Login| Sign Up| Help| Contact|

Patent Searching and Data


Matches 251 - 300 out of 2,238

Document Document Title
WO/2001/009076A2
This invention relates to new RAR selective retinoid agonists of formula (I) wherein the symbols are as defined in the specification to their pharmaceutically acceptable salts, individual isomers or to a racemic or non-racemic mixture; t...  
WO/2000/078853A1
The invention relates to the use of a cyclohexane polycarboxylic acid or of one of its derivatives, or of a mixture of one or more of said acids as plasticizers in the production of plastics which are rated toxicologically favourable. In...  
WO/2000/078701A1
The present invention relates to an improved process for the hydrogenation of phthalic acids over a supported palladium catalyst. Phthalic acids are hydrogenated with improved selectivity in aqueous solution over palladium on carbon cata...  
WO/2000/076991A1
A process is provided for preparing chiral cyclopropane carboxylic acids, preferably of structure (I) which are intermediates used in preparing acyl guanidine sodium/proton exchange (NHE) inhibitors.  
WO/2000/073253A1
Compounds are disclosed that have the chemical structure of Formula (II) and (IIB) and their produg esters and acid-addition salts, and that are useful as Interleukin-1 and Tumor Necrosis Factor-a modulators, and thus are useful in the t...  
WO/2000/046174A1
Disclosed herein is a method of preparing cyclohexanecarboxylic acid in which 1,3-butadiene and acrylic acid are subjected to [2+4] Diels-Alder reaction to produce 3-cyclohexene-1-carboxylic acid which is then hydrogenated. The [2+4] Die...  
WO/2000/046175A1
The present invention relates to a new microbial process for the preparation of compound formula (I) from a compound of general formula (II) wherein R stands for an alkali metal or ammonium ion, by the submerged cultivation of a mold str...  
WO/2000/014080A1
4-Methyl-4-(4-methylpent-3-en-1-yl)-2-oxetanone of formula (I) or its oligomer are new intermediate products for the preparation of a series of geranic acid derivatives. Geranic acid derivatives are important synthetic building blocks in...  
WO/1999/062913A1
Rare earth carboxylates in solid form are prepared or treated with a solubilizing agent to improve the solids solubility in aliphatic solvents. Other methods, such as treatment of the aliphatic solvent, to improve the solubility of solid...  
WO/1999/062875A1
The present invention relates to novel amidino compounds of formula (I), or a salt, solvate, or physiologically functional derivative thereof; wherein R?1¿ is selected from C¿1-4? alkyl, C¿3-4? cycloalkyl, C¿1-4? hydroxyalkyl, and C...  
WO/1999/054324A1
A process for the preparation of $i(cis)-6,6-dimethyl-3-oxa-bicyclo[3.1.0]hexan-2-one which comprises either: 1) reacting a sulphonic ester of $g(b),$g(b)-dimethyl-$g(g)-(hydroxymethyl)-$g(g)-butyrolacto ne with a compound of formula M(C...  
WO/1999/052877A1
Non-antibody multimeric receptor ligands, methods for making and identifying them and their use for agonizing or antagonizing multimeric receptors.  
WO/1999/052849A1
The present invention relates to the oxidation of a primary alcohol of Formula (II) to the carboxylic acid of Formula (I): R?1¿CH¿2?OH$m(7)R?1¿CO¿2?H.  
WO/1999/051562A1
The present invention provides new retinoid compounds and uses of the compounds in humans and animals for chemoprevention of skin and/or breast cancer and for therapy of leukemia.  
WO/1999/047489A1
The invention relates to a process for the manufacture of (2S,2'R,3'R)-2-(2,3-dicarboxyl-cyclopropyl)-glycine of formula (I), wherein R¿2? is hydrogen or tritium. The compounds can be used as a pharmacological tool to study the function...  
WO/1999/032426A1
Compounds of formula (I) in which R represents the remainder of an alcohol used in the pyrethroid series, in all their possible stereoisomer forms as well as their mixtures, and compositions comprising them. The compounds of formula (I) ...  
WO/1999/032427A1
The invention relates to a method for hydrogenating a benzene polycarboxylic acid or a derivative thereof or of a mixture comprised of two or more thereof with a gas containing hydrogen in the presence of a catalyst. Said catalyst compri...  
WO/1999/023056A1
The present invention relates to a high-efficiency anti-epileptic preparation that comprises one of several new derivatives of alicyclic carboxylic acid. In a same aspect, this invention also relates to the alkaline metal salts or alkali...  
WO/1999/021824A1
The invention is a novel series of cyclic amino acids which are useful in the treatment of epilepsy, faintness attacks, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorders, gastrointestinal disorder...  
WO/1999/012883A1
The invention relates to a method for producing cyclopentanone and cyclopentene-1-carboxylic acid or their esters of formula (I) COOR, wherein R represents hydrogen or an aliphatic radical with 1 to 6 C-atoms or a cycloaliphatic, araliph...  
WO/1998/030329A1
At least one functional group selected between nitro and carboxyl groups can be introduced into a substrate by bringing the substrate into contact with at least one reactant selected from among (i) nitrogen oxides and (ii) carbon monoxid...  
WO/1998/025875A1
Compounds of the formula (1) where the symbols have the meaning defined in the specification, have retinoid, retinoid antagonist and/or retinoid inverse-agonist-like biological activity.  
WO/1998/023575A1
The present invention relates to asiatic acid derivatives having a modified A-ring, which are represented by formula (1), and anticancer agents and liver-function protecting agents containing the same as an active component.  
WO/1998/018745A1
A process for the removal of catalyst poisons from hops and hop extracts is disclosed. After processing the hops to extract the alpha or beta acids therein, the alpha or beta acids are treated with activated nickel catalyst. The activate...  
WO/1998/010091A1
A process for preparing a particular optically active isomer of a 2-halo-2-fluorocyclopropanecarboxylic acid from a 2-halo-2-fluorocyclopropanecarboxylic ester comprising a mixture of optically active isomers. The process is characterize...  
WO/1997/047194A1
Compounds represented by formula (I), and pharmaceutically acceptacle salts thereof; and their method of preparation are provided. Compounds of the above formula are influenza virus neuraminidase inhibitors and can be used in treating pa...  
WO/1997/042156A1
The present invention provides compounds which inhibit an envelope virus by inhibiting the fusion of the virus with the host cell. The virus may be inhibited in an infected cell, a cell susceptible of infection or a mammal in need thereof.  
WO/1997/042155A1
The present invention provides compounds which inhibit an envelope virus by inhibiting the fusion of the virus with the host cell. The virus may be inhibited in an infected cell, a cell susceptible of infection or a mammal in need thereof.  
WO/1997/003941A1
The compounds 3-(2,2-dichloro-3,3,3-trifluoro-1-hydroxypropyl)-2,2-dimethy l-(1R,3R)-cyclopropane carboxylic acid, cis-3-(2,2-dichloro-3,3,3-trifluoro-1-hydroxypropyl)-2,2-dim ethyl-cyclopropane carboxylic acid and (1R,5S)-4-(1,1-dichlor...  
WO1996037201A3  
WO/1996/037201A2
Disclosed are novel classes of antiandrogenic compounds including saturated and unsaturated fatty acids, catechin gallates, their derivatives, and synthetic analogs, and their use in treating disorders associated with androgenic activiti...  
WO/1996/036631A1
The invention is directed to multiply-substituted fullerene derivatives of novel configurations, and methods for their preparation and use. The methods involve the combinatorial synthesis of a library of fullerene derivatives and compris...  
WO/1996/032382A1
Substituted 1-phenylpyrazole-3-carboxamides of formula (I) are disclosed for use as compounds having high affinity for human neurotensin receptors.  
WO/1996/020160A1
This invention relates to certain 1,3,3-(trisubstituted)cyclohexane dimers and related compounds which are useful in treating allergic and inflammatory diseases and for inhibiting the production of Tumor Necrosis Factor (TNF).  
WO/1996/017819A1
The object of the present invention is to provide asiatic acid derivatives (I), its pharmaceutically acceptable salts or esters. Asiatic acid, its trisaccharide asiaticoside and madecassic acid, extracted from Centella asiatica have been...  
WO/1996/015099A1
The present invention relates to therapeutically active heterocyclic compounds of formula (I) wherein n is 0, 1 or 2; and X is -O-, -S, -N(R5)- or -CH2-; and R1 is H, NH2, NHR5 or OH; and R2 and R3 independently are H, COOH, COOR5, CONH2...  
WO/1996/015096A1
Inhibitors for matrix metalloproteases, pharmaceutical compositions containing them, and a process for using them to treat a variety of physiological conditions. The compounds of the invention have the generalized formula (T)xA-B-D-E-G, ...  
WO/1996/015100A1
The present invention relates to therapeutically active heterocyclic compounds of formula (I), wherein n is 0, 1 or 2; and X is -O-, -S, -N(R5)- or -CH2-; and R1 is H, NH2, NHR5 or OH; and R2 and R3 independently are H, COOH; COOR5, CONH...  
WO/1996/010554A1
Disclosed is a process for the preparation of cyclopropanecarboxylic acid by the non-catalytic, oxidation of cyclopropanecarboxaldehyde using molecular oxygen as the oxidant. Also disclosed are processes for the preparation of amides, es...  
WO/1996/008473A1
An improved process for the preparation of R (+) 1,2,3,6-tetrahydro-4-phenyl-1-[(3-phenyl-3-cyclohexen-1-yl)m ethyl]pyridine by a novel synthesis is described where 5-oxo-3-phenyl-3-cyclohexene-carboxylic acid is converted in five operat...  
WO/1996/005191A1
Compounds, methods and compositions are provided for inducing natriuresis in a mammal. Methods for isolating and synthesizing the natriuretic compounds are also provided. Therapeutic methods using the natriuretic compounds are also provi...  
WO/1996/004230A1
Terpene-quinone with antitumor activity defined from a cyclocondensation reaction of Diels-Alder, used to obtain families or series of said compounds having a new structure and presenting a cytotoxic activity to cellular cultures P-388, ...  
WO/1996/003358A1
Halogenated compounds are prepared by ring opening reactions of highly fluorinated cyclopropanes with chlorine, bromine, iodine, or mixtures thereof at temperatures over 100 �C. A novel compound, which is one type of compound produced,...  
WO/1995/034300A1
Process for the preparation of (-)-pimara-9(11), 15-diene-19-oic acid(acanthoic acid) and pharmaceutical compositions comprising acanthoic acid useful for the treatment of diseases caused by an excessive production of interleukin-1 or tu...  
WO/1995/026928A1
Vanadium-containing Beta zeolite, and its use as catalyst in organic reactions.  
WO/1995/021149A1
A cyclooctadiene derivative represented by general formula (I), and an agrohorticultural bactericide, antimold and antithrombocytic agent each containing the derivative (I) (i) or (ii), wherein A1 to A4 represent each COOR5 (R5 being H, ...  
WO/1995/019337A1
The present invention relates to a high enantio-selective process for producing pure enantiomeric cyclopentane and cyclopentene-'beta'-amino acids of the general formula (I) in which A and L, A and D or E and L, D and E, R2, R3, T and R1...  
WO/1995/001960A1
The present invention relates to analogues of vitamin D, which lack the combined presence of the trans-fused six-membered C-ring and of five-membered D-ring, but still possess a central part consisting of a subsituted chain of five atoms...  
WO/1994/026687A1
Compounds of formula (I) wherein m is 1-4; R1-R4 independdently are hydrogen, lower alkyl of 1 to 6 carbons, Cl, Br, or I; R5 is hydrogen, lower alkyl of 1 to 6 carbons, Cl, Br, I, lower alkoxy or lower thioalkoxy of 1-6 carbons; R6 is h...  
WO/1994/025013A1
Novel indane and indene derivatives are described which are endothelin receptor antagonists.  

Matches 251 - 300 out of 2,238