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WO/2009/022041A1 |
The invention relates to an ointment for treating and healing human skin diseases, such as psoriasis, dermatitis, acne, herpes and fungal diseases, consisting of a composition obtained from ingredients such as petroleum jelly, clobetasol...
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WO/2009/002733A1 |
A method for producing benzoic acid or a methylbenzoic acid isomer is disclosed which comprises forming a dispersion comprising oxygen-containing gas bubbles dispersed in either toluene or an xylene isomer, wherein the bubbles have a mea...
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WO/2008/155520A2 |
The invention provides a compound of the general formula (I) for use in the topical treatment of infection, inflammation and/or pain: wherein R1 independently represents a methylene group, an ethylene group or a straight or branched chai...
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WO/2008/152334A2 |
The invention relates to novel derivatives of 3-phenyl acrylic acid of the following general formula (I), to a method for preparing the same, and to the use thereof in pharmaceutical compositions used in human or veterinary medicine (in ...
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WO/2008/134766A1 |
The present invention relates to cell culture medium compositions comprising lipophilic compounds and solubilizing agent and methods of using such compositions for the culturing of cells. The invention also relates to methods of treating...
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WO/2008/126104A2 |
Disclosed herein is a process for the preparation of the adamantyl derivative 6-[3-(l- Adamantyl) - 4 - methoxy phenyl] - 2 - naphthoic acid known as adapalene employing a novel intermediate 3 - Adamantyl - 4 - methoxyphenyl potassium tr...
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WO/2008/119458A1 |
The invention relates to novel substituted dibenzoic acid derivatives of formula (I), wherein A represents a group of formula (II) or (III), to methods for producing the same, and to their use in the treatment and/or prophylaxis of disea...
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WO/2008/109697A2 |
Compounds of Formula I, wherein Ar, L, m, R1, R2, R3, W, X, Y, Z are as defined in the claims, are described that are active on at least one of PPARα, PPARδ and PPARγ, which are useful for therapeutic and/or prophylactic methods invol...
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WO/2008/086942A2 |
A method for preparation of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid is disclosed based on "one pot" synthesis approach including a direct synthesis of boronic acid derivative from 2-(1-adamantyl)-4-bromoanisole and cyclobora...
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WO/2008/085512A1 |
Three different reaction steps were combined to provide methods for preparing p-hydroxystyrene and p-hydroxycinnamic acid monomers from tyrosine. The three steps include reductive alkylation of tyrosine, followed by oxidation to the N-ox...
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WO2007121312A9 |
The present invention provides chromium compounds which possess the ability to improve insulin sensitization, glucose tolerance, blood lipid metabolism, lean body mass, bioavailability, and safety as compared to chromium nicotinate, chro...
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WO/2008/080992A2 |
A process for preparation of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid from 2-(1-adamantyl)-4-bromanisolee is disclosed, based on transformation of 2-(1-adamantyl)-4-bromanisole into a Grignard's reagent by using metallic magn...
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WO/2008/082510A1 |
Ethers of aromatic acids are produced from halogenated aromatic acids in a reaction mixture containing a copper (I) or copper (II) source and an amino acid ligand that coordinates to copper.
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WO/2008/079225A1 |
Ethers of aromatic acids are produced from halogenated aromatic acids in a reaction mixture containing a copper (I) or copper (II) source and a diketone ligand that coordinates to copper.
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WO/2008/079218A1 |
Ethers of aromatic acids are produced from halogenated aromatic acids in a reaction mixture containing a copper (I) or copper (II) source and a diamine ligand that coordinates to copper.
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WO/2008/066819A1 |
2,5-dihydroxyterephthalic acid is produced in high yields and high purity from 2,5-dihaloterephthalic acid by contact with a copper source and a ligand that coordinates to copper under basic conditions.
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WO/2008/066820A1 |
Hydroxy aromatic acids are produced in high yields and high purity (>95%) from halogenated aromatic acids in a reaction mixture containing a copper source and a ligand that coordinates to copper.
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WO/2008/066827A1 |
Hydroxy aromatic acids are produced in high yields and high purity (>95%) from halogenated aromatic acids in a reaction mixture containing a copper source and a ligand that coordinates to copper.
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WO/2008/066823A1 |
Hydroxy aromatic acids are produced in high yields and high purity (>95%) from halogenated aromatic acids in a reaction mixture containing a copper source and a ligand that coordinates to copper.
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WO/2008/066821A1 |
2,5-dihydroxyterephthalic acid is produced in high yields and high purity from 2,5-dihaloterephthalic acid by contact with a copper source and a ligand that coordinates to copper under basic conditions.
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WO/2008/066822A1 |
Hydroxy aromatic acids are produced in high yields and high purity (>95%) from halogenated aromatic acids in a reaction mixture containing a copper source and a ligand that coordinates to copper.
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WO/2008/066825A1 |
2,5-dihydroxyterephthalic acid is produced in high yields and high purity from 2,5-dihaloterephthalic acid by contact with a copper source and a ligand that coordinates to copper under basic conditions.
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WO/2008/066824A1 |
2,5-dihydroxyterephthalic acid is produced in high yields and high purity from 2,5-dihaloterephthalic acid by contact with a copper source and a ligand that coordinates to copper under basic conditions.
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WO/2008/058402A1 |
The invention is directed to compounds and methods for treating protein folder disorders. In certain embodiments the invention provides compounds and methods for treating neurodegenerative diseases such as Alzheimer's disease, tauopathy,...
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WO/2008/053974A1 |
Disclosed is a radiation-sensitive composition containing a resist compound which enables to obtain a resist pattern with a good shape, while having high sensitivity, high resolution, high etching resistance and low outgas. Also disclose...
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WO/2008/048117A2 |
The present invention provides an improved synthesis of 9-oxo-9H-xanthen-4-yl-acetic acids, and in particular 5,6-dimethyl-9-oxo-9H-xanthen-4-yl-acetic acid (also known as 5,6-dimethylxanthenone-4-acetic acid and DMXAA and ASA404) from c...
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WO/2008/044034A1 |
The invention provides an acid addition salt of a compound of the formula (1) Also provided by the invention are processes for preparing the compound of formula (1) and alkyl analogues thereof, novel intermediates for use in the process ...
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WO/2008/044568A1 |
A bis(hydroxymethyl-hydroxyphenyl)alkane is reacted with hexamethylenetetramine in the presence of an acid, and the resulting reaction product is then hydrolyzed, thereby producing a bis(hydroxyl-formylphenyl)alkane, which is used as a d...
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WO/2008/018692A1 |
Disclosed herein are novel chalcone derivatives, which are low-molecular nonpeptide substances as interleukin-5 (IL-5) inhibitors having the effect of treating chronic allergic diseases, as well as a preparation method thereof and the us...
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WO/2008/015241A1 |
The present invention is related to a family of phenyl-prenyl-ether derivatives of formula (I), and to their use in the treatment of cognitive, neurodegenerative or neuronal diseases or disorders, such as Alzheimer's disease or 5 Parkins...
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WO/2008/001391A2 |
The present invention relates to compounds of structural formula (I) as site-specific inhibitor of histone methyltransferase, where R1 and R1 is -OCH or -OH, R2 and R2 is -OH or -OAc; a process of isolating compound of structural formula...
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WO/2007/133783A1 |
Halogenated cyclic lactones, polymers made from halogenated cyclic lactones and compositions containing such polymers provide antimicrobial properties and are suitable for use in making textiles, medical devices, delivery agents, packagi...
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WO/2007/125542A2 |
The present invention discloses a process for preparation of highly pure Adapalene, chemically designated as 6-[3-(l-adamantyl)-4-methoxy phenyl]-2-naphthoic acid (I) comprising: a) reacting 1-adamantanol with 4-bromophenol (II) in prese...
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WO/2007/121822A1 |
The current invention relates to a production method for mumbaistatin derivatives (I), wherein the basic framework of the anthraquinone is built up by means of a Diels-Alder reaction and the central methylene bridge is built up by means ...
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WO/2007/118964A1 |
The invention concerns polysubstituted N-(phenethyl)benzamide derivatives, pharmaceutical compositions containing same, as well as their therapeutic uses, in particular in the field of human and animal health. The invention also concerns...
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WO/2007/104242A1 |
The invention has disclosed 1,2,3-trihydroxy benzene and its derivatives or pharmaceutically acceptable salts of formula I for zinc ion metal-protease inhibition. These compounds are used for selective depressants of zinc ion metal-prote...
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WO/2007/102512A1 |
Disclosed is a compound which is useful as a synthetic intermediate for an anti-HIV agent having an integrase inhibitory activity. Also disclosed are a method for producing such a compound, and a method for producing an anti-HIV agent wh...
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WO/2007/102499A1 |
Disclosed are: a compound which is useful as an intermediate for the synthesis of an anti-HIV agent having an integrase-inhibiting activity; a process for production of the compound; and a process for production of an anti-HIV agent usin...
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WO/2007/093387A1 |
The present invention relates to new methoxylated aromatic compounds. It also relates to novel compositions comprising methoxylated aromatic compounds as well as to the use of these compositions as a medicament, in particular as a medica...
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WO/2007/074789A1 |
Disclosed is a novel process intermediate represented by the general formula (1) or (2): wherein X represents a halogen atom, a cyano group or the like; Y represents a halogen atom, a cyano group or the like; R1 represents a C1-C6 haloal...
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WO/2007/072217A2 |
The invention provides an improved process for the preparation of a benzonaphthalene derivative including, in particular, the manufacture of high purity adapalene. The invention further includes a method for assessing the color of adapal...
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WO/2007/068579A1 |
The invention concerns novel biphenyl compounds, as well as their use for preparing a pharmaceutical or cosmetic composition for preventing and/or treating pathological conditions for which a selective agonist activity for the gamma subt...
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WO/2007/068580A1 |
The invention concerns novel biphenyl derivatives and their use for preparing a pharmaceutical or cosmetic composition for preventing and/or treating pathological conditions in which a selective agonist activity for the gamma subtype of ...
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WO/2007/056500A2 |
Disclosed herein are novel di-aromatic compounds and methods for using various di-aromatic compounds for treatment and prevention of diseases and disorders related to estrogen receptors.
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WO/2007/045367A1 |
The present application relates to novel cyclopropylacetic acid derivatives, process for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment an...
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WO/2007/045433A1 |
The present application relates to dicarboxylic acid derivatives of general formula (I), methods for preparing the same, their use for the treatment and/or prevention of diseases, and their use for producing medicaments for the treatment...
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WO/2007/044184A1 |
This invention provides both metal carboxylates and tertiary ammonium carboxylates, in which carboxylates a benzoylphenyl group is present. Also provided are photoinitiator compositions which comprise a) (i) at least one metal carboxylat...
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WO/2007/034924A1 |
Disclosed is a metallo-β-lactamase inhibitor which can inactivate a β-lactam antibiotic and recover the anti-bacterial activity of the β-lactam antibiotic. A maleic acid derivative having a structure of the general formula (I) has an ...
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WO/2007/033192A1 |
. The present invention provides salt forms of the formula below wherein R is H or OH, and compositions thereof, useful as modulators of one or more GPCRs and which exhibit desirable characteristics for the same.
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WO/2007/020795A1 |
Gallic acid derivatives represented by the general formula (1): [wherein R1 is hydrogen, alkali metal, alkaline earth metal, transition metal, substituted or unsubstituted ammonium, or alkyl or alkenyl having 1 to 22 carbon atoms; and R2...
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