139A1 |
A process for the preparation of irones by a chemical oxidation of irone precursors, comprising treating an iris rhizome substrate selected from the group consisting of iris rhizomes, parts of such rhizomes, iris extracts, iris extractio...
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WO/1998/040068A1 |
This inventin relates to heterocyclic antineoplastic agents, including certain substituted furano[3,2-e]-indole-7-carboxylic acid derivatives, as well as to processes for their preparation, pharmaceutical compositions comprising the hete...
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WO/1998/028082A1 |
A process and system are disclosed for recovering mixed carotenoids from the alga $i(Dunaliella salina). The harvested cells are ruptured, typically by circulating the algal suspension at high pressure through a pump loop. The cells can ...
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WO/1998/023567A1 |
Improved methods for the recovery of xanthophylls from corn gluten meal are provided. More specifically, methods for the recovery of xanthophylls from corn gluten whereby relatively dry corn gluten is extracted with an organic alcohol fo...
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WO/1998/008522A1 |
Multivitamin products targeted to specific groups.
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WO/1998/003480A1 |
The present invention describes a process to recover highly pure $g(b)-carotene crystals from a crude crystal preparation obtained from a natural source. To remove impurities, the crude crystals are stirred in a solvent in which $g(b)-ca...
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WO/1998/000127A1 |
This invention relates to the novel retinoyloxy(substituted)alkylene butyrate compounds and pharmaceutical compositions containing same, to methods of treating, preventing or ameliorating cancer and other proliferative diseases in a subj...
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WO/1997/045121A1 |
A preparation for percutaneous administration comprising a substrate and, formed on at least one surface thereof, a pressure-sensitive adhesive layer containing an acrylic copolymer, 6-amino-5-chloro-1-isopropyl-2-(4-methyl-1-piperazinyl...
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WO/1997/043254A1 |
A process for the continuous production of 'alpha' and/or 'beta'-ionones or homologous compounds by means of concentrated sulphuric acid at temperatures of 20 to 90 �C in the presence of organic solvents or diluents with cooling, and t...
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WO/1997/032839A1 |
Esters and amides of 9-cis-retinoic acid are synthesized, formulated into pharmaceutically acceptable carriers and administered for the treatment of acne vulgaris, cystic acne, hyperpigmentation, hypopigmentation, psoriasis, dermal and e...
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WO/1997/031894A1 |
Process for the preparation of carotenoid having general formula (I) and pigments which contain said compound as basic component. They are obtained by reacting natural or synthetic compounds having general formula (II), or the plant extr...
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WO/1997/023436A1 |
A process for forming, isolating and purifying xanthophyll crystals, preferably lutein from marigold flower petals, zeaxanthin from wolfberries or capsanthin and capsorubin from red pepper, is disclosed. A xanthophyll diester-containing ...
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WO/1997/023441A1 |
The invention disclosed relates to a new class of abscisic acid (ABA) analogs of formula (I) wherein one of R1 is alkenyl, alkynyl, aryl, cycloalkenyl, other further substituted carbon chain including deuterium containing residues, and c...
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WO/1997/020812A1 |
Esters of retinol and 'alpha'-hydroxy acids are unusually effective as skin conditioners, with significant reductions in the irritation problems characteristic of retinol and 'alpha'-hydroxy acids in nonesterified form.
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WO/1997/015554A1 |
Chromoplasts and/or chloroplasts are isolated from plant material. This wet mass is digested in aqueous medium with pectin- and/or protein-cleaving enzymes, insoluble substances are removed, and a carotinoid-rich sediment is obtained aft...
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WO/1997/010196A1 |
Products of formula (I) extracted from a plant of the genus Commiphora, particularly the Commiphora mukul plant, wherein R is (a) a CH2OH grouping, (b) a COOH grouping, and salts or esters thereof are described. These products and the ex...
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WO/1997/009307A1 |
The present invention relates to active derivatives of sphingoid bases. Specifically, the invention relates to retinoylamide based derivatives of sphingoid bases. The present invention describes a method for obtaining these compounds. Th...
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WO/1997/009297A2 |
Aryl-substituted and aryl and (3-oxo-1-propenyl)-substituted benzopyran, benzothiopyran, 1,2-dihydroquinoline, and 5,6-dihydronaphthalene derivatives have retinoid negative hormone and/or antagonist-like biological activities. The invent...
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WO/1996/040607A1 |
An improved method for the recovery of xanthophylls from corn gluten is provided. More specifically, a method for the recovery of xanthophylls from corn gluten whereby relatively dry corn gluten is extracted with an organic alcohol follo...
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WO/1996/039870A1 |
The present invention relates to non-absorbable, non-digestible fat compositions fortified with a water soluble carotenoid/cyclodextrin complex. The compositions are useful as fat substitutes in food and pharmaceutical compositions. The ...
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WO/1996/039374A1 |
Compounds of Formula (1), wherein Z is selected from the group consisting of the radicals shown in Formula (2) and in Formula (3), Y is cycloalkyl or cycloalkenyl of 3 to 8 carbons optionally substituted with one or two R4 groups, or Y i...
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WO/1996/029306A1 |
Carotene is economically mass-produced from a native fat or oil in 5 process steps. The native fat or oil is converted with an alkanol with a C chain length of up to 4 catalytically into fatty acid alkyl ester and glycerine in a prior ar...
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WO/1996/006138A1 |
The invention concerns a method of extracting carotinoid dyes from pre-dried natural basic materials by means of compressed gases, such as propane and/or butane. In order to facilitate and complete the extraction process, organic entrain...
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WO/1996/005160A1 |
'beta'-Carotene, lycopene and canthaxanthin, as representative carotenoids, and to a lesser extent, retinoic acid, a representative retinoid, undergo extensive oxidation to yield substances, insofar as oxidized 'beta'-carotene is a model...
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WO/1996/004243A1 |
A process for purifying vitamin A consisting of heating a vitamin A preparation in an inert atmosphere, at a temperature below 170 �C and a pressure of less than 4 mm of mercury, said heating taking place in a vessel shielded from ligh...
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