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JP5043685B2 |
A new process is described, easy to perform on industrial scale, with high yield, for obtaining enantiomers of chrysanthemic acid starting from mixtures containing them. The process involves reacting said mixtures with enantiomers of 2- ...
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JP5047441B2 |
A process for producing compounds of formula (VIIa) and (VIIb) wherein X is a leaving group; Y and Y<1 >are idependently Cl or Br; and Z is Cl, Br or a haloalkyl group which process comprises a) reacting a compound of formula (VII) where...
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JP5038392B2 |
The present invention relates to a process for the preparation of cis substituted cyclic beta-aryl or heteroaryl carboxylic acid derivatives in high diastereo- and enantioselectivity by enantioselective hydrogenation in accordance with t...
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JP5040005B2 |
Manufacture of a fluorine-containing norbornene derivative having a fluorine-containing ketone structure comprises reacting a norbornene derivative and a fluoroalkylating agent. Manufacture of a fluorine-containing norbornene derivative ...
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JP2012153721A |
To provide a substance for the preparation of a medicament of non-insulin dependent diabetes mellitus, hypertension and/or metabolic syndrome.The substance includes the chemical structures of bicyclo[3.2.1]octane or the chemical structur...
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JP5003231B2 |
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JP4973304B2 |
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JP2012126689A |
To provide a method for producing a fluorinated adamantane derivative which is useful as a synthetic intermediate of medicine and agricultural chemical.The method for producing the fluorinated adamantane derivative represented by formula...
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JP4961689B2 |
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JP4954417B2 |
There is provided a method of synthesis of a radiolabelled platinum chemotherapeutic agent comprising the steps of: converting a metal halide to a radiolabelled platinum halide wherein the radiolabel is a radioisotope of Pt; and synthesi...
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JP4944344B2 |
The invention relates to a novel process for the preparation of certain cyclopropyl carboxylic acid esters and other cyclopropyl carboxylic acid derivatives; to the use of certain cyclopropyl carboxylic acid esters in a process for the p...
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JP4944440B2 |
Method for continuous production of alicyclic carboxylic acids or their derivatives comprises catalytic hydrogenation of aromatic carboxylic acids or their derivatives with a gas containing hydrogen and solid catalysts in a fixed bed, wh...
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JP2012051820A |
To provide a novel optical resolving agent comprising an optically active azulene derivative which facilitates separation in column chromatography by observation with the naked eye, and a novel method for producing optically active alcoh...
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JP4898079B2 |
The invention relates to a process for preparing cyclohexanedicarboxylic acids or derivatives thereof, such as esters and/or anhydrides, encompassing the reaction of diene/maleic acid anhydride mixtures, in particular of butadiene/maleic...
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JP2012503595A |
There is provided novel compounds capable of modulating the G-protein-coupled receptor GPR40, compositions comprising the compounds, and methods for their use for controlling insulin levels in vivo and for the treatment of conditions suc...
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JP2011241161A |
To provide a production method by which 2,3,5-tricarboxycyclopentylacetic acid of a production precursor of 2,3,5-tricarboxycyclopentylacetic acid-1,4:2,3-dianhydride can be produced in high purity under a mild condition by using inexpen...
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JP2011236229A |
To provide use of certain cyclopropyl carboxylic acid esters in a process for the preparation of intermediates that can be used in the synthesis of pharmaceutically active entities, and to provide the intermediates provided by these proc...
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JP2011528358A |
The present application describes modulators of MCP-1 or CCR-2 of formula (I), or stereoisomers or prodrugs or pharmaceutically acceptable salts thereof, wherein T, W, X, Y, Z, R1, R2, R4 and R6, are defined herein. In addition, methods ...
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JP4796607B2 |
In the presence of an imide compound (e.g., N-hydroxyphthalimide) shown by the formula (2): wherein R<1> and R<2> independently represents a hydrogen atom, a halogen atom, an alkyl group, an aryl group, a cycloalkyl group; or R<1> and R<...
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JP4788068B2 |
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JP4777970B2 |
A method for treating cardiovascular disease, including hyperlipidemia and atherosclerosis, using abietane diterpenoid compound or terpenoid compound isolated from Torreya nucifera as an effective ingredient. The abietane diterpenoid com...
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JP4769346B2 |
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JP4742210B2 |
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JP4742239B2 |
Processes for the preparation of certain [3.1.0]hexane derivatives which are useful as mGluR agonists, and intermediates prepared during such processes.
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JP4725136B2 |
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JP4725137B2 |
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JP2011516448T |
A manufacturing method of the compound shown by formula (I) useful as an intermediate in manufacture of a medicine active compound.
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JP2011516447T |
i. a. the manufacturing method of the compound shown by a formula (Ia) useful as an intermediate in manufacture of a medicine active compound.
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JP4687844B2 |
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JP4680382B2 |
Rare earth carboxylates in solid form are prepared or treated with a solubilizing agent to improve the solids solubility in aliphatic solvents. Other methods, such as treatment of the aliphatic solvent, to improve the solubility of solid...
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JP4664424B2 |
A new platinum complex which has strong antitumor activity and has effect with smaller doses and a pharmaceutical composition containing the same are provided. A spiro[4,4]nonme-1,6-diamineplatinum(II) complex which is represented by a f...
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JP4664497B2 |
The hydrogenation of esters of benzene-dicarboxylic acids is carried out on supported catalysts containing a Sub-Group VIIII metal on a macroporous support. ?>A process for the hydrogenation of benzene-dicarboxylic acid ester(s) with h...
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JP4654914B2 |
A method of efficiently extracting a high-purity stereoisomer from a mixture comprising the endo isomer and the exo isomer of a dicarboxylic acid having a norbomene or norbomane structure, or a derivative thereof. The present invention r...
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JP2011042791A |
To provide a photochromic material incorporatable in various polymer materials.The photochromic material includes a reaction product of (a) at least one ring-openable cyclic monomer and (b) a photochromic initiator. In other non-limiting...
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JP4633400B2 |
To provide a method for industrially and advantageously producing the corresponding alicyclic polyvalent carboxylic acid and an acid anhydride thereof by hydrogenating aromatic polyvalent carboxylic acids (an aromatic polyvalent carboxyl...
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JP4633052B2 |
The present invention relates to novel modified fatty acid analogs, where a positron or gamma-emitting label is placed at a position on a fatty acid backbone and an organic substituent is substituted at the 2,3; 3,4; 4,5; 5,6 and other s...
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JP4622406B2 |
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JP2011503004A |
Embodiments in accordance with the present invention provide for forming essentially pure diastereomers of 5/6-substituted norbornene-type monomers. Further, embodiments in accordance with the present invention encompass polymerizing suc...
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JP4615564B2 |
Various non-limiting embodiments disclosed herein related to photochromic materials comprising the reaction product of (a) at least one ring-opening cyclic monomer, and (b) a photochromic initiator. Other non-limiting embodiments related...
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JP4576642B2 |
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JP4574337B2 |
To provide a novel cycloalkenylcarboxylic acid, a novel bicycloalkenylcarboxylic acid and their salts, which can be suitably used, similarly to rosin, as compounding ingredients for an antifouling coating material and, in comparison with...
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JP2010237313A |
To provide a radiation sensitive resin composition as a chemically amplified resist that is excellent in depth of focus, LWR (Line Width Roughness), and MEEF (Mask Error Enhancement Factor), and excellent also in preventing the occurrenc...
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JP2010235481A |
To provide a method for producing a phenylcyclohexene compound, which produces a desired phenylcyclohexene compound with excellent site selectivity and in high yield and a method for producing a dicyclohexane compound, which simply produ...
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JP4550017B2 |
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JP4543575B2 |
To provide a racemate of (1S, 1'S, 3S, 3'S, 4S, 4'S)dicyclohexyl-3,3',4,4'- tetracarboxylic acid dianhydride (trans-DCDA-2) and (1R, 1'R, 3R, 3'R, 4R, 4'R)-dicyclohexyl-3,3',4,4'-tetracarboxylic acid dianhydride (trans-DCDA-3) which is u...
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JP4543576B2 |
To provide a racemate of (1R, 1'R, 3R, 3'R, 4S, 4'S)- dicyclohexyl-3,3',4,4'-tetracarboxylic acid dianhydride (cis-DCDA-y) and (1S, 1'S, 3S, 3'S, 4R, 4'R)-dicyclohexyl-3,3',4,4'-tetracarboxylic acid dianhydride (cis- DCDA-z) which is use...
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JP4546798B2 |
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JP4539580B2 |
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JP4535233B2 |
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JP4527379B2 |
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