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WO/2012/035017A1 |
A process for the preparation of a compound of formula (I) which are useful as intermediates in the preparation of pharmaceutically active compounds.
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WO/2011/162350A1 |
Provided are: a process for producing a high-quality aqueous solution of a diamine dicarboxylic acid salt by simple and easy steps; and a process for producing a polyamide. The process for producing a high-quality aqueous solution of a d...
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WO/2011/121849A1 |
Disclosed is a production method for a polyamide having a norbornane skeleton. A norbornane dicarboxylic acid compound represented by general formula (I) and a diisocyanate compound are reacted in a polar solvent. Thus, the disclosed nov...
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WO/2011/120778A1 |
The invention concerns three novel polymorphic forms and several novel salts of 1-(3 ',4'-dichloro-2-fluorobiphenyl-4-yl)cyclopropanecarboxylic acid, and their use in prevention or treatment of Alzheimer's Disease.
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WO/2011/113859A1 |
A process for preparing [(1R,2R)-4-oxo-1,2-cyclopentanedicarboxylic acid II, by the resolution of racemic 4-oxo-1,2-cyclopentanedicarboxylic acid (V), said process comprising: (a) reacting 4-oxo-1,2-cyclopentanedicarboxylic acid (V) with...
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WO/2011/099112A1 |
Provided is a technique for a process for the synthesis of acrolein by reacting glycerol with supercritical water and an acid. In a case where a reaction fluid having a high glycerol concentration is employed to improve the energy effici...
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WO/2011/027618A1 |
Provided are a novel tricyclodecane monomethanol monocarboxylic acid and derivatives thereof which can be employed as starting materials for highly heat-resistant alicyclic polyester or the like. The tricyclodecane monomethanol monocarbo...
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WO/2011/015287A2 |
The invention relates to a process for the preparation of a compound of formula (IA).
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WO/2011/006621A1 |
This invention relates to novel cyclo alkyl compounds suitable for labeling by 18F, methods of preparing such a compound, compositions comprising such compounds, kits comprising such compounds or compositions and uses of such compounds, ...
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WO/2010/150847A1 |
Disclosed are a dehydroabietic acid polymer having a repeating unit comprising a dehydroabietic acid skeleton derived from dehydroabietic acid and a composite material containing the polymer.
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WO/2010/127440A1 |
The present invention relates to substituted aromatic compounds of Formula (I) and their pharmaceutical uses. Particular aspects of the invention relate to the use of those compounds in the prevention and/or treatment of various diseases...
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WO/2010/123589A2 |
A method comprising providing a starting composition comprising a polyunsaturated fatty acid, a polyunsaturated fatty ester, a carboxylate salt of a polyunsaturated fatty acid, a polyunsaturated triglyceride, or a mixture thereof; self-m...
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WO/2010/116990A1 |
A cage 1, 2, 3, 4-cyclopentanetetracarboxylic acid (1, 3:2, 4)-dianhydride compound represented by formula [1], and a polyimide obtained by condensing the compound with a diamine. With the compound, it is possible to provide a polyimide ...
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WO/2010/105574A1 |
Preparation method of pimaric acid type resin acid includes the following steps: (1) adding refined resin acid, turpentine or rosin and maleic anhydride at a mass ratio of 1 :0.3-1.5 into a reaction bottle, dissolving them in C1-C10 lowe...
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WO/2010/095604A1 |
Provided is a manufacturing method for alicyclic tetracarboxylic acids such as bicyclo [3.3.0) octane-2-exo-4-exo-6-endo-8-endo-tetracarboxylic acid of high purity and high producibility. The alicyclic tetracarboxylic acid manufacturing ...
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WO/2010/067824A1 |
A process for industrially producing an intermediate for a compound that shows an inhibitory action on an activated blood coagulation factor X and that is useful as a preventive and/or therapeutic agent for thrombotic diseases has been d...
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WO/2010/054271A1 |
This disclosure is directed to the methods of enhancing hematopoietic stem cells (HSPC) and progenitor cell (HSPC) engraftment procedure. Treatment in vivo of a HSPC donor with compounds that reduce PGE2 biosynthesis or PGE2 receptor ant...
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WO/2010/038633A1 |
Disclosed is a production process which can produce a trans-dicyclohexane derivative in high yield. The production process comprises hydrogenating a specific phenyl-trans-cyclohexane derivative in the presence of a rhodium catalyst to pr...
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WO/2010/030095A2 |
This invention relates to diol-ester based plasticiser compound, particularly to plasticisers for polyvinyl chloride (PVC), and plastics containing the same. More specifically, this invention relates to plasticisers prepared by esterific...
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WO/2010/026711A1 |
Disclosed is a new platinum complex, and medical compound containing same, which has strong antineoplastic activity and is efficacious at smaller doses. The platinum complex has a spiro [4,4]nonane-1,6-diamine represented by general form...
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WO/2010/024298A1 |
Disclosed is a compound represented by formula (I) [wherein R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as defined in the description] or a pharmaceutically acceptable salt or solvate thereof.
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WO/2010/012650A1 |
There is provided novel compounds capable of modulating the G-protein-coupled receptor GPR40, compositions comprising the compounds, and methods for their use for controlling insulin levels in vivo and for the treatment of conditions suc...
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WO/2010/010869A1 |
A process for producing a hydrogenated aromatic polycarboxylic acid which comprises hydrogenating the aromatic ring of an aromatic polycarboxylic acid in the presence of a catalyst obtained by depositing rhodium and at least one of palla...
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WO/2010/009068A2 |
The present application describes modulators of MCP-1 or CCR-2 of formula,(I) or stereoisomers or prodrugs or pharmaceutically acceptable salts thereof, wherein T, W, X, Y, Z, R1, R2, R4 and R6, are defined herein. In addition, methods o...
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WO/2010/005003A1 |
Disclosed is a method for producing (1S,2R)-2-chloro-2-fluorocyclopropanecarboxylic acid with a high yield and high selectivity. Specifically disclosed is a method for producing (1S,2R)-2-chloro-2-fluorocyclopropanecarboxylic acid, where...
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WO/2009/146659A1 |
Disclosed is a process for preparing isopimaric acid, comprising the following steps: first step: dissolving thermally isomerized rosin in acetone, adding in drops a solution of isobutanolamine in acetone to form precipitate, standing, f...
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WO/2009/121788A1 |
A process for the preparation of a compound of formula (Ia): which are useful as intermediates in the preparation of i.a. pharmaceutically active compounds.
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WO/2009/112622A1 |
The present invention describes a method for producing mero sesquiterpenes, more specifically drimenylbenzenes and drimenylnaphthoquinones, by means of a Diels-Alder reaction between a labdane diterpene and a dienophyl. Subsequently, a...
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WO/2009/089365A2 |
A highly pure asiaticoside and a pharmaceutical grade asiatic acid can be prepared, along with salts of asiatic acid, for use in formulating therapeutic compositions that are suitable for treating arthritis, psoriasis and other inflammat...
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WO/2009/077590A1 |
The present invention relates to a method for producing 2,2-dichlorocyclopropane carboxylic acid esters, wherein an α,β-unsaturated carboxylic acid ester is reacted with chloroform in the presence of an aqueous alkali metal hydroxide s...
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WO/2009/015504A2 |
Disclosed are substituted mono- or bicyclic carboxy acids that block off-notes in consumables and methods of blocking off-notes in consumables including off -notes provided by sweeteners such as stevioside, swingle extract, glycerhizin, ...
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WO/2008/149370A2 |
A general method is disclosed for the conversion of aldehydes and alkenes to the corresponding carboxylic acids and 1,2-diols. The method is carried out in a catalyst-free aqueous medium under an atmosphere of oxygen or oxygen containing...
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WO/2008/148468A1 |
The present invention relates to di(hetero)arylcyclohexane derivatives of the formula (I), in which Ar1, Ar2, R1 and R2 have the meanings indicated in the claims. The compounds of the formula (I) are valuable pharmaceutical active compou...
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WO/2008/132720A1 |
It is in the scope of the invention to disclose a biocidic textiles and fabrics, comprising at least one insoluble proton sink or source (PSS). The textiles and fabrics is provided useful for killing living target cells (LTCs), or otherw...
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WO/2008/132128A2 |
Process for the manufacture of UK- 427,857 ( Maraviroc ) which comprises a step wherein enantiopure (S)-3-amino-3-phenylpropan-1-ol is manufactured from a mixture of its enantiomers by crystallizing or precipitating from a solution conta...
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WO/2008/092955A1 |
The present invention relates to synthesis procedures and intermediates of a compound offormula: (XVII) and the salts thereof.
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WO/2008/074677A1 |
The present invention relates to a process for the preparation of 1 -(2-cthyl-butyl)-cyclohexanecarboxylic acid which is useful as an intermediate in the preparation of, pharmaceutical active compounds, comprising reacting cyclohexanecar...
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WO/2008/064432A1 |
This invention relates to compounds of Formula (I), wherein A is a carboaromatic or heteroaromatic ring having one or more substituents; R6 Formula (A) is optionally substituted with one or more substituents; and n is 0, 1 or an integer ...
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WO/2008/024892A2 |
Novel compounds are provided which are 11-beta-hydroxysteroid dehydrogenase type I inhibitors. 11-Beta-hydroxysteroid dehydrogenase type I inhibitors are useful in treating, preventing, or slowing the progression of diseases requiring 11...
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WO/2008/008837A2 |
Novel methods of increasing the biosynthesis of aromatic amino acids and compositions containing the precursors of said aromatic amino acids or nicotinamide and methods of use thereof. In addition, methods of monitoring the therapeutic e...
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WO/2007/136573A2 |
Tricyclic compounds containing a cyclopropyl carboxylic acid or carboxylic acid derivative (e.g. amide) fused to a bicyclic ring, including pharmaceutically acceptable salts and prodrugs thereof, are agonists of G-protein coupled recepto...
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WO/2007/119580A1 |
Disclosed is a process for production of a carboxylic acid chloride compound represented by the general formula (III), which comprises reacting a carboxylic acid compound represented by the general formula (I) with an acid chlorinating a...
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WO/2007/103571A2 |
A blend of two different compounds may be applied together to form a nucleating agent additive composition. This additive composition is useful as an additive in thermoplastics, polyolefins and/or polymer resins. A blend of of a bicyclo[...
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WO/2007/089781A2 |
Diamino polyacetate benzene compounds are used as a selective fluorescence probe, sensor, or binders for divalent metal ions. The compounds provide for uses as divalent metal ion sensors in diagnostic applications and binders for environ...
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WO/2007/073856A2 |
The invention relates to novel compounds of formula (I), wherein W, X, Y, Z, A, B, D, Q1, Q2, and G have the meanings indicated in the description, several methods and intermediate products for the production thereof, the use thereof as ...
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WO/2007/063974A1 |
Disclosed is a process for hydrogenating an aromatic ring of an aromatic ring compound which proceeds under comparatively mild conditions. This process for hydrogenating an aromatic ring of an aromatic ring compound can be carried out in...
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WO/2007/058156A1 |
Disclosed is a novel tetracarboxylic acid compound having excellent characteristics such as high transparency, low dielectric property, low water absorption, low thermal expansion, solvent solubility and etching characteristics, while ex...
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WO/2007/022263A1 |
The present invention relates to compounds useful for detecting the activity of human MCAD, compounds useful for competitively inhibiting human MCAD, as well as methods of manufacture thereof .
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WO/2007/002128A2 |
The invention relates to compositions and processes for producing novel hop acid formulations having improved bioavailability, and the use of such compositions as anti-inflammatory agents, dietary supplements, and pharmaceuticals.
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WO/2007/001940A2 |
The present invention provides novel amino acid compounds useful in detecting and evaluating brain and body tumors. These compounds have the advantageous properties of rapid uptake and prolonged retention in tumors and can be labeled wit...
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