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WO/2005/021479A1 |
The present invention provides novel benzotropolone derivatives represented by the general formula: including neotheaflavate B and EGCGCa. The benzotropolone derivatives of the present invention are effective antioxidant and anti-inflamm...
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WO/2005/009330A2 |
The invention relates to a method of obtaining inhibitors of the type II dehydroquinase enzyme and the precursors thereof from (-)-quinic acid, the aforementioned compounds having a carboxycyclohexene structure. More specifically, the in...
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WO/2004/091604A1 |
This invention relates to compounds that alter PPAR activity. The invention also relates to pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, and methods...
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WO/2004/092145A1 |
Alpha substituted carboxylic acids of formula (I): wherein R' and R2 are as defined in the specification and R3 is A) formula (II); B) formula (III); C) formula (IV); and D) formula (V); wherein Y, Art, Are, AP, R4, R5, R6, R7, R6, R9, R...
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WO/2004/089887A1 |
A new industrially applicable process for the production of 9-(Z)-retinoic acid is described which is characterized by the conversion of an alkali metal salt of 3-methyl-4-oxocrotonic acid with a C15-triphenyl-phosphonium salt. 9-(Z)-ret...
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WO/2004/067489A2 |
The present invention relates to novel hydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and conditions such as, but not limited to aging, Alzheimer's Dis...
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WO/2004/052850A2 |
Methods and compounds for production of cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV are provided.
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WO/2003/087316A2 |
Incubations with Nocardia sp., NRRL 5646 were conducted to produce new derivatives of the abietane-diterpene chemoprotectant and antioxidant, carnosic acid. Reduction of the C-20 carboxylic acid functional group followed by methylation a...
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WO/2003/059339A1 |
Novel tricyclic−bis−enone derivatives (TBEs) as well as the process for the preparation of such TBEs are provided. Also provided are methods for prevention and&sol or treatment of cancer, Alzheimer's disease, Parkinson's disease, mul...
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WO/2003/053915A2 |
This invention relates to compounds of the Formula (I):(Chemical formula should be inserted here as it appears on abstract in paper form)(I)or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the tre...
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WO/2003/029391A1 |
A process for industrially and efficiently producing fat compositions containing oleanolic acid, maslinic acid, physiologically acceptable salts thereof and derivatives of the same. This process involves the step of extracting olive plan...
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WO/2003/011808A1 |
Are described compounds of Formula (I) in which R, R', R'', A, and D have the meanings described in the text, as useful agents in the cure of pathologies characterised by altered angiogenesis and as antitumorals.
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WO/2002/088061A1 |
A novel compound which is highly effective in ameliorating the cellular disorders caused by radicals and in inhibiting the neurotoxicity induced by excitatory neurotransmitters such as glutamic acid. It is a compound represented by the f...
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WO/2002/078924A2 |
Compounds and compositions comprising specific metal salts of hexahydrophthalic acid (HHPA) in order to provide highly desirable properties within thermoplastic articles are provided. The inventive HHPA derivatives are useful as nucleati...
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WO/2002/030915A2 |
A new family of compounds, particularly aryl-indane compounds, is disclosed. The compounds may be used as inhibitors of P-glycoprotein-mediated transport. Use of the compounds to enhance bioavailability and to modulate multi-drug resista...
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WO/2002/024629A1 |
The present invention is directed to certain novel compounds represented by structural formula (I), or a pharmaceutically acceptable salt thereof, wherein R?3¿, R?5¿, R?6¿, R?7¿, R?8¿, R?11¿, R?12¿, R?13¿, Q, W, X, Y and Z are de...
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WO/2002/018611A2 |
The invention relates to the production of genetically-modified, non-pathogenic organisms and a method for the improved preparation and isolation of trans-dihydroxycyclohexadiene carboxylic acids and/or derivatives thereof and the use of...
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WO/2002/002500A1 |
Compounds of formula (I), wherein R¿1? and R¿2? are, independently of one another, H, C¿1?-C¿6?alkyl, C¿1?-C¿6?halogenalkyl, C¿1?-C¿6?alkoxy, C¿1?-C¿6?alkoxy-C¿1?-C¿6?alkyl, or C¿1?-C¿6?alkoxy-C¿1?-C¿6?alkyloxy, and R¿3?...
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WO/2002/000609A2 |
Formula (I) compounds are described where the groups are as defined in the description, as well as processes for their preparation and their use as medicaments, particularly for the preparation of medicaments with phosphodiesterase IV in...
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WO/2001/095899A2 |
The present invention relates to cannabidiol derivatives and to pharmaceutical compositions comprising cannabidiol derivatives being antiinflammatory agents having analgesic, antianxiety, anticonvulsive, neuroprotective, antipsychotic an...
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WO2000066111A9 |
Method of treatment of lymphoproliferative and autoimmune disorders with a new composition of four boswellic acids including beta -boswellic acid, 3-O-acetyl- beta -boswellic acid, 11-keto- beta -boswellic acid, and 3-O-acetyl-11-keto- b...
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WO/2001/074770A1 |
The invention relates to novel C¿2? phenyl-substituted cyclic keto-enols of formula (I), in which W, X, Y, Z and CKE have the meanings as cited in the description. The invention also relates to methods for producing said C¿2? phenyl-su...
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WO/2001/068891A1 |
A method of purifying shikimic acid characterized by treating a shikimic acid-containing solution with an alkali, adsorbing shikimic acid by an anion exchange resin and then eluting it. As the anion exchange resin, it is preferable to us...
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WO/2001/051451A2 |
The present invention provides a method for preparing betulin-3-acetate including alcoholyzing betulin 3,28-dibenzoate; a process for preparing betulin-3-acetate including: (1) acylating betulin to provide betulin 3,28-dibenzoate and (2)...
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WO/2001/032169A1 |
The invention provides novel pharmaceutical compositions comprising as the active ingredient 4-phenyl pinene derivatives which are specific for the peripheral cannabinoid receptors. In particular, the compounds of the invention binds eff...
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WO/2001/016085A1 |
The process for producing a vic-dichloro acid fluoride compound in a short process and in good yield from the starting material which is inexpensive and readily available is provided. (R?H1¿-E¿H1?-)CR?H2¿R?H3¿CH¿2?-OCOR?HB¿ (I) is ...
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WO/2001/010885A2 |
The invention provides methods for separating outer birch bark from inner birch bark. The invention also provides methods for isolating betulin; lupeol; betulinic acid; 9,10-epoxy-18-hydroxyoctadecanoic acid; 9,10,18-trihydroxyoctadecano...
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WO/2000/073253A1 |
Compounds are disclosed that have the chemical structure of Formula (II) and (IIB) and their produg esters and acid-addition salts, and that are useful as Interleukin-1 and Tumor Necrosis Factor-a modulators, and thus are useful in the t...
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WO/2000/066525A1 |
Bicycloheptene compounds represented by general formula (1) and being useful as intermediates for the production of agricultural chemicals or drugs (wherein X is hydroxycarbonyl, hydroxymethyl, halogenomethyl, nitromethyl, or methylthiom...
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WO2000046235B1 |
The invention relates to novel betulinic acid derivatives of structural formula having modifications at C2, C3, C17, C20 and/or C29 positions, said derivatives being useful as inhibitors of tumor/cancer cells; process for preparation of ...
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WO/2000/063148A1 |
Salt of asiatic and madecassic acid with pharmaceutically acceptable organic bases, suitable for the preparation of pharmaceutical and cosmetic compositions for the topic and systemic treatment of erithema, varicose ulcers, venous insuff...
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WO/2000/058258A1 |
Compounds which are useful in the efficient synthesis of 2-amino-4-oxobicyclo[3.1.0]hexane-2,6-dicarboxylic acid. The compounds are 2-oxobicyclo[3.1.0]hexane-6-carboxylic acid derivatives represented by formula (1) [wherein R?1¿ represe...
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WO/2000/056702A1 |
The present invention relates to the use of certain resorcinol derivatives as skin lightening agents.
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WO/2000/039249A1 |
Ume ($i(Prunus mume) SIEB. et Zucc.) leaf, stem, nucleus and flower are extracted 5 times by volume as much methanol. The obtained extract has an antioxidative effect, an inhibitory effect on gastric mucosa damage, an aldose reductase in...
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WO/2000/037410A1 |
(1S,5R,6S)- or (1SR,5RS,6SR)-3-fluoro-2-oxobicylo[3.1.0]-hex-3-ene-6-carbox
ylic acid derivatives represented by general formula (1); a process for producing the same; and a process for efficiently producing a fluorine-containing amino a...
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WO/2000/026174A2 |
A process is disclosed, for preparing a derivative of a targeted natural product from plants. The targeted natural product is extracted from the desired part of the plant and the targeted natural product is transformed into the desired d...
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WO/2000/020371A1 |
Compounds and methods for treating prostaglandin mediated diseases, and certain pharmaceutical compositions thereof are disclosed. The compounds are represented by formula (II): Ar?1¿-W-Ar?2¿-X-Q. The compounds of the invention are str...
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WO/2000/010963A1 |
The invention relates to substituted cinnamic acids and cinnamic acid esters of formula (1), whereby X represents F, Cl or J and R?1¿ and R?2¿ are the same or different and represent hydrogen, an optionally substituted C¿1?-C¿10?-alk...
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WO/1999/051562A1 |
The present invention provides new retinoid compounds and uses of the compounds in humans and animals for chemoprevention of skin and/or breast cancer and for therapy of leukemia.
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WO/1999/043649A1 |
The invention relates to new arylphenyl-substituted cyclic keto-enols of the formula (I), where X is halogen, alkyl, alkoxy, alkenyloxy, alkylthio, alkyl sulfinyl, alkyl sulfonyl, halogen alkyl, halogen alkoxy, halogen alkenyloxy, nitro,...
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WO/1999/037600A1 |
The present invention relates to diterpene derivatives prepared from the components which are extracted from Acanthopanax Koreanum and represented by Chemical Formula (1).
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WO/1999/025672A1 |
The invention relates to a method for producing 1,6-hexanediol and 6-hydroxycaproic acid or their esters by the catalytic hydrogenation of adipic acid, adipic acid monoesters or adipic acid diesters or educt flows containing adipic acid ...
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WO/1998/052930A1 |
A process for producing cyclobutane derivatives useful as intermediates for cyclobutanenucleoside derivatives and the like useful as an antiviral agent; the novel intermediates; and a method for optical resolution. The cyclobutane deriva...
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WO/1998/046554A1 |
A novel process for the production of the natural antioxidant, carnosic acid, by extracting it from rosemary leaves with an aqueous solution of a lower alkyl alcohol in the presence of a water soluble acid is described. The extraction of...
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WO/1998/040344A1 |
2-(substituted benzoyl)-cycloalkyl-1-carboxylic acids of formula (I) wherein E is a C�1?-C�4? alkylene chain in which a carbon atom is optionally substituted; each of R and R�1?, being the same or different, is hydrogen, halogen, h...
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WO/1998/040337A1 |
An adamantane derivative having a functional group such as nitro, amino, hydroxyl, carboxyl, hydroxymethyl or isocyanato is oxidized with oxygen in the presence of an imide compound of general formula (2) (such as N-hydroxyphthalimide) o...
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WO/1998/039281A1 |
New 2-aryl-3-hydroxy-$g(D)?2�-cyclopentene-1-one derivatives of formula (I) are disclosed, in which A, B, D?1�, D?2�, G, W, X, Y et Z have the meanings given in the description, as well as processes for preparing the same and their...
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WO/1998/033758A1 |
A compound of formula (I), wherein R?1� and R?2� each represents a lower alkyl, or R?1� and R?2� may be bonded together to form a ring; X represents a spacer of which the number of atoms constituting the principal chain is 1 to 1...
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WO/1998/030329A1 |
At least one functional group selected between nitro and carboxyl groups can be introduced into a substrate by bringing the substrate into contact with at least one reactant selected from among (i) nitrogen oxides and (ii) carbon monoxid...
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WO/1998/023575A1 |
The present invention relates to asiatic acid derivatives having a modified A-ring, which are represented by formula (1), and anticancer agents and liver-function protecting agents containing the same as an active component.
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